Association of genetic polymorphisms in DNA repair genes ERCC2 Asp312Asn (rs1799793), ERCC2 Lys 751 Gln (rs13181), XRCC1 Arg399 Gln (rs25487) and XRCC3 Thr 241Met (rs861539) with the susceptibility of lung cancer in Saudi population

References

• Sung, H.; Ferlay, J.; Siegel, R. L.; Laversanne, M.; Soerjomataram, I.; Jemal, A.; Bray, F. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA. A Cancer J. Clin. 2021, 71, 209–249. DOI: 10.3322/caac.21660.
   PubMed Web of Science ®Google Scholar
• Santarpia, M.; Rolfo, C.; Peters, G. J.; Leon, L. G.; Giovannetti, E. On the Pharmacogenetics of Non-Small Cell Lung Cancer Treatment. Expert Opin. Drug Metab. Toxicol. . 2016, 12, 307–317. DOI: 10.1517/17425255.2016.1141894.
   PubMed Web of Science ®Google Scholar
• The Lancet Respiratory Medicine. Lung Cancer-Moving in the Right Direction. Lancet Respir Med 2017, 5, 599. DOI: 10.1016/S2213-2600(17)30271-0.
   PubMed Web of Science ®Google Scholar
• Granger, C. L. Physiotherapy Management of Lung Cancer. J. Physiother. 2016, 62, 60–67. DOI: 10.1016/j.jphys.2016.02.010.
   PubMed Web of Science ®Google Scholar
• Woodman, C.; Vundu, G.; George, A.; Wilson, C. M. Applications and Strategies in Nanodiagnosis and Nanotherapy in Lung Cancer. Semin. Cancer Biol. 2021, 69, 349–364. DOI: 10.1016/j.semcancer.2020.02.009.
   PubMed Web of Science ®Google Scholar
• Avino, P.; Scungio, M.; Stabile, L.; Cortellessa, G.; Buonanno, G.; Manigrasso, M. Second-Hand Aerosol from Tobacco and Electronic Cigarettes: Evaluation of the Smoker Emission Rates and Doses and Lung Cancer Risk of Passive Smokers and Vapers. Sci. Total Environ. 2018, 642, 137–147. DOI: 10.1016/j.scitotenv.2018.06.059.
   PubMed Web of Science ®Google Scholar
• Ceppi, M.; Munnia, A.; Cellai, F.; Bruzzone, M.; Peluso, M. E. M. Linking the Generation of DNA Adducts to Lung Cancer. Toxicology 2017, 390, 160–166. DOI: 10.1016/j.tox.2017.09.011.
   PubMed Web of Science ®Google Scholar
• Schwartz, A. G.; Cote, M. L. Epidemiology of Lung Cancer. Adv. Exp. Med. Biol. 2016, 893, 21–41. DOI: 10.1007/978-3-319-24223-1_2.
   PubMed Web of Science ®Google Scholar
• Akhtar, N.; Bansal, J. G. Risk Factors of Lung Cancer in Nonsmoker. Curr. Probl. Cancer. 2017, 41, 328–339. DOI: 10.1016/j.currproblcancer.2017.07.002.
   PubMed Web of Science ®Google Scholar
• Lacourt, A.; Pintos, J.; Lavoué, J.; Richardson, L.; Siemiatycki, J. Siemiatycki J Lung Cancer Risk among Workers in the Construction Industry: Results from Two Case-Control Studies in Montreal. BMC Public Health. 2015, 15, 941. DOI: 10.1186/s12889-015-2237-9.
   PubMed Web of Science ®Google Scholar
• Wang, Y.; Yue, S.; Zheng, B.; Hao, Z.; Chen, J. A General Method for Evaluating the Effects of Air Pollutants on Lung Cancer Prevalence. J. Air Waste Manag. Assoc. 2018, 68, 1366–1377. DOI: 10.1080/10962247.2018.1515124.
   PubMedGoogle Scholar
• Nazarkina, Z. K.; Khodyreva, S. N.; Marsin, S.; Lavrik, O. I.; Radicella, J. P. XRCC1 Interactions with Base Excision Repair DNA Intermediates. DNA Repair (Amst) 2007, 6, 254–264. DOI: 10.1016/j.dnarep.2006.10.002.
   PubMed Web of Science ®Google Scholar
• Shen, M. R.; Jones, I. M.; Mohrenweiser, H. Nonconservative Amino Acid Substitution Variants Exist at Polymorphic Frequency in DNA Repair Genes in Healthy Humans. Cancer Res. 1998, 58, 604–608.
   PubMed Web of Science ®Google Scholar
• Fan, J.; Liu, W.; Zhang, M.; Xing, C. A Literature Review and Systematic Meta-Analysis on XRCC3 Thr241Met Polymorphism Associating with Susceptibility of Oral Cancer. Oncol. Lett. 2019, 18, 3265–3273. DOI: 10.3892/ol.2019.10609.
   PubMed Web of Science ®Google Scholar
• Zhan, P.; Wang, Q.; Qian, Q.; Yu, L.-K. XRCC3 Thr241Met Gene Polymorphisms and Lung Cancer Risk: A Meta-Analysis. J. Exp. Clin. Cancer Res. 2013, 32, 1. DOI: 10.1186/1756-9966-32-1.
   PubMed Web of Science ®Google Scholar
• Xue, H.; Lu, Y.; Lin, B.; Chen, J.; Tang, F.; Huang, G. The Effect of XPD/ERCC2 Polymorphisms on Gastric Cancer Risk among Different Ethnicities: A Systematic Review and Meta-Analysis. PLoS One. 2012, 7, e43431. DOI: 10.1371/journal.pone.0043431.
   PubMed Web of Science ®Google Scholar
• Murphy, S. E.; Park, S. L.; Balbo, S.; Haiman, C. A.; Hatsukami, D. K.; Patel, Y.; Peterson, L. A.; Stepanov, I.; Stram, D. O.; Tretyakova, N.; et al. Tobacco Biomarkers and Genetic/Epigenetic Analysis to Investigate Ethnic/Racial Differences in Lung Cancer Risk among Smokers. NPJ Precis. Oncol. 2018, 2, 17. DOI: 10.1038/s41698-018-0057-y.
   PubMed Web of Science ®Google Scholar
• Catana, A.; Pop, M.; Marginean, D. H.; Blaga, I. C.; Porojan, M. D.; Popp, R. A.; Pop, I. V. XRCC3 Thr241Met Polymorphism is Not Associated with Lung Cancer Risk in a Romanian Population. Clujul Med. 2016, 89, 89–93. DOI: 10.15386/cjmed-523.
   PubMedGoogle Scholar
• Zhang, N.; Ouyang, Y.; Chang, J.; Liu, P.; Tian, X.; Yu, J. Pharmacogenetic Association between XRCC1 Polymorphisms and Response to Platinum-Based Chemotherapy in Asian Patients with NSCLC: A Meta-Analysis. Biomed Res. Int. 2020, 2020, 3520764. DOI: 10.1155/2020/3520764.
   PubMed Web of Science ®Google Scholar
• Zhao, Y.; Xie, Y.; Jia, D.; Ma, C.; Wei, D.; Zhang, X. Application of Gene Polymorphisms to Predict the Sensitivity of Patients with Locally Advanced Non-Small Cell Lung Cancer Undergoing Chemoradiotherapy. Am. J. Transl. Res. 2021, 13, 7382–7387.
   PubMed Web of Science ®Google Scholar
• Liu, H. X.; Li, J.; Ye, B. G. Correlation between Gene Polymorphisms of CYP1A1, GSTP1, ERCC2, XRCC1, and XRCC3 and Susceptibility to Lung Cancer. Genet. Mol. Res. 2016, 15, 1–10.
   Web of Science ®Google Scholar
• Tasnim, T.; Al-Mamun, M. M. A.; Nahid, N. A.; Islam, M. R.; Apu, M. N. H.; Bushra, M. U.; Rabbi, S. N. I.; Nahar, Z.; Chowdhury, J. A.; Ahmed, M. U.; et al. Genetic Variants of SULT1A1 and XRCC1 Genes and Risk of Lung Cancer in Bangladeshi Population. Tumour Biol. 2017, 39, 1010428317729270. DOI: 10.1177/1010428317729270.
   Google Scholar
• Uppal, V.; Mehndiratta, M.; Mohapatra, D.; Grover, R. K.; Puri, D. XRCC-1 Gene Polymorphism (Argrs25487 Gln) and Susceptibility to Development of Lung Cancer in Cohort of North Indian Population: A Pilot Study. J. Clin. Diagn. Res. 2014, 8, CC17–20.
   PubMedGoogle Scholar
• Zhu, D. Q.; Zou, Q.; Hu, C. H.; Su, J. L.; Zhou, G. H.; Liu, P. XRCC1 Genetic Polymorphism Acts a Potential Biomarker for Lung Cancer. Tumour Biol. 2015, 36, 3745–3750. DOI: 10.1007/s13277-014-3014-6.
   PubMedGoogle Scholar
• Li, W.; Zhang, M.; Huang, C.; Meng, J.; Yin, X.; Sun, G. Genetic Variants of DNA Repair Pathway Genes on Lung Cancer Risk. Pathol. Res. Pract. 2019, 215, 152548. DOI: 10.1016/j.prp.2019.152548.
   PubMed Web of Science ®Google Scholar
• Zhou, B.; Hu, X. M.; Wu, G. Y. Association between the XPG Gene Asp1104His Polymorphism and Lung Cancer Risk. Genet Mol Res 2016, 15, 1–8.
   Google Scholar
• Yu, T.; Xue, P.; Cui, S.; Zhang, L.; Zhang, G.; Xiao, M.; Zheng, X.; Zhang, Q.; Cai, Y.; Jin, C.; et al. Rs3212986 Polymorphism, a Possible Biomarker to Predict Smoking-Related Lung Cancer, Alters DNA Repair Capacity via Regulating ERCC1 Expression. Cancer Med. 2018, 7, 6317–6330. DOI: 10.1002/cam4.1842.
   PubMed Web of Science ®Google Scholar
• Chen, H. J.; Chang, W. S.; Hsia, T. C.; Miao, C. E.; Chen, W. C.; Liang, S. J.; Chen, A. C.; Chang, J. G.; Tsai, C. W.; Hsu, C. M.; et al. Contribution of Genotype of DNA Double-Strand Break Repair Gene XRCC3, Gender, and Smoking Behavior to Lung Cancer Risk in Taiwan. Anticancer Res. 2015, 35, 3893–3899.
   PubMed Web of Science ®Google Scholar
• Xing, Z. S.; Zhu, G.; Yang, Y. L.; Feng, G. Q.; Ding, G. C. Meta Analysis of XRCC3 Thr241Met Polymorphism and Lung Cancer Susceptibility of Populations in East Asia . Asian Pac. J. Trop. Med. 2014, 7, 483–487. DOI: 10.1016/S1995-7645(14)60079-1.
   PubMed Web of Science ®Google Scholar
• Pérez-Ramírez, C.; Cañadas-Garre, M.; Alnatsha, A.; Villar, E.; Delgado, J. R.; Calleja-Hernández, M. Á.; Faus-Dáder, M. J. Impact of DNA Repair, Folate and Glutathione Gene Polymorphisms on Risk of Non Small Cell Lung Cancer . Pathol. Res. Pract. 2018, 214, 44–52. DOI: 10.1016/j.prp.2017.11.015.
   PubMed Web of Science ®Google Scholar
• Basu, A. K. DNA Damage, Mutagenesis and Cancer. IJMS. 2018, 19, 970. DOI: 10.3390/ijms19040970.
   Google Scholar
• Abdulmonem, W. A.; Rasheed, Z.; Alsagaby, S.; Aljohani, A.; Alkhamiss, A.; Ahmed, A. A. Impact of ERCC2 Lys751Gln (rs13181), ERCC2 Asp312Asn (rs1799793) and XRCC1 Arg399Gln (rs25487) Polymorphisms on the Risk of Prostate Cancer among Cases from the Central Region of Saudi Arabia. Gene Reports 2021, 24, 101278. DOI: 10.1016/j.genrep.2021.101278.
   Web of Science ®Google Scholar
• Alanazi, M.; Pathan, A. A.; Ajaj, S. A.; Khan, W.; Shaik, J. P.; Al Tassan, N.; Parine, N. R. DNA Repair Genes XRCC1, XRCC3, XPD, and OGG1 Polymorphisms among the Central Region Population of Saudi Arabia. Biol. Res. 2013, 46, 161–167. DOI: 10.4067/S0716-97602013000200007.
   PubMed Web of Science ®Google Scholar
• Ali, A. M.; AbdulKareem, H.; Al Anazi, M.; Reddy Parine, N.; Shaik, J. P.; Alamri, A.; Ali Khan Pathan, A.; Warsy, A. Polymorphisms in DNA Repair Gene XRCC3 and Susceptibility to Breast Cancer in Saudi Females. Biomed. Res. Int. 2016, 2016, 1–9. DOI: 10.1155/2016/8721052.
   Web of Science ®Google Scholar
• Yin, J.; Vogel, U.; Ma, Y.; Guo, L.; Wang, H.; Qi, R. Polymorphism of the DNA Repair Gene ERCC2 Lys751Gln and Risk of Lung Cancer in a Northeastern Chinese Population. Cancer Genet. Cytogenet. 2006, 169, 27–32. DOI: 10.1016/j.cancergencyto.2006.03.008.
   PubMedGoogle Scholar
• Liang, G.; Xing, D.; Miao, X.; Tan, W.; Yu, C.; Lu, W.; Lin, D. Sequence Variations in the DNA Repair Gene XPD and Risk of Lung Cancer in a Chinese Population. Int. J. Cancer. 2003, 105, 669–673. DOI: 10.1002/ijc.11136.
   PubMed Web of Science ®Google Scholar
• Popanda, O.; Schattenberg, T.; Phong, C. T.; Butkiewicz, D.; Risch, A.; Edler, L.; Kayser, K.; Dienemann, H.; Schulz, V.; Drings, P.; et al. Specific Combinations of DNA Repair Gene Variants and Increased Risk for Non-Small Cell Lung Cancer. Carcinogenesis 2004, 25, 2433–2441. DOI: 10.1093/carcin/bgh264.
   PubMed Web of Science ®Google Scholar
• Saikia, B. J.; Phukan, R. K.; Sharma, S. K.; Sekhon, G. S.; Mahanta, J. Interaction of XRCC1 and XPD Gene Polymorphisms with Lifestyle and Environmental Factors regarding Susceptibility to Lung Cancer in a High Incidence Population in North East India. Asian Pac. J. Cancer Prev. 2014, 15, 1993–1999. DOI: 10.7314/apjcp.2014.15.5.1993.
   PubMedGoogle Scholar
• Park, J. Y.; Lee, S. Y.; Jeon, H.-S.; Park, S. H.; Bae, N. C.; Lee, E. B.; Cha, S. I.; Park, J.-H.; Kam, S.; Kim, I.-S.; Jung, T. H. Polymorphism of the DNA Repair Gene XRCC1 and Risk of Primary Lung Cancer. Cancer Epidemiol. Biomarkers Prev. 2002, 36, 15–17. DOI: 10.1016/S0169-5002(01)00447-0.
   Google Scholar
• Divine, K. K.; Gilliland, F. D.; Crowell, R. E.; Stidley, C. A.; Bocklage, T. J.; Cook, D. L.; Belinsky, S. A. The XRCC1 rs25487 Glutamine Allele is a Risk Factor for Adenocarcinoma of the Lung. Mutat. Res. 2001, 461, 273–278. DOI: 10.1016/S0921-8777(00)00059-8.
   PubMed Web of Science ®Google Scholar
• Ouyang, F. D.; Yang, F. L.; Chen, H. C.; Khan, M. A.; Huang, F. M.; Wan, X. X.; Xu, A. H.; Huang, X.; Zhou, M. J.; Fang, Q.; Zhang, D. Z. Polymorphisms of DNA Repair Genes XPD, XRCC1, and OGG1, and Lung Adenocarcinoma Susceptibility in Chinese Population. Tumour Biol. 2013, 34, 2843–2848. DOI: 10.1007/s13277-013-0844-6.
   PubMedGoogle Scholar
• Yang, H. Y.; Yang, S. Y.; Shao, F. Y.; Wang, H. Y.; Wang, Y. D. Updated Assessment of the Association of the XRCC1 Arg399Gln Polymorphism with Lung Cancer Risk in the Chinese Population. Asian Pac. J. Cancer Prev. 2015, 16, 495–500. DOI: 10.7314/apjcp.2015.16.2.495.
   PubMedGoogle Scholar
• Li, Y.; Huang, Y.; Cao, Y. S.; Zeng, J.; Tong, W. N.; Xu, S. L.; Zhuo, A. S. Assessment of the Association between XRCC1 Arg399Gln Polymorphism and Lung Cancer in Chinese. Tumour Biol. 2013, 34, 3681–3685. DOI: 10.1007/s13277-013-0950-5.
   PubMedGoogle Scholar
• Natukula, K.; Jamil, K.; Pingali, U. R.; Attili, V. S.; Madireddy, U. R. The Codon rs25487 Arg/Gln XRCC1 Polymorphism is Associated with Lung Cancer in Indians. Asian Pac. J. Cancer Prev. 2013, 14, 5275–5279. DOI: 10.7314/APJCP.2013.14.9.5275.
   PubMedGoogle Scholar
• David-Beabes, G. L.; London, S. J. Genetic Polymorphism of XRCC1 and Lung Cancer Risk among African-Americans and Caucasians. Lung Cancer 2001, 34, 333–339. DOI: 10.1016/S0169-5002(01)00256-2.
   PubMed Web of Science ®Google Scholar
• Shen, M.; Berndt, S. I.; Rothman, N.; Mumford, J. L.; He, X.; Yeager, M.; Welch, R.; Chanock, S.; Keohavong, P.; Donahue, M.; et al. Polymorphisms in the DNA Base Excision Repair Genes APEX1 and XRCC1 and Lung Cancer Risk in Xuan Wei, China. Anticancer Res. 2005, 25, 537–542.
   PubMed Web of Science ®Google Scholar
• Singh, A.; Singh, N.; Behera, D.; Sharma, S. Association and Multiple Interaction Analysis among Five XRCC1 Polymorphic Variants in Modulating Lung Cancer Risk in North Indian Population. DNA Repair (Amst) 2016, 47, 30–41. DOI: 10.1016/j.dnarep.2016.09.006.
   PubMed Web of Science ®Google Scholar
• Karkucak, M.; Yakut, T.; Evrensel, T.; Deligonul, A.; Gulten, T.; Ocakoglu, G.; Kurt, O. E.; Kanat, E. Cubukcu, I Sehitoglu I, XRCC1 Gene Polymorphisms and Risk of Lung Cancer in Turkish Patients. Int. J. Hum. Genet. 2012, 2, 113–117.
   Google Scholar
• Wang, Y.; Yang, H.; Li, H.; Li, L.; Wang, H.; Liu, C.; Zheng, Y. Association between X-ray Repair Cross Complementing Group 1 Codon 399 and 194 Polymorphisms and Lung Cancer Risk: A Meta-analysis . Cancer Lett. 2009, 285, 134–140. DOI: 10.1016/j.canlet.2009.05.005.
   PubMed Web of Science ®Google Scholar
• Kiyohara, C.; Takayama, K.; Nakanishi, Y. Association of Genetic Polymorphisms in the Base Excision Repair Pathway with Lung Cancer Risk: A Meta-Analysis. Lung Cancer 2006, 54, 267–283. DOI: 10.1016/j.lungcan.2006.08.009.
   PubMed Web of Science ®Google Scholar
• Misra, R. R.; Ratnasinghe, D.; Tangrea, J. A.; Virtamo, J.; Andersen, M. R.; Barrett, M.; Taylor, P. R.; Albanes, D. Polymorphisms in the DNA Repair Genes XPD, XRCC1, XRCC3, and APE/Ref-1, and the Risk of Lung Cancer among Male Smokers in Finland. Cancer Lett. 2003, 191, 171–178. DOI: 10.1016/S0304-3835(02)00638-9.
   PubMed Web of Science ®Google Scholar
• Sørensen, M.; López, A. G.; Andersen, P. K.; Vogel, U.; Autrup, H.; Tjønneland, A.; Overvad, K.; Raaschou-Nielsen, O. Stratification for Smoking in Case-Cohort Studies of Genetic Polymorphisms and Lung Cancer. Lung Cancer 2009, 63, 335–340. MarDOI: 10.1016/j.lungcan.2008.06.016.
   PubMed Web of Science ®Google Scholar
• IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. Tobacco Smoke and Involuntary Smoking. IARC Monogr. Eval. Carcinog. Risks Hum. 2004, 83, 1–1438.
   PubMedGoogle Scholar
• De Ruyck, K.; Szaumkessel, M.; De Rudder, I.; Dehoorne, A.; Vral, A.; Claes, K.; Velghe, A.; Van Meerbeeck, J.; Thierens, H. Polymorphisms in Base-Excision Repair and Nucleotide-Excision Repair Genes in Relation to Lung Cancer Risk. Mutat. Res. 2007, 631, 101–110. DOI: 10.1016/j.mrgentox.2007.03.010.
   PubMed Web of Science ®Google Scholar
• Ito, H.; Matsuo, K.; Hamajima, N.; Mitsudomi, T.; Sugiura, T.; Saito, T.; Yasue, T.; Lee, K. M.; Kang, D.; Yoo, K. Y.; et al. Gene-Environment Interactions between the Smoking Habit and Polymorphisms in the DNA Repair Genes, APE1 Asp148Glu and XRCC1 Argrs25487 Gln, in Japanese Lung Cancer Risk. Carcinogenesis 2004, 25, 1395–1401. AugDOI: 10.1093/carcin/bgh153.
   PubMed Web of Science ®Google Scholar