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Nucleosides, Nucleotides & Nucleic Acids Volume 39, 2020 - Issue 10-12
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Conference Proceedings

The effect of trehalose on intracellular and extracellular nucleotide metabolism. A pilot study

Mikolaj OpielkaDepartment of Biochemistry, Medical University of Gdansk, Gdansk, PolandCorrespondence[email protected]
ORCID Iconhttp://orcid.org/0000-0003-3423-3745View further author information
ORCID Icon,
Bartosz SobockiDepartment of Biochemistry, Medical University of Gdansk, Gdansk, PolandORCID Iconhttp://orcid.org/0000-0002-5074-9701View further author information
ORCID Icon,
Paulina MierzejewskaDepartment of Biochemistry, Medical University of Gdansk, Gdansk, PolandView further author information
&
Ryszard T. SmolenskiDepartment of Biochemistry, Medical University of Gdansk, Gdansk, PolandView further author information
Pages 1400-1409 | Received 13 Mar 2020, Accepted 18 May 2020, Published online: 22 Jun 2020

References

  • Hosseinpour-Moghaddam, K.; Caraglia, M.; Sahebkar, A. Autophagy Induction by Trehalose: Molecular Mechanisms and Therapeutic Impacts. J. Cell. Physiol. 2018, 233, 6524–6543. DOI: 10.1002/jcp.26583.
  • Tapia, H.; Koshland, D. E. Trehalose is a Versatile and Long-Lived Chaperone for Desiccation Tolerance. Curr. Biol. 2014, 24, 2758–2766. DOI: 10.1016/j.cub.2014.10.005.
  • Sergin, I.; Evans, T. D.; Zhang, X.; Bhattacharya, S.; Stokes, C. J.; Song, E.; Ali, S.; Dehestani, B.; Holloway, K. B.; Micevych, P. S.; et al. Exploiting Macrophage Autophagy-Lysosomal Biogenesis as a Therapy for Atherosclerosis. Nat. Commun. 2017, 8, 15750–15720. DOI: 10.1038/ncomms15750.
  • Cristofani, R.; Montagnani Marelli, M.; Cicardi, M. E.; Fontana, F.; Marzagalli, M.; Limonta, P.; Poletti, A.; Moretti, R. M. Dual Role of Autophagy on Docetaxel-Sensitivity in Prostate Cancer Cells. Cell Death Dis. 2018, 9, 889. DOI: 10.1038/s41419-018-0866-5.
  • Allavena, G.; Del Bello, B.; Tini, P.; Volpi, N.; Valacchi, G.; Miracco, C.; Pirtoli, L.; Maellaro, E. Trehalose Inhibits Cell Proliferation and Amplifies Long-Term Temozolomide- and Radiation-Induced Cytotoxicity in Melanoma Cells: A Role for Autophagy and Premature Senescence. J. Cell. Physiol. 2019, 234, 11708–11721. DOI: 10.1002/jcp.27838.
  • Kudo, T.; Takeuchi, K.; Ebina, Y.; Nakazawa, M. Inhibitory Effects of Trehalose on Malignant Melanoma Cell Growth: Implications for a Novel Topical Anticancer Agent on the Ocular Surface. ISRN Ophthalmol. 2012, 2012, 968493–968499. DOI: 10.5402/2012/968493.
  • Spina-Purrello, V.; Giliberto, S.; Barresi, V.; Nicoletti, V. G.; Giuffrida Stella, A. M.; Rizzarelli, E. Modulation of PARP-1 and PARP-2 Expression by L-Carnosine and Trehalose after LPS and INFγ-Induced Oxidative Stress. Neurochem. Res. 2010, 35, 2144–2153. DOI: 10.1007/s11064-010-0297-x.
  • Echigo, R.; Shimohata, N.; Karatsu, K.; Yano, F.; Kayasuga-Kariya, Y.; Fujisawa, A.; Ohto, T.; Kita, Y.; Nakamura, M.; Suzuki, S.; et al. Trehalose Treatment Suppresses Inflammation, Oxidative Stress, and Vasospasm Induced by Experimental Subarachnoid Hemorrhage. J. Transl. Med. 2012, 10, 80–13. DOI: 10.1186/1479-5876-10-80.
  • Kaplon, R. E.; Hill, S. D.; Bispham, N. Z.; Santos-Parker, J. R.; Nowlan, M. J.; Snyder, L. L.; Chonchol, M.; LaRocca, T. J.; McQueen, M. B.; Seals, D. R. Oral Trehalose Supplementation Improves Resistance Artery Endothelial Function in Healthy Middle-Aged and Older Adults. Aging (Albany NY) 2016, 8, 1167–1183. DOI: 10.18632/aging.100962.
  • Idzko, M.; Ferrari, D.; Eltzschig, H. K. Nucleotide Signalling during Inflammation. Nature 2014, 509, 310–317. DOI: 10.1038/nature13085.
  • Yegutkin, G. G. Nucleotide- and Nucleoside-Converting Ectoenzymes: Important Modulators of Purinergic Signalling Cascade. Biochim. Biophys. Acta 2008, 1783, 673–694. DOI: 10.1016/j.bbamcr.2008.01.024.
  • Kutryb-Zajac, B.; Mierzejewska, P.; Sucajtys-Szulc, E.; Bulinska, A.; Zabielska, M. A.; Jablonska, P.; Serocki, M.; Koszalka, P.; Milczarek, R.; Jasztal, A.; et al. Inhibition of LPS-Stimulated Ecto-Adenosine Deaminase Attenuates Endothelial Cell Activation. J. Mol. Cell. Cardiol. 2019, 128, 62–76. DOI: 10.1016/j.yjmcc.2019.01.004.
  • Yaku, K.; Okabe, K.; Hikosaka, K.; Nakagawa, T. NAD Metabolism in Cancer Therapeutics. Front. Oncol. 2018, 8, 622–629. DOI: 10.3389/fonc.2018.00622.
  • Mardones, P.; Rubinsztein, D. C.; Hetz, C. Mystery Solved: Trehalose Kickstarts Autophagy by Blocking Glucose Transport. Sci. Signal. 2016, 9, fs2–4. DOI: 10.1126/scisignal.aaf1937.
  • Pastor-Anglada, M.; Pérez-Torras, S. Emerging Roles of Nucleoside Transporters. Front. Pharmacol. 2018, 9, 606–608. DOI: 10.3389/fphar.2018.00606.
  • Kutryb-Zajac, B.; Koszalka, P.; Mierzejewska, P.; Bulinska, A.; Zabielska, M. A.; Brodzik, K.; Skrzypkowska, A.; Zelazek, L.; Pelikant-Malecka, I.; Slominska, E. M.; et al. Adenosine Deaminase Inhibition Suppresses Progression of 4T1 Murine Breast Cancer by Adenosine Receptor-Dependent Mechanisms. J. Cell. Mol. Med. 2018, 22, 5939–5954. DOI: 10.1111/jcmm.13864.
  • Jain, N. K.; Roy, I. Effect of Trehalose on Protein Structure. Protein Sci. 2009, 18, 24–36. DOI: 10.1002/pro.3.
  • Moreno, E.; Canet, J.; Gracia, E.; Lluís, C.; Mallol, J.; Canela, E. I.; Cortés, A.; Casadó, V. Molecular Evidence of Adenosine Deaminase Linking Adenosine A2A Receptor and CD26 Proteins. Front. Pharmacol. 2018, 9, 106–118. DOI: 10.3389/fphar.2018.00106.

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