Clostridioides difficile infection: an emerging zoonosis?

References

• Bagdasarian N, Rao K, Malani PN. Diagnosis and treatment of Clostridium difficile in adults. JAMA. 2015;313(4):398–408.
   PubMed Web of Science ®Google Scholar
• Crobach MJT, Planche T, Eckert C, et al. European society of clinical microbiology and infectious diseases: update of the diagnostic guidance document for Clostridium difficile infection. Clin Microbiol Infect. 2016;22(Suppl 4):S63–81.
   PubMed Web of Science ®Google Scholar
• Lee JC, Hung YP, Tsai BY, et al. Severe Clostridium difficile infections in intensive care units: diverse clinical presentations. J Microbiol Immunol Infect. Internet]. 2020 [cited 2021 Feb 7]; https://doi.org/10.1016/j.jmii.2020.07.012.
   Google Scholar
• Bartlett JG, Gerding DN. Clinical recognition and diagnosis of Clostridium difficile infection. Clin Infect Dis. 2008;46(Suppl 1):S12–18.
   PubMed Web of Science ®Google Scholar
• Kwok CS, Arthur AK, Anibueze CI, et al. Risk of Clostridium difficile infection with acid suppressing drugs and antibiotics: meta-analysis. Am J Gastroenterol. 2012;107(7):1011–1019.
   PubMed Web of Science ®Google Scholar
• Hung YP, Ko WC, Chou PH, et al., Proton-Pump inhibitor exposure aggravates Clostridium difficile–Associated colitis: evidence from a mouse model. J Infect Dis. 212(4): 654–663.
   PubMed Web of Science ®Google Scholar
• Tariq R, Singh S, Gupta A, et al. Association of gastric acid suppression with recurrent Clostridium difficile infection. JAMA Intern Med. 2017;177(6):784–791.
   PubMed Web of Science ®Google Scholar
• Hung YP, Lee JC, Tsai BY, et al. Risk factors of Clostridium difficile-associated diarrhea in hospitalized adults: vary by hospitalized duration. J Microbiol Immunol Infect. 2021;54(2):276–283.
   Google Scholar
• Davies K, Lawrence J, Berry C, et al. Risk factors for primary Clostridium difficile infection; results from the observational study of risk factors for Clostridium difficile infection in hospitalized patients with infective diarrhea (ORCHID). Front Public Health. 2020;8:293.
   PubMed Web of Science ®Google Scholar
• Chang TH, Hsu WY, Yang TI, et al. Increased age and proton pump inhibitors are associated with severe Clostridium difficile infections in children. J Microbiol Immunol Infect. 2020;53(4):578–584.
   PubMedGoogle Scholar
• Ofori E, Ramai D, Dhawan M, et al. Community-acquired Clostridium difficile: epidemiology, ribotype, risk factors, hospital and intensive care unit outcomes, and current and emerging therapies. J Hosp Infect. 2018;99(4):436–442.
   PubMed Web of Science ®Google Scholar
• Khanna S, Pardi DS, Aronson SL, et al., The epidemiology of community-acquired Clostridium difficile infection: a population-based study. Am J Gastroenterol. 2012;107(1): 89–95.
   PubMed Web of Science ®Google Scholar
• Tsai CS, Hung YP, Lee JC, et al., Community-onset Clostridium difficile infection at a tertiary medical center in southern Taiwan, 2007–2015. J Microbiol Immunol Infect. 2018;51(2): 243–250.
   PubMedGoogle Scholar
• Viprey VF, Davis GL, Benson AD, et al. Key differences in diagnosis and patient populations between community and in-patient Clostridioides difficile Infections (CDI): results from combatting bacterial resistance in Europe CDI (COMBACTE-CDI). [Cited 2021 Aug 21]. Available from: https://papers.ssrn.com/abstract=3812436.
   Google Scholar
• Chitnis AS, Holzbauer SM, Belflower RM, et al., Epidemiology of Community-Associated Clostridium difficile infection, 2009 through 2011. JAMA Intern Med. 2013;173(14): 1359–1367.
   PubMed Web of Science ®Google Scholar
• Songer JG, Anderson MA. Clostridium difficile: an important pathogen of food animals. Anaerobe. 2006;12(1):1–4.
   PubMed Web of Science ®Google Scholar
• Gould LH, Limbago B. Clostridium difficile in food and domestic animals: a new foodborne pathogen? Clin Infect Dis. 2010;51(5):577–582.
   PubMed Web of Science ®Google Scholar
• Marks SL, Kather EJ, Kass PH, et al. Genotypic and phenotypic characterization of Clostridium perfringens and Clostridium difficile in diarrheic and healthy dogs. J Vet Intern Med. 2002;16(5):533–540.
   PubMed Web of Science ®Google Scholar
• Clooten J, Kruth S, Arroyo L, et al. Prevalence and risk factors for Clostridium difficile colonization in dogs and cats hospitalized in an intensive care unit. Vet Microbiol. 2008;129(1–2):209–214.
   PubMed Web of Science ®Google Scholar
• Perrin J, Buogo C, Gallusser A, et al. Intestinal carriage of Clostridium difficile in neonate dogs. Zentralblatt Vet. 1993;40:222–226.
   PubMedGoogle Scholar
• Struble AL, Tang YJ, Kass PH, et al. Fecal shedding of clostridium difficile in dogs: a period prevalence survey in a veterinary medical teaching hospital. J Vet Diagn Invest. 1994;6(3):342–347.
   PubMed Web of Science ®Google Scholar
• Madewell BR, Bea JK, Kraegel SA, et al. Clostridium difficile: a survey of fecal carriage in cats in a veterinary medical teaching hospital. J Vet Diagn Invest. 1999;11(1):50–54.
   PubMed Web of Science ®Google Scholar
• Weese JS, Staempfli HR, Prescott JF, et al. The roles of clostridium difficile and enterotoxigenic clostridium perfringens in diarrhea in dogs. J Vet Intern Med. 2001;15(4):374–378.
   PubMed Web of Science ®Google Scholar
• Weese JS, Finley R, Reid-Smith RR, et al. Evaluation of Clostridium difficile in dogs and the household environment. Epidemiol Infect. 2010;138(8):1100–1104.
   PubMed Web of Science ®Google Scholar
• Schneeberg A, Rupnik M, Neubauer H, et al. Prevalence and distribution of Clostridium difficile PCR ribotypes in cats and dogs from animal shelters in Thuringia, Germany. Anaerobe. 2012;18(5):484–488.
   PubMed Web of Science ®Google Scholar
• Koene MGJ, Mevius D, Wagenaar JA, et al. Clostridium difficile in Dutch animals: their presence, characteristics and similarities with human isolates. Clin Microbiol Infect. 2012;18(8):778–784.
   PubMed Web of Science ®Google Scholar
• Wetterwik K-J, Trowald-Wigh G, Fernström -L-L, et al. Clostridium difficile in faeces from healthy dogs and dogs with diarrhea. Acta Vet Scand. 2013;55(1):23.
   PubMedGoogle Scholar
• Hussain I, Sharma RK, Borah P, et al. Isolation and characterization of Clostridium difficile from pet dogs in Assam, India. Anaerobe. 2015;36:9–13.
   PubMed Web of Science ®Google Scholar
• Alam MJ, McPherson J, Miranda J, et al. Molecular epidemiology of Clostridioides difficile in domestic dogs and zoo animals. Anaerobe. 2019;59:107–111.
   PubMed Web of Science ®Google Scholar
• Berry ASF, Kelly BJ, Barnhart D, et al. Gut microbiota features associated with Clostridioides difficile colonization in puppies. PloS One. 2019;14(8):e0215497.
   PubMed Web of Science ®Google Scholar
• Weese JS, Mshelbwala PP, Lohr F. Clostridium difficile shedding by healthy dogs in Nigeria and Malawi. Zoonoses Public Health. 2019;66(6):618–621.
   PubMed Web of Science ®Google Scholar
• Viegas FM, Ramos CP, Xavier RGC, et al. Fecal shedding of Salmonella spp., Clostridium perfringens, and Clostridioides difficile in dogs fed raw meat-based diets in Brazil and their owners’ motivation. PloS One. 2020;15(4):e0231275.
   PubMed Web of Science ®Google Scholar
• Busch K, Suchodolski JS, Kühner KA, et al. Clostridium perfringens enterotoxin and Clostridium difficile toxin A/B do not play a role in acute haemorrhagic diarrhoea syndrome in dogs. Vet Rec. 2015;176(10):253.
   PubMed Web of Science ®Google Scholar
• Rabold D, Espelage W, Abu Sin M, et al. The zoonotic potential of Clostridium difficile from small companion animals and their owners. PLoS One. 2018;13(2):e0193411.
   PubMed Web of Science ®Google Scholar
• Diniz AN, Coura FM, Rupnik M, et al. The incidence of Clostridioides difficile and Clostridium perfringens netF-positive strains in diarrheic dogs. Anaerobe. 2018;49:58–62.
   PubMed Web of Science ®Google Scholar
• Orden C, Blanco JL, Álvarez-Pérez S, et al. Isolation of Clostridium difficile from dogs with digestive disorders, including stable metronidazole-resistant strains. Anaerobe. 2017;43:78–81.
   PubMed Web of Science ®Google Scholar
• Lefebvre SL, Reid-Smith RJ, Waltner-Toews D, et al. Incidence of acquisition of methicillin-resistant Staphylococcus aureus, Clostridium difficile, and other health-care–associated pathogens by dogs that participate in animal-assisted interventions. J Am Vet Med Assoc. 2009;234(11):1404–1417.
   PubMed Web of Science ®Google Scholar
• Lefebvre SL, Reid-Smith R, Boerlin P, et al. Evaluation of the risks of shedding Salmonellae and other potential pathogens by therapy dogs fed raw diets in Ontario and Alberta. Zoonoses Public Health. 2008;55(8–10):470–480.
   PubMed Web of Science ®Google Scholar
• Andrés-Lasheras S, Martín-Burriel I, Mainar-Jaime RC, et al. Preliminary studies on isolates of Clostridium difficile from dogs and exotic pets. BMC Vet Res. 2018;14(1):77.
   PubMedGoogle Scholar
• Álvarez-Pérez S, Blanco JL, Harmanus C, et al. Prevalence and characteristics of Clostridium perfringens and Clostridium difficile in dogs and cats attended in diverse veterinary clinics from the Madrid region. Anaerobe. 2017;48:47–55.
   PubMed Web of Science ®Google Scholar
• Loo VG, Brassard P, Miller MA. Household Transmission of Clostridium difficile to family members and domestic pets. Infect Control Hosp Epidemiol. 2016;37(11):1342–1348.
   PubMed Web of Science ®Google Scholar
• Janezic S, Mlakar S, Rupnik M. Dissemination of Clostridium difficile spores between environment and households: dog paws and shoes. Zoonoses Public Health. 2018;65(6):669–674.
   PubMed Web of Science ®Google Scholar
• Chan G, Farzan A, DeLay J, et al. A retrospective study on the etiological diagnoses of diarrhea in neonatal piglets in Ontario, Canada, between 2001 and 2010. Can J Vet Res. 2013;77:254–260.
   PubMed Web of Science ®Google Scholar
• Yaeger M, Funk N, Hoffman L. A survey of agents associated with neonatal diarrhea in Iowa swine including clostridium difficile and porcine reproductive and respiratory syndrome virus. J Vet Diagn Invest. 2002;14(4):281–287.
   PubMed Web of Science ®Google Scholar
• Arruda PHE, Madson DM, Ramirez A, et al. Effect of age, dose and antibiotic therapy on the development of Clostridium difficile infection in neonatal piglets. Anaerobe. 2013;22:104–110.
   PubMed Web of Science ®Google Scholar
• Weese JS. Clostridium (Clostridioides) difficile in animals. J Vet Diagn Invest. 2020;32(2):213–221.
   PubMed Web of Science ®Google Scholar
• Songer JG, Uzal FA. Clostridial enteric infections in pigs. J Vet Diagn Invest. 2005;17(6):528–536.
   PubMed Web of Science ®Google Scholar
• Hopman NEM, Keessen EC, Harmanus C, et al. Acquisition of Clostridium difficile by piglets. Vet Microbiol. 2011;149(1–2):186–192.
   PubMed Web of Science ®Google Scholar
• Hawken P, Weese JS, Friendship R, et al. Longitudinal study of Clostridium difficile and methicillin-resistant Staphylococcus aureus associated with pigs from weaning through to the end of processing. J Food Prot. 2013;76(4):624–630.
   PubMed Web of Science ®Google Scholar
• Schneeberg A, Neubauer H, Schmoock G, et al. Clostridium difficile genotypes in piglet populations in Germany. J Clin Microbiol. 2013;51(11):3796–3803.
   PubMed Web of Science ®Google Scholar
• Knight DR, Squire MM, Riley TV. Nationwide surveillance study of Clostridium difficile in Australian neonatal pigs shows high prevalence and heterogeneity of PCR ribotypes. Appl Environ Microbiol. 2015;81(1):119–123.
   PubMed Web of Science ®Google Scholar
• Krutova M, Zouharova M, Matejkova J, et al. The emergence of Clostridium difficile PCR ribotype 078 in piglets in the Czech Republic clusters with Clostridium difficile PCR ribotype 078 isolates from Germany, Japan and Taiwan. Int J Med Microbiol. 2018;308(7):770–775.
   PubMed Web of Science ®Google Scholar
• Kim HY, Cho A, Kim JW, et al. High prevalence of Clostridium difficile PCR ribotype 078 in pigs in Korea. Anaerobe. 2018;51:42–46.
   PubMed Web of Science ®Google Scholar
• Asai T, Usui M, Hiki M, et al. Clostridium difficile isolated from the fecal contents of swine in Japan. J Vet Med Sci. 2013;75(4):539–541.
   PubMed Web of Science ®Google Scholar
• Cho A, Byun JW, Kim JW, et al. Low prevalence of Clostridium difficile in slaughter pigs in Korea. J Food Prot. 2015;78(5):1034–1036.
   PubMed Web of Science ®Google Scholar
• Rodriguez C, Avesani V, Van Broeck J, et al. Presence of Clostridium difficile in pigs and cattle intestinal contents and carcass contamination at the slaughterhouse in Belgium. Int J Food Microbiol. 2013;166(2):256–262.
   PubMed Web of Science ®Google Scholar
• Stein K, Egan S, Lynch H, et al. PCR-ribotype distribution of Clostridium difficile in Irish pigs. Anaerobe. 2017;48:237–241.
   PubMed Web of Science ®Google Scholar
• Weese JS, Wakeford T, Reid-Smith R, et al. Longitudinal investigation of Clostridium difficile shedding in piglets. Anaerobe. 2010;16(5):501–504.
   PubMed Web of Science ®Google Scholar
• Keessen EC, Donswijk CJ, Hol SP, et al. Aerial dissemination of Clostridium difficile on a pig farm and its environment. Environ Res. 2011;111(8):1027–1032.
   PubMed Web of Science ®Google Scholar
• Burt SA, Siemeling L, Kuijper EJ, et al. Vermin on pig farms are vectors for Clostridium difficile PCR ribotypes 078 and 045. Vet Microbiol. 2012;160(1–2):256–258.
   PubMed Web of Science ®Google Scholar
• Squire MM, Carter GP, Mackin KE, et al. Novel molecular type of Clostridium difficile in neonatal pigs, Western Australia. Emerg Infect Dis. 2013;19(5):790–792.
   PubMed Web of Science ®Google Scholar
• Wu YC, Lee JJ, Tsai BY, et al. Potentially hypervirulent Clostridium difficile PCR ribotype 078 lineage isolates in pigs and possible implications for humans in Taiwan. Int J Med Microbiol. 2016;306(2):115–122.
   PubMed Web of Science ®Google Scholar
• Tsai BY, Ko WC, Chen TH, et al. Zoonotic potential of the Clostridium difficile RT078 family in Taiwan. Anaerobe. 2016;41:125–130.
   PubMed Web of Science ®Google Scholar
• Wu YC, Chen CM, Kuo CJ, et al. Prevalence and molecular characterization of Clostridium difficile isolates from a pig slaughterhouse, pork, and humans in Taiwan. Int J Food Microbiol. 2017;242:37–44.
   PubMed Web of Science ®Google Scholar
• Rodriguez-Palacios A, Stämpfli HR, Duffield T, et al. Clostridium difficile PCR Ribotypes in Calves, Canada. Emerg Infect Dis. 2006;12(11):1730–1736.
   PubMed Web of Science ®Google Scholar
• Hammitt MC, Bueschel DM, Keel MK, et al. A possible role for Clostridium difficile in the etiology of calf enteritis. Vet Microbiol. 2008;127(3–4):343–352.
   PubMed Web of Science ®Google Scholar
• Rodriguez-Palacios A, Stämpfli HR, Stalker M, et al. Natural and experimental infection of neonatal calves with Clostridium difficile. Vet Microbiol. 2007;124(1–2):166–172.
   PubMed Web of Science ®Google Scholar
• Rodriguez-Palacios A, Pickworth C, Loerch S, et al. Transient fecal shedding and limited animal-to-animal transmission of Clostridium difficile by naturally infected finishing feedlot cattle. Appl Environ Microbiol. 2011;77(10):3391–3397.
   PubMed Web of Science ®Google Scholar
• Zidaric V, Pardon B, Dos Vultos T, et al. Different antibiotic resistance and sporulation properties within multiclonal Clostridium difficile PCR ribotypes 078, 126, and 033 in a single calf farm. Appl Environ Microbiol. 2012;78(24):8515–8522.
   PubMed Web of Science ®Google Scholar
• Bandelj P, Harmanus C, Blagus R, et al. Quantification of Clostridioides (Clostridium) difficile in feces of calves of different age and determination of predominant Clostridioides difficile ribotype 033 relatedness and transmission between family dairy farms using multilocus variable-number tandem-repeat analysis. BMC Vet Res. 2018;14:298.
   PubMed Web of Science ®Google Scholar
• Costa MC, Stämpfli HR, Arroyo LG, et al. Epidemiology of Clostridium difficile on a veal farm: prevalence, molecular characterization and tetracycline resistance. Vet Microbiol. 2011;152(3–4):379–384.
   PubMed Web of Science ®Google Scholar
• Knight DR, Thean S, Putsathit P, et al. Cross-sectional study reveals high prevalence of Clostridium difficile non-PCR ribotype 078 strains in Australian veal calves at slaughter. Appl Environ Microbiol. 2013;79(8):2630–2635.
   PubMed Web of Science ®Google Scholar
• Bandelj P, Blagus R, Briski F, et al. Identification of risk factors influencing Clostridium difficile prevalence in middle-size dairy farms. Vet Res. 2016;47(1):41.
   PubMedGoogle Scholar
• Magistrali CF, Maresca C, Cucco L, et al. Prevalence and risk factors associated with Clostridium difficile shedding in veal calves in Italy. Anaerobe. 2015;33:42–47.
   PubMed Web of Science ®Google Scholar
• Rodriguez C, Taminiau B, Van Broeck J, et al. Clostridium difficile in young farm animals and slaughter animals in Belgium. Anaerobe. 2012;18(6):621–625.
   PubMed Web of Science ®Google Scholar
• Kachrimanidou M, Tzika E, Filioussis G. Clostridioides (Clostridium) difficile in food-producing animals, horses and household pets: a comprehensive review. Microorganisms. 2019;7(12):667.
   Web of Science ®Google Scholar
• Houser BA, Soehnlen MK, Wolfgang DR, et al. Prevalence of Clostridium difficile toxin genes in the feces of veal calves and incidence of ground veal contamination. Foodborne Pathog Dis. 2012;9(1):32–36.
   PubMed Web of Science ®Google Scholar
• Knight DR, Putsathit P, Elliott B, et al. Contamination of Australian newborn calf carcasses at slaughter with Clostridium difficile. Clin Microbiol Infect. 2016;22(3):266.e1–7.
   PubMed Web of Science ®Google Scholar
• Hampikyan H, Bingol EB, Muratoglu K, et al. The prevalence of Clostridium difficile in cattle and sheep carcasses and the antibiotic susceptibility of isolates. Meat Sci. 2018;139:120–124.
   PubMed Web of Science ®Google Scholar
• Avberšek J, Pirš T, Pate M, et al. Clostridium difficile in goats and sheep in Slovenia: characterisation of strains and evidence of age-related shedding. Anaerobe. 2014;28:163–167.
   PubMed Web of Science ®Google Scholar
• Rahimi E, Jalali M, Weese JS. Prevalence of Clostridium difficilein raw beef, cow, sheep, goat, camel and buffalo meat in Iran. BMC Public Health. 2014;14(1):119.
   PubMedGoogle Scholar
• Bakri M. Prevalence of Clostridium difficile in raw cow, sheep, and goat meat in Jazan, Saudi Arabia. Saudi J Biol Sci. 2018;25(4):783–785.
   PubMed Web of Science ®Google Scholar
• Båverud V, Gustafsson A, Franklin A, et al. Clostridium difficile associated with acute colitis in mature horses treated with antibiotics. Equine Vet J. 1997;29(4):279–284.
   PubMed Web of Science ®Google Scholar
• Weese JS, Staempfli HR, Prescott JF. A prospective study of the roles of Clostridium difficile and enterotoxigenic Clostridium perfringens in equine diarrhoea. Equine Vet J. 2001;33(4):403–409.
   PubMed Web of Science ®Google Scholar
• Arroyo LG, Weese JS, Staempfli HR. Experimental Clostridium difficile enterocolitis in foals. J Vet Intern Med. 2004;18(5):734–738.
   PubMed Web of Science ®Google Scholar
• Arroyo LG, Stämpfli HR, Weese JS. Potential role of Clostridium difficile as a cause of duodenitis-proximal jejunitis in horses. J Med Microbiol. 2006;55(5):605–608.
   PubMed Web of Science ®Google Scholar
• Båverud V, Gustafsson A, Franklin A, et al. Clostridium difficile: prevalence in horses and environment, and antimicrobial susceptibility. Equine Vet J. 2003;35(5):465–471.
   PubMed Web of Science ®Google Scholar
• Schoster A, Staempfli HR, Abrahams M, et al. Effect of a probiotic on prevention of diarrhea and Clostridium difficile and Clostridium perfringens shedding in foals. J Vet Intern Med. 2015;29:925–931.
   PubMed Web of Science ®Google Scholar
• Medina-Torres CE, Weese JS, Staempfli HR. Prevalence of Clostridium difficile in horses. Vet Microbiol. 2011;152(1–2):212–215.
   PubMed Web of Science ®Google Scholar
• Schoster A, Arroyo LG, Staempfli HR, et al. Presence and molecular characterization of Clostridium difficile and Clostridium perfringens in intestinal compartments of healthy horses. BMC Vet Res. 2012;8(1):94.
   PubMedGoogle Scholar
• Schoster A, Staempfli HR, Arroyo LG, et al. Longitudinal study of Clostridium difficile and antimicrobial susceptibility of Escherichia coli in healthy horses in a community setting. Vet Microbiol. 2012;159(3–4):364–370.
   PubMed Web of Science ®Google Scholar
• Kecerova Z, Cizek A, Nyc O, et al. Clostridium difficile isolates derived from Czech horses are resistant to enrofloxacin; cluster to clades 1 and 5 and ribotype 033 predominates. Anaerobe. 2019;56:17–21.
   PubMed Web of Science ®Google Scholar
• Songer JG. Clostridial enteric diseases of domestic animals. Clin Microbiol Rev. 1996;9:216–234.
   PubMed Web of Science ®Google Scholar
• Abdel-Glil MY, Thomas P, Schmoock G, et al. Presence of Clostridium difficile in poultry and poultry meat in Egypt. Anaerobe. 2018;51:21–25.
   PubMed Web of Science ®Google Scholar
• Zidaric V, Zemljic M, Janezic S, et al. High diversity of Clostridium difficile genotypes isolated from a single poultry farm producing replacement laying hens. Anaerobe. 2008;14(6):325–327.
   PubMed Web of Science ®Google Scholar
• Indra A, Lassnig H, Baliko N, et al. Clostridium difficile: ein neuer Zoonoseerreger? Wien Klin Wochenschr. 2009;121(3–4):91–95.
   PubMed Web of Science ®Google Scholar
• Simango C. Prevalence of Clostridium difficile in the environment in a rural community in Zimbabwe. Trans R Soc Trop Med Hyg. 2006;100(12):1146–1150.
   PubMed Web of Science ®Google Scholar
• Simango C, Mwakurudza S. Clostridium difficile in broiler chickens sold at market places in Zimbabwe and their antimicrobial susceptibility. Int J Food Microbiol. 2008;124(3):268–270.
   PubMed Web of Science ®Google Scholar
• Weese JS, Reid-Smith RJ, Avery BP, et al. Detection and characterization of Clostridium difficile in retail chicken. Lett Appl Microbiol. 2010;50(4):362–365.
   PubMed Web of Science ®Google Scholar
• Songer JG, Trinh HT, Killgore GE, et al. Clostridium difficile in retail meat products, USA, 2007. Emerg Infect Dis. 2009;15(5):819–821.
   PubMed Web of Science ®Google Scholar
• Varshney JB, Very KJ, Williams JL, et al. Characterization of Clostridium difficile isolates from human fecal samples and retail meat from Pennsylvania. Foodborne Pathog Dis. 2014;11(10):822–829.
   PubMed Web of Science ®Google Scholar
• Bingol EB, Hampikyan H, Muratoglu K, et al. Characterisation and antibiotic susceptibility profile of Clostridioides (Clostridium) difficile isolated from chicken carcasses. J Vet Res. 2020;64(3):407–412.
   PubMed Web of Science ®Google Scholar
• Lee JY, Lee DY, Cho YS. Prevalence of Clostridium difficile isolated from various raw meats in Korea. Food Sci Biotechnol. 2018;27(3):883–889.
   PubMed Web of Science ®Google Scholar
• De Boer E, Zwartkruis-Nahuis A, Heuvelink AE, et al. Prevalence of Clostridium difficile in retailed meat in the Netherlands. Int J Food Microbiol. 2011;144(3):561–564.
   PubMed Web of Science ®Google Scholar
• Hussain I, Borah P, Sharma RK, et al. Molecular characteristics of Clostridium difficile isolates from human and animals in the North Eastern region of India. Mol Cell Probes. 2016;30(5):306–311.
   PubMed Web of Science ®Google Scholar
• Razmyar J, Jamshidi A, Khanzadi S, et al. Toxigenic Clostridium difficile in retail packed chicken meat and broiler flocks in northeastern Iran. Iran J Vet Res. 2017;18:271–274.
   PubMed Web of Science ®Google Scholar
• Metcalf D, Avery BP, Janecko N, et al. Clostridium difficile in seafood and fish. Anaerobe. 2011;17(2):85–86.
   PubMed Web of Science ®Google Scholar
• Norman KN, Harvey RB, Andrews K, et al. Survey of Clostridium difficile in retail seafood in College Station, Texas. Food Addit Contam. 2014;31(6):1127–1129.
   PubMed Web of Science ®Google Scholar
• Tkalec V, Jamnikar-Ciglenecki U, Rupnik M, et al. Clostridioides difficile in national food surveillance, Slovenia, 2015 to 2017. Euro Surveill. 2020;25(6):1900479.
   PubMedGoogle Scholar
• Moono P, Foster NF, Hampson DJ, et al. Clostridium difficile Infection in Production Animals and Avian Species: a Review. Foodborne Pathog Dis. 2016;13(12):647–655.
   PubMed Web of Science ®Google Scholar
• Norman KN, Harvey RB, Scott HM, et al. Varied prevalence of Clostridium difficile in an integrated swine operation. Anaerobe. 2009;15(6):256–260.
   PubMed Web of Science ®Google Scholar
• Krijger IM, Meerburg BG, Harmanus C, et al. Clostridium difficile in wild rodents and insectivores in the Netherlands. Lett Appl Microbiol. 2019;69(1):35–40.
   PubMed Web of Science ®Google Scholar
• de Oliveira CA, de Paula Gabardo M, Guedes RMC, et al. Rodents are carriers of Clostridioides difficile strains similar to those isolated from piglets. Anaerobe. 2018;51:61–63.
   PubMed Web of Science ®Google Scholar
• Susick EK, Putnam M, Bermudez DM, et al. Longitudinal study comparing the dynamics of Clostridium difficile in conventional and antimicrobial free pigs at farm and slaughter. Vet Microbiol. 2012;157(1–2):172–178.
   PubMed Web of Science ®Google Scholar
• Grzeskowiak L, Martínez-Vallespín B, Dadi TH, et al. Formula feeding predisposes neonatal piglets to Clostridium difficile gut infection. J Infect Dis. 2018;217(9):1442–1452.
   PubMed Web of Science ®Google Scholar
• Kim K, Pickering LK, DuPont HL, et al. In vitro and in vivo neutralizing activity of human colostrum and milk against purified toxins A and B of Clostridium difficile. J Infect Dis. 1984;150(1):57–62.
   PubMed Web of Science ®Google Scholar
• Tran H, Anderson CL, Bundy JW, et al. Effects of spray-dried porcine plasma on fecal microbiota in nursery pigs. J Anim Sci. 2018;96(3):1017–1031.
   PubMed Web of Science ®Google Scholar
• Norén T, Johansson K, Unemo M. Clostridium difficile PCR ribotype 046 is common among neonatal pigs and humans in Sweden. Clin Microbiol Infect. 2014;20(1):O2–O6.
   PubMed Web of Science ®Google Scholar
• Knetsch CW, Connor TR, Mutreja A, et al. Whole genome sequencing reveals potential spread of Clostridium difficile between humans and farm animals in the Netherlands, 2002 to 2011. Euro Surveill. 2014;19(45):20954.
   PubMedGoogle Scholar
• Knight DR, Squire MM, Collins DA, et al. Genome analysis of Clostridium difficile PCR ribotype 014 lineage in Australian pigs and humans reveals a diverse genetic repertoire and signatures of long-range interspecies transmission. Front Microbiol. 2016;7:2138.
   PubMed Web of Science ®Google Scholar
• Knetsch CW, Kumar N, Forster SC, et al. Zoonotic transfer of Clostridium difficile harboring antimicrobial resistance between farm animals and humans. J Clin Microbiol. 2018; 56(3). https://doi.org/10.1128/JCM.01384-17
   Google Scholar
• Werner A, Mölling P, Fagerström A, et al. Whole genome sequencing of Clostridioides difficile PCR ribotype 046 suggests transmission between pigs and humans. PLoS One. 2020;15(12):e0244227.
   PubMed Web of Science ®Google Scholar