1,968
Views
0
CrossRef citations to date
0
Altmetric
Original Research

Hydroxychloroquine as pre-exposure prophylaxis against COVID-19 infection among healthcare workers: a prospective cohort study

ORCID Icon, ORCID Icon, , , , , & show all
Pages 781-787 | Received 24 Oct 2021, Accepted 22 Nov 2021, Published online: 20 Dec 2021

References

  • Bourgeault IL, Maier CB, Dieleman M, et al. The COVID-19 pandemic presents an opportunity to develop more sustainable health workforces. Hum Resour Health. 2020;18(1):83.
  • Nguyen LH, Drew DA, Graham MS, et al. Coronavirus pandemic epidemiology consortium. Risk of COVID-19 among front-line health-care workers and the general community: a prospective cohort study. Lancet Public Health. 2020;5:e475–83.
  • Cook TM. Personal protective equipment during the coronavirus disease (COVID) 2019 pandemic – a narrative review. Anaesthesia. 2020;75(7):920–927.
  • Kumar A, Kubota Y, Chernov M, et al. Potential role of zinc supplementation in prophylaxis and treatment of COVID-19. Med Hypotheses. 2020;144:109848.
  • Cutolo M, Paolino S, Smith V. Evidences for a protective role of vitamin D in COVID-19. RMD Open. 2020;6(3):e001454.
  • Andrade BS, Rangel FS, Santos NO, et al. Repurposing approved drugs for guiding COVID-19 prophylaxis: a systematic review. Front Pharmacol. 2020;11:590598.
  • Liu J, Cao R, Xu M, et al. Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro. Cell Discov. 2020;6:16.
  • Niburski K, Niburski O. Impact of Trump’s promotion of unproven COVID-19 treatments and subsequent internet trends: observational study. J Med Internet Res. 2020;22(11):e20044.
  • Mehra MR, Ruschitzka F, Patel AN. Retraction-Hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19: a multinational registry analysis. Lancet. 2020;395(10240):1820.
  • Singh H, Chauhan P, Kakkar AK. Hydroxychloroquine for the treatment and prophylaxis of COVID-19: the journey so far and the road ahead. Eur J Pharmacol. 2021;890:173717.
  • Indian Council of Medical Research. Revised advisory on the use of Hydroxychloroquine (HCQ) as prophylaxis for SARS-CoV-2 infection. [Internet] 2020. [updated 2020 May 22; cited 2021 May 22; cited 2021 May 22; cited 2021 May 22]. Available from: https://www.icmr.gov.in/pdf/covid/techdoc/V5_Revised_advisory_on_the_use_of_HCQ_SARS_CoV2_infection.pdf
  • Bhattacharya R, Chowdhury S, Nandi A, et al. Pre-exposure hydroxychloroquine prophylaxis for covid-19 in healthcare workers: a retrospective cohort. Int J Res Med Sci. 2020;9(1):89–96.
  • Barnabas RV, Brown ER, Bershteyn A, et al. Hydroxychloroquine as postexposure prophylaxis to prevent severe acute respiratory syndrome coronavirus 2 infection: a randomized trial. Ann Intern Med. 2021;174(3):344–352.
  • Grau-Pujol B, Camprubí D, Marti-Soler H, et al. Pre-exposure prophylaxis with hydroxychloroquine for COVID-19: initial results of a double-blind, placebo-controlled randomized clinical trial. Res Square. 2020. DOI:https://doi.org/10.21203/rs.3.rs-72132/v1.
  • Abella BS, Jolkovsky EL, Biney BT, et al. Efficacy and safety of hydroxychloroquine vs placebo for pre-exposure SARS-CoV-2 prophylaxis among health care workers: a randomized clinical trial. JAMA Intern Med. 2021;181(2):195–202.
  • Rajasingham R, Bangdiwala AS, Nicol MR, et al. Hydroxychloroquine as pre-exposure prophylaxis for coronavirus disease 2019 (COVID-19) in healthcare workers: a randomized trial. Clin Infect Dis. 2021;72(11):e835–e843.
  • Boulware DR, Pullen MF, Bangdiwala AS, et al. A randomized trial of hydroxychloroquine as postexposure prophylaxis for Covid-19. N Engl J Med. 2020;383:517–525.
  • Mitjà O, Marc CM, Ubals M, et al. A cluster-randomized trial of hydroxychloroquine for prevention of Covid-19. N Engl J Med. 2021;384:417–427.
  • World Health Organisation. WHO Coronavirus (COVID-19) dashboard. [Internet] 2021. cited 2021 Oct 16]. Available from: https://covid19.who.int/
  • Burki T. Global COVID-19 vaccine inequity. Lancet Infect Dis. 2021;21(7):922–923.
  • Stricker RB, Fesler MC. Hydroxychloroquine pre-exposure prophylaxis for COVID-19 in healthcare workers from india: a meta-analysis. J Infect Public Health. 2021;14(9):1161–1163.
  • World Health Organisation. Coronavirus disease (COVID-19): solidarity Trial and hydroxychloroquine. [updated 2020 Jun 19; cited 2021 Oct 16]. Available from: https://www.who.int/news-room/q-a-detail/coronavirus-disease-covid-19-hydroxychloroquine.
  • Martins-Filho PR, Ferreira LC, Heimfarth L, et al. Efficacy and safety of hydroxychloroquine as pre-and post-exposure prophylaxis and treatment of COVID-19: a systematic review and meta-analysis of blinded, placebo-controlled, randomized clinical trials. Lancet Reg Health Am. 2021; 2: 100062.
  • Dinesh B, Cs J, Kaur CP, et al. Hydroxychloroquine for SARS CoV2 prophylaxis in healthcare workers - a multicentric cohort study assessing effectiveness and safety. J Assoc Physicians India. 2021;69(6):17–23.
  • World Health Organization. Drugs to prevent COVID-19: a WHO living guideline. [ updated 2021 Mar 19; cited 2021 Oct 16]. Available from: https://www.who.int/publications/i/item/WHO-2019-nCoV-prophylaxes-2021-1
  • Cruciani M, Pati I, Masiello F, et al. Ivermectin for prophylaxis and treatment of COVID-19: a systematic review and meta-analysis. Diagnostics (Basel). 2021 Sep 8;11(9):1645.
  • Reardon S. Flawed ivermectin preprint highlights challenges of COVID drug studies. Nature. 2021 Aug;596(7871):173–174.
  • Bergwerk M, Gonen T, Lustig Y, et al. Covid-19 breakthrough infections in vaccinated health care workers. N Engl J Med. 2021;385(16):1474–1484.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.