The war against bacteria, from the past to present and beyond

References

• Waksman SA, Flynn JE. History of the word ‘antibiotic.’ J Hist Med Allied Sci. 1973 Jul;28(3):284–286.
   PubMedGoogle Scholar
• Munita JM, Arias CA. Mechanisms of antibiotic resistance. Microbiol Spectr. 2016 Apr 4;(2):https://doi.org/10.1128/microbiolspec.VMBF-0016-2015.
   Google Scholar
• Davies J, Davies D. Origins and evolution of antibiotic resistance. Microbiol Mol Biol Rev. 2010 Sep;74(3):417–433.
   PubMed Web of Science ®Google Scholar
• Fair RJ, Tor Y. Antibiotics and bacterial resistance in the 21st century. Perspect Medicin Chem. 2014 Aug;28(6):25–64.
   Google Scholar
• Payandeh J, Volgraf M. Ligand binding at the protein-lipid interface: strategic considerations for drug design. Nat Rev Drug Discov. 2021Jul13;20:710–722. Epub ahead of print
   PubMed Web of Science ®Google Scholar
• Wright PM, Seiple IB, Myers AG. The evolving role of chemical synthesis in antibacterial drug discovery. Angew Chem Int Ed Engl. 2014 Aug 18;53(34):8840–8869.
   PubMed Web of Science ®Google Scholar
• Antimicrobials PE. Understanding pharmacology in nursing practice. 2019 Sep;4:147–165.
   Google Scholar
• Ribeiro CFA, Silveira GGOS, Cândido ES, et al. Effects of antibiotic treatment on gut microbiota and how to overcome its negative impacts on human health. ACS Infect Dis. 2020 Oct 9;6(10):2544–2559.
   PubMed Web of Science ®Google Scholar
• Santacroce L, Charitos IA, Bottalico L. A successful history: probiotics and their potential as antimicrobials. Expert Rev Anti Infect Ther. 2019 Aug;17(8):635–645.
   PubMed Web of Science ®Google Scholar
• Santacroce L, Man A, Charitos IA, et al. Current knowledge about the connection between health status and gut microbiota from birth to elderly. A narrative review. Front Biosci (Landmark Ed). 2021 May 30;26(6):135–148.
   PubMed Web of Science ®Google Scholar
• Bottalico L, Castellaneta F, Charitos IA. From hydrotherapy to the discovery of the gut microbiota: the historical gastrointestinal health concept. Pharmacophore. 2020;11:82–90.
   Web of Science ®Google Scholar
• Leekha S, Terrell CL, Edson RS. General principles of antimicrobial therapy. Mayo Clin Proc. 2011 Feb;86(2):156–167.
   PubMed Web of Science ®Google Scholar
• Zuskin E, Lipozencić J, Pucarin-Cvetković J, et al. Ancient medicine--a review. Acta dermatovenerologica Croatica: ADC. 2008;16(3):149–157.
   PubMed Web of Science ®Google Scholar
• Yanling J, Xin L, Zhiyuan L The antibacterial drug discovery, drug discovery, hany A. El-Shemy, IntechOpen. January 23 rd 2013. Available from: https://www.intechopen.com/chapters/41532
   Google Scholar
• Santacroce L, Topi S, Haxhirexha K, et al. Medicine and healing in the pre-socratic thought - a brief analysis of magic and rationalism in ancient herbal therapy. Endocr Metab Immune Disord Drug Targets. 2021;21(2):282–287.
   PubMed Web of Science ®Google Scholar
• Skaltsa E. History of Pharmacy. Kallipos (Greece): Association of Greek Academic Libraries; 2015. p. 1–323.
   Google Scholar
• Budge EA. Wallis the gods of the Egyptians. 1. 1904. 414–415.
   Google Scholar
• Santacroce L, Bottalico L, Haxhirexha K, et al. Pre-chemistry concepts and medical therapy among ancient physicians through the pre-socratic philosophers. Endocr Metab Immune Disord Drug Targets. 2020;20(9):1470–1477.
   PubMed Web of Science ®Google Scholar
• Nunn JF. Ancient Egyptian medicine. Norman (OK MA): University of Oklahoma Press; 2002.
   Google Scholar
• Gesundheit B, Zlotnick E, Steinberg A. [Medicine, physicians and medical ethics in Jewish tradition through the ages]. Harefuah. 2014 Aug;153(8):489–492. 496.
   PubMedGoogle Scholar
• Laskaratos Ι. (Λασκαρατος Ι), history of medicine (Ιστορία της Ιατρικής). text in Greek: Medical publishing PH Pascalidis (Ιατρικες εκδοσεις ΠΧ Πασχαλίδης); 2012.
   Google Scholar
• Saini A. Physicians of ancient India. J Family Med Prim Care. 2016 Apr-Jun;5(2):254–258.
   PubMedGoogle Scholar
• Inchingolo F, Santacroce L, Ballini A, et al. Oral cancer: a historical review. Int J Environ Res Public Health. 2020 May 2;17(9):3168.
   PubMed Web of Science ®Google Scholar
• Frey EF. The earliest medical texts. Clio Med. 1985-1986;20(1–4):79–90.
   PubMedGoogle Scholar
• Smith WD. Hippocrates. Cambridge (MA): The Hippocratic Corpus, Vol VII. Loeb Classical Library, Harvard University Press; 1923. p. 1–416.
   Google Scholar
• Mammas IN, Spandidos DA. Paediatric virology in the Hippocratic corpus. Exp Ther Med. 2016 Aug;12(2):541–549.
   PubMed Web of Science ®Google Scholar
• Pappas G, Kiriaze IJ, Falagas ME. Insights into infectious disease in the era of hippocrates. Int J Infect Dis. 2008 Jul;12(4):347–350.
   PubMed Web of Science ®Google Scholar
• Pinault JR. How Hippocrates cured the plague. J Hist Med Allied Sci. 1986 January;41(1):52–57.
   PubMed Web of Science ®Google Scholar
• Littman RJ. The plague of Athens: epidemiology and paleopathology. Mt Sinai J Med. 2009 Oct;76(5):456–467.
   PubMedGoogle Scholar
• Hippocrate AJ. Sophocle et la déscription de la peste chez thucydide [Hippocrates, Sophocles and the description of the plague of Thucydides]. Sudhoffs Arch Z Wissenschaftsgesch Beih. 1989(27):213–221.
   Google Scholar
• Santacroce L, Bottalico L, Charitos IA. Greek medicine practice at Ancient Rome: the physician molecularist asclepiades. Medicines (Basel). 2017 Dec 12;4(4):92.
   PubMedGoogle Scholar
• Morgan JP. Dioscorides on pharmacy and medicine. JAMA. 1987;257(15):2093–2094.
   Google Scholar
• Bouras-Vallianatos P. Galen in late antique medical handbooks. Bouras-Vallianatos P, Zipser B, editors. Brill’s Companion to the Reception of Galen. Chapter 2. Leiden (NL): Brill; 2019. Available from https://www.ncbi.nlm.nih.gov/books/NBK540285/
   Google Scholar
• Charitos IA, Gagliano-Candela R, Santacroce L, et al. Venoms and poisonings during the centuries. A narrative review. Endocr Metab Immune Disord Drug Targets. 2020Sep3; Epub ahead of print 20: https://doi.org/10.2174/1871530320666200904105816.
   Google Scholar
• Topi S, Santacroce L, Bottalico L, et al. Gastric cancer in history: a perspective interdisciplinary study. Cancers (Basel). 2020 Jan 22;12(2):264.
   PubMed Web of Science ®Google Scholar
• Constantelos DJ. Medicine and social welfare in the Byzantine Empire. Med Secoli. 1999;11(2):337–355.
   PubMedGoogle Scholar
• Valiakos E, Marselos M, Sakellaridis N, et al. Ethnopharmacological approach to the herbal medicines of the “antidotes” in Nikolaos myrepsos׳ dynameron. J Ethnopharmacol. 2015 Apr;163(163):68–82.
   PubMed Web of Science ®Google Scholar
• Zunic L, Skrbo A, Dobraca A. Historical contribution of pharmaceutics to botany and pharmacognosy development. Mater Sociomed. 2017 Dec;29(4):291–300.
   PubMedGoogle Scholar
• Prioreschi P. A history of medicine: byzantine and Islamic medicine. US: Horatius press; 2001.
   Google Scholar
• Amr SS, Tbakhi A. Abu Bakr Muhammad ibn Zakariya al razi (rhazes): philosopher, physician and alchemist. Ann Saudi Med. 2007 Jul-Aug;27(4):305–307.
   PubMed Web of Science ®Google Scholar
• Peset JL. Plagues and diseases in history. In: International encyclopedia of the social & behavioral sciences. 2015. p. 174–179.
   Google Scholar
• Santacroce L, Bottalico L, Topi S, et al. The “scourge of the renaissance.” A short review about Treponema pallidum infection. Endocr Metab Immune Disord Drug Targets. 2020;20(3):335–344.
   PubMed Web of Science ®Google Scholar
• Charitos IA, D’Agostino D, Topi S, et al. 40 Years of helicobacter pylori: a revolution in biomedical thought. Gastroenterol Insights. 2021;12(12):111–135.
   Web of Science ®Google Scholar
• Lee MR. Ipecacuanha: the South American vomiting root. J R Coll Physicians Edinb. 2008 Dec;38(4):355–360.
   PubMedGoogle Scholar
• Safier N. Beyond Brazilian Nature: the editorial itineraries of marcgraf and piso’s historia naturalis brasiliae. In: Michiel Van Grosen, The Legacy of Dutch Brazil. New York: Cambridge University Press; 2014. p. 168–186.
   Google Scholar
• Schottenhammer A. “Peruvian balsam”: an example of transoceanic transfer of medicinal knowledge. J Ethnobiol Ethnomed. 2020 Nov 9;16(1):69.
   PubMed Web of Science ®Google Scholar
• Munger RS. Guaiacum, the holy wood from the New World. J Hist Med Allied Sci. 1949;4(2):196–229.
   PubMedGoogle Scholar
• DeFilipps RA, Krupnick GA. The medicinal plants of myanmar. PhytoKeys. 2018 Jun;102(102):1–341.
   Web of Science ®Google Scholar
• Malik AS, Shaukat MS, Qureshi AA, et al. Comparative effectiveness of chewing stick and toothbrush: a randomized clinical trial. N Am J Med Sci. 2014 Jul;6(7):333–337.
   PubMedGoogle Scholar
• Graves RR, Frazier WC. Food microorganisms influencing the growth of staphylococcus aureus. Appl Microbiol. 1963;11(6):513–516.
   PubMedGoogle Scholar
• Newsom SW. Pioneers in infection control-Joseph lister. J Hosp Infect. 2003 Dec;55(4):246–253.
   PubMed Web of Science ®Google Scholar
• Alberti G. [Vincenzo Tiberio]. Riforma Med. 1952 Dec 20;66(51):1397–1398.
   PubMedGoogle Scholar
• Il giornale della Previdenza dei Medici e degli Odontoiatri, Numero 7/2006, pp.14,15
   Google Scholar
• La chimica nella scuola, Società chimica Italiana; 2019, pp.7–16. Available from: http://www.soc.chim.it/sites/default/files/cns/pdf/2019-3.pdf (access 2021 Jul 30)
   Google Scholar
• Gonçalves T, Colour VU. Me blue: the history and the biotechnological potential of pyocyanin. Molecules. 2021 Feb 10;26(4):927.
   PubMed Web of Science ®Google Scholar
• Maruta H. From chemotherapy to signal therapy (1909-2009): a century pioneered by Paul ehrlich. Drug Discov Ther. 2009 Apr;3(2):37–40.
   PubMedGoogle Scholar
• Kaufmann SH. Remembering Emil von Behring: from tetanus treatment to antibody cooperation with phagocytes. mBio. 2017 Feb 28;8(1): 00117–17.
   PubMed Web of Science ®Google Scholar
• Gould K. Antibiotics: from prehistory to the present day. J Antimicrob Chemother. 2016 Mar;71(3):572–575.
   PubMed Web of Science ®Google Scholar
• Pouillard J. [A forgotten discovery: doctor of medicine Ernest Duchesne’s thesis (1874-1912)]. Histoire des sciences medicales. 2002 Jan-Mar;36(1):11–20.
   PubMedGoogle Scholar
• Gaynes R. The discovery of penicillin—new insights after more than 75 years of clinical use. Emerg Infect Dis. 2017 May;23(5):849–853.
   Web of Science ®Google Scholar
• Lobanovska M, Pilla G. Penicillin’s discovery and antibiotic resistance: lessons for the future? Yale J Biol Med. 2017 Mar 29;90(1):135–145.
   PubMed Web of Science ®Google Scholar
• Silver LL. Challenges of antibacterial discovery. Clin Microbiol Rev. 2011 Jan;24(1):71–109.
   PubMed Web of Science ®Google Scholar
• Supuran CT. Special Issue: sulfonamides. Molecules. 2017 Sep 29;22(10):1642.
   PubMed Web of Science ®Google Scholar
• van Miert AS. The sulfonamide-diaminopyrimidine story. J Vet Pharmacol Ther. 1994 Aug;17(4):309–316.
   PubMed Web of Science ®Google Scholar
• Ligon BL. Penicillin: its discovery and early development. Semin Pediatr Infect Dis. 2004 Jan;15(1):52–57.
   PubMedGoogle Scholar
• Waksman SA, Woodruff HB. Actinomyces antibioticus, a new soil organism antagonistic to pathogenic and non-pathogenic bacteria. J Bacteriol. 1941 Aug;42(2):231–249.
   PubMedGoogle Scholar
• NCBI:txid1890. Available from: https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=1890 ( access date 20 August, 2021)
   Google Scholar
• Pulsawat N, Kitani S, Fukushima E, et al. Hierarchical control of virginiamycin production in Streptomyces virginiae by three pathway-specific regulators: vmsS, VmsT and VmsR. Microbiology (Reading). 2009 Apr;155(4):1250–1259.
   PubMed Web of Science ®Google Scholar
• Woodruff HB, Selman A. Waksman, winner of the 1952 Nobel prize for physiology or medicine. Appl Environ Microbiol. 2014 Jan;80(1):2–8.
   PubMed Web of Science ®Google Scholar
• Kingston W, Streptomycin, Schatz V. Waksman, and the balance of credit for discovery. J Hist Med Allied Sci. 2004 Jul;59(3):441–462.
   PubMed Web of Science ®Google Scholar
• Levine DP. Vancomycin: a history. Clin Infect Dis. 2006 Jan 1;42(Suppl 1):S5–12.
   PubMed Web of Science ®Google Scholar
• Nelson ML, Levy SB. The history of the tetracyclines. Ann N Y Acad Sci. 2011 Dec;1241:17–32. 1241.
   PubMed Web of Science ®Google Scholar
• Geddes AM, Klugman KP, Rolinson GN. Introduction: historical perspective and development of amoxicillin/clavulanate. Int J Antimicrob Agents. 2007 Dec;30(2):S109–12.
   PubMed Web of Science ®Google Scholar
• Mohr KI. History of antibiotics research. Curr Top Microbiol Immunol. 2016(398):237–272.
   Google Scholar
• Chan Tompkins NH, Harnicar SJ. Prescribing trends with daptomycin (Cubicin) for the treatment of gram-positive infections. P T. 2008 May;33(5):282–288.
   PubMedGoogle Scholar
• Butler MS, Hansford KA, Blaskovich MA, et al. Glycopeptide antibiotics: back to the future. J Antibiot (Tokyo). 2014 Sep;67(9):631–644.
   PubMed Web of Science ®Google Scholar
• Blaskovich MAT, Hansford KA, Butler MS, et al. Developments in glycopeptide antibiotics. ACS Infect Dis. 2018 May 11;4(5):715–735.
   PubMed Web of Science ®Google Scholar
• Mosca A, Dalfino L, Romanelli F, et al. Effectiveness of colistin with rifampicin and meropenem against colistin-resistant Acinetobacter baumannii strains: an in vitro study”. Pharmacophore. 2020;11(2):1–6.
   Web of Science ®Google Scholar
• van Hal SJ, Fowler VG Jr. Is it time to replace vancomycin in the treatment of methicillin-resistant staphylococcus aureus infections? Clin Infect Dis. 2013 Jun;56(12):1779–1788.
   PubMed Web of Science ®Google Scholar
• Al-Obeid S, Haddad Q, Cherkaoui A, et al. First detection of an invasive staphylococcus aureus strain (D958) with reduced susceptibility to glycopeptides in Saudi Arabia. J Clin Microbiol. 2010 Jun;48(6):2199–2204.
   PubMed Web of Science ®Google Scholar
• Tiwari HK, Sen MR. Emergence of vancomycin resistant Staphylococcus aureus (VRSA) from a tertiary care hospital from northern part of India. BMC Infect Dis. 2006 Oct;6(6):156.
   PubMed Web of Science ®Google Scholar
• Chaiwongkarjohn S, Pramyothin P, Suwantarat N, et al. A report on the first case of vancomycin-intermediate staphylococcus aureus (VISA) in Hawaii. Hawaii Med J. 2011 Nov;70(11):233–236.
   PubMedGoogle Scholar
• Ruiz NM, Rámirez-Ronda CH. Tetracyclines, macrolides, lincosamides & chloramphenicol. Bol Asoc Med P R. 1990 Jan;82(1):8–17.
   PubMedGoogle Scholar
• Soares GM, Figueiredo LC, Faveri M, et al. Mechanisms of action of systemic antibiotics used in periodontal treatment and mechanisms of bacterial resistance to these drugs. J Appl Oral Sci. 2012 May-Jun;20(3):295–309.
   PubMed Web of Science ®Google Scholar
• Melander RJ, Zurawski DV, Narrow-spectrum antibacterial MC. Agents. Medchemcomm. 2018;9(1):12–21.
   PubMed Web of Science ®Google Scholar
• Baquero F, Levin BR. Proximate and ultimate causes of the bactericidal action of antibiotics. Nat Rev Microbiol. 2021 Feb;19(2):123–132.
   PubMed Web of Science ®Google Scholar
• Kohanski MA, Dwyer DJ, Collins JJ. How antibiotics kill bacteria: from targets to networks. Nat Rev Microbiol. 2010 Jun;8(6):423–435.
   PubMed Web of Science ®Google Scholar
• Aminov R, History of antimicrobial drug discovery: major classes and health impact, biochemical pharmacology, Vol 133, 2017, 4–19, https://doi.org/https://doi.org/10.1016/j.bcp.2016.10.001)
   Google Scholar
• Then RL. History and future of antimicrobial diaminopyrimidines. J Chemother. 1993 Dec;5(6):361–368.
   PubMed Web of Science ®Google Scholar
• Kunikawa S, Tanaka A, Takasuna Y, et al. A novel 2,4-diaminopyrimidine derivative as selective inhibitor of protein kinase C theta prevents allograft rejection in a rat heart transplant model. Bioorg Med Chem. 2018 Nov 1;26(20):5499–5509.
   PubMed Web of Science ®Google Scholar
• Pandey N, Cascella M. Beta lactam antibiotics. StatPearls:Treasure Island (FL): StatPearls Publishing; 2021. [Internet]. Jan.Available from: https://www.ncbi.nlm.nih.gov/books/NBK545311/ (access date Aug)
   Google Scholar
• Barker CI, Germovsek E, Sharland M. What do I need to know about penicillin antibiotics? Arch Dis Child Educ Pract Ed. 2017 Feb;102(1):44–50.
   PubMed Web of Science ®Google Scholar
• Miller EL. The penicillins: a review and update. J Midwifery Womens Health. 2002 Nov-Dec;47(6):426–434.
   PubMed Web of Science ®Google Scholar
• Tan JS, File TM Jr. Antipseudomonal penicillins. Med Clin North Am. 1995 Jul;79(4):679–693.
   PubMed Web of Science ®Google Scholar
• Kong KF, Schneper L, Mathee K. Beta-lactam antibiotics: from antibiosis to resistance and bacteriology. APMIS. 2010 Jan;118(1):1–36.
   PubMed Web of Science ®Google Scholar
• Yip DW, Gerriets V. Penicillin. StatPearls:Treasure Island (FL): StatPearls Publishing; 2021. [Internet]. Jan. Available from: https://www.ncbi.nlm.nih.gov/books/NBK554560/(access date Sept)
   Google Scholar
• Wright AJ. The penicillins. Mayo Clin Proc. 1999;74(3):290–307.
   PubMed Web of Science ®Google Scholar
• Bui T, Preuss CV. Cephalosporins. StatPearls: Treasure Island (FL): StatPearls Publishing; Updated 2021 Feb [Internet]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK551517/ (access date 17 Jan)
   Google Scholar
• O’Donnell JN, Rhodes NJ, Lopez J, et al. alternative β-lactams for the treatment of nosocomial pneumonia: a systematic review and meta-analysis. Int J Antimicrob Agents. 2018 Oct;52(4):451–458.
   PubMed Web of Science ®Google Scholar
• El-Gamal MI, Brahim I, Hisham N, et al. Recent updates of carbapenem antibiotics. Eur J Med Chem. 2017(131):185–195.
   Google Scholar
• Paterson DL, Depestel DD. Doripenem. Clin Infect Dis. 2009 Jul 15;49(2):291–298.
   PubMed Web of Science ®Google Scholar
• Brewer NS, Hellinger WC. The monobactams. Mayo Clin Proc. 1991 Nov;66(11):1152–1157.
   PubMed Web of Science ®Google Scholar
• Caruso C, Valluzzi RL, Colantuono S, et al. β-lactam allergy and cross-reactivity: a clinician’s guide to selecting an alternative antibiotic. J Asthma Allergy. 2021 Jan;18(14:31):46.
   Google Scholar
• Shutter MC, Akhondi H. Tetracycline. StatPearls: Treasure Island (FL): StatPearls Publishing; Updated 2021 Jul 8 Internet]; Available from: https://www.ncbi.nlm.nih.gov/books/NBK549905/ (access date Jan)
   Google Scholar
• Liang C, Pedersen JA, Balser TC. Aminoglycoside antibiotics may interfere with microbial amino sugar analysis. J Chromatogr A. 2009 Jul 3;1216(27):5296–5301.
   PubMed Web of Science ®Google Scholar
• Böttger EC, Aminoglycosides: CD. time for the resurrection of a neglected class of antibacterials? ACS Infect Dis. 2020 Feb 14;6(2):168–172.
   PubMed Web of Science ®Google Scholar
• Shakil S, Khan R, Zarrilli R, et al. Aminoglycosides versus bacteria–a description of the action, resistance mechanism, and nosocomial battleground. J Biomed Sci. 2008;15(1):5–14.
   PubMed Web of Science ®Google Scholar
• Patel PH, Hashmi MF. Macrolides. StatPearls: Treasure Island (FL): StatPearls Publishing; Updated 2021 Jun 14 [Internet]; Available from: https://www.ncbi.nlm.nih.gov/books/NBK551495/(access date Jan)
   Google Scholar
• Hajimirzaei N, Khalili NP, Boroumand B, et al. Comparative study of the effect of macrolide antibiotics erythromycin, clarithromycin, and azithromycin on the erg1 gene expression in H9c2 cardiomyoblast cells. Drug Res (Stuttg). 2020 Aug;70(8):341–347.
   PubMed Web of Science ®Google Scholar
• Spížek J, Lincosamides: ŘT. Chemical structure, biosynthesis, mechanism of action, resistance, and applications. Biochem Pharmacol. 2017 Jun;133(133):20–28.
   PubMed Web of Science ®Google Scholar
• Angela A, Raffaele DP, Federica R, et al. Multi-year prevalence and macrolide resistance of mycoplasma genitalium in clinical samples from a southern Italian hospital. Eur J Clin Microbiol Infect Dis. 2021 Apr;40(4):893–895.
   PubMed Web of Science ®Google Scholar
• Velkov T, Roberts KD, Nation RL, Velkov T, Roberts KD, Nation RL, et al. Pharmacology of polymyxins: new insights into an ‘old’ class of antibiotics. Future Microbiol. 2013 Jun;8(6):711–724.
   PubMed Web of Science ®Google Scholar
• Ayoub Moubareck C. Polymyxins and bacterial membranes: a review of antibacterial activity and mechanisms of resistance. Membranes (Basel). 2020 Aug 8;10(8):181.
   Web of Science ®Google Scholar
• Burman WJ, Gallicano K, Peloquin C. Comparative pharmacokinetics and pharmacodynamics of the rifamycin antibacterials. Clin Pharmacokinet. 2001;40(5):327–341.
   PubMed Web of Science ®Google Scholar
• Koo HL, DuPont HL. Rifaximin: a unique gastrointestinal-selective antibiotic for enteric diseases. Curr Opin Gastroenterol. 2010 Jan;26(1):17–25.
   PubMed Web of Science ®Google Scholar
• Pham TDM, Ziora ZM, Blaskovich MAT. Quinolone antibiotics. Medchemcomm. 2019;10(10):1719–1739.
   PubMed Web of Science ®Google Scholar
• Madaan A, Verma R, Kumar V, et al. 1,8-Naphthyridine derivatives: a review of multiple biological activities. Arch Pharm (Weinheim). 2015;348(12):837–860.
   PubMed Web of Science ®Google Scholar
• Stefancich G, Artico M, Corelli F, et al. 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1H-pyrrol-1-yl)-quinoline-3-carb oxylic acid, a new fluorinated compounds of oxacin family with high broad-spectrum antibacterial activities. Il Farmaco; edizione scientifica. 1985 Apr;40(4):237–248.
   PubMedGoogle Scholar
• Rowen RC, Michel DJ, Thompson JC. Norfloxacin: clinical pharmacology and clinical use. Pharmacotherapy. 1987;7(4):92–110.
   PubMed Web of Science ®Google Scholar
• Edwards DI. Nitroimidazole drugs–action and resistance mechanisms. I. mechanisms of action. J Antimicrob Chemother. 1993 Jan;31(1):9–20.
   PubMed Web of Science ®Google Scholar
• Liu K, Zhu HL. Nitroimidazoles as anti-tumor agents. Anticancer Agents Med Chem. 2011 Sep;11(7):687–691.
   PubMed Web of Science ®Google Scholar
• Henson KE, Levine MT, Wong EA, et al. Glycopeptide antibiotics: evolving resistance, pharmacology and adverse event profile. Expert Rev Anti Infect Ther. 2015;13(10):1265–1278.
   PubMed Web of Science ®Google Scholar
• Howden BP, Davies JK, Johnson PD, et al. Reduced vancomycin susceptibility in staphylococcus aureus, including vancomycin-intermediate and heterogeneous vancomycin-intermediate strains: resistance mechanisms, laboratory detection, and clinical implications. Clin Microbiol Rev. 2010 Jan;23(1):99–139.
   PubMed Web of Science ®Google Scholar
• Schalock PC, Zug KA. Bacitracin. Cutis. 2005 Aug;76(2):105–107.
   PubMed Web of Science ®Google Scholar
• May JM, Owens TW, Mandler MD, et al. The antibiotic novobiocin binds and activates the ATPase that powers lipopolysaccharide transport. J Am Chem Soc. 2017 Dec 6;139(48):17221–17224.
   PubMed Web of Science ®Google Scholar
• Oong GC, Tadi P. Chloramphenicol; StatPearls: Treasure Island (FL): StatPearls Publishing.2021. [Updated Jul 9]. In: [Internet]; Jan. Available from: https://www.ncbi.nlm.nih.gov/books/NBK555966/ (access date 30Jul)
   Google Scholar
• Li J, Xie S, Ahmed S, et al. Antimicrobial activity and resistance: influencing factors. Front Pharmacol. 2017 Jun;13(8):364.
   Web of Science ®Google Scholar
• CDC’s Antibiotic Resistance Threats in the United States. Centers for Disease Control and Prevention,USA,2019. Available from: https://www.cdc.gov/drugresistance/pdf/threats-report/2019-ar-threats-report-508.pdf (access date 2021 Jul 30)
   Google Scholar
• Reygaert WC. An overview of the antimicrobial resistance mechanisms of bacteria. AIMS Microbiol. 2018 Jun 26;4(3):482–501.
   PubMed Web of Science ®Google Scholar
• Leone D, Valenzano A, Grande G, et al. [Drug/food interactions: an actual therapeutic outcome]. La Clinica terapeutica. 2004 Apr;155(4):139–147.
   PubMedGoogle Scholar
• Bush K, Bradford PA. β-lactams and β-lactamase inhibitors: an overview. Cold Spring Harb Perspect Med. 2016 Aug 1;6(8):a025247.
   PubMed Web of Science ®Google Scholar
• Blázquez B, Llarrull LI, Luque-Ortega JR, et al. Regulation of the expression of the β-lactam antibiotic-resistance determinants in methicillin-resistant Staphylococcus aureus (MRSA). Biochemistry. 2014 Mar 18;53(10):1548–1550.
   PubMed Web of Science ®Google Scholar
• James CE, Mahendran KR, Molitor A, et al. beta-lactam antibiotics enter bacteria: a dialogue with the porins. PLoS One. 2009;4(5):e5453.
   PubMed Web of Science ®Google Scholar
• Limoli DH, Jones CJ, Wozniak DJ. Bacterial extracellular polysaccharides in biofilm formation and function. Microbiol Spectr. 2015 Jun 3;(3):https://doi.org/10.1128/microbiolspec.MB-0011-2014.
   Google Scholar
• Kanhere A, Vingron M. Horizontal gene transfers in prokaryotes show differential preferences for metabolic and translational genes. BMC Evol Biol. 2009 Jan;10(9):9.
   Web of Science ®Google Scholar
• Sultan I, Rahman S, Jan AT, et al. Antibiotics, resistome and resistance mechanisms: a bacterial perspective. Front Microbiol. 2018 Sep;21(9):2066.
   Web of Science ®Google Scholar
• Verraes C, Van Boxstael S, Van Meervenne E, et al. Antimicrobial resistance in the food chain: a review. Int J Environ Res Public Health. 2013 Jun 28;10(7):2643–2669.
   PubMed Web of Science ®Google Scholar
• Partridge SR, Kwong SM, Firth N, et al. Mobile genetic elements associated with antimicrobial resistance. Clin Microbiol Rev. 2018 Aug 1;31(4):e00088–17.
   PubMed Web of Science ®Google Scholar
• Bennett PM. Plasmid encoded antibiotic resistance: acquisition and transfer of antibiotic resistance genes in bacteria. Br J Pharmacol. 2008 Mar;153(Suppl1):S347–57.
   PubMed Web of Science ®Google Scholar
• Svara F, Rankin DJ. The evolution of plasmid-carried antibiotic resistance. BMC Evol Biol. 2011 May;19(11):130.
   Web of Science ®Google Scholar
• Yajjala VK, Widhelm TJ, Endres JL, et al. Generation of a transposon mutant library in staphylococcus aureus and staphylococcus epidermidis using bursa aurealis. Methods Mol Biol. 2016(1373):103–110
   PubMedGoogle Scholar
• Guay GG, Khan SA, Rothstein DM. The tet(K) gene of plasmid pT181 of Staphylococcus aureus encodes an efflux protein that contains 14 transmembrane helices. Plasmid. 1993 Sep;30(2):163–166.
   PubMed Web of Science ®Google Scholar
• Krauland MG, Marsh JW, Paterson DL, et al. Integron-mediated multidrug resistance in a global collection of nontyphoidal salmonella enterica isolates. Emerg Infect Dis. 2009 Mar;15(3):388–396.
   PubMed Web of Science ®Google Scholar
• Guédon G, Libante V, Coluzzi C, et al. The obscure world of integrative and mobilizable elements, highly widespread elements that pirate bacterial conjugative systems. Genes (Basel). 2017 Nov 22;8(11):337.
   PubMed Web of Science ®Google Scholar
• Bello-López JM, Cabrero-Martínez OA, Ibáñez-Cervantes G, et al. Horizontal gene transfer and its association with antibiotic resistance in the genus Aeromonas spp. Microorganisms. 2019 Sep 18;7(9):363.
   Web of Science ®Google Scholar
• Martinez JL. The role of natural environments in the evolution of resistance traits in pathogenic bacteria. Proc Biol Sci. 2009 Jul 22;276(1667):2521–2530.
   PubMed Web of Science ®Google Scholar
• Redgrave LS, Sutton SB, Webber MA, et al. Fluoroquinolone resistance: mechanisms, impact on bacteria, and role in evolutionary success. Trends Microbiol. 2014 Aug;22(8):438–445.
   PubMed Web of Science ®Google Scholar
• Wiedemann B, Heisig P. Mechanisms of quinolone resistance. Infection. 1994;22(Suppl 2):S73–9.
   PubMed Web of Science ®Google Scholar
• Garneau-Tsodikova S, Labby KJ. Mechanisms of resistance to aminoglycoside antibiotics: overview and perspectives. Medchemcomm. 2016 Jan 1;7(1):11–27.
   PubMed Web of Science ®Google Scholar
• Schweizer I, Blättner S, Maurer P, et al. New aspects of the interplay between penicillin binding proteins, murm, and the two-component system ciarh of penicillin-resistant streptococcus pneumoniae serotype 19a isolates from hungary. Antimicrob Agents Chemother. 2017 Jun 27;61(7):e00414–17.
   PubMed Web of Science ®Google Scholar
• Mosca A, Carucci A, Santacroce L, et al. Streptococcus pneumoniae nasopharyngeal colonization in young healthy children: rate of carriage, serotype distribution, and antibiotic resistance. New Microbiol. 2003 Apr;26(2):187–192.
   PubMed Web of Science ®Google Scholar
• Fishovitz J, Hermoso JA, Chang M, et al. Penicillin-binding protein 2a of methicillin-resistant staphylococcus aureus. IUBMB Life. 2014 Aug;66(8):572–577.
   PubMed Web of Science ®Google Scholar
• Lowy FD. Antimicrobial resistance: the example of Staphylococcus aureus. J Clin Invest. 2003 May;111(9):1265–1273.
   PubMed Web of Science ®Google Scholar
• Seppälä H, Skurnik M, Soini H, et al. A novel erythromycin resistance methylase gene (ermTR) in streptococcus pyogenes. Antimicrob Agents Chemother. 1998 Feb;42(2):257–262.
   PubMed Web of Science ®Google Scholar
• Weisblum B. Erythromycin resistance by ribosome modification. Antimicrob Agents Chemother. 1995 Mar;39(3):577–585.
   PubMed Web of Science ®Google Scholar
• Abdolmaleki Z, Mashak Z, Safarpoor Dehkordi F. Phenotypic and genotypic characterization of antibiotic resistance in the methicillin-resistant Staphylococcus aureus strains isolated from hospital cockroaches. Antimicrob Resist Infect Control. 2019 Mar;8(8):54.
   PubMed Web of Science ®Google Scholar
• Gardete S, Tomasz A. Mechanisms of vancomycin resistance in Staphylococcus aureus. J Clin Invest. 2014 Jul;124(7):2836–2840.
   PubMed Web of Science ®Google Scholar
• Jian Y, Lv H, Liu J, et al. Dynamic changes of staphylococcus aureus susceptibility to vancomycin, teicoplanin, and linezolid in a central teaching hospital in Shanghai, China, 2008-2018. Front Microbiol. 2020 May;11(11):908.
   PubMed Web of Science ®Google Scholar
• Mainardi JL, Shlaes DM, Goering RV, et al. Decreased teicoplanin susceptibility of methicillin-resistant strains of Staphylococcus aureus. J Infect Dis. 1995;171(6):1646–1650.
   PubMed Web of Science ®Google Scholar
• Miller K, O’Neill AJ, Wilcox MH, et al. Delayed development of linezolid resistance in staphylococcus aureus following exposure to low levels of antimicrobial agents. Antimicrob Agents Chemother. 2008 Jun;52(6):1940–1944.
   PubMed Web of Science ®Google Scholar
• Meziane-Cherif D, Stogios PJ, Evdokimova E, et al. Structural basis for the evolution of vancomycin resistance D,D-peptidases. Proc Natl Acad Sci U S A. 2014 Apr 22;111(16):5872–5877.
   PubMed Web of Science ®Google Scholar
• Cetinkaya Y, Falk P, Mayhall CG. Vancomycin-resistant enterococci. Clin Microbiol Rev. 2000 Oct;13(4):686–707.
   PubMed Web of Science ®Google Scholar
• Peterson E, Kaur P. Antibiotic resistance mechanisms in bacteria: relationships between resistance determinants of antibiotic producers, environmental bacteria, and clinical pathogens. Front Microbiol. 2018 Nov;30(9):2928.
   Web of Science ®Google Scholar
• Charitos IA, Topi S, Castellaneta F, et al. Current Issues and Perspectives in Patients with Possible Sepsis at Emergency Departments. Antibiotics (Basel). 2019 May 7;8(2):56.
   PubMed Web of Science ®Google Scholar
• World Health Organization. 2017. Global priority list of antibiotic-resistant bacteria to guide research, discovery, and development of new antibiotics. Available from: http://www.who.int/medicines/publications/WHO-PPL-Short_Summary_25Feb-ET_NM_WHO.pdf?ua1 (access date 4 Jul, 2021)
   Google Scholar
• De Oliveira DMP, Forde BM, Kidd TJ, et al. Antimicrobial Resistance in ESKAPE Pathogens. Clin Microbiol Rev. 2020;33(3):e00181–19.
   PubMed Web of Science ®Google Scholar
• Gnoni A, De Nitto E, Scacco S, et al. A new look at the structures of old sepsis actors by exploratory data analysis tools. Antibiotics (Basel). 2019 Nov 14;8(4):225.
   Web of Science ®Google Scholar
• Nikaido H. Multidrug resistance in bacteria. Annu Rev Biochem. 2009;78:119–146.
   PubMed Web of Science ®Google Scholar
• Li X-Z, Nikaido H. Efflux-mediated drug resistance in bacteria: an update. Drugs. 2009 Aug 20;69(12):1555–1623.
   PubMed Web of Science ®Google Scholar
• Klare I, Konstabel C, Badstübner D, et al. Occurrence and spread of antibiotic resistances in enterococcus faecium. Int J Food Microbiol. 88(2–3): 269–290.
   PubMed Web of Science ®Google Scholar
• Calfee DP. Methicillin-resistant staphylococcus aureus and vancomycin-resistant enterococci, and other gram-positives in healthcare. Curr Opin Infect Dis. 2012 Aug;25(4):385–394.
   PubMed Web of Science ®Google Scholar
• Catry B, Laevens H, Devriese LA, et al. Antimicrobial resistance in livestock. J Vet Pharmacol Ther. 2003 Apr;26(2):81–93.
   PubMed Web of Science ®Google Scholar
• Nilsson O. Vancomycin resistant enterococci in farm animals - occurrence and importance. Infect Ecol Epidemiol. 2012;2.
   Google Scholar
• Charpentier E, Courvalin P. Antibiotic resistance in listeria spp. Antimicrob Agents Chemother. 1999 Sep;43(9):2103–2108.
   PubMed Web of Science ®Google Scholar
• Leclercq R. Antibiotic resistance in streptococci and enterococci. In: Horaud T, Bouvet A, Leclercq R, et al., editors. Streptococci and the Host. Advances in Experimental Medicine and Biology, vol 418. Boston (MA); Springer;1997.
   Google Scholar
• Schrag SJ, Beall B, Dowell S Resistant pneumococcal infections, 2001. Available from: https://www.who.int/drugresistance/technicalguidance/en/resistantinfection.pdf
   Google Scholar
• Centers for Disease Control and Prevention (CDC), USA, Active Bacterial Core surveillance (ABCs), 2018. Available on https://www.cdc.gov/abcs/reports-findings/surv-reports.html (access date 2021 May 2)
   Google Scholar
• European Antimicrobial Resistance Surveillance Network. 2019. Surveillance of antimicrobial resistance in Europe. annual report of the European antimicrobial resistance surveillance network (EARS-Net) 2018. Available from: https://www.ecdc.europa.eu/sites/default/files/documents/surveillance-antimicrobial-resistance-Europe-2018.pdf (access date 2021 Jun 20)
   Google Scholar
• Nagy-Bota MC, Man A, Santacroce L, et al. Essential oils as alternatives for root-canal treatment and infection control against enterococcus faecalis—a preliminary study. Appl Sci. 2021;11(11):1422.
   Google Scholar
• Santacroce L, Losacco T. Abdominal sepsis in surgical patients. pathophysiology and prevention. Recenti Prog Med. 2006 Jul-Aug;97(7–8):411–416.
   PubMedGoogle Scholar
• Carretta DM, Silva AM, D’Agostino D, et al. Cardiac involvement in COVID-19 patients: a contemporary review. Infect Dis Rep. 2021 Jun 1;13(2):494–517.
   PubMed Web of Science ®Google Scholar
• Santacroce L, Cagiano R, Carlaio RG, et al. Dentistry oral hygiene and endocarditis. Pathophysiology and prophylactic therapy. Recenti Prog Med. 2008 Oct;99(10):516–521.
   PubMedGoogle Scholar
• Bottalico L, Tatullo M, Marrelli M, et al. Lights and shadows of dental implants: focus on mucositis and perimplantitis and their biological markers. J Biol Regul Homeost Agents. 2016 Jul-Sep;30(3):859–861.
   PubMed Web of Science ®Google Scholar
• Mangini F, Santacroce L, Bottalico L. Periodontitis and systemic diseases. Clin Ter. 2006 Nov-Dec;157(6):541–548.
   PubMedGoogle Scholar
• Santacroce L, Carlaio RG, Bottalico L. Does it make sense that diabetes is reciprocally associated with periodontal disease? Endocr Metab Immune Disord Drug Targets. 2010 Mar;10(1):57–70.
   PubMedGoogle Scholar
• Santacroce L, Cagiano R, Del Prete R, et al. Helicobacter pylori infection and gastric MALTomas: an up-to-date and therapy highlight. Clin Ter. 2008 Nov-Dec;159(6):457–462.
   PubMed Web of Science ®Google Scholar
• Al-Waili BR, Al-Thawadi S, Hajjar SA. Impact of the revised penicillin susceptibility breakpoints for Streptococcus pneumoniae on antimicrobial resistance rates of meningeal and non-meningeal pneumococcal strains. Ann Saudi Med. 2013 Mar-Apr;33(2):111–115.
   PubMed Web of Science ®Google Scholar
• Weinstein MP, Lewis JS 2nd. The clinical and laboratory standards institute subcommittee on antimicrobial susceptibility testing: background, organization, functions, and processes. J Clin Microbiol. 2020;58(3):e01864–19.
   PubMed Web of Science ®Google Scholar
• Levitus M, Rewane A, Perera TB. Vancomycin-Resistant Enterococci. StatPearls: Treasure Island (FL): StatPearls Publishing; 2020.Updated Jul 21 [Internet]; 2021. Available from: https://www.ncbi.nlm.nih.gov/books/NBK513233/. (access date Jan)
   Google Scholar
• Aminzadeh Z, Yadegarynia D, Fatemi A, et al. Vancomycin minimum inhibitory concentration for methicillin-resistant staphylococcus aureus infections; is there difference in mortality between patients? Jundishapur J Microbiol. 2014 Oct;7(10):e12831.
   PubMed Web of Science ®Google Scholar
• The LJ. VISA/GISA problem: therapeutic implications. Clin Microbiol Infect. 2001;7(Suppl 4):8–15.
   Google Scholar
• McGuinness WA, Malachowa N, DeLeo FR. Vancomycin resistance in staphylococcus aureus. Yale J Biol Med. 2017 Jun 23;90(2):269–281.
   PubMed Web of Science ®Google Scholar
• Cavallo JD, Mérens A. Spectre d’activité antibactérien d’un antibiotique et catégorisation clinique [Antibacterial spectrum of an antibiotic and clinical categorization]. Pathol Biol. 2008 Jul;56(5):300–304.
   PubMedGoogle Scholar
• The PEW Charitable Trusts. 2019. Antibiotics currently in global clinicaldevelopment. Available from: https://www.pewtrusts.org/-/media/assets/2019/08/arp_antibiotics_currently_in_global_clinical_development_data_table_v2.pdf. (access date 2021 Jul 30)
   Google Scholar
• Shaeer KM, Zmarlicka MT, Chahine EB, et al. Plazomicin: a next-generation aminoglycoside. Pharmacotherapy. 2019;39:77–93.
   PubMed Web of Science ®Google Scholar
• Snydman DR, McDermott LA, Jacobus NV, et al. Evaluation of the in vitro activity of eravacycline against a broad spectrum of recent clinical anaerobic isolates. Antimicrob Agents Chemother. 2018;62:e02206–17.
   PubMed Web of Science ®Google Scholar
• Dougherty JA, Sucher AJ, Chahine EB, et al. Omadacycline: a new tetracycline antibiotic. Ann Pharmacother. 2019;53:486–500.
   PubMed Web of Science ®Google Scholar
• U.S. Food and Drug Administration. 2019. FDA approves new antibiotic to treat community-acquired bacterial pneumonia. Available from: https://www.fda.gov/news-events/press-announcements/fda-approves-new-antibiotic-treat-community-acquired-bacterial-pneumonia (access date 26 Aug, 2021)
   Google Scholar
• Papp-Wallace KM, Barnes MD, Alsop J, et al. Relebactam is apotent inhibitor of the KPC-2 beta-lactamase and restores imipenem susceptibility in KPC-producing enterobacteriaceae. Antimicrob Agents Chemother. 2018(62):00174–18
   Google Scholar
• Alexander E, Goldberg L, Das AF, et al. Oral lefamulin vs moxifloxacin for early clinical response among adults with community-acquired bacterial pneumonia: the LEAP 2 randomized clinical trial. JAMA. 1661–1671;2019(322).
   Google Scholar
• Kyorin Pharmaceutical Co. Ltd. 2019. Kyorin pharmaceutical receives marketing approval for oral quinolone antibacterial agent “Lasvic tablets 75mg. Available from: https://www.kyorin-pharm.co.jp/en/news/2019/001368.shtml (access date 2021 Jul 6)
   Google Scholar
• Bonomo RA. Cefiderocol: a novel siderophore cephalosporindefeating carbapenem-resistant pathogens. Clin Infect Dis. 2019;(69):S519–S520.
   PubMed Web of Science ®Google Scholar
• Martin-Loeches I, Dale GE, Torres A. Murepavadin: a new antibiotic class in the pipeline. Expert Rev Anti Infect Ther. 2018;(16): 259–26.
   Google Scholar
• Mohsen S, Dickinson JA, Somayaji R. Update on the adverse effects of antimicrobial therapies in community practice. Can Fam Physician. 2020 Sep;66(9):651–659.
   PubMed Web of Science ®Google Scholar
• Trac MH, McArthur E, Jandoc R, et al. Macrolide antibiotics and the risk of ventricular arrhythmia in older adults. CMAJ. 2016 Apr 19;188(7):E120–E129.
   PubMed Web of Science ®Google Scholar
• Bui T, Preuss CV. Cephalosporins; StatPearls: Treasure Island (FL): StatPearls Publishing; 2021. [Updated Feb 17]. In: [Internet]; Jan. Available from: https://www.ncbi.nlm.nih.gov/books/NBK551517/ (access dateJul22)
   Google Scholar
• Phillips ME, Eastwood JB, Curtis JR, et al. Tetracycline poisoning in renal failure. Br Med J. 1974 Apr 20;2(5911):149–151.
   PubMed Web of Science ®Google Scholar
• Selimoglu E. Aminoglycoside-induced ototoxicity. Curr Pharm Des. 2007;13(1):119–126.
   PubMed Web of Science ®Google Scholar
• Mathews B, Thalody AA, Miraj SS, et al. Effects of fluoroquinolones: a retrospective cohort study in a south Indian tertiary healthcare facility. Antibiotics (Basel). 2019 Jul 27;8(3):104.
   Web of Science ®Google Scholar
• Rubini G, Ferrari C, Carretta D, et al. Usefulness of 18F-FDG PET/CT in patients with cardiac implantable electronic device suspected of late infection. J Clin Med. 2020 Jul 15;9(7):2246.
   Web of Science ®Google Scholar
• Nes IF, Johnsborg O. Exploration of antimicrobial potential in LAB by genomics. Curr Opin Biotechnol. 2004 Apr;15(2):100–104.
   PubMed Web of Science ®Google Scholar
• Arena F, Giani T, Pollini S, et al. Molecular antibiogram in diagnostic clinical microbiology: advantages and challenges. Future Microbiol. 2017 Apr;12:361–364.
   PubMed Web of Science ®Google Scholar
• Santacroce L, Cagiano R, Del Prete R, et al. T. Helicobacter pylori infection and gastric MALTomas: an up-to-date and therapy highlight. Clin Ter. 2008 Nov-Dec;159(6):457–462.
   PubMed Web of Science ®Google Scholar
• Joshi S. Hospital antibiogram: a necessity. Indian J Med Microbiol. 2010 Oct-Dec;28(4):277–280.
   PubMed Web of Science ®Google Scholar
• Centers for Disease Control and Prevention (CDC), USA. Collecting Cultures: a Clinician Guide, 2019. Available from: https://www.cdc.gov/antibiotic-use/core-elements/collecting-cultures.html (access date 4 Sept, 2021)
   Google Scholar
• Boehme MS, Somsel PA, Downes FP. Systematic review of antibiograms: a national laboratory system approach for improving antimicrobial susceptibility testing practices in michigan. 433021. 2010;125(Suppl2):63–72.
   Google Scholar
• Jenkins SG, Schuetz AN. Current concepts in laboratory testing to guide antimicrobial therapy. Mayo Clin Proc. 2012 Mar;87(3):290–308.
   PubMed Web of Science ®Google Scholar
• Andrews JM. Determination of minimum inhibitory concentrations. J Antimicrob Chemother. 2001 Jul;48(Suppl 1):5–16.
   PubMed Web of Science ®Google Scholar
• Updated GJ. EUCAST clinical breakpoints against aspergillus, implications for the clinical microbiology laboratory. J Fungi (Basel). 2020 Dec 6;6(4):343.
   Google Scholar
• Balouiri M, Sadiki M, Ibnsouda SK. Methods for in vitro evaluating antimicrobial activity: a review. J Pharm Anal. 2016 Apr;6(2):71–79.
   PubMed Web of Science ®Google Scholar
• Khan ZA, Siddiqui MF, Current PS. Emerging methods of antibiotic susceptibility testing. Diagnostics (Basel). 2019May3;9(2):49.
   PubMedGoogle Scholar
• Hesje CK, Tillotson GS, Blondeau JM. MICs, MPCs and PK/PDs: a match (sometimes) made in hosts. Expert Rev Respir Med. 2007 Aug 1;1(1):7–16.
   PubMedGoogle Scholar
• Karchmer AW. Definitive treatment for methicillin-susceptible staphylococcus aureus bacteremia: data versus a definitive answer? Clin Infect Dis. 2017 Jul 1;65(1):107–109.
   PubMed Web of Science ®Google Scholar