Proteomic investigations of dengue virus infection: key discoveries over the last 10 years

References

• Roy SK, Bhattacharjee S. Dengue virus: epidemiology, biology, and disease aetiology. Can J Microbiol. 2021;67(10):687–702. doi: 10.1139/cjm-2020-0572
   PubMed Web of Science ®Google Scholar
• Guo C, Zhou Z, Wen Z, et al. Global epidemiology of dengue outbreaks in 1990-2015: a systematic review and meta-analysis. Front Cell Infect Microbiol. 2017;7:317. doi: 10.3389/fcimb.2017.00317
   PubMed Web of Science ®Google Scholar
• Diamond MS, Pierson TC. Molecular insight into dengue virus pathogenesis and its implications for disease control. Cell. 2015;162(3):488–492. doi: 10.1016/j.cell.2015.07.005
   PubMed Web of Science ®Google Scholar
• Zeng Z, Zhan J, Chen L, et al. Global, regional, and national dengue burden from 1990 to 2017: A systematic analysis based on the global burden of disease study 2017. EClinicalMedicine. 2021;32:100712. doi: 10.1016/j.eclinm.2020.100712
   PubMedGoogle Scholar
• Burki T. Bangladesh faces record dengue outbreak. Lancet. 2023;402(10400):439. doi: 10.1016/S0140-6736(23)01610-0
   PubMed Web of Science ®Google Scholar
• Bagcchi S. Nepal faces an outbreak of dengue. Lancet Infect Dis. 2023;23(1):35. doi: 10.1016/S1473-3099(22)00821-0
   PubMed Web of Science ®Google Scholar
• Munayco CV, Valderrama Rosales BY, Mateo Lizarbe SY, et al. Notes from the Field: Dengue Outbreak - Peru, 2023. MMWR Morb Mortal Wkly Rep. 2024;73(4):86–88. doi: 10.15585/mmwr.mm7304a4
   PubMed Web of Science ®Google Scholar
• Nabeshima T, Ngwe Tun MM, Thuy NTT, et al. An outbreak of a novel lineage of dengue virus 2 in Vietnam in 2022. J Med Virol. 2023;95(11):e29255. doi: 10.1002/jmv.29255
   PubMed Web of Science ®Google Scholar
• Marczell K, Garcia E, Roiz J, et al. The macroeconomic impact of a dengue outbreak: case studies from Thailand and Brazil. PloS Negl Trop Dis. 2024;18(6):e0012201. doi: 10.1371/journal.pntd.0012201
   PubMedGoogle Scholar
• Guzman MG, Gubler DJ, Izquierdo A, et al. Dengue infection. Nat Rev Dis Primers. 2016;2(1):16055. doi: 10.1038/nrdp.2016.55
   PubMedGoogle Scholar
• Wan SW, Wu-Hsieh BA, Lin YS, et al. The monocyte-macrophage-mast cell axis in dengue pathogenesis. J Biomed Sci. 2018;25(1):77. doi: 10.1186/s12929-018-0482-9
   PubMedGoogle Scholar
• Perera N, Brun J, Alonzi DS, et al. Antiviral effects of deoxynojirimycin (DNJ)-based iminosugars in dengue virus-infected primary dendritic cells. Antiviral Res. 2022;199:105269. doi: 10.1016/j.antiviral.2022.105269
   PubMed Web of Science ®Google Scholar
• Helgers LC, Keijzer NCH, van Hamme JL, et al. Dengue Virus Infects Human Skin Langerhans Cells through Langerin for Dissemination to Dendritic Cells. J Invest Dermatol. 2024;144(5):1099–1111.e3. doi: 10.1016/j.jid.2023.09.287
   PubMed Web of Science ®Google Scholar
• Meuren LM, Prestes EB, Papa MP, et al. Infection of endothelial cells by dengue virus induces ROS production by different sources affecting virus replication, cellular activation, death and vascular permeability. Front Immunol. 2022;13:810376. doi: 10.3389/fimmu.2022.810376
   PubMed Web of Science ®Google Scholar
• Chumchanchira C, Ramphan S, Sornjai W, et al. Glycolysis is reduced in dengue virus 2 infected liver cells. Sci Rep. 2024;14(1):8355. doi: 10.1038/s41598-024-58834-w
   PubMed Web of Science ®Google Scholar
• Chatel-Chaix L, Fischl W, Scaturro P, et al. A combined genetic-proteomic approach identifies residues within dengue virus NS4B critical for interaction with NS3 and viral replication. J Virol. 2015;89(14):7170–7186. doi: 10.1128/JVI.00867-15
   PubMed Web of Science ®Google Scholar
• Hidari KI, Suzuki T. Dengue virus receptor. Trop Med Health. 2011;39(4 Suppl):S37–S43. doi: 10.2149/tmh.2011-S03
   PubMedGoogle Scholar
• Sinha S, Singh K, Ravi Kumar YS, et al. Dengue virus pathogenesis and host molecular machineries. J Biomed Sci. 2024;31(1):43. doi: 10.1186/s12929-024-01030-9
   PubMed Web of Science ®Google Scholar
• Khan MB, Yang ZS, Lin CY, et al. Dengue overview: an updated systemic review. J Infect Public Health. 2023;16(10):1625–1642. doi: 10.1016/j.jiph.2023.08.001
   PubMed Web of Science ®Google Scholar
• Wang WH, Urbina AN, Chang MR, et al. Dengue hemorrhagic fever - A systemic literature review of current perspectives on pathogenesis, prevention and control. J Microbiol Immunol Infect. 2020;53(6):963–978. doi: 10.1016/j.jmii.2020.03.007
   PubMedGoogle Scholar
• Vijay J, Anuradha N, Anbalagan VP. Clinical presentation and platelet profile of dengue fever: a retrospective study. Cureus. 2022;14(8):e28626. doi: 10.7759/cureus.28626
   PubMed Web of Science ®Google Scholar
• Muller DA, Depelsenaire AC, Young PR. Clinical and Laboratory Diagnosis of Dengue Virus Infection. J Infect Dis. 2017;215(suppl_2):S89–S95. doi: 10.1093/infdis/jiw649
   PubMedGoogle Scholar
• Lima MRQ, Nunes PCG, Dos Santos FB. Serological diagnosis of dengue. Methods Mol Biol. 2022;2409:173–196.
   PubMedGoogle Scholar
• Meng JX, Hu QM, Zhang LM, et al. Isolation and genetic evolution of dengue virus from the 2019 outbreak in Xishuangbanna, Yunnan Province, China. Vector Borne Zoonotic Dis. 2023;23(6):331–340. doi: 10.1089/vbz.2022.0091
   PubMed Web of Science ®Google Scholar
• Ngwe Tun MM, Muthugala R, Nabeshima T, et al. Complete genome analysis and characterization of neurotropic dengue virus 2 cosmopolitan genotype isolated from the cerebrospinal fluid of encephalitis patients. PLOS ONE. 2020;15(6):e0234508. doi: 10.1371/journal.pone.0234508
   PubMed Web of Science ®Google Scholar
• Aebersold R, Mann M. Mass-spectrometric exploration of proteome structure and function. Nature. 2016;537(7620):347–355. doi: 10.1038/nature19949
   PubMed Web of Science ®Google Scholar
• Kang L, Weng N, Jian W. LC-MS bioanalysis of intact proteins and peptides. Biomed Chromatogr. 2020;34(1):e4633. doi: 10.1002/bmc.4633
   PubMed Web of Science ®Google Scholar
• Cassidy L, Kaulich PT, Maass S, et al. Bottom-up and top-down proteomic approaches for the identification, characterization, and quantification of the low molecular weight proteome with focus on short open reading frame-encoded peptides. Proteomics. 2021;21(23–24):e2100008. doi: 10.1002/pmic.202100008
   PubMed Web of Science ®Google Scholar
• Shuken SR. An introduction to mass spectrometry-based proteomics. J Proteome Res. 2023;22(7):2151–2171. doi: 10.1021/acs.jproteome.2c00838
   PubMed Web of Science ®Google Scholar
• Noor Z, Ahn SB, Baker MS, et al. Mass spectrometry-based protein identification in proteomics-a review. Brief Bioinform. 2021;22(2):1620–1638. doi: 10.1093/bib/bbz163
   PubMed Web of Science ®Google Scholar
• Muliawan SY, Kit LS, Devi S, et al. Inhibitory potential of Quercus lusitanica extract on dengue virus type 2 replication. Southeast Asian J Trop Med Public Health. 2006;37 Suppl 3:132–135.
   PubMedGoogle Scholar
• Noisakran S, Sengsai S, Thongboonkerd V, et al. Identification of human hnRNP C1/C2 as a dengue virus NS1-interacting protein. Biochem Biophys Res Commun. 2008;372(1):67–72. doi: 10.1016/j.bbrc.2008.04.165
   PubMed Web of Science ®Google Scholar
• Perera R, Kuhn RJ. Structural proteomics of dengue virus. Curr Opin Microbiol. 2008;11(4):369–377. doi: 10.1016/j.mib.2008.06.004
   PubMed Web of Science ®Google Scholar
• Khan AM, Miotto O, Nascimento EJ, et al. Conservation and variability of dengue virus proteins: implications for vaccine design. PLOS Negl Trop Dis. 2008;2(8):e272. doi: 10.1371/journal.pntd.0000272
   PubMed Web of Science ®Google Scholar
• Prusis P, Lapins M, Yahorava S, et al. Proteochemometrics analysis of substrate interactions with dengue virus NS3 proteases. Bioorg Med Chem. 2008;16(20):9369–9377. doi: 10.1016/j.bmc.2008.08.081
   PubMed Web of Science ®Google Scholar
• Kanlaya R, Pattanakitsakul SN, Sinchaikul S, et al. Vimentin interacts with heterogeneous nuclear ribonucleoproteins and dengue nonstructural protein 1 and is important for viral replication and release. Mol Biosyst. 2010;6(5):795–806. doi: 10.1039/b923864f
   PubMedGoogle Scholar
• Paingankar MS, Gokhale MD, Deobagkar DN. Dengue-2-virus-interacting polypeptides involved in mosquito cell infection. Arch Virol. 2010;155(9):1453–1461. doi: 10.1007/s00705-010-0728-7
   PubMed Web of Science ®Google Scholar
• Khadka S, Vangeloff AD, Zhang C, et al. A physical interaction network of dengue virus and human proteins. Mol Cell Proteomics. 2011;10(12):M111 012187. doi: 10.1074/mcp.M111.012187
   PubMed Web of Science ®Google Scholar
• Le Breton M, Meyniel-Schicklin L, Deloire A, et al. Flavivirus NS3 and NS5 proteins interaction network: a high-throughput yeast two-hybrid screen. BMC Microbiol. 2011;11(1):234. doi: 10.1186/1471-2180-11-234
   PubMedGoogle Scholar
• Pattanakitsakul SN, Rungrojcharoenkit K, Kanlaya R, et al. Proteomic analysis of host responses in HepG2 cells during dengue virus infection. J Proteome Res. 2007;6(12):4592–4600. doi: 10.1021/pr070366b
   PubMed Web of Science ®Google Scholar
• Sirot LK, Poulson RL, McKenna MC, et al. Identity and transfer of male reproductive gland proteins of the dengue vector mosquito, Aedes aegypti: potential tools for control of female feeding and reproduction. Insect Biochem Mol Biol. 2008;38(2):176–189. doi: 10.1016/j.ibmb.2007.10.007
   PubMed Web of Science ®Google Scholar
• Higa LM, Caruso MB, Canellas F, et al. Secretome of HepG2 cells infected with dengue virus: implications for pathogenesis. Biochim Biophys Acta. 2008;1784(11):1607–1616. doi: 10.1016/j.bbapap.2008.06.015
   PubMed Web of Science ®Google Scholar
• Kanlaya R, Pattanakitsakul SN, Sinchaikul S, et al. Alterations in actin cytoskeletal assembly and junctional protein complexes in human endothelial cells induced by dengue virus infection and mimicry of leukocyte transendothelial migration. J Proteome Res. 2009;8(5):2551–2562. doi: 10.1021/pr900060g
   PubMed Web of Science ®Google Scholar
• Albuquerque LM, Trugilho MR, Chapeaurouge A, et al. Two-dimensional difference gel electrophoresis (DiGE) analysis of plasmas from dengue fever patients. J Proteome Res. 2009;8(12):5431–5441. doi: 10.1021/pr900236f
   PubMed Web of Science ®Google Scholar
• Pattanakitsakul SN, Poungsawai J, Kanlaya R, et al. Association of Alix with late endosomal lysobisphosphatidic acid is important for dengue virus infection in human endothelial cells. J Proteome Res. 2010;9(9):4640–4648. doi: 10.1021/pr100357f
   PubMed Web of Science ®Google Scholar
• Kanlaya R, Pattanakitsakul SN, Sinchaikul S, et al. The ubiquitin-proteasome pathway is important for dengue virus infection in primary human endothelial cells. J Proteome Res. 2010;9(10):4960–4971. doi: 10.1021/pr100219y
   PubMed Web of Science ®Google Scholar
• Tchankouo-Nguetcheu S, Khun H, Pincet L, et al. Differential protein modulation in midguts of Aedes aegypti infected with chikungunya and dengue 2 viruses. PLOS ONE. 2010;5(10):e13149. doi: 10.1371/journal.pone.0013149
   PubMed Web of Science ®Google Scholar
• Lin YS, Yeh TM, Lin CF, et al. Molecular mimicry between virus and host and its implications for dengue disease pathogenesis. Exp Biol Med (Maywood). 2011;236(5):515–523. doi: 10.1258/ebm.2011.010339
   PubMed Web of Science ®Google Scholar
• Poungsawai J, Kanlaya R, Pattanakitsakul SN, et al. Subcellular localizations and time-course expression of dengue envelope and non-structural 1 proteins in human endothelial cells. Microb Pathog. 2011;51(3):225–229. doi: 10.1016/j.micpath.2011.04.011
   PubMed Web of Science ®Google Scholar
• Patramool S, Surasombatpattana P, Luplertlop N, et al. Proteomic analysis of an Aedes albopictus cell line infected with dengue serotypes 1 and 3 viruses. Parasit Vectors. 2011;4(1):138. doi: 10.1186/1756-3305-4-138
   PubMedGoogle Scholar
• Mishra KP, Shweta S, Diwaker D, et al. Dengue virus infection induces upregulation of hn RNP-H and PDIA3 for its multiplication in the host cell. Virus Res. 2012;163(2):573–579. doi: 10.1016/j.virusres.2011.12.010
   PubMed Web of Science ®Google Scholar
• Testa JS, Shetty V, Sinnathamby G, et al. Conserved MHC class I-presented dengue virus epitopes identified by immunoproteomics analysis are targets for cross-serotype reactive T-cell response. J Infect Dis. 2012;205(4):647–655. doi: 10.1093/infdis/jir814
   PubMed Web of Science ®Google Scholar
• Wang J, Fan P, Wei Y, et al. Isobaric tags for relative and absolute quantification-based proteomic analysis of host-pathogen protein interactions in the midgut of Aedes albopictus during dengue virus infection. Front Microbiol. 2022;13:990978. doi: 10.3389/fmicb.2022.990978
   PubMed Web of Science ®Google Scholar
• Garishah FM, Boahen CK, Vadaq N, et al. Longitudinal proteomic profiling of the inflammatory response in dengue patients. PloS Negl Trop Dis. 2023;17(1):e0011041. doi: 10.1371/journal.pntd.0011041
   PubMed Web of Science ®Google Scholar
• Alsaiari AA, Hakami MA, Alotaibi BS, et al. Rational design of multi-epitope-based vaccine by exploring all dengue virus serotypes proteome: an immunoinformatic approach. Immunol Res. 2024;72(2):242–259. doi: 10.1007/s12026-023-09429-6
   PubMed Web of Science ®Google Scholar
• Zhang M, Zheng X, Wu Y, et al. Differential proteomics of Aedes albopictus salivary gland, midgut and C6/36 cell induced by dengue virus infection. Virology. 2013;444(1–2):109–118. doi: 10.1016/j.virol.2013.06.001
   PubMed Web of Science ®Google Scholar
• Shrinet J, Srivastava P, Kumar A, et al. Differential proteome analysis of chikungunya virus and dengue virus coinfection in Aedes mosquitoes. J Proteome Res. 2018;17(10):3348–3359. doi: 10.1021/acs.jproteome.8b00211
   PubMed Web of Science ®Google Scholar
• Chisenhall DM, Londono BL, Christofferson RC, et al. Effect of dengue-2 virus infection on protein expression in the salivary glands of Aedes aegypti mosquitoes. Am J Trop Med Hyg. 2014;90(3):431–437. doi: 10.4269/ajtmh.13-0412
   PubMed Web of Science ®Google Scholar
• Chisenhall DM, Christofferson RC, McCracken MK, et al. Infection with dengue-2 virus alters proteins in naturally expectorated saliva of Aedes aegypti mosquitoes. Parasit Vectors. 2014;7(1):252. doi: 10.1186/1756-3305-7-252
   PubMedGoogle Scholar
• Chowdhury A, Modahl CM, Misse D, et al. High resolution proteomics of Aedes aegypti salivary glands infected with either dengue, Zika or chikungunya viruses identify new virus specific and broad antiviral factors. Sci Rep. 2021;11(1):23696. doi: 10.1038/s41598-021-03211-0
   PubMed Web of Science ®Google Scholar
• Osorio J, Villa-Arias S, Camargo C, et al. wMel Wolbachia alters female post-mating behaviors and physiology in the dengue vector mosquito Aedes aegypti. Commun Biol. 2023;6(1):865. doi: 10.1038/s42003-023-05180-8
   PubMed Web of Science ®Google Scholar
• Rainey SM, Geoghegan V, Lefteri DA, et al. Differences in proteome perturbations caused by the wolbachia strain wAu suggest multiple mechanisms of wolbachia-mediated antiviral activity. Sci Rep. 2023;13(1):11737. doi: 10.1038/s41598-023-38127-4
   PubMed Web of Science ®Google Scholar
• Kojin BB, Jakes E, Biedler JK, et al. Partial masculinization of Aedes aegypti females by conditional expression of Nix. PLOS Negl Trop Dis. 2022;16(7):e0010598. doi: 10.1371/journal.pntd.0010598
   PubMed Web of Science ®Google Scholar
• Subbaraman N. Science snipes at Oxitec transgenic-mosquito trial. Nat Biotechnol. 2011;29(1):9–11. doi: 10.1038/nbt0111-9a
   PubMed Web of Science ®Google Scholar
• Uno N, Ross TM. Dengue virus and the host innate immune response. Emerg Microbes Infect. 2018;7(1):167. doi: 10.1038/s41426-018-0168-0
   PubMedGoogle Scholar
• Ngono AE, Shresta S. Immune Response to Dengue and Zika. Annu Rev Immunol. 2018;36(1):279–308. doi: 10.1146/annurev-immunol-042617-053142
   PubMed Web of Science ®Google Scholar
• Lee MF, Voon GZ, Lim HX, et al. Innate and adaptive immune evasion by dengue virus. Front Cell Infect Microbiol. 2022;12:1004608. doi: 10.3389/fcimb.2022.1004608
   PubMed Web of Science ®Google Scholar
• Narayan R, Tripathi S. Intrinsic ADE: the dark side of antibody dependent enhancement during dengue infection. Front Cell Infect Microbiol. 2020;10:580096. doi: 10.3389/fcimb.2020.580096
   PubMed Web of Science ®Google Scholar
• Ma Y, Li M, Xie L, et al. Seroepidemiologic study on convalescent sera from dengue fever patients in Jinghong, Yunnan. Virol Sin. 2022;37(1):19–29. doi: 10.1016/j.virs.2021.12.001
   PubMed Web of Science ®Google Scholar
• Lee PX, Ong LC, Libau EA, et al. Relative contribution of dengue IgG antibodies acquired during gestation or breastfeeding in mediating dengue disease Enhancement and protection in type I interferon receptor-deficient mice. PloS Negl Trop Dis. 2016;10(6):e0004805. doi: 10.1371/journal.pntd.0004805
   PubMed Web of Science ®Google Scholar
• Teo A, Tan HD, Loy T, et al. Understanding antibody-dependent enhancement in dengue: are afucosylated IgG1s a concern? PLOS Pathog. 2023;19(3):e1011223. doi: 10.1371/journal.ppat.1011223
   PubMed Web of Science ®Google Scholar
• Simmons CP, Chau TN, Thuy TT, et al. Maternal antibody and viral factors in the pathogenesis of dengue virus in infants. J Infect Dis. 2007;196(3):416–424. doi: 10.1086/519170
   PubMed Web of Science ®Google Scholar
• Thomas S, Smatti MK, Ouhtit A, et al. Antibody-Dependent Enhancement (ADE) and the role of complement system in disease pathogenesis. Mol Immunol. 2022;152:172–182. doi: 10.1016/j.molimm.2022.11.010
   PubMed Web of Science ®Google Scholar
• Thulin NK, Brewer RC, Sherwood R, et al. Maternal Anti-dengue IgG fucosylation predicts susceptibility to dengue disease in infants. Cell Rep. 2020;31(6):107642. doi: 10.1016/j.celrep.2020.107642
   PubMed Web of Science ®Google Scholar
• Oosterhoff JJ, Larsen MD, van der Schoot CE, et al. Afucosylated IgG responses in humans - structural clues to the regulation of humoral immunity. Trends Immunol. 2022;43(10):800–814. doi: 10.1016/j.it.2022.08.001
   PubMed Web of Science ®Google Scholar
• Wang TT, Sewatanon J, Memoli MJ, et al. IgG antibodies to dengue enhanced for FcgammaRIIIA binding determine disease severity. Science. 2017;355(6323):395–398. doi: 10.1126/science.aai8128
   PubMed Web of Science ®Google Scholar
• Yang Y, Qiao L. Data-independent acquisition proteomics methods for analyzing post-translational modifications. Proteomics. 2023;23(7–8):e2200046. doi: 10.1002/pmic.202200046
   PubMed Web of Science ®Google Scholar
• Riley NM, Bertozzi CR, Pitteri SJ. A Pragmatic Guide to Enrichment Strategies for Mass Spectrometry-Based Glycoproteomics. Mol Cell Proteomics. 2021;20:100029. doi: 10.1074/mcp.R120.002277
   PubMed Web of Science ®Google Scholar
• Trugilho MRO, Hottz ED, Brunoro GVF, et al. Platelet proteome reveals novel pathways of platelet activation and platelet-mediated immunoregulation in dengue. PLOS Pathog. 2017;13(5):e1006385. doi: 10.1371/journal.ppat.1006385
   PubMed Web of Science ®Google Scholar
• Arioz BI, Cotuk A, Yaka EC, et al. Proximity extension assay-based proteomics studies in neurodegenerative disorders and multiple sclerosis. Eur J Neurosci. 2024;59(6):1348–1358. doi: 10.1111/ejn.16226
   PubMed Web of Science ®Google Scholar
• Lamy R, Ma’ayeh S, Chlamydas S, et al. Proximity extension assay (PEA) platform to detect vitreous biomarkers of diabetic retinopathy. Methods Mol Biol. 2023;2678:135–145.
   PubMedGoogle Scholar
• Oktarianti R, Senjarini K, Hayano T, et al. Proteomic analysis of immunogenic proteins from salivary glands of Aedes aegypti. J Infect Public Health. 2015;8(6):575–582. doi: 10.1016/j.jiph.2015.04.022
   PubMed Web of Science ®Google Scholar
• Gavor E, Choong YK, Liu Y, et al. Identification of Aedes aegypti salivary gland proteins interacting with human immune receptor proteins. PLOS Negl Trop Dis. 2022;16(9):e0010743. doi: 10.1371/journal.pntd.0010743
   PubMed Web of Science ®Google Scholar
• Modhiran N, Watterson D, Muller DA, et al. Dengue virus NS1 protein activates cells via toll-like receptor 4 and disrupts endothelial cell monolayer integrity. Sci Transl Med. 2015;7(304):304ra142. doi: 10.1126/scitranslmed.aaa3863
   PubMed Web of Science ®Google Scholar
• Berthoux L. The restrictome of flaviviruses. Virol Sin. 2020;35(4):363–377. doi: 10.1007/s12250-020-00208-3
   PubMed Web of Science ®Google Scholar
• Valdez F, Salvador J, Palermo PM, et al. Schlafen 11 Restricts Flavivirus Replication. J Virol. 2019;93(15):e00104–00119. doi: 10.1128/JVI.00104-19
   PubMed Web of Science ®Google Scholar
• Chemudupati M, Kenney AD, Bonifati S, et al. From APOBEC to ZAP: Diverse mechanisms used by cellular restriction factors to inhibit virus infections. Biochim Biophys Acta Mol Cell Res. 2019;1866(3):382–394. doi: 10.1016/j.bbamcr.2018.09.012
   PubMed Web of Science ®Google Scholar
• Giovannoni F, Damonte EB, Garcia CC, et al. Cellular promyelocytic leukemia protein is an important dengue virus restriction factor. PLOS ONE. 2015;10(5):e0125690. doi: 10.1371/journal.pone.0125690
   PubMed Web of Science ®Google Scholar
• Giovannoni F, Ladelfa MF, Monte M, et al. Dengue Non-structural Protein 5 Polymerase Complexes With Promyelocytic Leukemia Protein (PML) Isoforms III and IV to Disrupt PML-nuclear bodies in infected cells. Front Cell Infect Microbiol. 2019;9:284. doi: 10.3389/fcimb.2019.00284
   PubMed Web of Science ®Google Scholar
• Carpp LN, Rogers RS, Moritz RL, et al. Quantitative proteomic analysis of host-virus interactions reveals a role for golgi brefeldin a resistance factor 1 (GBF1) in dengue infection. Mol Cell Proteomics. 2014;13(11):2836–2854. doi: 10.1074/mcp.M114.038984
   PubMed Web of Science ®Google Scholar
• Shah PS, Link N, Jang GM, et al. Comparative Flavivirus-Host Protein Interaction Mapping Reveals Mechanisms of Dengue and Zika Virus Pathogenesis. Cell. 2018;175(7):1931–1945 e1918. doi: 10.1016/j.cell.2018.11.028
   PubMed Web of Science ®Google Scholar
• De Maio FA, Risso G, Iglesias NG, et al. The Dengue Virus NS5 Protein Intrudes in the cellular spliceosome and modulates splicing. PLOS Pathog. 2016;12(8):e1005841. doi: 10.1371/journal.ppat.1005841
   PubMed Web of Science ®Google Scholar
• Dechtawewat T, Paemanee A, Roytrakul S, et al. Mass spectrometric analysis of host cell proteins interacting with dengue virus nonstructural protein 1 in dengue virus-infected HepG2 cells. Biochim Biophys Acta. 2016;1864(9):1270–1280. doi: 10.1016/j.bbapap.2016.04.008
   PubMed Web of Science ®Google Scholar
• Rabelo K, Trugilho MRO, Costa SM, et al. The effect of the dengue non-structural 1 protein expression over the HepG2 cell proteins in a proteomic approach. J Proteomics. 2017;152:339–354. doi: 10.1016/j.jprot.2016.11.001
   PubMed Web of Science ®Google Scholar
• Martinez-Betancur V, Marin-Villa M, Martinez-Gutierrez M. Infection of epithelial cells with dengue virus promotes the expression of proteins favoring the replication of certain viral strains. J Med Virol. 2014;86(8):1448–1458. doi: 10.1002/jmv.23857
   PubMed Web of Science ®Google Scholar
• Zhai LH, Chen KF, Hao BB, et al. Proteomic characterization of post-translational modifications in drug discovery. Acta Pharmacol Sin. 2022;43(12):3112–3129. doi: 10.1038/s41401-022-01017-y
   PubMed Web of Science ®Google Scholar
• Bagwan N, El Ali HH, Lundby A. Proteome-wide profiling and mapping of post translational modifications in human hearts. Sci Rep. 2021;11(1):2184. doi: 10.1038/s41598-021-81986-y
   PubMed Web of Science ®Google Scholar
• Schor S, Pu S, Nicolaescu V, et al. The cargo adapter protein CLINT1 is phosphorylated by the numb-associated kinase BIKE and mediates dengue virus infection. J Biol Chem. 2022;298(6):101956. doi: 10.1016/j.jbc.2022.101956
   PubMed Web of Science ®Google Scholar
• Miao M, Yu F, Wang D, et al. Proteomics profiling of Host cell response via protein expression and phosphorylation upon dengue virus infection. Virol Sin. 2019;34(5):549–562. doi: 10.1007/s12250-019-00131-2
   PubMed Web of Science ®Google Scholar
• Wongtrakul J, Thongtan T, Pannengpetch S, et al. Phosphoproteomic analysis of dengue virus infected U937 cells and identification of pyruvate kinase M2 as a differentially phosphorylated phosphoprotein. Sci Rep. 2020;10(1):14493. doi: 10.1038/s41598-020-71407-x
   PubMed Web of Science ®Google Scholar
• Allgoewer K, Wu S, Choi H, et al. Re-mining serum proteomics data reveals extensive post-translational modifications upon Zika and dengue infection. Mol Omics. 2023;19(4):308–320. doi: 10.1039/D2MO00258B
   PubMed Web of Science ®Google Scholar
• Kandel Y, Pinch M, Lamsal M, et al. Exploratory phosphoproteomics profiling of Aedes aegypti malpighian tubules during blood meal processing reveals dramatic transition in function. PLOS ONE. 2022;17(7):e0271248. doi: 10.1371/journal.pone.0271248
   PubMed Web of Science ®Google Scholar
• Liao KC, Chuo V, Ng WC, et al. Identification and characterization of host proteins bound to dengue virus 3’ UTR reveal an antiviral role for quaking proteins. RNA. 2018;24(6):803–814. doi: 10.1261/rna.064006.117
   PubMed Web of Science ®Google Scholar
• Phillips SL, Soderblom EJ, Bradrick SS, et al. Identification of proteins bound to dengue viral RNA in vivo reveals new host proteins important for virus replication. MBio. 2016;7(1):e01865–01815. doi: 10.1128/mBio.01865-15
   PubMed Web of Science ®Google Scholar
• Viktorovskaya OV, Greco TM, Cristea IM, et al. Identification of RNA binding proteins associated with dengue virus RNA in infected cells reveals temporally distinct Host factor requirements. PLOS Negl Trop Dis. 2016;10(8):e0004921. doi: 10.1371/journal.pntd.0004921
   PubMed Web of Science ®Google Scholar
• Pando-Robles V, Oses-Prieto JA, Rodriguez-Gandarilla M, et al. Quantitative proteomic analysis of Huh-7 cells infected with Dengue virus by label-free LC-MS. J Proteomics. 2014;111:16–29. doi: 10.1016/j.jprot.2014.06.029
   PubMed Web of Science ®Google Scholar
• Suttitheptumrong A, Rawarak N, Reamtong O, et al. Plectin is required for trans-endothelial permeability: a model of plectin dysfunction in human endothelial cells after TNF-alpha Treatment and dengue virus infection. Proteomics. 2018;18(23):e1800215. doi: 10.1002/pmic.201800215
   PubMed Web of Science ®Google Scholar
• Ojha A, Bhasym A, Mukherjee S, et al. Platelet factor 4 promotes rapid replication and propagation of dengue and Japanese encephalitis viruses. EBioMedicine. 2019;39:332–347. doi: 10.1016/j.ebiom.2018.11.049
   PubMed Web of Science ®Google Scholar
• Aviner R, Li KH, Frydman J, et al. Cotranslational prolyl hydroxylation is essential for flavivirus biogenesis. Nature. 2021;596(7873):558–564. doi: 10.1038/s41586-021-03851-2
   PubMed Web of Science ®Google Scholar
• Falconi-Agapito F, Kerkhof K, Merino X, et al. Dynamics of the magnitude, breadth and depth of the antibody response at epitope level following dengue infection. Front Immunol. 2021;12:686691. doi: 10.3389/fimmu.2021.686691
   PubMed Web of Science ®Google Scholar
• Allgoewer K, Maity S, Zhao A, et al. New Proteomic Signatures to Distinguish Between Zika and Dengue Infections. Mol Cell Proteomics. 2021;20:100052. doi: 10.1016/j.mcpro.2021.100052
   PubMed Web of Science ®Google Scholar
• Wee S, Alli-Shaik A, Kek R, et al. Multiplex targeted mass spectrometry assay for one-shot flavivirus diagnosis. Proc Natl Acad Sci USA. 2019;116(14):6754–6759. doi: 10.1073/pnas.1817867116
   PubMed Web of Science ®Google Scholar
• Han L, Ao X, Lin S, et al. Quantitative comparative proteomics reveal biomarkers for dengue disease severity. Front Microbiol. 2019;10:2836. doi: 10.3389/fmicb.2019.02836
   PubMed Web of Science ®Google Scholar
• Jadhav M, Nayak M, Kumar S, et al. Clinical proteomics and cytokine profiling for dengue fever disease severity biomarkers. Omics: A J Intgr Biol. 2017;21(11):665–677. doi: 10.1089/omi.2017.0135
   PubMed Web of Science ®Google Scholar
• Nhi DM, Huy NT, Ohyama K, et al. A proteomic approach identifies candidate early biomarkers to predict severe dengue in children. PloS Negl Trop Dis. 2016;10(2):e0004435. doi: 10.1371/journal.pntd.0004435
   PubMed Web of Science ®Google Scholar
• Palanichamy Kala M, St John AL, Rathore APS. Dengue: update on clinically relevant therapeutic strategies and vaccines. Curr Treat Options Infect Dis. 2023;15(2):27–52. doi: 10.1007/s40506-023-00263-w
   PubMedGoogle Scholar
• Owen L, Laird K, Shivkumar M. Antiviral plant-derived natural products to combat RNA viruses: targets throughout the viral life cycle. Lett Appl Microbiol. 2022;75(3):476–499. doi: 10.1111/lam.13637
   PubMed Web of Science ®Google Scholar
• Altamish M, Khan M, Baig MS, et al. Therapeutic potential of medicinal plants against dengue infection: a mechanistic viewpoint. ACS Omega. 2022;7(28):24048–24065. doi: 10.1021/acsomega.2c00625
   PubMed Web of Science ®Google Scholar
• Paemanee A, Hitakarun A, Wintachai P, et al. A proteomic analysis of the anti-dengue virus activity of andrographolide. Biomed Pharmacother. 2019;109:322–332. doi: 10.1016/j.biopha.2018.10.054
   PubMed Web of Science ®Google Scholar
• Tan WL, Lee YK, Ho YF, et al. Comparative proteomics reveals that YK51, a 4-Hydroxypandurantin-A analogue, downregulates the expression of proteins associated with dengue virus infection. Peer J. 2018;5:e3939. doi: 10.7717/peerj.3939
   PubMedGoogle Scholar
• Ullah A, Atia Tul W, Gong P, et al. Identification of new inhibitors of NS5 from dengue virus using saturation transfer difference (STD-NMR) and molecular docking studies. RSC Adv. 2022;13(1):355–369. doi: 10.1039/D2RA04836A
   PubMed Web of Science ®Google Scholar
• Denolly S, Guo H, Martens M, et al. Dengue virus NS1 secretion is regulated via importin-subunit beta1 controlling expression of the chaperone GRp78 and targeted by the clinical drug ivermectin. MBio. 2023;14(5):e0144123. doi: 10.1128/mbio.01441-23
   PubMedGoogle Scholar
• Wilder-Smith A. Dengue vaccine development: status and future. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2020;63(1):40–44. doi: 10.1007/s00103-019-03060-3
   PubMed Web of Science ®Google Scholar
• Wilder-Smith A. Dengue vaccine development by the year 2020: challenges and prospects. Curr Opin Virol. 2020;43:71–78. doi: 10.1016/j.coviro.2020.09.004
   PubMed Web of Science ®Google Scholar
• Thomas SJ, Yoon IK. A review of Dengvaxia(R): development to deployment. Hum Vaccin Immunother. 2019;15(10):2295–2314. doi: 10.1080/21645515.2019.1658503
   PubMed Web of Science ®Google Scholar
• Krishnan GS, Joshi A, Akhtar N, et al. Immunoinformatics designed T cell multi epitope dengue peptide vaccine derived from non structural proteome. Microb Pathog. 2021;150:104728. doi: 10.1016/j.micpath.2020.104728
   PubMed Web of Science ®Google Scholar
• Yewdell JW. MHC class I immunopeptidome: past, present, and future. Mol Cell Proteomics. 2022;21(7):100230. doi: 10.1016/j.mcpro.2022.100230
   PubMed Web of Science ®Google Scholar
• Mayer RL, Impens F. Immunopeptidomics for next-generation bacterial vaccine development. Trends Microbiol. 2021;29(11):1034–1045. doi: 10.1016/j.tim.2021.04.010
   PubMed Web of Science ®Google Scholar
• Sharma P, Sharma P, Sheeba, et al. Top down computational approach: a vaccine development step to find novel superantigenic HLA binding epitopes from dengue virus proteome. Int J Pept ResearchTher. 2021;27(2):1469–1480. doi: 10.1007/s10989-021-10184-1
   PubMed Web of Science ®Google Scholar
• Friedman-Klabanoff DJ, Birkhold M, Short MT, et al. Safety and immunogenicity of AGS-v PLUS, a mosquito saliva peptide vaccine against arboviral diseases: a randomized, double-blind, placebo-controlled Phase 1 trial. EBioMedicine. 2022;86:104375. doi: 10.1016/j.ebiom.2022.104375
   PubMed Web of Science ®Google Scholar
• Chao CH, Wu WC, Lai YC, et al. Dengue virus nonstructural protein 1 activates platelets via toll-like receptor 4, leading to thrombocytopenia and hemorrhage. PLOS Pathog. 2019;15(4):e1007625. doi: 10.1371/journal.ppat.1007625
   PubMed Web of Science ®Google Scholar
• Ojha A, Nandi D, Batra H, et al. Platelet activation determines the severity of thrombocytopenia in dengue infection. Sci Rep. 2017;7(1):41697. doi: 10.1038/srep41697
   PubMed Web of Science ®Google Scholar
• Chuang YC, Lin YS, Liu HS, et al. Molecular mimicry between dengue virus and coagulation factors induces antibodies to inhibit thrombin activity and enhance fibrinolysis. J Virol. 2014;88(23):13759–13768. doi: 10.1128/JVI.02166-14
   PubMed Web of Science ®Google Scholar
• Maringer K, Yousuf A, Heesom KJ, et al. Proteomics informed by transcriptomics for characterising active transposable elements and genome annotation in Aedes aegypti. BMC Genomics. 2017;18(1):101. doi: 10.1186/s12864-016-3432-5
   PubMedGoogle Scholar