Application of proteomics in research on traditional Chinese medicine

References

• Veith I (Translator), Barnes LL (Foreword). The yellow emperor’s classic of internal medicine. Oakland (CA): University of California Press; 2015.
   Google Scholar
• The State Council of the People’s Republic of China. Traditional Chinese medicine hospitals growing. 2016. Available from: http://english.gov.cn/state_council/ministries/2016/01/14/content_281475271868348.htm.
   Google Scholar
• China Unveils Plans to Boost Traditional Chinese Medicine. CRI’s English service. China Radio International, 2016. Available from: http://english.cri.cn/12394/2016/02/20/3441s917412.htm.
   Google Scholar
• Abdulla S. Phytotherapy - good science or big business? Nature. 1999. Available from: http://www.nature.com/news/1999/990513/full/news990513-8.html.
   Google Scholar
• Lin LL, Wang YH, Lai CY, et al. Systems biology of meridians, acupoints, and Chinese herbs in disease. Evid-Based Complement Altern Med. 2012;2012:1–13.
   Web of Science ®Google Scholar
• Yan SK, Liu RH, Jin HZ, et al. “Omics” in pharmaceutical research: overview, applications, challenges, and future perspectives. Chin J Nat Med. 2015;13(1):3–21.
   PubMed Web of Science ®Google Scholar
• Wilkins MR, Pasquali C, Appel RD, et al. From proteins to proteomes: large scale protein identification by two-dimensional electrophoresis and arnino acid analysis. Nat Biotech. 1996;14(1):61–65.
   Web of Science ®Google Scholar
• James P. Protein identification in the post-genome era: the rapid rise of proteomics. Q Rev Biophys. 1997;30(4):279–331.
   PubMed Web of Science ®Google Scholar
• Cho WC-S. Application of proteomics in Chinese medicine research. Am J Chin Med. 2007;35(6):911–922.
   PubMed Web of Science ®Google Scholar
• Liu X, Guo D-A. Application of proteomics in the mechanistic study of traditional Chinese medicine. Biochem Soc Trans. 2011;39(5):1348–1352.
   PubMed Web of Science ®Google Scholar
• Lao Y, Wang X, Xu N, et al. Application of proteomics to determine the mechanism of action of traditional Chinese medicine remedies. J Ethnopharmacol. 2014;155(1):1–8.
   PubMed Web of Science ®Google Scholar
• Sulistio YA, Heese K. Proteomics in traditional Chinese medicine with an emphasis on alzheimer’s disease. Evid-Based Complement Altern Med. 2015;2015:1–17.
   Web of Science ®Google Scholar
• Wang Y, Yu RY, He QY. Proteomic analysis of anticancer TCMs targeted at mitochondria. Evid-Based Complement Altern Med. 2015;2015:1–14.
   Google Scholar
• Moro CF, Fukao Y, Shibato J, et al. Unraveling the seed endosperm proteome of the lotus (Nelumbo nucifera Gaertn.) utilizing 1DE and 2DE separation in conjunction with tandem mass spectrometry. Proteomics. 2015;15:1717–1735.
   PubMed Web of Science ®Google Scholar
• Hua Y, Wang S, Liu Z, et al. iTRAQ-based quantitative proteomic analysis of cultivated Pseudostellaria heterophylla and its wild-type. J Proteomics. 2016;139:13–25.
   PubMed Web of Science ®Google Scholar
• Jiang TT, Wang C, Wei LL, et al. Serum protein gamma-glutamyl hydrolase, Ig gamma-3 chain C region, and haptoglobin are associated with the syndromes of pulmonary tuberculosis in traditional Chinese medicine. BMC Complement Altern Med. 2015;15(243):1–11.
   PubMed Web of Science ®Google Scholar
• Liu J, Li Y, Wei L, et al. Screening and identification of potential biomarkers and establishment of the diagnostic serum proteomic model for the traditional Chinese medicine syndromes of tuberculosis. J Ethnopharmacol. 2014;155(2):1322–1331.
   PubMed Web of Science ®Google Scholar
• Sun H, Zhang A, Yan G, et al. Acupuncture targeting and regulating multiple signaling pathways related to Zusanli acupoint using iTRAQ-based quantitative proteomic analysis. Acupunct Relat Ther. 2014;2(3):51–56.
   Google Scholar
• Zhang A, Yan G, Sun H, et al. Deciphering the biological effects of acupuncture treatment modulating multiple metabolism pathways. Sci Rep. 2016;6:19942.
   PubMed Web of Science ®Google Scholar
• Zhan S, Fan X, Zhang F, et al. A proteomic study of Shengmai injection’s mechanism on preventing cardiac ischemia-reperfusion injury via energy metabolism modulation. Mol Biosyst. 2015;11(2):540–548.
   PubMed Web of Science ®Google Scholar
• Yue Q, Feng L, Cao B, et al. Proteomic analysis revealed the important role of vimentin in human cervical carcinoma heLa cells treated with gambogic acid. Mol Cell Proteomics. 2016;15(1):26–44.
   PubMed Web of Science ®Google Scholar
• Wang X, Zhang A, Wang P, et al. Metabolomics coupled with proteomics advancing drug discovery toward more agile development of targeted combination therapies. Mol Cell Proteomics. 2013;12(5):1226–1238.
   PubMed Web of Science ®Google Scholar
• Lin LL, Hsia CR, Hsu CL, et al. Integrating transcriptomics and proteomics to show that tanshinone IIA suppresses cell growth by blocking glucose metabolism in gastric cancer cells. BMC Genomics. 2015;16(41):1–17.
   PubMed Web of Science ®Google Scholar
• Gao L, Qiao X, Liang Z, et al. Application of on-line two-dimensional liquid chromatography in comparative proteomean alysis of antlers with different growing stages. Chin J Chromatogr. 2010;28(2):146–151.
   Google Scholar
• Huo Y-S, Huo H, Zhang J. The contribution of deer velvet antler research to the modern biological medicine. Chin J Integr Med. 2014;20(10):723–728.
   PubMed Web of Science ®Google Scholar
• Lin Y-L, Wen T-N, Chang S-T, et al. Proteomic analysis of differently cultured endemic medicinal mushroom antrodia cinnamomea T.T. Chang et W.N. Chou from Taiwan. Int J Med Mushrooms. 2011;13(5):473–482.
   PubMed Web of Science ®Google Scholar
• Wang Y, Yan H, Wang Y, et al. Proteomics and transcriptome analysis coupled with pharmacological test reveals the diversity of anti-thrombosis proteins from the medicinal insect, Eupolyphaga sinensis. Insect Biochem Mol Biol. 2012;42(8):537–544.
   PubMed Web of Science ®Google Scholar
• Liu R, Duan JA, Wu H, et al. Analysis and identification of water soluble components of water buffalo horn. Acta Pharmaceutica Sin. 2015;50(5):594–598.
   PubMedGoogle Scholar
• Zhang S, Lai X, Li B, et al. Application of differential proteomic analysis to authenticate ophiocordyceps sinensis. Curr Microbiol. 2016;72:337–343.
   PubMed Web of Science ®Google Scholar
• Xiong XG, Chen J, Agrawal GK. Proteomics study on the essence of wind syndrome caused by Gan-yang hyperactivity in Chinese medicine. Chin J Integr Tradit West Med. 2011;31(7):913–920.
   Google Scholar
• Wei M, Liu YP, Fh G. Plasma proteomic analysis of patients with chronic hepatitis B of damp-heat retention in the middle-jiao syndrome. Chin J Integr Tradit West Med. 2011;31(10):1341–1345.
   Google Scholar
• Lü L, Jia LQ, Ma W. Experimental study on the lleum tissue proteins differentially expressed in Pi-qi deficiency syndrome Rats. Chin J Integr Tradit West Med. 2012;32(5):685–688.
   Google Scholar
• Hao YM, Hong MC, Wang WJ, et al. Study on proteins in urine of chronic renal failure patients of different TCM syndrome types. Chin J Integr Tradit West Med. 2012;32(9):1196–1199.
   Google Scholar
• Hao YM, Hong MC, Wang WJ, et al. Study on correlated proteins in the urine of chronic renal failure patients of Chinese medicine damp syndrome based on SELDI-TOF-MS technique. Chin J Integr Tradit West Med. 2012;32(11):1496–1499.
   Google Scholar
• Liu ZZ, Yu ZY, OuYang XN, et al. Applied research on serum protein fingerprints for prediction of Qi deficiency syndrome and phlegm and blood stasis in patients with non-small cell lung cancer. J Tradit Chin Med. 2012;32(3):350–354.
   PubMed Web of Science ®Google Scholar
• Liu Y, Liu P, Dai R, et al. Analysis of plasma proteome from cases of the different traditional Chinese medicine syndromes in patients with chronic hepatitis B. J Pharm Biomed Anal. 2012;59:173–178.
   PubMed Web of Science ®Google Scholar
• Yu M, Lü L, Wang CX, et al. Comparative proteomics analysis of the ileum of Pi-yang deficiency model rats. Chin J Integr Tradit West Med. 2013;33(1):71–75.
   Google Scholar
• Wang Y, Chuo W-J, Li C, et al. Energy metabolism disorder and myocardial injury in chronic myocardial ischemia with Qi deficiency and blood stasis syndrome based on 2-DE proteomics. Chin J Integr Med. 2013;19(8):616–620.
   PubMed Web of Science ®Google Scholar
• Bonafede M, Dick A, Noyes K, et al. The effect of acupuncture utilization on health care utilization. Med Care. 2008;46(1):41–48.
   PubMed Web of Science ®Google Scholar
• Goldman N, Chen M, Fujita T, et al. Adenosine A1 receptors mediate local anti-nociceptive effects of acupuncture. Nat Neurosci. 2010;13(7):833–888.
   Web of Science ®Google Scholar
• Torres-Rosas R, Yehia G, Pena G, et al. Dopamine mediates vagal modulation of the immune system by electroacupuncture. Nat Med. 2014;20(3):291–295.
   PubMed Web of Science ®Google Scholar
• Kim S-T, Moon W, Chae Y, et al. The effect of electroaucpuncture for 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced proteomic changes in the mouse striatum. J Physiol Sci. 2010;60(1):27–34.
   PubMed Web of Science ®Google Scholar
• Li W-J, Pan S-Q, Zeng Y-S, et al. Identification of acupuncture-specific proteins in the process of electro-acupuncture after spinal cord injury. Neurosci Res. 2010;67(4):307–316.
   PubMed Web of Science ®Google Scholar
• Gao YH, Chen SP, Wang JY, et al. Differential proteomics analysis of the analgesic effect of electroacupuncture intervention in the hippocampus following neuropathic pain in rats. BMC Complement Altern Med. 2012;12(241):1–11.
   Google Scholar
• Lee SH, Kim SY, Kim JH, et al. Phosphoproteomic analysis of electroacupuncture analgesia in an inflammatory pain rat model. Mol Med Rep. 2012;6(1):157–162.
   PubMed Web of Science ®Google Scholar
• Lai X, Wang J, Nabar NR, et al. Proteomic response to acupuncture treatment in spontaneously hypertensive rats. PLoS One. 2012;7(9):e44216.
   PubMed Web of Science ®Google Scholar
• Xu YD, Cui JM, Wang Y, et al. Proteomic analysis reveals the deregulation of inflammation-related proteins in acupuncture-treated rats with asthma onset. Evid-Based Complement Altern Med. 2012;2012:1–14.
   Google Scholar
• Gao Y, Chen S, Xu Q, et al. Proteomic analysis of differential proteins related to anti-nociceptive effect of electroacupuncture in the hypothalamus following neuropathic pain in rats. Neurochem Res. 2013;38(7):1467–1478.
   PubMed Web of Science ®Google Scholar
• Bae CH, Kim DS, Jun YL, et al. Proteomic analysis of the effect of acupuncture on the suppression of kainic acid-induced neuronal destruction in mouse hippocampus. Evid-Based Complement Altern Med. 2013;2013:1–8.
   Web of Science ®Google Scholar
• Xu YD, Wang Y, Park GH, et al. Non-specific physiological background effects of acupuncture revealed by proteomic analysis in normal rats. BMC Complement Altern Med. 2014;14(375):1–7.
   PubMed Web of Science ®Google Scholar
• Nie K, Zhang XZ, Zhao L, et al. Effect of acupuncture on transmembrane signal pathway in AD mice: an analysis on lipid-rat proteomics. Chin J Integr Tradit West Med. 2014;34(8):991–996.
   Google Scholar
• Liu Y, Li W, Hu L, et al. Downregulation of nitric oxide by electroacupuncture against hypoxicischemic brain damage in rats via nuclear factorkappaB/neuronal nitric oxide synthase. Mol Med Rep. 2015;11(2):837–842.
   PubMed Web of Science ®Google Scholar
• Guo Z, Tu Y, Guo TW, et al. Electroacupuncture pretreatment exhibits anti-depressive effects by regulating hippocampal proteomics in rats with chronic restraint stress. Neural Regen Res. 2015;10(8):1298–1304.
   PubMed Web of Science ®Google Scholar
• Kim HJ, Park HJ, Hong MS, et al. Effect by acupuncture on hypothalamic expression of maternally separated rats: proteomic approach. Neurol Res. 2010;32(Suppl 1):69–73.
   PubMed Web of Science ®Google Scholar
• Xu X, Wang MM, Sun ZL, et al. Discovery of serum proteomic biomarkers for prediction of response to moxibustion treatment in rats with collagen-induced arthritis: an exploratory analysis. Acupunct Med. 2015;0:1–10.
   Google Scholar
• Qiu X, Gong L, Sun X, et al. Efficacy of acupuncture and identification of tear protein expression changes using iTRAQ quantitative proteomics in rabbits. Curr Eye Res. 2011;36(10):886–894.
   PubMed Web of Science ®Google Scholar
• Pan S, Zhan X, Su X, et al. Proteomic analysis of serum proteins in acute ischemic stroke patients treated with acupuncture. Exp Biol Med. 2011;236(3):325–333.
   Web of Science ®Google Scholar
• Zhang H, Song J, Shi J. Screen anti-influenza virus serum marker of Lonicera japonica by proteomics technology. China J Chin Mater Med. 2011;36(8):1071–1074.
   Google Scholar
• Fan R, He F, Wang Y, et al. Changes of protein expression profile in vascular t issues of spontaneously hypertensive rats treated by a compound Chinese herbal medicine. J Chin Integr Med. 2011;9(6):643–650.
   PubMedGoogle Scholar
• Li Y, Ligr M, McCarron JP, et al. Natura-alpha targets forkhead box m1 and inhibits androgen-dependent and -independent prostate cancer growth and invasion. Clin Cancer Res. 2011;17(13):4414–4424.
   PubMed Web of Science ®Google Scholar
• Ma C, Yao Y, Yue QX, et al. Differential proteomic analysis of platelets suggested possible signal cascades network in platelets treated with salvianolic acid B. PLoS One. 2011;6(2):1–9.
   Google Scholar
• Yue QX, Xie FB, Song XY, et al. Proteomic studies on protective effects of salvianolic acids, notoginsengnosides and combination of salvianolic acids and notoginsengnosides against cardiac ischemic-reperfusion injury. J Ethnopharmacol. 2012;141(2):659–667.
   PubMed Web of Science ®Google Scholar
• Wei DF, Wei YX, Cheng WD, et al. Proteomic analysis of the effect of triterpenes from Patrinia heterophylla on leukemia K562 cells. J Ethnopharmacol. 2012;144(3):576–583.
   PubMed Web of Science ®Google Scholar
• Manavalan A, Ramachandran U, Sundaramurthi H, et al. Gastrodia elata blume (tianma) mobilizes neuro-protective capacities. Int J Biochem Mol Biol. 2012;3(2):219–241.
   PubMedGoogle Scholar
• Ramachandran U, Manavalan A, Sundaramurthi H, et al. Tianma modulates proteins with various neuro-regenerative modalities in differentiated human neuronal SH-SY5Y cells. Neurochem Int. 2012;60(8):827–836.
   PubMed Web of Science ®Google Scholar
• Chen J, Chen L, Liu W, et al. Effects of Gymnadenia conopse achohol extract oil early protein profiles in lung tissue of rats exposed to silica. Chin J lnd Hyg Occup Dis. 2012;30(6):432–435.
   Google Scholar
• Zhou YC, Liu B, Li YJ, et al. Effects of buyang huanwu decoction on ventricular remodeling and differential protein profile in a rat model of myocardial infarction. Evid-Based Complement Altern Med. 2012;2012:1–11.
   Google Scholar
• Hsiao CY, Hung CY, Tsai TH, et al. A study of the wound healing mechanism of a traditional Chinese medicine, angelica sinensis, using a proteomic approach. Evid-Based Complement Altern Med. 2012;2012:1–14.
   Web of Science ®Google Scholar
• Hsiao CY, Tsai TH, Chak KF. The molecular basis of wound healing processes induced by lithospermi radix: a proteomics and biochemical analysis. Evid-Based Complement Altern Med. 2012;2012:1–15.
   Web of Science ®Google Scholar
• Ogawa K, Omatsu T, Matsumoto C, et al. Protective effect of the Japanese traditional medicine juzentaihoto on myelosuppression induced by the anticancer drug TS-1 and identification of a potential biomarker of this effect. BMC Complement Altern Med. 2012;12(1):118.
   PubMed Web of Science ®Google Scholar
• Chak K-F, Hsiao C-Y, Chen T-Y. A study of the effect of shiunko, a traditional Chinese herbal medicine, on fibroblasts and its implication on wound healing processes. Adv Wound Care. 2013;2(8):448–455.
   Google Scholar
• Cui Y, Rong CL, Wang JM, et al. Mechanism-based anti-anxiety effects of polysaccharides extracted from Shudihuang (Radix Rehmanniae Preparata) by two-dimensional electrophoresis analysis in rat hippocampus proteins. J Tradit Chin Med. 2013;33(4):524–530.
   PubMed Web of Science ®Google Scholar
• Lian F, Wu HC, Sun ZG, et al. Effects of Liuwei Dihuang Granule on the outcomes of in vitro fertilization pre-embryo transfer in infertility women with Kidney-yin deficiency syndrome and the proteome expressions in the follicular fluid. Chin J Integr Med. 2014;20(7):503–509.
   PubMed Web of Science ®Google Scholar
• Li X, Zhang S, Wang K, et al. iTRAQ-based quantitative proteomics study on the neuroprotective effects of extract of Acanthopanax senticosus harm on SH-SY5Y cells overexpressing A53T mutant α-synuclein. Neurochem Int. 2014;72:37–47.
   PubMed Web of Science ®Google Scholar
• Wang HL, Zhang J, Sit WH, et al. Cordyceps cicadae induces G2/M cell cycle arrest in MHCC97H human hepatocellular carcinoma cells: a proteomic study. Chin Med. 2014;9(15):1–12.
   PubMed Web of Science ®Google Scholar
• Miao Q, Zhao YY, Miao PP, et al. Proteomics approach to analyze protein profiling related with ADME/Tox in rat treated with Scutellariae radix and Coptidis rhizoma as well as their compatibility. J Ethnopharmacol. 2015;173:241–250.
   PubMed Web of Science ®Google Scholar
• Liu Z, Huang J, Huo Y, et al. Identification of proteins implicated in the increased heart rate in ShenSongYangXin-treated bradycardia Rabbits by iTRAQ-based quantitative proteomics. Evid-Based Complement Altern Med. 2015;2015:1–7.
   Google Scholar
• Guo CC, Zheng LH, Fu JY, et al. Antiosteoporotic effects of Huangqi Sanxian decoction in cultured Rat Osteoblasts by proteomic characterization of the target and mechanism. Evid-Based Complement Altern Med. 2015;2015:1–10.
   Web of Science ®Google Scholar
• Chen HJ, Shen YC, Shiao YJ, et al. Multiplex brain proteomic analysis revealed the molecular therapeutic effects of Buyang Huanwu decoction on cerebral ischemic stroke mice. PLoS One. 2015;10(10):1–27.
   Google Scholar
• Liu X, Shi Y. Intervention effect of traditional Chinese medicine Yi Tang Kang on metabolic syndrome of spleen deficiency. Asian Pac J Trop Med. 2015;8(2):162–168.
   PubMed Web of Science ®Google Scholar
• Han S, Woo JK, Jung Y, et al. Evodiamine selectively targets cancer stem-like cells through the p53-p21-Rb pathway. Biochem Biophys Res Commun. 2016;469(4):1153–1158.
   PubMed Web of Science ®Google Scholar
• Liu XX, Tang L, Ge R, et al. iTRAQ-based quantitative proteomic analysis of the anti-apoptotic effect of hyperin, which is mediated by Mcl-1 and Bid, in H2O2-injured EA.hy926 cells. Int J Mol Med. 2016;37(4):1083–1090.
   PubMed Web of Science ®Google Scholar
• Li R, Zhao L, Wu N, et al. Proteomic analysis allows for identifying targets of Yinchenwuling Powder in hyperlipidemic rats. J Ethnopharmacol. 2016;185:60–67.
   PubMed Web of Science ®Google Scholar
• Wei W, Li X, Hao J, et al. Proteomic analysis of functional dyspepsia in stressed rats treated with traditional Chinese medicine “Wei Kangning”. J Gastroenterol Hepatol. 2011;26(9):1425–1433.
   PubMed Web of Science ®Google Scholar
• Sun XG, Fu XQ, Cai HB, et al. Proteomic analysis of protective effects of polysaccharides from Salvia miltiorrhiza against immunological liver injury in mice. Phytother Res. 2011;25(7):1087–1094.
   PubMed Web of Science ®Google Scholar
• Hansen J, Palmfeldt J, Vang S, et al. Quantitative proteomics reveals cellular targets of celastrol. PLoS One. 2011;6(10):1–12.
   Google Scholar
• Jia YH, Zhang YX, Li LJ, et al. Dingxin recipe prevents ischemia/reperfusion-induced arrhythmias via up-regulating prohibitin and suppressing inflammatory responses. Chin J Integr Med. 2012;18(2):120–129.
   PubMed Web of Science ®Google Scholar
• Wang HL, Wu G, Park HJ, et al. Protective effect of Phellinus linteus polysaccharide extracts against thioacetamideinduced liver fibrosis in rats: a proteomics analysis. Chin Med. 2012;7(23):1–10.
   PubMed Web of Science ®Google Scholar
• Wang Q-S, Cui Y-L, Dong T-J, et al. Ethanol extract from a Chinese herbal formula, “Zuojin Pill”, inhibit the expression of inflammatory mediators in lipopolysaccharide-stimulated RAW 264.7 mouse macrophages. J Ethnopharmacol. 2012;141(1):377–385.
   PubMed Web of Science ®Google Scholar
• Zheng L, Zhang W, Jiang M, et al. Expression profiling and proteomic analysis of JIN Chinese herbal formula in lung carcinoma H460 Xenografts. Evid-Based Complement Altern Med. 2013;2013:1–10.
   Web of Science ®Google Scholar
• Xie HD, Tao YY, Lü J, et al. Proteomic analysis of the effect of Fuzheng Huayu recipe on fibrotic liver in rats. Evid-Based Complement Altern Med. 2013;2013:1–10.
   Google Scholar
• Zhu XX, Xia OD, Han WL, et al. XiaoYaoSan improves depressive-like behavior in rats through modulation of β-Arrestin 2-mediated pathways in hippocampus. Evid-Based Complement Altern Med. 2014;2014:1–13.
   Google Scholar
• Qi HY, Li L, Yu J, et al. Proteomic identification of Nrf2-mediated phase II enzymes critical for protection of Tao Hong Si Wu decoction against oxygen glucose deprivation injury in PC12 cells. Evid-Based Complement Altern Med. 2014;2014:1–11.
   Google Scholar
• Zhang L, Jin J, Zhang L, et al. Quantitative analysis of differential protein expression in cervical carcinoma cells after zeylenone treatment by stable isotope labeling with amino acids in cell culture. J Proteomics. 2015;126:279–287.
   PubMed Web of Science ®Google Scholar
• Wang SM, Lin LZ, Zhou DH, et al. Expression of prolyl 4-hydroxylase beta-polypeptide in non-small cell lung cancer treated with Chinese medicines. Chin J Integr Med. 2015;21(9):689–696.
   PubMed Web of Science ®Google Scholar
• Qi H, Chen L, Ning L, et al. Proteomic analysis of β-asarone induced cytotoxicity in human glioblastoma U251 cells. J Pharm Biomed Anal. 2015;115:292–299.
   PubMed Web of Science ®Google Scholar
• Chen YY, Li Q, Pan CS, et al. QiShenYiQi Pills, a compound in Chinese medicine, protects against pressure overload-induced cardiac hypertrophy through a multi-component and multi-target mode. Sci Rep. 2015;5:11802.
   PubMed Web of Science ®Google Scholar
• Zhao J, Cheng Y, Yang C, et al. Botanical drug puerarin attenuates 6-hydroxydopamine (6-OHDA)-induced neurotoxicity via upregulating mitochondrial enzyme arginase-2. Mol Neurobiol. 2016;53(4):2200–2211.
   PubMed Web of Science ®Google Scholar
• Fu WM, Zhang JF, Wang H, et al. Apoptosis induced by 1,3,6,7-tetrahydroxyxanthone in Hepatocellular carcinoma and proteomic analysis. Apoptosis. 2012;17(8):842–851.
   PubMed Web of Science ®Google Scholar
• Li X, Zhao Y, Liu P, et al. Senegenin inhibits hypoxia/reoxygenation-induced neuronal apoptosis by upregulating RhoGDIalpha. Mol Neurobiol. 2015;52(3):1561–1571.
   PubMed Web of Science ®Google Scholar
• Zhang Z, Li G, Szeto SS, et al. Examining the neuroprotective effects of protocatechuic acid and chrysin on in vitro and in vivo models of Parkinson disease. Free Radic Biol Med. 2015;84:331–343.
   PubMed Web of Science ®Google Scholar
• Wang MJ, Dong Q, Wang H, et al. Oblongifolin M, an active compound isolated from a Chinese medical herb Garcinia oblongifolia, potently inhibits enterovirus 71 reproduction through downregulation of ERp57. Oncotarget. 2016;7(8):8797–8808.
   PubMed Web of Science ®Google Scholar
• Guo H, Xiong D. The proteomic research of the cure of experimental diabetes deafness by granules of eliminating phlegm and removing blood stasis. J Tradit Chin Med. 2011;31(2):88–97.
   PubMed Web of Science ®Google Scholar
• Sun H, Zhang A, Yan G, et al. Proteomics study on the hepatoprotective effects of traditional Chinese medicine formulae Yin-Chen-Hao-Tang by a combination of two-dimensional polyacrylamide gel electrophoresis and matrix-assisted laser desorption/ionization-time of flight mass spectrometry. J Pharm Biomed Anal. 2013;75:173–179.
   PubMed Web of Science ®Google Scholar
• Li JP, Zeng Y, Lei XM, et al. Tri-dimensional omics analysis on effect of Zhuanggu Zhitong capsule against experimental postmenopausal osteoporosis. China J Chin Mater Med. 2014;39(16):3203–3207.
   Google Scholar
• Pan T-L, Wang P-W, Huang C-H, et al. Herbal formula, Scutellariae radix and Rhei rhizoma attenuate dimethylnitrosamine-induced liver fibrosis in a rat model. Sci Rep. 2015;5:11734.
   PubMed Web of Science ®Google Scholar
• Jiang T, Wang ZY, Shen R, et al. Quantitative proteomics analysis for effect of acanthopanax senticosus extract on neuroinflammation. Pak J Pharm Sci. 2015;28(1):313–318.
   PubMed Web of Science ®Google Scholar
• Zhao P, Yang L, Li J, et al. Combining systems pharmacology, transcriptomics, proteomics, and metabolomics to dissect the therapeutic mechanism of Chinese herbal Bufei Jianpi formula for application to COPD. Int J Chronic Obstr Pulm Dis. 2016;11:553–566.
   PubMed Web of Science ®Google Scholar
• Feng L-X, Jing C-J, Tang K-L, et al. Clarifying the signal network of salvianolic acid B using proteomic assay and bioinformatic analysis. Proteomics. 2011;11(8):1473–1485.
   PubMed Web of Science ®Google Scholar
• Wang Z-Y, Kang H, Ji -L-L, et al. Proteomic characterization of the possible molecular targets of pyrrolizidine alkaloid isoline-induced hepatotoxicity. Environ Toxicol Pharmacol. 2012;34(2):608–617.
   PubMed Web of Science ®Google Scholar
• Pan T-L, Wang P-W, Hung Y-C, et al. Proteomic analysis reveals tanshinone IIA enhances apoptosis of advanced cervix carcinoma CaSki cells through mitochondria intrinsic and endoplasmic reticulum stress pathways. Proteomics. 2013;13:3411–3423.
   PubMed Web of Science ®Google Scholar
• Li D, Song X, Yue Q, et al. Proteomic and bioinformatic analyses of possible target-related proteins of gambogic acid in human breast carcinoma MDA-MB-231 cells. Chin J Nat Med. 2015;13(1):41–51.
   PubMed Web of Science ®Google Scholar
• Wang J, Zhang C-J, Chia WN, et al. Haem-activated promiscuous targeting of artemisinin in plasmodium falciparum. Nat Commun. 2015;6:10111.
   PubMed Web of Science ®Google Scholar
• Zhang Q, Edward K, Briggs JP, et al. The art and science of traditional medicine part 1: TCM today-a case for integration. Science. 2014;346(6216 Suppl):S1–S25.
   Google Scholar
• Albert And Mary Lasker Foundation. Artemisinin therapy for malaria. 2011 Lasker Awards. 2011. Available from: http://www.laskerfoundation.org/awards/show/artemisinin-therapy-for-malaria/.
   Google Scholar
• Nesvizhskii AI. Proteogenomics: concepts, applications and computational strategies. Nat Methods. 2014;11(11):1114–1125.
   PubMed Web of Science ®Google Scholar
• Xu Y, Dou D, Ran X, et al. Integrative analysis of proteomics and metabolomics of anaphylactoid reaction induced by Xuesaitong injection. J Chromatogr A. 2015;1416:103–111.
   PubMed Web of Science ®Google Scholar
• Sun YL, Hou T, Liu SF, et al. Population pharmacokinetic modeling of the Qishe pill in three major traditional Chinese medicine-defined constitutional types of healthy Chinese subjects: study protocol for a randomized controlled trial. Trials. 2015;16(64):1–10.
   PubMedGoogle Scholar