Antimicrobial resistance in low- and middle-income countries: current status and future directions

References

• Holmes AH, Moore LS, Sundsfjord A, et al. Understanding the mechanisms and drivers of antimicrobial resistance. Lancet. 2016 Jan 9;387(10014)176–187.
   PubMed Web of Science ®Google Scholar
• Tacconelli E, Carrara E, Savoldi A, et al. Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis. Lancet Infect Dis. 2018 Mar;18(3)318–327.
   PubMed Web of Science ®Google Scholar
• Klein EY, Tseng KK, Pant S, et al., Tracking global trends in the effectiveness of antibiotic therapy using the drug resistance index. BMJ Glob Health. 2019;4(2): e001315.
   PubMed Web of Science ®Google Scholar
• Teillant A, Gandra S, Barter D, et al. Potential burden of antibiotic resistance on surgery and cancer chemotherapy antibiotic prophylaxis in the USA: a literature review and modelling study. Lancet Infect Dis. 2015 Dec;15(12)1429–1437.
   PubMed Web of Science ®Google Scholar
• O’Neill J Review on Antimicrobial Resistance. Tackling drug-resistant infections globally: final report and recommendations. UK: HM Government and Welcome Trust; 2016.
   Google Scholar
• Laxminarayan R, Van Boeckel T, Frost I, et al. The lancet infectious diseases commission on antimicrobial resistance: 6 years later. Lancet Infect Dis. 2020 Apr;20(4)e51–e60.
   PubMed Web of Science ®Google Scholar
• Laxminarayan R, Duse A, Wattal C, et al. Antibiotic resistance-the need for global solutions. Lancet Infect Dis. 2013 Dec;13(12):1057–1098.
   PubMed Web of Science ®Google Scholar
• Global Action Plan on Antimicrobial Resistance. Geneva, Switzerland: World Health Organization (WHO);2015.
   Google Scholar
• Global antimicrobial resistance and use surveillance system (GLASS) report 2021. Geneva, Switzerland: World Health Organization (WHO); 2021.
   Google Scholar
• Seale AC, Gordon NC, Islam J, et al. AMR surveillance in low and middle-income settings - A roadmap for participation in the global antimicrobial surveillance system (GLASS). Wellcome Open Res. 2017;2:92.
   PubMedGoogle Scholar
• Annual Report: Antimicrobial Resistance Surveillance and Research Network. January 2019 to December 2019. New Delhi, India: Indian Council of Medical Research (ICMR); 2020.
   Google Scholar
• Singh-Moodley A, Perovic O Characterisation of Staphylococcus aureus bloodstream isolates from Gauteng and Western Cape Provinces, South Africa, 2016 and 2017. Public Health Surveill Bull. Johannesburg, South Africa: National Institute for Communicable Diseases (NICD), National Health Laboratory Service (NHLS); 2018.
   Google Scholar
• Perovic O, Iyaloo S, Kularatne R, et al. Prevalence and trends of staphylococcus aureus bacteraemia in hospitalized patients in South Africa, 2010 to 2012: laboratory-based surveillance mapping of antimicrobial resistance and molecular epidemiology. PloS One. 2015;10(12):e0145429.
   PubMed Web of Science ®Google Scholar
• Laxminarayan R, Klugman KP. Communicating trends in resistance using a drug resistance index. BMJ Open. 2011;1(2):e000135.
   PubMed Web of Science ®Google Scholar
• Cope Z. Value Transfer. In: The Wealth of (Some) Nations. London, United Kingdom: Pluto Press; 2019. p. 9–21.
   Google Scholar
• Kirchhelle C. Pharming animals: a global history of antibiotics in food production (1935–2017). Palgrave Commun. 2018 2018 08 07;4(1):96.
   Google Scholar
• Landers TF, Cohen B, Wittum TE, et al. A review of antibiotic use in food animals: perspective, policy, and potential. Public Health Rep. 2012 Jan-Feb;127(1)4–22.
   Google Scholar
• Graham JP, Leibler JH, Price LB, et al. The animal-human interface and infectious disease in industrial food animal production: rethinking biosecurity and biocontainment. Public Health Rep. 2008 May-Jun;123(3)282–299.
   Google Scholar
• Daka D, Gs S, Yihdego D. Antibiotic-resistance staphylococcus aureus isolated from cow’s milk in the Hawassa area, South Ethiopia. Ann Clin Microbiol Antimicrob. 2012 Sep 17; 11(1):26.
   PubMedGoogle Scholar
• Ateba CN, Mbewe M, Moneoang MS, et al. Antibiotic-resistant staphylococcus aureus isolated from milk in the Mafikeng Area, North West province, South Africa. S Afr J Sci. 2010;106(11/12):1–6. .
   Web of Science ®Google Scholar
• Finley RL, Collignon P, Larsson DG, et al. The scourge of antibiotic resistance: the important role of the environment. Clin Infect Dis. 2013 Sep;57(5)704–710.
   PubMed Web of Science ®Google Scholar
• Liu YY, Wang Y, Walsh TR, et al. Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study. Lancet Infect Dis. 2016 Feb;16(2)161–168.
   PubMed Web of Science ®Google Scholar
• Arcilla MS, van Hattem JM, Matamoros S, et al. Dissemination of the mcr-1 colistin resistance gene. Lancet Infect Dis. 2016 Feb;16(2)147–149.
   PubMedGoogle Scholar
• Sales of veterinary antimicrobial agents in 31 European countries in 2018. Trends from 2010 to 2018. Tenth ESVAC report. Amsterdam, The Netherlands: European Surveillance of Veterinary Antimicrobial Consumption, Veterinary Medicine Division, European Medicines Agency (EMA); 2020.
   Google Scholar
• Van Boeckel TP, Brower C, Gilbert M, et al. Global trends in antimicrobial use in food animals. Proc Natl Acad Sci U S A. 2015 May 5;112(18)5649–5654.
   PubMed Web of Science ®Google Scholar
• Lam Y, Fry JP, Hu E, et al. Industrial Food Animal Production in Low- and Middle-Income Countries: a Landscape Assessment. Baltimore, MD, United States: Johns Hopkins Center for a Livable Future; 2016.
   Google Scholar
• Sans P, Combris P. World meat consumption patterns: an overview of the last fifty years (1961-2011). Meat Sci. 2015 Nov; 109:106–111.
   PubMed Web of Science ®Google Scholar
• Lam Y, Fry JP, Nachman KE, et al. Applying an environmental public health lens to the industrialization of food animal production in ten low- and middle-income countries. Global Health. 2019 Jun 13;15(1):40.
   PubMedGoogle Scholar
• Wallace R. Big Farms Make Big Flu: dispatches on Influenza, Agribusiness, and the Nature of Science. New York, NY, United States: Monthly Review Press, NYU Press; 2016.
   Google Scholar
• Iskandar K, Molinier L, Hallit S, et al. Drivers of antibiotic resistance transmissionin low- and middle-income Countriesfrom a “One Health” perspective-A review. Antibiotics (Basel). 2020 Jul 1;9(7):372.
   Web of Science ®Google Scholar
• Laxminarayan R, Chaudhury RR. Antibiotic resistance in India: drivers and opportunities for action. PLoS Med. 2016 Mar;13(3):e1001974.
   PubMed Web of Science ®Google Scholar
• Gandra S, Joshi J, Trett A, et al. Scoping Report on Antimicrobial Resistance in India. Washington D.C., USA: Center for Disease Dynamics, Economics and Policy (CDDEP); 2017.
   Google Scholar
• Antimicrobial resistance and primary health care. Technical series on primary health care. Geneva, Switzerland: World Health Organization (WHO); 2018.
   Google Scholar
• Auta A, Hadi MA, Oga E, et al. Global access to antibiotics without prescription in community pharmacies: a systematic review and meta-analysis. J Infect. 2019;78(1):8–18.
   PubMed Web of Science ®Google Scholar
• Center for Disease Dynamics, Economics and Policy. State of the World’s Antibiotics 2015. Washington D.C., USA: Center for Disease Dynamics, Economics and Policy (CDDEP); 2015.
   Google Scholar
• Llor C, Bjerrum L. Antimicrobial resistance: risk associated with antibiotic overuse and initiatives to reduce the problem. Ther Adv Drug Saf. 2014 Dec;5(6):229–241.
   PubMedGoogle Scholar
• Sulis G, Adam P, Nafade V, et al., Antibiotic prescription practices in primary care in low- and middle-income countries: a systematic review and meta-analysis. PLoS Med. 2020;17(6): e1003139.
   PubMed Web of Science ®Google Scholar
• Mackintosh M, Channon A, Karan A, et al. What is the private sector? understanding private provision in the health systems of low-income and middle-income countries. Lancet. 2016 Aug 6;388(10044)596–605.
   PubMed Web of Science ®Google Scholar
• Malik MA. Univeral health coverage assessment, Pakistan. Karachi, Pakistan: Global Network for Health Equity, Aga Khan University; 2015.
   Google Scholar
• Nafade V, Huddart S, Sulis G, et al. Over-the-counter antibiotic dispensing by pharmacies: a standardised patient study in Udupi district, India. BMJ Glob Health. 2019;4(6):e001869.
   PubMed Web of Science ®Google Scholar
• World Health Organization (WHO). WHO informal consultation on fever management in peripheral health care settings: a global review of evidence and practice. Geneva, Switzerland: World Heatlh Organization (WHO); 2013.
   Google Scholar
• D’Acremont V, Kilowoko M, Kyungu E, et al. Beyond malaria--causes of fever in outpatient Tanzanian children. N Engl J Med. 2014 Feb 27;370(9)809–817.
   PubMed Web of Science ®Google Scholar
• Crump JA, Morrissey AB, Nicholson WL, et al. Etiology of severe non-malaria febrile illness in Northern Tanzania: a prospective cohort study. PLoS Negl Trop Dis. 2013;7(7):e2324.
   PubMed Web of Science ®Google Scholar
• Mayxay M, Castonguay-Vanier J, Chansamouth V, et al. Causes of non-malarial fever in Laos: a prospective study. Lancet Glob Health. 2013 Jul;1(1)e46–54.
   PubMed Web of Science ®Google Scholar
• Acestor N, Cooksey R, Newton PN, et al. Mapping the aetiology of non-malarial febrile illness in Southeast Asia through a systematic review--terra incognita impairing treatment policies. PloS One. 2012;7(9):e44269.
   PubMed Web of Science ®Google Scholar
• Mørch K, Manoharan A, Chandy S, et al. Acute undifferentiated fever in India: a multicentre study of aetiology and diagnostic accuracy. BMC Infect Dis. 2017 Oct 4;17(1)665.
   PubMedGoogle Scholar
• Maze MJ, Bassat Q, Feasey NA, et al. The epidemiology of febrile illness in sub-Saharan Africa: implications for diagnosis and management. Clin Microbiol Infect. 2018 Aug;24(8)808–814.
   PubMed Web of Science ®Google Scholar
• Moreira J, Bressan CS, Brasil P, et al. Epidemiology of acute febrile illness in Latin America. Clin Microbiol Infect. 2018 Aug;24(8)827–835.
   PubMed Web of Science ®Google Scholar
• Shimelis T, Tadesse BT, WG F, et al. Aetiology of acute febrile illness among children attending a tertiary hospital in southern Ethiopia. BMC Infect Dis. 2020 Nov 30;20(1)903.
   PubMed Web of Science ®Google Scholar
• Bhargava A, Ralph R, Chatterjee B, et al. Assessment and initial management of acute undifferentiated fever in tropical and subtropical regions. Bmj. 2018 Nov 29;363:k4766.
   PubMedGoogle Scholar
• Sulis G, Daniels B, Kwan A, et al. Antibiotic overuse in the primary health care setting: a secondary data analysis of standardised patient studies from India, China and Kenya. BMJ Glob Health. 2020 Sep;5(9). DOI:10.1136/bmjgh-2020-003393.
   Web of Science ®Google Scholar
• Farooqui HH, Mehta A, Selvaraj S, et al. Outpatient antibiotic prescription rate and pattern in the private sector in India: evidence from medical audit data. PloS One. 2019;14(11):e0224848.
   PubMed Web of Science ®Google Scholar
• Klein EY, Van Boeckel TP, Martinez EM, et al. Global increase and geographic convergence in antibiotic consumption between 2000 and 2015. Proc Natl Acad Sci U S A. 2018 Apr 10;115(15)E3463–E3470.
   PubMed Web of Science ®Google Scholar
• Fink G, D’Acremont V, Leslie HH, et al. Antibiotic exposure among children younger than 5 years in low-income and middle-income countries: a cross-sectional study of nationally representative facility-based and household-based surveys. Lancet Infect Dis. 2020 Feb;20(2):179-187.
   Web of Science ®Google Scholar
• Chandy SJ, Thomas K, Mathai E, et al. Patterns of antibiotic use in the community and challenges of antibiotic surveillance in a lower-middle-income country setting: a repeated cross-sectional study in Vellore, South India. J Antimicrob Chemother. 2013 Jan;68(1)229–236.
   PubMed Web of Science ®Google Scholar
• Shrestha P, Roberts T, Homsana A, et al. Febrile illness in Asia: gaps in epidemiology, diagnosis and management for informing health policy. Clin Microbiol Infect. 2018 Aug;24(8)815–826.
   PubMed Web of Science ®Google Scholar
• Angus DC, Van Der Poll T. Severe sepsis and septic shock. N Engl J Med. 2013 Aug 29;369(9):840–851.
   PubMed Web of Science ®Google Scholar
• Aabenhus R, Jensen JU, Jørgensen KJ, et al. Biomarkers as point-of-care tests to guide prescription of antibiotics in patients with acute respiratory infections in primary care. Cochrane Database Syst Rev. 2014 Nov;6(11):Cd010130.
   Google Scholar
• Kapasi AJ, Dittrich S, González IJ, et al. Host biomarkers for distinguishing bacterial from non-bacterial causes of acute febrile illness: a comprehensive review. PloS One. 2016;11(8):e0160278.
   PubMed Web of Science ®Google Scholar
• Antibiotic Use and Resistance in Bangladesh. Situation Analysis and Recommendations. Washington D.C. and New Delhi: Global Antibiotic Resistance Partnership (GARP) - Bangladesh National Working Group. Center for Disease Dynamics, Economics and Policy (CDDEP); 2018.
   Google Scholar
• Khan MS, Bory S, Rego S, et al. Is enhancing the professionalism of healthcare providers critical to tackling antimicrobial resistance in low- and middle-income countries?. Hum Resour Health. 2020 Feb 11;18(1)10.
   PubMed Web of Science ®Google Scholar
• González-Plaza JJ, Blau K, Milaković M, et al. Antibiotic-manufacturing sites are hot-spots for the release and spread of antibiotic resistance genes and mobile genetic elements in receiving aquatic environments. Environ Int. 2019 Sep;130:104735.
   PubMed Web of Science ®Google Scholar
• Nijsingh N, Munthe C, Larsson DGJ, et al. Managing pollution from antibiotics manufacturing: charting actors, incentives and disincentives. Environ Health. 2019;181:95. 2019.
   PubMed Web of Science ®Google Scholar
• Woodcock J. Safeguarding Pharmaceutical Supply Chains in a Global Economy. Congressional Testimony. Washington D.C., USA: House Committee on Energy and Commerce, Subcommittee on Health; 2019.
   Google Scholar
• Thai PK, Ky LX, Binh VN, et al. Occurrence of antibiotic residues and antibiotic-resistant bacteria in effluents of pharmaceutical manufacturers and other sources around Hanoi, Vietnam. Sci Total Environ. 2018 Dec 15;645:393–400.
   PubMed Web of Science ®Google Scholar
• Khan GA, Berglund B, Khan KM, et al. Occurrence and abundance of antibiotics and resistance genes in rivers, canal and near drug formulation facilities--a study in Pakistan. PloS One. 2013;8(6):e62712.
   PubMed Web of Science ®Google Scholar
• Lübbert C, Baars C, Dayakar A, et al. Environmental pollution with antimicrobial agents from bulk drug manufacturing industries in Hyderabad, South India, is associated with dissemination of extended-spectrum beta-lactamase and carbapenemase-producing pathogens. Infection. 2017 Aug;45(4)479–491.
   PubMed Web of Science ®Google Scholar
• Davis M. The Prevalence of Slums. In: Planet of Slums. New York, NY, United States: Verso. 2006; 20–49.
   Google Scholar
• Mourkas E, Florez-Cuadrado D, Pascoe B, et al. Gene pool transmission of multidrug resistance among campylobacter from livestock, sewage and human disease. Environ Microbiol. 2019 Dec;21(12)4597–4613.
   PubMed Web of Science ®Google Scholar
• Korzeniewska E, Korzeniewska A, Harnisz M, et al. Antibiotic resistant escherichia coli in hospital and municipal sewage and their emission to the environment. Ecotoxicol Environ Saf. 2013 May;91:96–102.
   PubMed Web of Science ®Google Scholar
• Progress on drinking water, sanitation and hygiene: 2017 update and SDG baselines. Geneva, Switzerland: World Health Organization (WHO) and the United Nations Children’s Fund (UNICEF); 2017.
   Google Scholar
• Davis M. Slum ecology. In: Planet of Slums. New York, NY, United States: Verso. 2006;120–150.
   Google Scholar
• Biswas R, Arya K, Deshpande S, et al. More toilet infrastructures do not nullify open defecation: a perspective from squatter settlements in megacity Mumbai. Appl Water Sci. 2020 03 19;10(4):96. 2020.
   Web of Science ®Google Scholar
• Ramay BM, Caudell MA, Cordón-Rosales C, et al. Antibiotic use and hygiene interact to influence the distribution of antimicrobial-resistant bacteria in low-income communities in Guatemala. Sci Rep. 2020 Aug 13;10(1):13767.
   PubMed Web of Science ®Google Scholar
• Oloruntoba EO, Folarin TB, Ayede AI, et al. Hygiene and sanitation risk factors of diarrhoeal disease among under-five children in Ibadan, Nigeria. Afr Health Sci. 2014 Dec;14(4)1001–1011.
   PubMed Web of Science ®Google Scholar
• Azupogo F, Abdul-Rahaman F, Gyanteh B, et al. Hygiene and sanitation practices and the risk of morbidity among children 6–23 months of age in Kumbungu District, Ghana. Adv Public Health. 2019:4313759.
   Google Scholar
• Pickering AJ, Davis J, Walters SP, et al. Hands, water, and health: fecal contamination in Tanzanian communities with improved, non-networked water supplies. Environ Sci Technol. 2010 May 1;44(9)3267–3272.
   PubMed Web of Science ®Google Scholar
• Refugee data finder.: united Nations high commissioner for refugees (UNHCR). 2020. Available from: [2021 Apr 9]. https://www.unhcr.org/refugee-statistics/
   Google Scholar
• Nellums LB, Thompson H, Holmes A, et al. Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis. Lancet Infect Dis. 2018 Jul;18(7)796–811.
   PubMed Web of Science ®Google Scholar
• Castelli F, Sulis G. Migration and infectious diseases. Clin Microbiol Infect. 2017 May;23(5):283–289.
   PubMed Web of Science ®Google Scholar
• Bokhary H, Rashid H, Hill-Cawthorne GA, et al. The Rise of Antimicrobial Resistance in Mass Gatherings. In: Laher Ieditor. Handbook of Healthcare in the Arab World. Cham: Springer International Publishing; 2020. p. 1–16.
   Google Scholar
• Leangapichart T, Rolain JM, Memish ZA, et al. Emergence of drug resistant bacteria at the Hajj: a systematic review. Travel Med Infect Dis. 2017 Jul-Aug;18:3–17.
   PubMed Web of Science ®Google Scholar
• Fouz N, Pangesti KNA, Yasir M, et al. The contribution of wastewater to the transmission of antimicrobial resistance in the environment: implications of mass gathering settings. Trop Med Infect Dis. 2020;5(1):33.
   Google Scholar
• World Drug Report 2010. New York, NY, USA: United Nations Office on Drugs and Crime (UNODC); 2010.
   Google Scholar
• Johnston A, Holt DW. Substandard drugs: a potential crisis for public health. Br J Clin Pharmacol. 2014 Aug;78(2):218–243.
   PubMed Web of Science ®Google Scholar
• World Health Organization (WHO). A Study on the Public Health and Socioeconomic Impact of Substandard and Falsified Medical Products. Geneva, Switzerland: World Health Organization (WHO); 2017.
   Google Scholar
• Ozawa S, Evans DR, Bessias S, et al. Prevalence and estimated economic burden of substandard and falsified medicines in low- and middle-income Countries: a systematic review and meta-analysis. JAMA Network Open. 2018 Aug 3;1(4)e181662.
   PubMed Web of Science ®Google Scholar
• Koech LC, Irungu BN, Ng’ang’a MM, et al. Quality and brands of amoxicillin formulations in Nairobi, Kenya. Biomed Res Int. 2020;2020:7091278.
   PubMed Web of Science ®Google Scholar
• Tabernero P, Swamidoss I, Mayxay M, et al. A random survey of the prevalence of falsified and substandard antibiotics in the Lao PDR. J Antimicrob Chemother. 2019 Aug 1;74(8)2417–2425.
   PubMed Web of Science ®Google Scholar
• Global AMR R&D Hub. Available from: [cited 2021 Apr 9]. Available from: https://globalamrhub.org/
   Google Scholar
• WAAAR: world alliance against antibiotic resistance WAAAR. [cited 2021 Apr 9]. Available from: https://waaar.org/en/
   Google Scholar
• Alliance to save our antibiotics. Available from: [2021 Apr 9]. https://www.saveourantibiotics.org/
   Google Scholar
• AMR Insights: towards a world free from AMR 2017. Available from: [cited 2021 Apr 9]. Available from: https://www.amr-insights.eu/about-us/
   Google Scholar
• ReAct group - action on antibiotic resistance. Available from: [cited 2021 Apr 9]. Available from: https://www.reactgroup.org
   Google Scholar
• Cox JA, Vlieghe E, Mendelson M, et al. Antibiotic stewardship in low- and middle-income countries: the same but different?. Clin Microbiol Infect. 2017 Nov;23(11)812–818.
   PubMed Web of Science ®Google Scholar
• Maki G, Smith I, Paulin S, et al. Feasibility study of the world health organization health care facility-based antimicrobial stewardship toolkit for low- and middle-income Countries. Antibiotics (Basel). 2020 Aug 29;9(9):556.
   Web of Science ®Google Scholar
• Huttner B, Saam M, Moja L, et al. How to improve antibiotic awareness campaigns: findings of a WHO global survey. BMJ Glob Health. 2019;4(3):e001239.
   PubMedGoogle Scholar
• The Global Response to AMR: Momentum, success, and critical gaps. Wellcome; 2020.
   Google Scholar
• OIE Annual Report on Antimicrobial Agents Intended for Use in Animals. Better understanding of the global situation. Paris, France: World Organization for Animal Health (OIE); 2020.
   Google Scholar
• Laxminarayan R, Matsoso P, Pant S, et al. Access to effective antimicrobials: a worldwide challenge. Lancet. 2016 Jan 9;387(10014)168–175.
   PubMed Web of Science ®Google Scholar
• Do NTT, Vu HTL, Nguyen CTK, et al. Community-based antibiotic access and use in six low-income and middle-income countries: a mixed-method approach. Lancet Glob Health. 2021 Mar 10;(5). DOI:10.1016/S2214-109X(21)00024-3.
   Web of Science ®Google Scholar
• Santa-Ana-Tellez Y, Mantel-Teeuwisse AK, Dreser A, et al. Impact of over-the-counter restrictions on antibiotic consumption in Brazil and Mexico. PloS One. 2013;8(10):e75550.
   PubMed Web of Science ®Google Scholar
• Gautham M, Spicer N, Chatterjee S, et al. What are the challenges for antibiotic stewardship at the community level? an analysis of the drivers of antibiotic provision by informal healthcare providers in rural India. Soc Sci Med. 2021;275:113813.
   PubMed Web of Science ®Google Scholar
• Al Amin M, Hoque MN, Siddiki AZ, et al. Antimicrobial resistance situation in animal health of Bangladesh. Vet World. 2020 Dec;13(12)2713–2727.
   PubMed Web of Science ®Google Scholar
• Khan MS, Durrance-Bagale A, Mateus A, et al. What are the barriers to implementing national antimicrobial resistance action plans? A novel mixed-methods policy analysis in Pakistan. Health Policy Plan. 2020 Oct 1;35(8)973–982.
   PubMed Web of Science ®Google Scholar
• Allwell-Brown G, Hussain-Alkhateeb L, Kitutu FE, et al. Trends in reported antibiotic use among children under 5 years of age with fever, diarrhoea, or cough with fast or difficult breathing across low-income and middle-income countries in 2005–17: a systematic analysis of 132 national surveys from 73 countries. Lancet Glob Health. 2020;86:e799–e807. 2020.
   PubMed Web of Science ®Google Scholar
• Collignon P, Beggs JJ. Socioeconomic enablers for contagion: factors impelling the antimicrobial resistance epidemic. Antibiotics (Basel). 2019 Jun 30;8(3):86.
   PubMed Web of Science ®Google Scholar
• Making antibiotics responsibly. A common manufacturing framework to tackle antimicrobial resistance. Geneva, Switzerland: AMR Industry Alliance; 2019.
   Google Scholar
• Gilbert N. Industry says voluntary plan to curb antibiotic pollution is working, but critics want regulation. Science. New York, NY, United States: American Association for the Advancement of Science (AAAS); 2020.
   Google Scholar
• Fadlallah R, Alkhaled L, Brax H, et al. Extent of physician-pharmaceutical industry interactions in low- and middle-income countries: a systematic review. Eur J Public Health. 2018 Apr 1;28(2)224–230.
   PubMed Web of Science ®Google Scholar
• Vilar-Compte D, Camacho-Ortiz A, Ponce-de-León S. Infection control in limited resources Countries: challenges and priorities. Curr Infect Dis Rep. 2017 May;19(5):20.
   PubMed Web of Science ®Google Scholar
• Getahun H, Smith I, Trivedi K, et al. Tackling antimicrobial resistance in the COVID-19 pandemic. Bull World Health Organ. 2020 Jul 1;98(7)442–442a.
   PubMed Web of Science ®Google Scholar
• Huttner BD, Catho G, Pano-Pardo JR, et al. COVID-19: don’t neglect antimicrobial stewardship principles!. Clin Microbiol Infect. 2020 Jul;26(7)808–810.
   PubMed Web of Science ®Google Scholar
• Sulis G, Batomen B, Kotwani A, et al., Sales of antibiotics and hydroxychloroquine in India during the COVID-19 epidemic: an interrupted time series analysis. PLoS Med. 2021;18(7): e1003682.
   PubMed Web of Science ®Google Scholar
• King LM, Lovegrove MC, Shehab N, et al. Trends in US outpatient antibiotic prescriptions during the coronavirus disease 2019 pandemic. Clin Infect Dis. 2020:ciaa1896.
   PubMed Web of Science ®Google Scholar
• Malcolm W, Seaton RA, Haddock G, et al. Impact of the COVID-19 pandemic on community antibiotic prescribing in Scotland. J Antimicrob Chemother. 2020;2(4). DOI:10.1093/jacamr/dlaa105.
   Google Scholar
• Amsden GW. Anti-inflammatory effects of macrolides--an underappreciated benefit in the treatment of community-acquired respiratory tract infections and chronic inflammatory pulmonary conditions?. J Antimicrob Chemother. 2005 Jan;55(1):10–21.
   PubMed Web of Science ®Google Scholar
• Zarogoulidis P, Papanas N, Kioumis I, et al. Macrolides: from in vitro anti-inflammatory and immunomodulatory properties to clinical practice in respiratory diseases. Eur J Clin Pharmacol. 2012 May;68(5):479–503.
   PubMed Web of Science ®Google Scholar
• Clinical management of COVID-19. Interim guidance - 27 May 2020. Geneva, Switzerland: World Health Organization (WHO), 2020. Available from: https://www.who.int/publications/i/item/clinical-management-of-covid-19.
   Google Scholar
• Lansbury L, Lim B, Baskaran V, et al. Co-infections in people with COVID-19: a systematic review and meta-analysis. J Infect. 2020 Aug;81(2):266–275.
   PubMed Web of Science ®Google Scholar
• Montrucchio G, Corcione S, Sales G, et al. Carbapenem-resistant klebsiella pneumoniae in ICU-admitted COVID-19 patients: keep an eye on the ball. J Glob Antimicrob Resist. 2020;23:398–400
   PubMedGoogle Scholar
• Adam D. Scientists fear that ‘covidization’ is distorting research. Nature. 2020 Dec;588(7838):381–382.
   PubMed Web of Science ®Google Scholar