Current rates of purchasing of antibiotics without a prescription across sub-Saharan Africa; rationale and potential programmes to reduce inappropriate dispensing and resistance

References

• Cassini A, Högberg LD, Plachouras D, et al. Attributable deaths and disability-adjusted life-years caused by infections with antibiotic-resistant bacteria in the EU and the European economic area in 2015: a population-level modelling analysis. Lancet Infect Dis. 2019;19(1):56–66. doi: 10.1016/S1473-3099(18)30605-4
   PubMed Web of Science ®Google Scholar
• Murray CJL, Ikuta KS, Sharara F. Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis. Lancet. 2022;399(10325):629–655. doi: 10.1016/S0140-6736(21)02724-0
   PubMed Web of Science ®Google Scholar
• Dadgostar P. Antimicrobial resistance: implications and costs. Infect Drug Resist. 2019;12: 3903–3910. doi: 10.2147/IDR.S234610
   PubMed Web of Science ®Google Scholar
• World Bank Group. Pulling Together to Beat Superbugs knowledge and implementation Gaps in Addressing antimicrobial resistance. 2019. [cited 2023 Apr5]. Available from: https://openknowledge.worldbank.org/bitstream/handle/10986/32552/Pulling-Together-to-Beat-Superbugs-Knowledge-and-Implementation-Gaps-in-Addressing-Antimicrobial-Resistance.pdf?sequence=1&isAllowed=y
   Google Scholar
• Aiken AM, Rehman AM, de Kraker MEA, et al. Mortality associated with third-generation cephalosporin resistance in Enterobacterales bloodstream infections at eight sub-Saharan African hospitals (MBIRA): a prospective cohort study. Lancet Infect Dis. 2023. doi: 10.1016/S1473-3099(23)00233-5
   PubMedGoogle Scholar
• O’Neill J TACKLING DRUG-RESISTANT INFECTIONS GLOBALLY: FINAL REPORT and RECOMMENDATIONS - THE REVIEW on ANTIMICROBIAL RESISTANCE. 2016. [cited 2023 Mar 20]. Available from: https://amr-review.org/sites/default/files/160525_Final%20paper_with%20cover.pdf
   Google Scholar
• Poudel AN, Zhu S, Cooper N, et al. The economic burden of antibiotic resistance: a systematic review and meta-analysis. PLoS One. 2023;18(5):e0285170. doi: 10.1371/journal.pone.0285170
   PubMed Web of Science ®Google Scholar
• The World Bank. Final report - DRUG-RESISTANT INFECTIONS. A threat to our economic future. Mar 2017. [cited 2023 Mar 20]. Available from: http://documents1.worldbank.org/curated/en/323311493396993758/pdf/final-report.pdf
   Google Scholar
• Gautam A. Antimicrobial resistance: the next probable pandemic. J Nepal Med Assoc. 2022;60(246):225–228. doi: 10.31729/jnma.7174
   PubMed Web of Science ®Google Scholar
• OECD Health Policy Studies. Stemming the Superbug Tide. 2018. [cited 2023 Mar 21]. Available from: https://www.oecd-ilibrary.org/sites/9789264307599-en/index.html?itemId=/content/publication/9789264307599-en&mimeType=text/html
   Google Scholar
• WHO. Implementation handbook for national action plans on antimicrobial resistance: guidance for the human health sector. 2022. [cited 2023 Mar 20]. Available from: https://www.who.int/publications/i/item/9789240041981
   Google Scholar
• Willemsen A, Reid S, Assefa Y. A review of national action plans on antimicrobial resistance: strengths and weaknesses. Antimicrob Resist Infect Control. 2022;11(1):90. doi: 10.1186/s13756-022-01130-x
   PubMed Web of Science ®Google Scholar
• WHO. The WHO AWaRe (Access, Watch, Reserve) antibiotic book. 2022. [cited 2023 Mar 19]. Available from: https://www.who.int/publications/i/item/9789240062382
   Google Scholar
• Duffy E, Ritchie S, Metcalfe S, et al. Antibacterials dispensed in the community comprise 85%-95% of total human antibacterial consumption. J Clin Pharm Ther. 2018;43(1):59–64. doi: 10.1111/jcpt.12610
   PubMed Web of Science ®Google Scholar
• Nkengasong JN, Tessema SK. Africa needs a New public Health order to tackle infectious disease threats. Cell. 2020;183(2):296–300. doi: 10.1016/j.cell.2020.09.041
   PubMed Web of Science ®Google Scholar
• Bell D, Schultz Hansen K. Relative burdens of the COVID-19, malaria, tuberculosis, and HIV/AIDS epidemics in sub-Saharan Africa. Am J Trop Med Hyg. 2021;105(6):1510–1515. doi: 10.4269/ajtmh.21-0899
   PubMed Web of Science ®Google Scholar
• Dwyer-Lindgren L, Cork MA, Sligar A, et al. Mapping HIV prevalence in sub-Saharan Africa between 2000 and 2017. Nature. 2019;570(7760):189–193. doi: 10.1038/s41586-019-1200-9
   PubMed Web of Science ®Google Scholar
• Williams PCM, Isaacs D, Berkley JA. Antimicrobial resistance among children in sub-Saharan Africa. Lancet Infect Dis. 2018;18(2):e33–e44. doi: 10.1016/S1473-3099(17)30467-X
   PubMed Web of Science ®Google Scholar
• Godman B, Egwuenu A, Wesangula E, et al. Tackling antimicrobial resistance across sub-Saharan Africa: current challenges and implications for the future. Expert Opin Drug Saf. 2022;21(8):1089–1111. doi: 10.1080/14740338.2022.2106368
   PubMed Web of Science ®Google Scholar
• Venne DM, Hartley DM, Malchione MD, et al. Review and analysis of the overlapping threats of carbapenem and polymyxin resistant E. coli and klebsiella in Africa. Antimicrob Resist Infect Control. 2023;12(1):29. doi: 10.1186/s13756-023-01220-4
   PubMed Web of Science ®Google Scholar
• Charani E, Mendelson M, Pallett SJC, et al. An analysis of existing national action plans for antimicrobial resistance-gaps and opportunities in strategies optimising antibiotic use in human populations. Lancet Glob Health. 2023;11(3):e466–e474. doi: 10.1016/S2214-109X(23)00019-0
   PubMed Web of Science ®Google Scholar
• Harant A. Assessing transparency and accountability of national action plans on antimicrobial resistance in 15 African countries. Antimicrob Resist Infect Control. 2022;11(1):15. doi: 10.1186/s13756-021-01040-4
   PubMed Web of Science ®Google Scholar
• WHO. Global action plan on antimicrobial resistance - report by the secretariat. 2016. [cited 2023 Mar 20]. Available from: https://apps.who.int/gb/ebwha/pdf_files/WHA69/A69_24-en.pdf
   Google Scholar
• WHO. MONITORING and EVALUATION of the GLOBAL ACTION PLAN on ANTIMICROBIAL RESISTANCE - Framework and recommended indicators. 2019. [cited 2023 Mar 21]. Available from: https://apps.who.int/iris/bitstream/handle/10665/325006/9789241515665-eng.pdf?sequence=1&isAllowed=y
   Google Scholar
• Elton L, Thomason MJ, Tembo J, et al. Antimicrobial resistance preparedness in sub-Saharan African countries. Antimicrob Resist Infect Control. 2020;9(1):145. doi: 10.1186/s13756-020-00800-y
   PubMed Web of Science ®Google Scholar
• Pallett SJ, Charani E, Hawkins L, et al. National action plans for antimicrobial resistance and variations in surveillance data platforms. Bull World Health Organ. 2023;101(8):501–12f. doi: 10.2471/BLT.22.289403
   PubMedGoogle Scholar
• Hein W, Aglanu LM, Mensah-Sekyere M, et al. Fighting antimicrobial resistance: development and implementation of the Ghanaian national action plan (2017-2021). Antibiotics. 2022;11(5):613. doi: 10.3390/antibiotics11050613
   Google Scholar
• Kariuki S, Kering K, Wairimu C, et al. Antimicrobial resistance rates and surveillance in sub-Saharan Africa: where are we Now? Infect Drug Resist. 2022;15:3589–3609. doi: 10.2147/IDR.S342753
   PubMed Web of Science ®Google Scholar
• Torres NF, Chibi B, Kuupiel D, et al. The use of non-prescribed antibiotics; prevalence estimates in low-and-middle-income countries. A systematic review and meta-analysis. Arch Public Health. 2021;79(1):2. doi: 10.1186/s13690-020-00517-9
   PubMed Web of Science ®Google Scholar
• Alhomoud F, Aljamea Z, Almahasnah R, et al. Self-medication and self-prescription with antibiotics in the middle East-do they really happen? A systematic review of the prevalence, possible reasons, and outcomes. Int J Infect Dis. 2017;57:3–12. doi: 10.1016/j.ijid.2017.01.014
   PubMed Web of Science ®Google Scholar
• Godman B, Haque M, McKimm J, et al. Ongoing strategies to improve the management of upper respiratory tract infections and reduce inappropriate antibiotic use particularly among lower and middle-income countries: findings and implications for the future. Curr Med Res Opin. 2020;36(2):301–327. doi: 10.1080/03007995.2019.1700947
   PubMed Web of Science ®Google Scholar
• Cambaco O, Alonso Menendez Y, Kinsman J, et al. Community knowledge and practices regarding antibiotic use in rural Mozambique: where is the starting point for prevention of antibiotic resistance? BMC Public Health. 2020;20(1):1183. doi: 10.1186/s12889-020-09243-x
   PubMed Web of Science ®Google Scholar
• Do NTT, Vu HTL, Nguyen CTK, et al. Community-based antibiotic access and use in six low-income and middle-income countries: a mixed-method approach. Lancet Glob Health. 2021;9(5):e610–e9. doi: 10.1016/S2214-109X(21)00024-3
   PubMed Web of Science ®Google Scholar
• Auta A, Hadi MA, Oga E, et al. Global access to antibiotics without prescription in community pharmacies: a systematic review and meta-analysis. J Infect. 2019;78(1):8–18. doi: 10.1016/j.jinf.2018.07.001
   PubMed Web of Science ®Google Scholar
• Nepal G, Bhatta S. Self-medication with antibiotics in WHO southeast Asian region: a systematic review. Cureus. 2018;10(4):e2428. doi: 10.7759/cureus.2428
   PubMed Web of Science ®Google Scholar
• Yeika EV, Ingelbeen B, Kemah BL, et al. Comparative assessment of the prevalence, practices and factors associated with self-medication with antibiotics in Africa. Trop Med Int Health. 2021;26(8):862–881. doi: 10.1111/tmi.13600
   PubMed Web of Science ®Google Scholar
• Belachew SA, Hall L, Selvey LA. Non-prescription dispensing of antibiotic agents among community drug retail outlets in sub-Saharan African countries: a systematic review and meta-analysis. Antimicrob Resist Infect Control. 2021;10(1):13. doi: 10.1186/s13756-020-00880-w
   PubMed Web of Science ®Google Scholar
• Li J, Zhou P, Wang J, et al. Worldwide dispensing of non-prescription antibiotics in community pharmacies and associated factors: a mixed-methods systematic review. Lancet Infect Dis. 2023;23(9):e361–e370. doi: 10.1016/S1473-3099(23)00130-5
   PubMed Web of Science ®Google Scholar
• Sakeena MHF, Bennett AA, McLachlan AJ. Non-prescription sales of antimicrobial agents at community pharmacies in developing countries: a systematic review. Int J Antimicrob Agents. 2018;52(6):771–782. doi: 10.1016/j.ijantimicag.2018.09.022
   PubMed Web of Science ®Google Scholar
• Kiragga AN, Najjemba L, Galiwango R, et al. Community purchases of antimicrobials during the COVID-19 pandemic in Uganda: an increased risk for antimicrobial resistance. PLOS Glob Public Health. 2023;3(2):e0001579. doi: 10.1371/journal.pgph.0001579
   PubMedGoogle Scholar
• Sachdev C, Anjankar A, Agrawal J. Self-medication with antibiotics: an element increasing resistance. Cureus. 2022;14(10):e30844. doi: 10.7759/cureus.30844
   PubMed Web of Science ®Google Scholar
• Sefah IA, Ogunleye OO, Essah DO, et al. Rapid Assessment of the potential paucity and price increases for suggested medicines and protection equipment for COVID-19 across developing countries with a particular focus on Africa and the implications. Front Pharmacol. 2020;11:588106. doi: 10.3389/fphar.2020.588106
   PubMed Web of Science ®Google Scholar
• Langford BJ, So M, Raybardhan S, et al. Antibiotic prescribing in patients with COVID-19: rapid review and meta-analysis. Clin Microbiol Infect. 2021;27(4):520–531. doi: 10.1016/j.cmi.2020.12.018
   PubMed Web of Science ®Google Scholar
• Alshaikh FS, Godman B, Sindi ON, et al. Prevalence of bacterial coinfection and patterns of antibiotics prescribing in patients with COVID-19: a systematic review and meta-analysis. PLoS One. 2022;17(8):e0272375. doi: 10.1371/journal.pone.0272375
   PubMed Web of Science ®Google Scholar
• Satria YAA, Utami MS, Prasudi A. Prevalence of antibiotics prescription amongst patients with and without COVID-19 in low- and middle-income countries: a systematic review and meta-analysis. Pathogens And Global Health. 2022;117(5):1–13. doi: 10.1080/20477724.2022.2160892
   PubMed Web of Science ®Google Scholar
• Bednarčuk N, Golić Jelić A, Šatara S S, et al. Antibiotic utilization during COVID-19: are we over-prescribing? Antibiotics. 2023;12(2):308. doi: 10.3390/antibiotics12020308
   Google Scholar
• Sulis G, Batomen B, Kotwani A, et al. Sales of antibiotics and hydroxychloroquine in India during the COVID-19 epidemic: an interrupted time series analysis. PLOS Med. 2021;18(7):e1003682. doi: 10.1371/journal.pmed.1003682
   PubMed Web of Science ®Google Scholar
• Nino-Orrego MJ, Baracaldo-Santamaría D, Patricia Ortiz C, et al. Prescription for COVID-19 by non-medical professionals during the pandemic in Colombia: a cross-sectional study. Ther Adv Drug Saf. 2022;13:20420986221101964. doi: 10.1177/20420986221101964
   Web of Science ®Google Scholar
• Jacobs TG, Robertson J, van den Ham HA, et al. Assessing the impact of law enforcement to reduce over-the-counter (OTC) sales of antibiotics in low- and middle-income countries; a systematic literature review. BMC Health Serv Res. 2019;19(1):536. doi: 10.1186/s12913-019-4359-8
   PubMed Web of Science ®Google Scholar
• Ocan M, Obuku EA, Bwanga F, et al. Household antimicrobial self-medication: a systematic review and meta-analysis of the burden, risk factors and outcomes in developing countries. BMC Public Health. 2015;15(1):742. doi: 10.1186/s12889-015-2109-3
   PubMed Web of Science ®Google Scholar
• Batista AD, Rodrigues DA, Figueiras A, et al. Antibiotic dispensation without a prescription worldwide: a systematic review. Antibiotics. 2020;9(11):786. doi: 10.3390/antibiotics9110786
   Google Scholar
• Oga-Omenka C, Okafor U, Sulis G. Engaging pharmacists and medicine vendors in antimicrobial stewardship in LMICs. Lancet Infect Dis. 2023;23(7):786–787. doi: 10.1016/S1473-3099(23)00342-0
   PubMed Web of Science ®Google Scholar
• Edessa D, Assefa N, Dessie Y, et al. Non-prescribed antibiotic use for children at community levels in low- and middle-income countries: a systematic review and meta-analysis. J Of Pharm Policy And Pract. 2022;15(1):57. doi: 10.1186/s40545-022-00454-8
   PubMedGoogle Scholar
• Sulis G, Gandra S. Access to antibiotics: not a problem in some LMICs. Lancet Glob Health. 2021;9(5):e561–e2. doi: 10.1016/S2214-109X(21)00085-1
   PubMed Web of Science ®Google Scholar
• Wirtz VJ, Herrera-Patino JJ, Santa-Ana-Tellez Y, et al. Analysing policy interventions to prohibit over-the-counter antibiotic sales in four Latin American countries. Trop Med Int Health. 2013;18(6):665–673. doi: 10.1111/tmi.12096
   PubMed Web of Science ®Google Scholar
• Santa-Ana-Tellez Y, Mantel-Teeuwisse AK, Dreser A, et al. Impact of over-the-counter restrictions on antibiotic consumption in Brazil and Mexico. PLoS One. 2013;8(10):e75550. doi: 10.1371/journal.pone.0075550
   PubMed Web of Science ®Google Scholar
• Godman B, Egwuenu A, Haque M, et al. Strategies to improve antimicrobial utilization with a Special focus on developing countries. Life. 2021;11(6):528. doi: 10.3390/life11060528
   PubMedGoogle Scholar
• Nguyen TTP, Do TX, Nguyen HA, et al. A national survey of dispensing practice and customer knowledge on antibiotic use in Vietnam and the implications. Antibiotics. 2022;11(8):1091. doi: 10.3390/antibiotics11081091
   Google Scholar
• Kuang L, Liu Y, Wei W, et al. Non-prescription sale of antibiotics and service quality in community pharmacies in Guangzhou, China: a simulated client method. PLoS One. 2020;15(12):e0243555. doi: 10.1371/journal.pone.0243555
   PubMed Web of Science ®Google Scholar
• Saleem Z, Hassali MA, Godman B, et al. Sale of WHO AWaRe groups antibiotics without a prescription in Pakistan: a simulated client study. J Of Pharm Policy And Pract. 2020;13(1):26. doi: 10.1186/s40545-020-00233-3
   PubMedGoogle Scholar
• Bavestrello L, Cabello A, Casanova D. Impact of regulatory measures in the trends of community consumption of antibiotics in Chile. Rev Med Chil. 2002;130(11):1265–1272. doi: 10.4067/S0034-98872002001100009
   PubMed Web of Science ®Google Scholar
• Hoxha I, Malaj A, Tako R, et al. Survey on how antibiotics are dispensed in community pharmacies in Albania. Int J Pharm Pharm Sci. 2015;7:449–450.
   Google Scholar
• Marković-Peković V, Grubiša N, Burger J, et al. Initiatives to reduce nonprescription sales and dispensing of antibiotics: findings and implications. J Res Pharm Pract. 2017;6(2):120–125. doi: 10.4103/jrpp.JRPP_17_12
   PubMed Web of Science ®Google Scholar
• NBFIRA. 2022 Annual report. [cited 2023 Mar 22]. Available from: https://www.nbfira.org.bw/nbfira-2022-annual-report
   Google Scholar
• Statistics Botswana. Population census Available at URL. 2022 [cited 23 Mar 2023. https://statsbots.org.bw/census-2022
   Google Scholar
• Kibuule D, Nambahu L, Sefah IA, Kurdi A, et al. Activities in Namibia to limit the prevalence and mortality from COVID-19 including community pharmacy activities and the implications. Sch Acad J Pharm. 2021;10(5):82–92. doi: 10.36347/sajp.2021.v10i05.001
   Google Scholar
• Kamati M, Godman B, Kibuule D. Prevalence of self-medication for acute respiratory infections in young children in Namibia: findings and implications. J Res Pharm Pract. 2019;8(4):220–224. doi: 10.4103/jrpp.JRPP_19_121
   PubMed Web of Science ®Google Scholar
• Republic of Namibia. Medicines and related substances Control act, 2003 - act 13 of 2003. [cited 2023 Mar 20]. Available from: https://namiblii.org/akn/na/act/2003/13/eng%402008-08-01
   Google Scholar
• Anstey Watkins J, Wagner F, Xavier Gómez-Olivé F, et al. Rural South African community perceptions of antibiotic Access and use: qualitative evidence from a Health and demographic surveillance system site. Am J Trop Med Hyg. 2019;100(6):1378–1390. doi: 10.4269/ajtmh.18-0171
   PubMed Web of Science ®Google Scholar
• Mokwele RN, Schellack N, Bronkhorst E, et al. Using mystery shoppers to determine practices pertaining to antibiotic dispensing without a prescription among community pharmacies in South Africa—a pilot survey. JAC-Antimicrobial Resistance. 2022;4(1): doi: 10.1093/jacamr/dlab196
   PubMedGoogle Scholar
• Kalungia AC, Burger J, Godman B, et al. Non-prescription sale and dispensing of antibiotics in community pharmacies in Zambia. Expert Rev Anti Infect Ther. 2016;14(12):1215–1223. doi: 10.1080/14787210.2016.1227702
   PubMed Web of Science ®Google Scholar
• Afari-Asiedu S, Kinsman J, Boamah-Kaali E, et al. To sell or not to sell; the differences between regulatory and community demands regarding access to antibiotics in rural Ghana. J Of Pharm Policy And Pract. 2018;11(1):30. doi: 10.1186/s40545-018-0158-6
   PubMedGoogle Scholar
• Torres NF, Chibi B, Middleton LE, et al. Evidence of factors influencing self-medication with antibiotics in low and middle-income countries: a systematic scoping review. Public Health. 2019;168:92–101. doi: 10.1016/j.puhe.2018.11.018
   PubMed Web of Science ®Google Scholar
• Belachew SA, Hall L, Erku DA, et al. No prescription? No problem: drivers of non-prescribed sale of antibiotics among community drug retail outlets in low and middle income countries: a systematic review of qualitative studies. BMC Public Health. 2021;21(1):1056. doi: 10.1186/s12889-021-11163-3
   PubMed Web of Science ®Google Scholar
• Chowdhury M, Stewart Williams J, Wertheim H, et al. Rural community perceptions of antibiotic access and understanding of antimicrobial resistance: qualitative evidence from the Health and demographic surveillance system site in Matlab. Glob Health Action. 2019;12(sup1):1824383. doi: 10.1080/16549716.2020.1824383
   PubMedGoogle Scholar
• Davis A, Lembo T, Laurie E, et al. How public health crises expose systemic, day-to-day health inequalities in low- and-middle income countries: an example from East Africa. Antimicrob Resist Infect Control. 2022;11(1):34. doi: 10.1186/s13756-022-01071-5
   PubMed Web of Science ®Google Scholar
• Afari-Asiedu S, Oppong FB, Tostmann A, et al. Determinants of inappropriate antibiotics use in rural Central Ghana using a mixed methods approach. Front Public Health. 2020;8:90. doi: 10.3389/fpubh.2020.00090
   PubMed Web of Science ®Google Scholar
• Bert F, Previti C, Calabrese F, et al. Antibiotics self medication among children: a systematic review. Antibiotics. 2022;11(11):1583. doi: 10.3390/antibiotics11111583
   Google Scholar
• Sefah IA, Akwaboah E, Sarkodie E, et al. Evaluation of healthcare students; knowledge on antibiotic use antimicrobial resistance and antimicrobial stewardship programs and associated factors in a tertiary University in Ghana: findings and implications. Antibiotics. 2022;11(12):1679. doi: 10.3390/antibiotics11121679
   Google Scholar
• Lubwama M, Onyuka J, Ayazika KT, et al. Knowledge, attitudes, and perceptions about antibiotic use and antimicrobial resistance among final year undergraduate medical and pharmacy students at three universities in East Africa. PLoS One. 2021;16(5):e0251301. doi: 10.1371/journal.pone.0251301
   PubMed Web of Science ®Google Scholar
• Servia-Dopazo M, Figueiras A. Determinants of antibiotic dispensing without prescription: a systematic review. J Antimicrob Chemother. 2018;73(12):3244–3253. doi: 10.1093/jac/dky319
   PubMed Web of Science ®Google Scholar
• Basu S, Copana R, Morales R Jr., et al. Keeping it real: antibiotic use problems and stewardship Solutions in low- and middle-income countries. Pediatr Infect Dis J. 2022;41(3s):S18–s25. doi: 10.1097/INF.0000000000003321
   PubMed Web of Science ®Google Scholar
• Belachew SA, Hall L, Selvey LA. Community drug retail outlet staff’s knowledge, attitudes and practices towards non-prescription antibiotics use and antibiotic resistance in the Amhara region, Ethiopia with a focus on non-urban towns. Antimicrob Resist Infect Control. 2022;11(1):64. doi: 10.1186/s13756-022-01102-1
   PubMed Web of Science ®Google Scholar
• Simon B, Kazaura M. Prevalence and factors associated with parents self-medicating under-fives with antibiotics in Bagamoyo district Council, Tanzania: a cross-sectional study. Patient Prefer Adherence. 2020;14: 1445–1453. doi: 10.2147/PPA.S263517
   PubMed Web of Science ®Google Scholar
• Dixon J, MacPherson EE, Nayiga S, et al. Antibiotic stories: a mixed-methods, multi-country analysis of household antibiotic use in Malawi, Uganda and Zimbabwe. BMJ Glob Health. 2021;6(11):e006920. doi: 10.1136/bmjgh-2021-006920
   PubMed Web of Science ®Google Scholar
• Green DL, Keenan K, Fredricks KJ, et al. The role of multidimensional poverty in antibiotic misuse: a mixed-methods study of self-medication and non-adherence in Kenya, Tanzania, and Uganda. Lancet Glob Health. 2023;11(1):e59–e68. doi: 10.1016/S2214-109X(22)00423-5
   PubMed Web of Science ®Google Scholar
• Abdelrahman Hussain M, Osman Mohamed A, Sandel Abkar A, et al. Knowledge, attitude and practice of community pharmacists in relation to dispensing antibiotics without prescription in Sudan: a cross-sectional study. Integr Pharm Res Pract. 2022;11:107–116. doi: 10.2147/IPRP.S363079
   PubMed Web of Science ®Google Scholar
• Belachew SA, Hall L, Selvey LA. “Handing out non-prescribed antibiotics is storing up trouble for the next generation!” Unpacking multistakeholder views of drivers and potential solutions in Ethiopia. BMC Health Serv Res. 2023;23(1):830. doi: 10.1186/s12913-023-09819-4
   PubMed Web of Science ®Google Scholar
• Afari-Asiedu S, Abdulai MA, Tostmann A, et al. Interventions to improve dispensing of antibiotics at the community level in low and middle income countries: a systematic review. J Glob Antimicrob Resist. 2022;29:259–274. doi: 10.1016/j.jgar.2022.03.009
   PubMed Web of Science ®Google Scholar
• Lubogo P, Lukyamuzi JE, Kyambadde D, et al. Cost-effectiveness analysis of integrated community case management delivery models utilizing drug sellers and community health workers for treatment of under-five febrile cases of malaria, pneumonia, diarrhoea in rural Uganda. Malar J. 2021;20(1):407. doi: 10.1186/s12936-021-03944-3
   PubMed Web of Science ®Google Scholar
• Opanga S, Rizvi N, Wamaitha A, et al. Availability of medicines in community pharmacy to manage patients with COVID-19 in Kenya; pilot study and implications. Sch Acad J Pharm. 2021;10(3):36–42. doi: 10.36347/sajp.2021.v10i03.001
   Google Scholar
• Mukokinya MMA, Opanga S, Oluka M, et al. Dispensing of antimicrobials in Kenya: a cross-sectional pilot study and its implications. J Res Pharm Pract. 2018;7(2):77–82. doi: 10.4103/jrpp.JRPP_17_88
   PubMed Web of Science ®Google Scholar
• Langford BJ, So M, Raybardhan S, et al. Bacterial co-infection and secondary infection in patients with COVID-19: a living rapid review and meta-analysis. Clin Microbiol Infect. 2020;26(12):1622–1629. doi: 10.1016/j.cmi.2020.07.016
   PubMed Web of Science ®Google Scholar
• Mustafa ZU, Saleem MS, Ikram MN, et al. Co-infections and antimicrobial use among hospitalized COVID-19 patients in Punjab, Pakistan: findings from a multicenter, point prevalence survey. Pathog Glob Health. 2022;116(7):421–427. doi: 10.1080/20477724.2021.1999716
   PubMed Web of Science ®Google Scholar
• Hsu J. How COVID-19 is accelerating the threat of antimicrobial resistance. BMJ. 2020;369:m1983. doi: 10.1136/bmj.m1983
   PubMed Web of Science ®Google Scholar
• Iwu CJ, Jordan P, Jaja IF, et al. Treatment of COVID-19: implications for antimicrobial resistance in Africa. Pan Afr Med J. 2020;35(Suppl 2):119. doi: 10.11604/pamj.supp.2020.35.2.23713
   PubMedGoogle Scholar
• Suleiman S, Islam M, Akter M, et al. A meta-meta-analysis of co-infection, secondary infections, and antimicrobial resistance in COVID-19 patients. J Infect Public Health. 2023;16(10):1562–1590. doi: 10.1016/j.jiph.2023.07.005
   PubMedGoogle Scholar
• Rather IA, Kim BC, Bajpai VK, et al. Self-medication and antibiotic resistance: crisis, current challenges, and prevention. Saudi J Biol Sci. 2017;24(4):808–812. doi: 10.1016/j.sjbs.2017.01.004
   PubMed Web of Science ®Google Scholar
• Pokharel S, Raut S, Adhikari B. Tackling antimicrobial resistance in low-income and middle-income countries. BMJ Glob Health. 2019;4(6):e002104. doi: 10.1136/bmjgh-2019-002104
   PubMed Web of Science ®Google Scholar
• Sulis G, Sayood S, Katukoori S, et al. Exposure to World Health organization’s AWaRe antibiotics and isolation of multidrug resistant bacteria: a systematic review and meta-analysis. Clin Microbiol Infect. 2022;28(9):1193–1202. doi: 10.1016/j.cmi.2022.03.014
   PubMed Web of Science ®Google Scholar
• Klein EY, Milkowska-Shibata M, Tseng KK, et al. Assessment of WHO antibiotic consumption and access targets in 76 countries, 2000-15: an analysis of pharmaceutical sales data. Lancet Infect Dis. 2021;21(1):107–115. doi: 10.1016/S1473-3099(20)30332-7
   PubMed Web of Science ®Google Scholar
• Doan T, Worden L, Hinterwirth A, et al. Macrolide and nonmacrolide resistance with mass azithromycin distribution. N Engl J Med. 2020;383(20):1941–1950. doi: 10.1056/NEJMoa2002606
   PubMed Web of Science ®Google Scholar
• Sharland M, Gandra S, Huttner B, et al. Encouraging AWaRe-ness and discouraging inappropriate antibiotic use-the new 2019 essential medicines list becomes a global antibiotic stewardship tool. Lancet Infect Dis. 2019;19(12):1278–1280. doi: 10.1016/S1473-3099(19)30532-8
   PubMed Web of Science ®Google Scholar
• Zanichelli V, Sharland M, Cappello B, et al. The WHO AWaRe (Access, Watch, Reserve) antibiotic book and prevention of antimicrobial resistance. Bull World Health Organ. 2023;101(4):290–296. doi: 10.2471/BLT.22.288614
   Web of Science ®Google Scholar
• Sharland M, Zanichelli V, Ombajo LA, et al. The WHO essential medicines list AWaRe book: from a list to a quality improvement system. Clin Microbiol Infect. 2022;28(12):1533–1535. doi: 10.1016/j.cmi.2022.08.009
   PubMed Web of Science ®Google Scholar
• Rehman IU, Asad MM, Bukhsh A, et al. Knowledge and practice of pharmacists toward antimicrobial stewardship in Pakistan. Pharmacy. 2018;6(4):116. doi: 10.3390/pharmacy6040116
   Web of Science ®Google Scholar
• Khuluza F, Heide L, Postma M. Availability and affordability of antimalarial and antibiotic medicines in Malawi. PLoS One. 2017;12(4):e0175399. doi: 10.1371/journal.pone.0175399
   PubMed Web of Science ®Google Scholar
• Vacca CP, Nino CY, Reveiz L. Restriction of antibiotic sales in pharmacies in Bogota, Colombia: a descriptive study. Revista Panamericana de Salud Publica = Pan Am J Public Health. 2011;30(6):586–591.
   PubMed Web of Science ®Google Scholar
• Hongoro C, Kumaranayake L. Do they work? Regulating for-profit providers in Zimbabwe. Health Policy Plan. 2000;15(4):368–377. doi: 10.1093/heapol/15.4.368
   PubMed Web of Science ®Google Scholar
• Kumaranayake L, Mujinja P, Hongoro C, et al. How do countries regulate the health sector? Evidence from Tanzania and Zimbabwe. Health Policy Plan. 2000;15(4):357–367. doi: 10.1093/heapol/15.4.357
   PubMed Web of Science ®Google Scholar
• Nyazema N, Viberg N, Khoza S, et al. Low sale of antibiotics without prescription: a cross-sectional study in Zimbabwean private pharmacies. J Antimicrob Chemother. 2007;59(4):718–726. doi: 10.1093/jac/dkm013
   PubMed Web of Science ®Google Scholar
• Meyer JC, Schellack N, Stokes J, et al. Ongoing initiatives to improve the quality and efficiency of medicine use within the public healthcare system in South Africa; a preliminary study. Front Pharmacol. 2017;8:751. doi: 10.3389/fphar.2017.00751
   PubMed Web of Science ®Google Scholar
• WHO. Global action plan on antimicrobial resistance. 2016. [cited 2023 Mar 20]. Available from: https://www.who.int/publications/i/item/9789241509763
   Google Scholar
• Nisabwe L, Brice H, Umuhire MC, et al. Knowledge and attitudes towards antibiotic use and resistance among undergraduate healthcare students at University of Rwanda. J Of Pharm Policy And Pract. 2020;13(1):7. doi: 10.1186/s40545-020-00207-5
   PubMedGoogle Scholar
• Mate I, Come CE, Gonçalves MP, et al. Knowledge, attitudes and practices regarding antibiotic use in Maputo city, Mozambique. PLoS One. 2019;14(8):e0221452. doi: 10.1371/journal.pone.0221452
   PubMed Web of Science ®Google Scholar
• Chukwu EE, Oladele DA, Awoderu OB, et al. A national survey of public awareness of antimicrobial resistance in Nigeria. Antimicrob Resist Infect Control. 2020;9(1):72. doi: 10.1186/s13756-020-00739-0
   PubMed Web of Science ®Google Scholar
• Akande-Sholabi W, Ajamu AT, Adisa R. Prevalence, knowledge and perception of self-medication practice among undergraduate healthcare students. J Of Pharm Policy And Pract. 2021;14(1):49. doi: 10.1186/s40545-021-00331-w
   PubMedGoogle Scholar
• Russom M, Bahta M, Debesai M, et al. Knowledge, attitude and practice of antibiotics and their determinants in Eritrea: an urban population-based survey. BMJ Open. 2021;11(9):e046432. doi: 10.1136/bmjopen-2020-046432
   PubMed Web of Science ®Google Scholar
• Mudenda S, Hankombo M, Saleem Z, et al. Knowledge, attitude, and practices of community pharmacists on antibiotic resistance and antimicrobial stewardship in Lusaka, Zambia. J Biomed Res Environ Sci. 2021;2(10):1005–1014. doi: 10.37871/jbres1343
   Google Scholar
• Godman B, Grobler C, Van-De-Lisle M, et al. Pharmacotherapeutic interventions for bipolar disorder type II: addressing multiple symptoms and approaches with a particular emphasis on strategies in lower and middle-income countries. Expert Opin Pharmacother. 2019;20(18):2237–2255. doi: 10.1080/14656566.2019.1684473
   PubMed Web of Science ®Google Scholar
• Ogunleye OO, Basu D, Mueller D, et al. Response to the novel corona virus (COVID-19) pandemic across Africa: successes, challenges, and implications for the future. Front Pharmacol. 2020;11:1205. doi: 10.3389/fphar.2020.01205
   PubMed Web of Science ®Google Scholar
• Haque M, Abubakar AR, Ogunleye OO, et al. Changes in availability, utilization, and prices of medicines and protection equipment for COVID-19 in an urban population of Northern Nigeria. J Res Pharm Pract. 2021;10(1):17–22. doi: 10.4103/jrpp.JRPP_20_92
   PubMed Web of Science ®Google Scholar
• Godman B, Basu D, Pillay Y, et al. Review of Ongoing activities and challenges to improve the care of patients with type 2 diabetes across Africa and the implications for the future. Front Pharmacol. 2020;11:108. doi: 10.3389/fphar.2020.00108
   PubMed Web of Science ®Google Scholar
• Godman B, Basu D, Pillay Y, et al. Ongoing and planned activities to improve the management of patients with type 1 diabetes across Africa; implications for the future. Hosp Pract. 2020;48(2):51–67. doi: 10.1080/21548331.2020.1745509
   PubMedGoogle Scholar
• Etando A, Amu AA, Haque M, et al. Challenges and innovations brought about by the COVID-19 pandemic regarding medical and pharmacy education especially in Africa and implications for the future. Healthcare. 2021;9(12):1722. doi: 10.3390/healthcare9121722
   Web of Science ®Google Scholar
• Mwita JC, Ogunleye OO, Olalekan A, et al. Key issues surrounding appropriate antibiotic use for prevention of surgical site infections in low- and middle-income countries: a narrative review and the implications. IJGM. 2021;14:515–530. doi: 10.2147/IJGM.S253216
   Google Scholar
• Godman B, Fadare J, Kwon HY, et al. Evidence-based public policy making for medicines across countries: findings and implications for the future. J Comp Eff Res. 2021;10(12):1019–1052. doi: 10.2217/cer-2020-0273
   PubMed Web of Science ®Google Scholar
• Gad M, Salem A, Oortwijn W, et al. Mapping of Current obstacles for rationalizing use of medicines (CORUM) in Europe: Current situation and potential Solutions. Front Pharmacol. 2020;11:144. doi: 10.3389/fphar.2020.00144
   PubMed Web of Science ®Google Scholar
• Ogunleye OO, Godman B, Fadare JO, et al. Coronavirus disease 2019 (COVID-19) pandemic across Africa: Current status of vaccinations and implications for the future. Vaccines. 2022;10(9):1553. doi: 10.3390/vaccines10091553
   Web of Science ®Google Scholar
• Saleem Z, Godman B, Cook A, et al. Ongoing efforts to improve antimicrobial utilization in hospitals among African countries and implications for the future. Antibiotics. 2022;11(12):1824. doi: 10.3390/antibiotics11121824
   Google Scholar
• Adekoya I, Maraj D, Steiner L, et al. Comparison of antibiotics included in national essential medicines lists of 138 countries using the WHO Access, Watch, Reserve (AWaRe) classification: a cross-sectional study. Lancet Infect Dis. 2021;21(10):1429–1440. doi: 10.1016/S1473-3099(20)30854-9
   PubMed Web of Science ®Google Scholar
• Imran L, Rehan ST, Lee KY. How universal Health coverage can curb the escalating antimicrobial resistance in Pakistan: a call to action for the country’s healthcare system. Trop Med Health. 2022;50(1):86. doi: 10.1186/s41182-022-00478-5
   PubMed Web of Science ®Google Scholar
• Muzzamil M, Mehedi Hasan M, Nisa M, et al. Delivering quality health care to people in low-income countries such as Pakistan; the clear link between AMR and UHC. Ann Med Surg (Lond). 2022;81:104490. doi: 10.1016/j.amsu.2022.104490
   PubMed Web of Science ®Google Scholar
• Sharland M, Pulcini C, Harbarth S, et al. Classifying antibiotics in the WHO essential medicines list for optimal use-be AWaRe. Lancet Infect Dis. 2018;18(1):18–20. doi: 10.1016/S1473-3099(17)30724-7
   PubMed Web of Science ®Google Scholar
• Barasa EW, Molyneux S, English M, et al. Setting healthcare priorities at the macro and meso levels: a framework for Evaluation. Int J Health Policy Manag. 2015;4(11):719–732. doi: 10.15171/ijhpm.2015.167
   PubMed Web of Science ®Google Scholar
• Smith T, McNeil K, Mitchell R, et al. A study of macro-, meso- and micro-barriers and enablers affecting extended scopes of practice: the case of rural nurse practitioners in Australia. BMC Nurs. 2019;18(1):14. doi: 10.1186/s12912-019-0337-z
   PubMed Web of Science ®Google Scholar
• Bahta M, Weldemariam DG, Tesfamariam S, et al. Determinants of dispensing antibiotics without prescription in Eritrea: a mixed-method qualitative study on pharmacy professionals’ perspective. BMJ Open. 2021;11(8):e049000. doi: 10.1136/bmjopen-2021-049000
   PubMed Web of Science ®Google Scholar
• Gebretekle GB, Serbessa MK. Exploration of over the counter sales of antibiotics in community pharmacies of Addis Ababa, Ethiopia: pharmacy professionals’ perspective. Antimicrob Resist Infect Control. 2016;5(1):2. doi: 10.1186/s13756-016-0101-z
   PubMed Web of Science ®Google Scholar
• Erku DA, Aberra SY. Non-prescribed sale of antibiotics for acute childhood diarrhea and upper respiratory tract infection in community pharmacies: a 2 phase mixed-methods study. Antimicrob Resist Infect Control. 2018;7(1):92. doi: 10.1186/s13756-018-0389-y
   PubMed Web of Science ®Google Scholar
• Bogale AA, Amhare AF, Chang J, et al. Knowledge, attitude, and practice of self-medication with antibiotics among community residents in Addis Ababa, Ethiopia. Expert Rev Anti Infect Ther. 2019;17(6):459–466. doi: 10.1080/14787210.2019.1620105
   PubMed Web of Science ®Google Scholar
• Demissie F, Ereso K, Paulos G. Self-medication practice with antibiotics and its associated factors among community of Bule-Hora Town, South West Ethiopia. Drug Healthc Patient Saf. 2022;14:9–18. doi: 10.2147/DHPS.S325150
   PubMed Web of Science ®Google Scholar
• Edessa D, Sisay M, Hagos B, et al. Antimicrobial use and management of childhood diarrhea at community drug retail outlets in Eastern Ethiopia: a matched questionnaire-based and simulated patient-case study. Pediatric Health Med Ther. 2022;13:63–79. doi: 10.2147/PHMT.S348204
   PubMed Web of Science ®Google Scholar
• Sambakunsi CS, Småbrekke L, Varga CA, et al. Knowledge, attitudes and practices related to self-medication with antimicrobials in Lilongwe, Malawi. Malawi Med J. 2019;31(4):225–232. doi: 10.4314/mmj.v31i4.2
   PubMed Web of Science ®Google Scholar
• Machongo RB, Mipando ALN. “I don’t hesitate to use the left-over antibiotics for my child” practices and experiences with antibiotic use among caregivers of paediatric patients at Zomba central hospital in Malawi. BMC Pediatr. 2022;22(1):466. doi: 10.1186/s12887-022-03528-3
   PubMed Web of Science ®Google Scholar
• Torres NF, Solomon VP, Middleton LE. Identifying the commonly used antibiotics for self-medication in urban Mozambique: a qualitative study. BMJ Open. 2020;10(12):e041323. doi: 10.1136/bmjopen-2020-041323
   PubMed Web of Science ®Google Scholar
• Tuyishimire J, Okoya F, Adebayo AY, et al. Assessment of self-medication practices with antibiotics among undergraduate university students in Rwanda. Pan Afr Med J. 2019;33:307. doi: 10.11604/pamj.2019.33.307.18139
   PubMed Web of Science ®Google Scholar
• Mboya EA, Sanga LA, Ngocho JS. Irrational use of antibiotics in the Moshi municipality Northern Tanzania: a cross sectional study. Pan Afr Med J. 2018;31:165. doi: 10.11604/pamj.2018.31.165.15991
   PubMed Web of Science ®Google Scholar
• Emgård M, Mwangi R, Mayo C, et al. Antibiotic use in children under 5 years of age in Northern Tanzania: a qualitative study exploring the experiences of the caring mothers. Antimicrob Resist Infect Control. 2022;11(1):130. doi: 10.1186/s13756-022-01169-w
   PubMed Web of Science ®Google Scholar
• Mabilika RJ, Mpolya E, Shirima G. Prevalence and predictors of self-medication with antibiotics in selected urban and rural districts of the Dodoma region, Central Tanzania: a cross-sectional study. Antimicrob Resist Infect Control. 2022;11(1):86. doi: 10.1186/s13756-022-01124-9
   PubMed Web of Science ®Google Scholar
• Kibuule D, Kagoya HR, Godman B. Antibiotic use in acute respiratory infections in under-fives in Uganda: findings and implications. Expert Rev Anti Infect Ther. 2016;14(9):863–872. doi: 10.1080/14787210.2016.1206468
   PubMed Web of Science ®Google Scholar
• Amin ET, Charles N, Fondugallah JA, et al. Prevalence of antimicrobial self-medication among patients attending two hospitals in the Buea Health district, Cameroon. Arch Community Med Public Health. 2019;024–8. doi: 10.17352/2455-5479.000048
   Google Scholar
• Shembo AKP, Musumari PM, Srithanaviboonchai K, et al. A qualitative study on community use of antibiotics in Kinshasa, democratic Republic of Congo. PLoS One. 2022;17(4):e0267544. doi: 10.1371/journal.pone.0267544
   PubMed Web of Science ®Google Scholar
• Ahiabu MA, Magnussen P, Bygbjerg IC, et al. Treatment practices of households and antibiotic dispensing in medicine outlets in developing countries: the case of Ghana. Res Social Adm Pharm. 2018;14(12):1180–1188. doi: 10.1016/j.sapharm.2018.01.013
   PubMed Web of Science ®Google Scholar
• Mensah BN, Agyemang IB, Afriyie DK, et al. Self-medication practice in Akuse, a rural setting in Ghana. Niger Postgrad Med J. 2019;26(3):189–194. doi: 10.4103/npmj.npmj_87_19
   PubMedGoogle Scholar
• Afari-Asiedu S, Hulscher M, Abdulai MA, et al. Every medicine is medicine; exploring inappropriate antibiotic use at the community level in rural Ghana. BMC Public Health. 2020;20(1):1103. doi: 10.1186/s12889-020-09204-4
   PubMed Web of Science ®Google Scholar
• Kretchy J-P, Adase SK, Gyansa-Lutterodt M. The prevalence and risks of antibiotic self-medication in residents of a rural community in Accra, Ghana. Scientific African. 2021;14:e01006. doi: 10.1016/j.sciaf.2021.e01006
   Google Scholar
• Amponsah SK, Odamtten G, Adams I, et al. A comparative analysis of pattern and attitude towards self-medication among pharmacy and non-pharmacy students in University of Ghana. Pan Afr Med J. 2022;41:254. doi: 10.11604/pamj.2022.41.254.31013
   PubMed Web of Science ®Google Scholar
• Nyarko E, Akoto FM, Doku-Amponsah K, et al. Perceived antimicrobial dispensing practices in medicine outlets in Ghana: a maximum difference experiment design. PLoS One. 2023;18(7):e0288519. doi: 10.1371/journal.pone.0288519
   PubMed Web of Science ®Google Scholar
• Khalid GM, Jatau AI, Ibrahim UI, et al. Antibiotics self-medication among undergraduate pharmacy students in Northern Nigeria. Medicine Access @ Point Of Care. 2019;3:2399202619846847. doi: 10.1177/2399202619846847
   Google Scholar
• Abubakar U, Tangiisuran B. Knowledge and practices of community pharmacists towards non-prescription dispensing of antibiotics in Northern Nigeria. Int J Clin Pharm. 2020;42(2):756–764. doi: 10.1007/s11096-020-01019-y
   PubMed Web of Science ®Google Scholar
• Hussain MA, Mohamed AO, Abdelkarim OA, et al. Prevalence and predictors of antibiotic self-medication in Sudan: a descriptive cross-sectional study. Antibiotics. 2023;12(3):612. doi: 10.3390/antibiotics12030612
   Google Scholar
• Ateshim Y, Bereket B, Major F, et al. Prevalence of self-medication with antibiotics and associated factors in the community of Asmara, Eritrea: a descriptive cross sectional survey. BMC Public Health. 2019;19(1):726. doi: 10.1186/s12889-019-7020-x
   PubMed Web of Science ®Google Scholar
• Seid MA, Hussen MS. Knowledge and attitude towards antimicrobial resistance among final year undergraduate paramedical students at University of Gondar, Ethiopia. BMC Infect Dis. 2018;18(1):312. doi: 10.1186/s12879-018-3199-1
   PubMed Web of Science ®Google Scholar
• Torres NF, Solomon VP, Middleton LE. Pharmacists’ practices for non-prescribed antibiotic dispensing in Mozambique. Pharm Pract. 2020;18(3):1965. doi: 10.18549/PharmPract.2020.3.1965
   PubMed Web of Science ®Google Scholar
• Mboya EA, Davies ML, Horumpende PG, et al. Inadequate knowledge on appropriate antibiotics use among clients in the Moshi municipality Northern Tanzania. PLoS One. 2020;15(9):e0239388. doi: 10.1371/journal.pone.0239388
   PubMed Web of Science ®Google Scholar
• Sindato C, Mboera LEG, Katale BZ, et al. Knowledge, attitudes and practices regarding antimicrobial use and resistance among communities of Ilala, Kilosa and Kibaha districts of Tanzania. Antimicrob Resist Infect Control. 2020;9(1):194. doi: 10.1186/s13756-020-00862-y
   PubMed Web of Science ®Google Scholar
• Gabriel S, Manumbu L, Mkusa O, et al. Knowledge of use of antibiotics among consumers in Tanzania. JAC Antimicrob Resist. 2021;3(4):dlab183. doi: 10.1093/jacamr/dlab183
   PubMedGoogle Scholar
• Nkinda L, Kilonzi M, Felix FF, et al. Drivers of irrational use of antibiotics among children: a mixed-method study among prescribers and dispensers in Tanzania. BMC Health Serv Res. 2022;22(1):961. doi: 10.1186/s12913-022-08359-7
   PubMed Web of Science ®Google Scholar
• Elong Ekambi GA, Okalla Ebongue C, Penda IC, et al. Knowledge, practices and attitudes on antibiotics use in Cameroon: self-medication and prescription survey among children, adolescents and adults in private pharmacies. PLoS One. 2019;14(2):e0212875. doi: 10.1371/journal.pone.0212875
   PubMed Web of Science ®Google Scholar
• Abbey M, Chinbuah MA, Gyapong M, et al. Community perceptions and practices of treatment seeking for childhood pneumonia: a mixed methods study in a rural district, Ghana. BMC Public Health. 2016;16(1):848. doi: 10.1186/s12889-016-3513-z
   PubMedGoogle Scholar
• Afari-Asiedu S, Hulscher M, Abdulai MA, et al. Stakeholders’ perspectives on training over the counter medicine sellers and community-based Health planning and services facilities to dispense antibiotics in Ghana. J Of Pharm Policy And Pract. 2021;14(1):62. doi: 10.1186/s40545-021-00349-0
   PubMedGoogle Scholar
• Omulo S, Thumbi SM, Lockwood S, et al. Evidence of superficial knowledge regarding antibiotics and their use: results of two cross-sectional surveys in an urban informal settlement in Kenya. PLoS One. 2017;12(10):e0185827. doi: 10.1371/journal.pone.0185827
   PubMed Web of Science ®Google Scholar
• Muloi D, Fèvre EM, Bettridge J, et al. A cross-sectional survey of practices and knowledge among antibiotic retailers in Nairobi, Kenya. J Glob Health. 2019;9(2):010412. doi: 10.7189/jogh.09.020412
   PubMed Web of Science ®Google Scholar
• Badger-Emeka LI, Emeka PM, Okosi M. Evaluation of the extent and reasons for increased non-prescription antibiotics use in a University town, Nsukka Nigeria. Int J Health Sci (Qassim). 2018;12(4):11–17.
   PubMedGoogle Scholar
• Ajibola O, Omisakin OA, Eze AA, et al. Self-medication with antibiotics, attitude and knowledge of antibiotic resistance among community residents and undergraduate students in Northwest Nigeria. Diseases. 2018;6(2):32. doi: 10.3390/diseases6020032
   PubMedGoogle Scholar
• Akande-Sholabi W, Ajamu AT. Antimicrobial stewardship: assessment of knowledge, awareness of antimicrobial resistance and appropriate antibiotic use among healthcare students in a Nigerian University. BMC Med Educ. 2021;21(1):488. doi: 10.1186/s12909-021-02912-4
   PubMed Web of Science ®Google Scholar
• Abdu-Aguye SN, Barde KG, Yusuf H, et al. Investigating knowledge of antibiotics, antimicrobial resistance and antimicrobial stewardship concepts among final year undergraduate pharmacy students in Northern Nigeria. Integr Pharm Res Pract. 2022;11:187–195. doi: 10.2147/IPRP.S385692
   PubMed Web of Science ®Google Scholar
• Mudenda S, Mukela M, Matafwali SK, et al. Knowledge, attitudes, and practices towards antibiotic use and antimicrobial resistance among pharmacy students at the University of Zambia: implications for antimicrobial stewardship programmes. Sch Acad J Pharm. 2022;8(8):117–124. doi: 10.36347/sajp.2022.v11i08.002
   Google Scholar
• Mokoena TTW, Schellack N, Brink AJ. Driving antibiotic stewardship awareness through the minibus-taxi community across the Tshwane district, South Africa-a baseline evaluation. JAC Antimicrob Resist. 2021;3(3):dlab106. doi: 10.1093/jacamr/dlab106
   PubMedGoogle Scholar
• Eze P, Lawani LO, Agu UJ, et al. Factors associated with catastrophic health expenditure in sub-Saharan Africa: a systematic review. PLoS One. 2022;17(10):e0276266. doi: 10.1371/journal.pone.0276266
   PubMed Web of Science ®Google Scholar
• Miljeteig I, Defaye FB, Wakim P, et al. Financial risk protection at the bedside: how Ethiopian physicians try to minimize out-of-pocket health expenditures. PLoS One. 2019;14(2):e0212129. doi: 10.1371/journal.pone.0212129
   PubMed Web of Science ®Google Scholar
• Iskandar K, Molinier L, Hallit S, et al. Surveillance of antimicrobial resistance in low- and middle-income countries: a scattered picture. Antimicrob Resist Infect Control. 2021;10(1):63. doi: 10.1186/s13756-021-00931-w
   PubMed Web of Science ®Google Scholar
• Versporten A, Zarb P, Caniaux I, et al. Antimicrobial consumption and resistance in adult hospital inpatients in 53 countries: results of an internet-based global point prevalence survey. Lancet Glob Health. 2018;6(6):e619–e29. doi: 10.1016/S2214-109X(18)30186-4
   PubMed Web of Science ®Google Scholar
• van den Bosch CM, Hulscher ME, Natsch S, et al. Applicability of generic quality indicators for appropriate antibiotic use in daily hospital practice: a cross-sectional point-prevalence multicenter study. Clin Microbiol Infect. 2016;22(10):e888.1–.e.9. doi: 10.1016/j.cmi.2016.07.011
   Web of Science ®Google Scholar
• van den Bosch CM, Geerlings SE, Natsch S, et al. Quality indicators to measure appropriate antibiotic use in hospitalized adults. Clin Infect Dis. 2015;60(2):281–291. doi: 10.1093/cid/ciu747
   PubMed Web of Science ®Google Scholar
• Kallen MC, Prins JM. A systematic review of quality indicators for appropriate antibiotic use in hospitalized adult patients. Infect Dis Rep. 2017;9(1):6821. doi: 10.4081/idr.2017.6821
   PubMed Web of Science ®Google Scholar
• Campbell SM, Braspenning J, Hutchinson A, et al. Research methods used in developing and applying quality indicators in primary care. Qual Saf Health Care. 2002;11(4):358–364. doi: 10.1136/qhc.11.4.358
   PubMed Web of Science ®Google Scholar
• Campbell SM, Kontopantelis E, Hannon K, et al. Framework and indicator testing protocol for developing and piloting quality indicators for the UK quality and outcomes framework. BMC Fam Pract. 2011;12(1):85. doi: 10.1186/1471-2296-12-85
   PubMedGoogle Scholar
• Campbell SM, Godman B, Diogene E, et al. Quality indicators as a tool in improving the introduction of new medicines. Basic Clin Pharmacol Toxicol. 2015;116(2):146–157. doi: 10.1111/bcpt.12295
   PubMed Web of Science ®Google Scholar
• Moura ML, Boszczowski I, Mortari N, et al. The impact of restricting over-the-counter sales of antimicrobial drugs: preliminary analysis of national data. Medicine (Baltimore). 2015;94(38):e1605. doi: 10.1097/MD.0000000000001605
   PubMed Web of Science ®Google Scholar
• Lopes-Júnior R, de Sá Del Fiol F, Araujo JL, et al. Decrease in penicillin sales in Brazil after over-the-counter restrictions. Antimicrob Agents Chemother. 2015;59(9):5862–5863. doi: 10.1128/AAC.01030-15
   PubMed Web of Science ®Google Scholar
• Mattos KPH, Visacri MB, Quintanilha JCF, et al. Brazil’s resolutions to regulate the sale of antibiotics: impact on consumption and Escherichia coli resistance rates. J Glob Antimicrob Resist. 2017;10:195–199. doi: 10.1016/j.jgar.2017.05.023
   PubMed Web of Science ®Google Scholar
• Kitutu FE, Kalyango JN, Mayora C, et al. Integrated community case management by drug sellers influences appropriate treatment of paediatric febrile illness in South Western Uganda: a quasi-experimental study. Malar J. 2017;16(1):425. doi: 10.1186/s12936-017-2072-9
   PubMedGoogle Scholar
• WHO. Anatomical therapeutic Chemical (ATC) classification. 2021. [cited2023 Mar 18]. Available from:https://www.who.int/tools/atc-ddd-toolkit/atc-classification
   Google Scholar
• DRIVE-AB WP1A. QUALITY INDICATORS & QUANTITY METRICS OF ANTIBIOTIC USE. 2014. [cited 2023 Mar 23]. Available from: http://drive-ab.eu/wp-content/uploads/2014/09/WP1A_Final-QMs-QIs_final.pdf
   Google Scholar
• Falco MF, Meyer JC, Putter SJ, et al. Perceptions of and practical experience with the national surveillance Centre in managing medicines availability amongst users within public healthcare facilities in South Africa: findings and implications. Healthcare. 2023;11(13):1838. doi: 10.3390/healthcare11131838
   Web of Science ®Google Scholar
• Kalungia A, Godman B. Implications of non-prescription antibiotic sales in China. Lancet Infect Dis. 2019;19(12):1272–1273. doi: 10.1016/S1473-3099(19)30408-6
   PubMed Web of Science ®Google Scholar
• Nafade V, Huddart S, Sulis G, et al. Over-the-counter antibiotic dispensing by pharmacies: a standardised patient study in Udupi district, India. BMJ Glob Health. 2019;4(6):e001869. doi: 10.1136/bmjgh-2019-001869
   PubMed Web of Science ®Google Scholar
• Sengupta S, Barman P, Lo J. Opportunities to overcome implementation challenges of infection prevention and Control in low-middle income countries. Curr Treat Options Infect Dis. 2019;11(3):267–280. doi: 10.1007/s40506-019-00200-w
   Google Scholar
• Cadogan CA, Hughes CM. On the frontline against COVID-19: community pharmacists’ contribution during a public health crisis. Res Social Adm Pharm. 2021;17(1):2032–2035. doi: 10.1016/j.sapharm.2020.03.015
   PubMed Web of Science ®Google Scholar
• Hedima EW, Adeyemi MS, Ikunaiye NY. Community pharmacists: on the frontline of health service against COVID-19 in LMICs. Res Social Adm Pharm. 2021;17(1):1964–1966. doi: 10.1016/j.sapharm.2020.04.013
   PubMed Web of Science ®Google Scholar
• Erku DA, Belachew SA, Abrha S, et al. When fear and misinformation go viral: pharmacists’ role in deterring medication misinformation during the ‘infodemic’ surrounding COVID-19. Res Social Adm Pharm. 2021;17(1):1954–1963. doi: 10.1016/j.sapharm.2020.04.032
   PubMed Web of Science ®Google Scholar
• Lambert M, Smit CCH, De Vos S, et al. A systematic literature review and meta-analysis of community pharmacist-led interventions to optimise the use of antibiotics. Br J Clin Pharmacol. 2022;88(6):2617–2641. doi: 10.1111/bcp.15254
   PubMed Web of Science ®Google Scholar
• Finnis A Can pharmacists prescribe antibiotics? The new plans for prescriptions in England, explained. 2023. [cited 2023 Jul 20]. Available from: https://inews.co.uk/news/health/pharmacists-can-prescribe-antibiotics-new-plans-pharmacy-prescriptions-england-explained-2330773
   Google Scholar
• Sarwar MR, Saqib A, Iftikhar S, et al. Knowledge of community pharmacists about antibiotics, and their perceptions and practices regarding antimicrobial stewardship: a cross-sectional study in Punjab, Pakistan. Infect Drug Resist. 2018;11:133–145. doi: 10.2147/IDR.S148102
   PubMed Web of Science ®Google Scholar
• Chowdhury F, Sturm-Ramirez K, Mamun AA, et al. Effectiveness of an educational intervention to improve antibiotic dispensing practices for acute respiratory illness among drug sellers in pharmacies, a pilot study in Bangladesh. BMC Health Serv Res. 2018;18(1):676. doi: 10.1186/s12913-018-3486-y
   PubMedGoogle Scholar
• Chang J, Xu S, Zhu S, et al. Assessment of non-prescription antibiotic dispensing at community pharmacies in China with simulated clients: a mixed cross-sectional and longitudinal study. Lancet Infect Dis. 2019;19(12):1345–1354. doi: 10.1016/S1473-3099(19)30324-X
   PubMed Web of Science ®Google Scholar
• Kimathi G, Kiarie J, Njarambah L, et al. A cross-sectional study of antimicrobial use among self-medicating COVID-19 cases in Nyeri County, Kenya. Antimicrob Resist Infect Control. 2022;11(1):111. doi: 10.1186/s13756-022-01150-7
   PubMed Web of Science ®Google Scholar
• WHO. Kenya national action plan on antimicrobial resistance: review of progress in the human health sector. 2022. [cited 2023 Mar20]. Available from: https://www.who.int/publications/i/item/9789240062689
   Google Scholar
• Santa-Ana-Tellez Y, Mantel-Teeuwisse AK, Leufkens HGM, et al. Seasonal variation in Penicillin use in Mexico and Brazil: analysis of the impact of over-the-counter restrictions. Antimicrob Agents Chemother. 2015;59(1):105–110. doi: 10.1128/AAC.03629-14
   PubMed Web of Science ®Google Scholar
• Onwunduba A, Ekwunife O, Onyilogwu E. Impact of point-of-care C-reactive protein testing intervention on non-prescription dispensing of antibiotics for respiratory tract infections in private community pharmacies in Nigeria: a cluster randomized controlled trial. Int J Infect Dis. 2023;127:137–143. doi: 10.1016/j.ijid.2022.12.006
   PubMed Web of Science ®Google Scholar
• Markovic-Pekovic V, Grubisa N. Self-medication with antibiotics in the Republic of Srpska community pharmacies: pharmacy staff behavior. Pharmacoepidemiol Drug Saf. 2012;21(10):1130–1133. doi: 10.1002/pds.3218
   PubMed Web of Science ®Google Scholar
• Arparsrithongsagul S, Kulsomboon V, Zuckerman IH. Multidisciplinary perspective intervention with community involvement to decrease antibiotic sales in village groceries in Thailand. Asia Pac J Public Health. 2015;27(2):Np2480–8. doi: 10.1177/1010539513479968
   PubMed Web of Science ®Google Scholar
• Cox JA, Vlieghe E, Mendelson M, et al. Antibiotic stewardship in low- and middle-income countries: the same but different? Clin Microbiol Infect. 2017;23(11):812–818. doi: 10.1016/j.cmi.2017.07.010
   PubMed Web of Science ®Google Scholar
• Nabadda S, Kakooza F, Kiggundu R, et al. Implementation of the World Health organization global antimicrobial resistance surveillance system in Uganda, 2015-2020: mixed-methods study using national surveillance data. JMIR Public Health Surveill. 2021;7(10):e29954. doi: 10.2196/29954
   PubMedGoogle Scholar
• Schäfermann S, Hauk C, Wemakor E, et al. Substandard and falsified antibiotics and medicines against noncommunicable diseases in Western Cameroon and Northeastern democratic Republic of Congo. Am J Trop Med Hyg. 2020;103(2):894–908. doi: 10.4269/ajtmh.20-0184
   PubMed Web of Science ®Google Scholar
• Zabala GA, Bellingham K, Vidhamaly V, et al. Substandard and falsified antibiotics: neglected drivers of antimicrobial resistance? BMJ Glob Health. 2022;7(8):e008587. doi: 10.1136/bmjgh-2022-008587
   PubMed Web of Science ®Google Scholar
• Waffo Tchounga CA, Sacré PY, Ciza Hamuli P, et al. Prevalence of poor quality ciprofloxacin and metronidazole tablets in three cities in Cameroon. Am J Trop Med Hyg. 2023;108(2):403–411. doi: 10.4269/ajtmh.22-0221
   PubMed Web of Science ®Google Scholar
• Sami SA, Marma KKS, Chakraborty A, et al. A comprehensive review on global contributions and recognition of pharmacy professionals amidst COVID-19 pandemic: moving from present to future. Futur J Pharm Sci. 2021;7(1):119. doi: 10.1186/s43094-021-00273-9
   PubMed Web of Science ®Google Scholar
• Kampamba - Mutati R, Mwila C, Mudenda S, et al. Continuing professional development needs of pharmacy professionals in Zambia: findings and future directions. Pharm Educ. 2022;22(1):301–311. doi: 10.46542/pe.2022.221.301311
   Web of Science ®Google Scholar
• Enz C NEW DIRECTIONS for CROSS- CULTURAL STUDIES: LINKING ORGANIZATIONAL and SOCIETAL CULTURES. [cited 2023 Mar 20]. Available from: https://ecommons.cornell.edu/bitstream/handle/1813/72141/Enz101_Linking_Organizational_And_Societal_Cultures.pdf?sequence=1
   Google Scholar
• Fischer M. [cited 2023 Jul 20]. Available from: https://www.washingtonpost.com/news/worldviews/wp/2013/05/16/a-revealing-map-of-the-worlds-most-and-least-ethnically-diverse-countries/
   Google Scholar
• Cliff-Eribo K O, Sammons H, Star K, et al. Adverse drug reactions in Nigerian children: a retrospective review of reports submitted to the Nigerian pharmacovigilance Centre from 2005 to 2012. Paediatr Int Child Health. 2016;36(4):300–304. doi: 10.1179/2046905515Y.0000000059
   PubMed Web of Science ®Google Scholar
• Joseph AM, Fernandez V, Kritzman S, et al. COVID-19 misinformation on social media: a scoping review. Cureus. 2022;14(4):e24601. doi: 10.7759/cureus.24601
   PubMed Web of Science ®Google Scholar
• Muric G, Wu Y, Ferrara E. COVID-19 vaccine hesitancy on social media: building a public twitter data set of antivaccine content, vaccine misinformation, and conspiracies. JMIR Public Health Surveill. 2021;7(11):e30642–e. doi: 10.2196/30642
   PubMedGoogle Scholar
• Hernandez RG, Hagen L, Walker K, et al. The COVID-19 vaccine social media infodemic: healthcare providers’ missed dose in addressing misinformation and vaccine hesitancy. Hum Vaccin Immunother. 2021;17(9):2962–2964. doi: 10.1080/21645515.2021.1912551
   PubMed Web of Science ®Google Scholar
• Schellack N, Strydom M, Pepper MS, et al. Social media and COVID-19;Perceptions and public deceptions of ivermectin, colchicine and Hydroxychloroquine: lessons for future pandemics. Antibiotics. 2022;11(4):445. doi: 10.3390/antibiotics11040445
   Google Scholar
• Wang Q, Huang R. The impact of COVID-19 pandemic on sustainable development goals - a survey. Environ Res. 2021;202:111637–. doi: 10.1016/j.envres.2021.111637
   PubMed Web of Science ®Google Scholar
• Morton S, Pencheon D, Squires N. Sustainable development goals (SDGs), and their implementation: a national global framework for health, development and equity needs a systems approach at every level. Br Med Bull. 2017;124(1):81–90. doi: 10.1093/bmb/ldx031
   PubMed Web of Science ®Google Scholar
• Odey GO, Alawad AGA, Atieno OS, et al. COVID-19 pandemic: impacts on the achievements of sustainable development goals in Africa. Pan Afr Med J. 2021;38:251. doi: 10.11604/pamj.2021.38.251.27065
   PubMed Web of Science ®Google Scholar
• Ogunnigbo O, Nabiryo M, Atteh M, et al. Exploring the antimicrobial stewardship educational needs of healthcare students and the potential of an antimicrobial prescribing app as an educational tool in selected African countries. Antibiotics. 2022;11(5):691. doi: 10.3390/antibiotics11050691
   Google Scholar
• Olaoye O, Tuck C, Khor WP, et al. Improving Access to antimicrobial prescribing guidelines in 4 African countries: development and pilot implementation of an app and cross-sectional Assessment of attitudes and behaviour survey of healthcare workers and patients. Antibiotics. 2020;9(9):555. doi: 10.3390/antibiotics9090555
   Google Scholar
• Appiah B, Asamoah-Akuoko L, Samman E, et al. The impact of antimicrobial resistance awareness interventions involving schoolchildren, development of an animation and parents engagements: a pilot study. Antimicrob Resist Infect Control. 2022;11(1):26. doi: 10.1186/s13756-022-01062-6
   PubMed Web of Science ®Google Scholar
• Wonodi C, Obi-Jeff C, Adewumi F, et al. Conspiracy theories and misinformation about COVID-19 in Nigeria: implications for vaccine demand generation communications. Vaccine. 2022;40(13):2114–2121. doi: 10.1016/j.vaccine.2022.02.005
   PubMed Web of Science ®Google Scholar
• Stewart R, Madonsela A, Tshabalala N, et al. The importance of social media users’ responses in tackling digital COVID-19 misinformation in Africa. Digit Health. 2022;8:20552076221085070. doi: 10.1177/20552076221085070
   Web of Science ®Google Scholar
• Interagency Coordination Group on Antimicrobial Resistance. NO TIME to WAIT: SECURING the FUTURE from DRUG-RESISTANT INFECTIONS - REPORT to the SECRETARY-GENERAL of the UNITED NATIONS. 2019 APR. [cited 2023 Mar 19]. Available from: https://www.who.int/antimicrobial-resistance/interagency-coordination-group/IACG_final_report_EN.pdf?ua=1
   Google Scholar
• Akpan MR, Isemin NU, Udoh AE, et al. Implementation of antimicrobial stewardship programmes in African countries: a systematic literature review. J Glob Antimicrob Resist. 2020;22:317–324. doi: 10.1016/j.jgar.2020.03.009
   PubMed Web of Science ®Google Scholar
• Siachalinga L, Mufwambi W, Lee IH. Impact of antimicrobial stewardship interventions to improve antibiotic prescribing for hospital inpatients in Africa: a systematic review and meta-analysis. J Hosp Infect. 2022;129:124–143. doi: 10.1016/j.jhin.2022.07.031
   PubMed Web of Science ®Google Scholar
• Siachalinga L, Godman B, Mwita JC, et al. Current antibiotic use among hospitals in the sub-Saharan Africa region. IDR. 2023;16:2179–2190. doi: 10.2147/IDR.S398223
   Google Scholar
• Otieno PA, Campbell S, Maley S, et al. A systematic review of pharmacist-led antimicrobial stewardship programs in sub-Saharan Africa. Int J Clin Pract. 2022;2022:3639943. doi: 10.1155/2022/3639943
   PubMed Web of Science ®Google Scholar
• Kamere N, Garwe ST, Akinwotu OO, et al. Scoping review of national antimicrobial stewardship activities in eight African countries and adaptable recommendations. Antibiotics. 2022;11(9):1149. doi: 10.3390/antibiotics11091149
   Google Scholar
• Abena PM, Decloedt EH, Bottieau E, et al. Chloroquine and Hydroxychloroquine for the prevention or treatment of COVID-19 in Africa: caution for inappropriate off-label use in healthcare settings. Am J Trop Med Hyg. 2020;102(6):1184–1188. doi: 10.4269/ajtmh.20-0290
   PubMed Web of Science ®Google Scholar