VEGF and eNOS variants may influence intervertebral disc degeneration

References

• VDR, V. D. R. Vitamin D Receptor (VDR) Genetic Polymorphisms Associated with İntervertebral Disc Degeneration. J. Genet. Genomics 2015, 42, 5e140.
   Web of Science ®Google Scholar
• Mayer, J. E.; Iatridis, J. C.; Chan, D.; Qureshi, S. A.; Gottesman, O.; Hecht, A. C. Genetic Polymorphisms Associated with İntervertebral Disc Degeneration. Spine J. 2013, 13, 299–317. DOI: 10.1016/j.spinee.2013.01.041.
   PubMed Web of Science ®Google Scholar
• Burke, J.; Watson, R.; McCormack, D.; Dowling, F.; Walsh, M.; Fitzpatrick, J. Intervertebral Discs Which Cause Low Back Pain Secrete High Levels of Proinflammatory Mediators. J. Bone Joint Surgery Br. Volume 2002, 84-B, 196–201. DOI: 10.1302/0301-620X.84B2.0840196.
   Google Scholar
• Shibuya, M. Differential Roles of Vascular Endothelial Growth Factor Receptor-1 and Receptor-2 in Angiogenesis. J. Biochem. Mol. Biol. 2006, 39, 469–478. DOI: 10.5483/bmbrep.2006.39.5.469.
   PubMedGoogle Scholar
• Paré‐Brunet, L.; Glubb, D.; Evans, P.; Berenguer‐Llergo, A.; Etheridge, A. S.; Skol, A. D.; Di Rienzo, A.; Duan, S.; Gamazon, E. R.; Innocenti, F. Discovery and Functional Assessment of Gene Variants in the Vascular Endothelial Growth Factor Pathway. Hum. Mutat. 2014, 35, 227–235. DOI: 10.1002/humu.22475.
   PubMed Web of Science ®Google Scholar
• Yang, B.; Cross, D. F.; Ollerenshaw, M.; Millward, B. A.; Demaine, A. G. Polymorphisms of the Vascular Endothelial Growth Factor and Susceptibility to Diabetic Microvascular Complications in Patients with Type 1 Diabetes Mellitus. J. Diabetes Complications 2003, 17, 1–6. DOI: 10.1016/S1056-8727(02)00181-2.
   PubMed Web of Science ®Google Scholar
• Bian, K.; Murad, F. What is Next in Nitric Oxide Research? From Cardiovascular System to Cancer Biology. Nitric Oxide 2014, 43, 3–7. DOI: 10.1016/j.niox.2014.08.006.
   PubMed Web of Science ®Google Scholar
• Yang, C.; Qi, Z-y.; Shao, C.; Xing, W-k.; Wang, Z. Association between Three eNOS Polymorphisms and İntracranial Aneurysms Risk: A Meta-Analysis. Medicine 2015, 94, e452. DOI: 10.1097/MD.0000000000000452.
   PubMed Web of Science ®Google Scholar
• Amle, D.; Mir, R.; Khaneja, A.; Agarwal, S.; Ahlawat, R.; Ray, P. C.; Saxena, A. Association of 18bp İnsertion/Deletion Polymorphism, at− 2549 Position of VEGF Gene, with Diabetic Nephropathy in Type 2 Diabetes Mellitus Patients of North Indian Population. J. Diabetes Metab. Disord. 2015, 14, 1–6. DOI: 10.1186/s40200-015-0144-3.
   PubMedGoogle Scholar
• Ordóñez, A. J.; Carreira, J. M.; Franco, A. G.; Sánchez, L. M.; Alvarez, M. V.; García, E. C. Two Expressive Polymorphisms on the Endothelial Nitric Oxide Synthase Gene (intron4, 27 bp Repeat and− 786 T/C) and the Venous Thromboembolism. Thromb. Res. 2000, 99, 563–566. DOI: 10.1016/S0049-3848(00)00288-7.
   PubMed Web of Science ®Google Scholar
• Choi, K. S.; Cohn, M. J.; Harfe, B. D. Identification of Nucleus Pulposus Precursor Cells and Notochordal Remnants in the Mouse: İmplications for Disk Degeneration and Chordoma Formation. Dev. Dyn. 2008, 237, 3953–3958. DOI: 10.1002/dvdy.21805.
   PubMed Web of Science ®Google Scholar
• Li, Y.-L.; Zhao, H.; Ren, X.-B. Relationship of VEGF/VEGFR with İmmune and Cancer Cells: Staggering or Forward? Cancer Biol. Med. 2016, 13, 206–214. DOI: 10.20892/j.issn.2095-3941.2015.0070.
   PubMed Web of Science ®Google Scholar
• Butt, C.; Lim, S.; Greenwood, C.; Rahman, P. VEGF, FGF1, FGF2 and EGF Gene Polymorphisms and Psoriatic Arthritis. BMC Musculoskelet. Disord. 2007, 8, 1–7. DOI: 10.1186/1471-2474-8-1.
   PubMed Web of Science ®Google Scholar
• Lu, X.-Y.; Ding, X.-H.; Zhong, L.-J.; Xia, H.; Chen, X.-D.; Huang, H. Expression and Significance of VEGF and p53 in Degenerate İntervertebral Disc Tissue. Asian Pac. J. Trop. Med. 2013, 6, 79–81. DOI: 10.1016/S1995-7645(12)60206-5.
   PubMed Web of Science ®Google Scholar
• Lee, J. M.; Song, J. Y.; Baek, M.; Jung, H. Y.; Kang, H.; Han, I. B.; Kwon, Y. D.; Shin, D. E. Interleukin‐1β İnduces Angiogenesis and İnnervation in Human İntervertebral Disc Degeneration. J. Orthop. Res. 2011, 29, 265–269. DOI: 10.1002/jor.21210.
   PubMed Web of Science ®Google Scholar
• David, G.; Ciurea, A.; Iencean, S. M.; Mohan, A. Angiogenesis in the Degeneration of the Lumbar İntervertebral Disc. J. Med. Life. 2010, 3, 154–161.
   PubMedGoogle Scholar
• Brogan, I. J.; Khan, N.; Isaac, K.; Hutchinson, J. A.; Pravica, V.; Hutchinson, I. V. Novel Polymorphisms in the Promoter and 5′ UTR Regions of the Human Vascular Endothelial Growth Factor Gene. Hum. Immunol. 1999, 60, 1245–1249. DOI: 10.1016/S0198-8859(99)00132-9.
   PubMed Web of Science ®Google Scholar
• Kapahi, R.; Manjari, M.; Uppal, M. S.; Singh, N. R.; Sambyal, V.; Guleria, K. Association of− 2549 İnsertion/Deletion Polymorphism of Vascular Endothelial Growth Factor with Breast Cancer in North Indian Patients. Genet. Test. Mol. Biomarkers 2013, 17, 242–248. DOI: 10.1089/gtmb.2012.0222.
   PubMed Web of Science ®Google Scholar
• Bleda, S.; De Haro, J.; Varela, C.; Esparza, L.; Ferruelo, A.; Acin, F. Vascular Endothelial Growth Factor Polymorphisms Are İnvolved in the Late Vascular Complications in Type II Diabetic Patients. Diab. Vasc. Dis. Res. 2012, 9, 68–74. DOI: 10.1177/1479164111426162.
   PubMed Web of Science ®Google Scholar
• Han, S. W.; Kim, G. W.; Seo, J. S.; Kim, S. J.; Sa, K. H.; Park, J. Y.; Lee, J.; Kim, S. Y.; Goronzy, J. J.; Weyand, C. M.; Kang, Y. M. VEGF Gene Polymorphisms and Susceptibility to Rheumatoid Arthritis. Rheumatology (Oxford) 2004, 43, 1173–1177. DOI: 10.1093/rheumatology/keh281.
   PubMed Web of Science ®Google Scholar
• Lv, H-z.; Lin, T.; Xia, L-p.; Shen, H.; Zhu, X-y.; Zhang, J-t.; Xiao, W-g.; Lu, J. Vascular Endothelial Growth Factor Gene Polymorphisms and Rheumatoid Arthritis. J. Investig. Med. 2011, 59, 593–598. DOI: 10.2310/JIM.0b013e31820c9e21.
   PubMed Web of Science ®Google Scholar
• Wang, M.; Zhou, X.; Zhang, H.; Liu, R.; Xu, N. Associations of the VEGF Level, VEGF rs2010963 G/C Gene Polymorphism and Ankylosing Spondylitis Risk in a Chinese Han Population. Immunol. Lett. 2016, 179, 56–60. DOI: 10.1016/j.imlet.2016.09.003.
   PubMed Web of Science ®Google Scholar
• Han, I.; Ropper, A.; Teng, Y.; Shin, D.; Jeon, Y.; Park, H.; Shin, D.; Park, Y.; Kim, K.; Kim, N.-K. Association between VEGF and eNOS Gene Polymorphisms and Lumbar Disc Degeneration in a Young Korean Population. 2013.
   Google Scholar
• Vnukov, V.; Krolevets, I.; Panina, S.; Milyutina, N.; Ananyan, A.; Plotnikov, A.; Zabrodin, M. The Association between NO-Synthase Gene Polymorphisms and the Development of Post-Traumatic Knee Osteoarthritis among Residents of Rostov Region. Russ. J. Genet. Appl. Res. 2017, 7, 197–202. DOI: 10.1134/S2079059717020150.
   Google Scholar
• Brisby, H.; Byröd, G.; Olmarker, K.; Miller, V. M.; Aoki, Y.; Rydevik, B. Nitric Oxide as a Mediator of Nucleus Pulposus‐İnduced Effects on Spinal Nerve Roots. J. Orthop. Res. 2000, 18, 815–820. DOI: 10.1002/jor.1100180520.
   PubMed Web of Science ®Google Scholar
• Kang, J. D.; Georgescu, H. I.; McIntyre-Larkin, L.; Stefanovic-Racic, M.; Donaldson, W. F.; III; Evans, C. H. Herniated Lumbar İntervertebral Discs Spontaneously Produce Matrix Metalloproteinases, Nitric Oxide, İnterleukin-6, and Prostaglandin E2. Spine (Phila Pa 1976) 1996, 21, 271–277.
   PubMed Web of Science ®Google Scholar
• Yan, Q.; Feng, Q.; Beier, F. Endothelial Nitric Oxide Synthase Deficiency in Mice Results in Reduced Chondrocyte Proliferation and Endochondral Bone Growth. Arthritis Rheum. 2010, 62, 2013–2022. DOI: 10.1002/art.27486.
   PubMed Web of Science ®Google Scholar
• Wang, X. L.; Sim, A. S.; Badenhop, R. F.; Mccredie, R. M.; Wilcken, D. E. A Smoking–Dependent Risk of Coronary Artery Disease Associated with a Polymorphism of the Endothelial Nitric Oxide Synthase Gene. Nat. Med. 1996, 2, 41–45. DOI: 10.1038/nm0196-41.
   PubMed Web of Science ®Google Scholar
• Cilenšek, I.; Mankoč, S.; Petrovič, M. G.; Petrovič, D. The 4a/4a Genotype of the VNTR Polymorphism for Endothelial Nitric Oxide Synthase (eNOS) Gene Predicts Risk for Proliferative Diabetic Retinopathy in Slovenian Patients (Caucasians) with Type 2 Diabetes Mellitus. Mol. Biol. Rep. 2012, 39, 7061–7067. DOI: 10.1007/s11033-012-1537-8.
   PubMed Web of Science ®Google Scholar
• Bunjevacki, V.; Maksimovic, N.; Jekic, B.; Milic, V.; Lukovic, L.; Novakovic, I.; Damjanov, N.; Radunovic, G.; Damnjanovic, T. Polymorphisms of the eNOS Gene Are Associated with Disease Activity in Rheumatoid Arthritis. Rheumatol. Int. 2016, 36, 597–602. DOI: 10.1007/s00296-015-3401-3.
   PubMedGoogle Scholar
• Pehlivan, S.; Aydeniz, A.; Sever, T.; Altindag, O.; Pehlivan, M.; Gursoy, S.; Oguzkan-Balci, S. The Functional Variants of Endothelial Nitric Oxide Synthase Gene Associated with Rheumatoid Arthritis in Turkish Adults. Clin. Rheumatol. 2017, 36, 537–540. DOI: 10.1007/s10067-016-3416-5.
   PubMed Web of Science ®Google Scholar
• Sari, I.; Igci, Y. Z.; Can, G.; Taylan, A.; Solmaz, D.; Gogebakan, B.; Akar, S.; Eslik, Z.; Bozkaya, G.; Akkoc, N. Is There a Relationship between Endothelial Nitric Oxide Synthase Gene Polymorphisms and Ankylosing Spondylitis? Clinics 2013, 68, 305–309. DOI: 10.6061/clinics/2013(03)OA04.
   PubMed Web of Science ®Google Scholar