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Research Articles

In vitro galactose impairs energy metabolism in the brain of young rats: protective role of antioxidants

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Pages 967-985 | Received 07 Jun 2022, Accepted 04 Jun 2023, Published online: 15 Jun 2023

References

  • McCorvie, T. J.; Gleason, T. J.; Fridovich-Keil, J. L.; Timson, D. J. Misfolding of Galactose 1-Phosphate Uridylyltransferase Can Result in Type I Galactosemia. Biochim. Biophys. Acta 2013, 1832, 1279–1293. DOI: 10.1016/j.bbadis.2013.04.004.
  • Coelho, A. I.; Trabuco, M.; Ramos, R.; Silva, M. J.; Almeida, I. T. d.; Leandro, P.; Rivera, I.; Vicente, J. B. Functional and Structural Impact of the Most Prevalent Missense Mutations in Classic Galactosemia. Mol. Genet. Genomic. Med. 2014, 2, 484–496. DOI: 10.1002/mgg3.94.
  • Timmers, I.; Jansma, B. M.; Rubio-Gozalbo, M. E. From Mind to Mouth: Event Related Potentials of Sentence Production in Classic Galactosemia. PLoS One 2012, 7, e52826. DOI: 10.1371/journal.pone.0052826.
  • Timson, D. J. The Molecular Basis of Galactosemia—Past, Present and Future. Gene 2016, 589, 133–141. DOI: 10.1016/j.gene.2015.06.077.
  • Ferreira, A. G. K.; Lima, D. D.; Delwing, D.; MacKedanz, V.; Tagliari, B.; Kolling, J.; Schuck, P. F.; Wajner, M.; Wyse, A. T. S. Proline Impairs Energy Metabolism in Cerebral Cortex of Young Rats. Metab. Brain Dis. 2010, 25, 161–168. DOI: 10.1007/s11011-010-9193-y.
  • Scannevin, R. H.; Chollate, S.; Jung, M. Y.; Shackett, M.; Patel, H.; Bista, P.; Zeng, W.; Ryan, S.; Yamamoto, M.; Lukashev, M.; et al. Fumarates Promote Cytoprotection of Central Nervous System Cells against Oxidative Stress via the Nuclear Factor (Erythroid-Derived 2)-like 2 Pathway. J. Pharmacol. Exp. Ther. 2012, 341, 274–284. DOI: 10.1124/jpet.111.190132.
  • Rodrigues, A. F.; Biasibetti, H.; Zanotto, B. S.; Sanches, E. F.; Schmitz, F.; Nunes, V. T.; Pierozan, P.; Manfredini, V.; Magro, D. D. D.; Netto, C. A.; et al. D-Galactose Causes Motor Coordination Impairment, and Histological and Biochemical Changes in the Cerebellum of Rats. Mol. Neurobiol. 2017, 54, 4127–4137. DOI: 10.1007/s12035-016-9981-4.
  • Rodrigues, A. F.; Biasibetti, H.; Zanotto, B. S.; Sanches, E. F.; Pierozan, P.; Schmitz, F.; Nunes, V. T.; Parisi, M. M.; Barbé-Tuana, F.; Netto, C. A.; et al. Intracerebroventricular D-Galactose Administration Impairs Memory and Alters Activity and Expression of Acetylcholinesterase in the Rat. Int. J. Dev. Neurosci. 2016, 50, 1–6. DOI: 10.1016/j.ijdevneu.2016.01.007.
  • Beal, M. F. Does Impairment of Energy Metabolism Result in Excitotoxic Neuronal Death in Neurodegenerative Illnesses? Ann. Neurol. 1992, 31, 119–130. DOI: 10.1002/ana.410310202.
  • Bubber, P.; Haroutunian, V.; Fisch, G.; Blass, J. P.; Gibson, G. E. Mitochondrial Abnormalities in Alzheimer Brain: Mechanistic Implications. Ann. Neurol. 2005, 57, 695–703. DOI: 10.1002/ana.20474.
  • Erecińska, M.; Silver, I. A. Ions and Energy in Mammalian Brain. Prog. Neurobiol. 1994, 43, 37–71. DOI: 10.1016/0301-0082(94)90015-9.
  • Nunomura, A.; Castellani, R. J.; Zhu, X.; Moreira, P. I.; Perry, G.; Smith, M. A. Involvement of Oxidative Stress in Alzheimer Disease. J. Neuropathol. Exp. Neurol. 2006, 65, 631–641. DOI: 10.1097/01.jnen.0000228136.58062.bf.
  • Gitzelmann, R. Galactose-1-Phosphate in the Pathophysiology of Galactosemia. Eur. J. Pediatr. 1995, 154, S45–S49. DOI: 10.1007/BF02143803.
  • Avrova, N. F.; Shestak, K. I.; Zakharova, I. O.; Sokolova, T. V.; Leont’ev, V. G. The Difference in the Effect of Glutamate and NO Synthase Inhibitor on Free Calcium Concentration and Na+,K+-ATPase Activity in Synaptosomes from Various Brain Regions. Neurochem. Res. 1999, 24, 1101–1106. DOI: 10.1023/a:1020752101736.
  • Delwing, D.; Tagliari, B.; Chiarani, F.; Wannmacher, C. M. D.; Wajner, M.; De Souza Wyse, A. T. α-Tocopherol and Ascorbic Acid Administration Prevents the Impairment of Brain Energy Metabolism of Hyperargininemic Rats. Cell. Mol. Neurobiol. 2006, 26, 177–189. DOI: 10.1007/s10571-006-9022-3.
  • Da Silva, C. G.; Bueno, A. R. F.; Schuck, P. F.; Leipnitz, G.; Ribeiro, C. A. J.; Rosa, R. B.; Dutra Filho, C. S.; Wyse, A. T. S.; Wannmacher, C. M. D.; Wajner, M. Inhibition of Creatine Kinase Activity from Rat Cerebral Cortex by D-2-Hydroxyglutaric Acid in Vitro. Neurochem. Int. 2004, 44, 45–52. DOI: 10.1016/S0197-0186(03)00098-6.
  • Leong, S. F.; Lai, J. C.; Lim, L.; Clark, J. B. Energy-Metabolising Enzymes in Brain Regions of Adult and Aging Rats. J. Neurochem. 1981, 37, 1548–1556. DOI: 10.1111/j.1471-4159.1981.tb06326.x.
  • Fischer, J. C.; Ruitenbeek, W.; Berden, ‘J. A.; Trijbels, ‘J. M. F.; Veerkamp, ‘J. H.; Stadhouders, ‘A. M.; Sengers, R. C. A.; Janssen, A. J. M. Differential Investigation of the Capacity of Succinate Oxidation in Human Skeletal Muscle. Clin. Chim. Acta 1985, 153, 23–36. DOI: 10.1016/0009-8981(85)90135-4.
  • Rustin, P.; Chretien, D.; Bourgeron, T.; Gérard, B.; Rötig, A.; Saudubray, J. M.; Munnich, A. Biochemical and Molecular Investigations in Respiratory Chain Deficiencies. Clin. Chim. Acta 1994, 228, 35–51. DOI: 10.1016/0009-8981(94)90055-8.
  • Wyse, A. T. S.; Brusque, A. M.; Silva, C. G.; Streck, E. L.; Wajner, M.; Wannmacher, C. Inhibition of Na+,K+-ATPase from Rat Brain Cortex by Propionic Acid. Neuroreport 1998, 9, 1719–1721. DOI: 10.1097/00001756-199806010-00009.
  • Chan, M.-K.; Delfert, D.; Junger, A. K. D. A Direct Calorimetric Assay for Ca2+-Stimulated ATPase Activity. Anal. Biochem. 1986, 157, 375–380. DOI: 10.1016/0003-2697(86)90640-8.
  • Lowry, O. H.; Rosebrough, N. J.; Farr, A. L.; Randall, R. J. Protein Measurement with the Folin Phenol Reagent. J. Biol. Chem. 1951, 193, 265–275. DOI: 10.1016/s0021-9258(19)52451-6.
  • Delwing, D.; Delwing De Lima, D.; Scolaro, B.; Kuss, G. G.; Cruz, J. G. P.; Wyse, A. T. S. Protective Effect of Antioxidants on Cerebrum Oxidative Damage Caused by Arginine on Pyruvate Kinase Activity. Metab. Brain Dis. 2009, 24, 469–479. DOI: 10.1007/s11011-009-9152-7.
  • Rosa Feksa, L.; Renata Cornelio, A.; Regla Vargas, C.; Terezinha de Souza Wyse, A.; Severo Dutra-Filho, C.; Wajner, M.; Milton Duval Wannmacher, C. Alanine Prevents the Inhibition of Pyruvate Kinase Activity Caused by Tryptophan in Cerebral Cortex of Rats. Metab. Brain Dis. 2003, 18, 129–137. DOI: 10.1023/a:1023811019023.
  • Delwing-de Lima, D.; Fröhlich, M.; Dalmedico, L.; Aurélio, J. G. M.; Delwing-Dal Magro, D.; Pereira, E. M.; Wyse, A. T. S. Galactose Alters Markers of Oxidative Stress and Acetylcholinesterase Activity in the Cerebrum of Rats: Protective Role of Antioxidants. Metab. Brain Dis. 2017, 32, 359–368. DOI: 10.1007/s11011-016-9915-x.
  • Armstrong, J. S. Mitochondrial Medicine: Pharmacological Targeting of Mitochondria in Disease. Br. J. Pharmacol. 2007, 151, 1154–1165. DOI: 10.1038/sj.bjp.0707288.
  • de Souza Wyse, A. T.; Streck, E. L.; Worm, P.; Wajner, A.; Ritter, F.; Netto, C. A. Preconditioning Prevents the Inhibition of Na +, K +-ATPase Activity after Brain Ischemia. Neurochem. Res. 2000, 25, 971–975. DOI: 10.1023/a:10075045253012000.
  • Delwing, D.; Delwing, D.; Sanna, R. J.; Wofchuk, S.; Wyse, A. T. S. Proline Promotes Decrease in Glutamate Uptake in Slices of Cerebral Cortex and Hippocampus of Rats. Life Sci. 2007, 81, 1645–1650. DOI: 10.1016/j.lfs.2007.09.031.
  • Wyse, A. T.; Bavaresco, C. S.; Bandinelli, C.; Streck, E. L.; Franzon, R.; Dutra-Filho, C. S.; Wajner, M. Nitric Oxide Synthase Inhibition by L-NAME Prevents the Decrease of Na+,K+-ATPase Activity in Midbrain of Rats Subjected to Arginine Administration. Neurochem. Res. 2001, 26, 515–520. DOI: 10.1023/a:1010912929042.
  • Wu, G.; Fang, Y.-Z.; Yang, S.; Lupton, J. R.; Turner, N. D. Glutathione metabolism and its implications for health. J Nutr. 2004, 134, 489–92. DOI: 10.1093/jn/134.3.489.
  • Delwing, D.; Delwing, D.; Bavaresco, C. S.; Wyse, A. T. S. Protective Effect of Nitric Oxide Synthase Inhibition or Antioxidants on Brain Oxidative Damage Caused by Intracerebroventricular Arginine Administration. Brain Res. 2008, 1193, 120–127. DOI: 10.1016/j.brainres.2007.11.052.
  • Delwing, D.; Delwing, D.; Chiarani, F.; Kurek, A. G.; Wyse, A. T. S. Proline Reduces Brain Cytochrome c Oxidase: Prevention by Antioxidants. Int. J. Dev. Neurosci. 2007, 25, 17–22. DOI: 10.1016/j.ijdevneu.2006.11.005.
  • Delwing, D.; Tagliari, B.; Streck, E. L.; Wannamacher, C. M. D.; Wajner, M.; Wyse, A. T. D. S. Reduction of Energy Metabolism in Rat Hippocampus by Arginine Administration. Brain Res. 2003, 983, 58–63. DOI: 10.1016/S0006-8993(03)03029-4.
  • Streck, E. L.; Matté, C.; Vieira, P. S.; Calcagnotto, T.; Wannmacher, C. M. D.; Wajner, M.; Wyse, A. T. S. Impairment of Energy Metabolism in Hippocampus of Rats Subjected to Chemically-Induced Hyperhomocysteinemia. Biochim. Biophys. Acta 2003, 1637, 187–192. DOI: 10.1016/S0925-4439(03)00019-X.
  • Schmitz, F.; Pierozan, P.; Rodrigues, A. F.; Biasibetti, H.; Coelho, D. M.; Mussulini, B. H.; Pereira, M. S. L.; Parisi, M. M.; Barbé-Tuana, F.; de Oliveira, D. L.; et al. Chronic Treatment with a Clinically Relevant Dose of Methylphenidate Increases Glutamate Levels in Cerebrospinal Fluid and Impairs Glutamatergic Homeostasis in Prefrontal Cortex of Juvenile Rats. Mol. Neurobiol. 2016, 53, 2384–2396. DOI: 10.1007/s12035-015-9219-x.
  • Young, I. S.; Woodside, J. V. Antioxidants in Health and Disease. J. Clin. Pathol. 2001, 54, 176–186. DOI: 10.1136/jcp.54.3.176.
  • Al-Aubaidy, H. A.; Jelinek, H. F. Oxidative DNA Damage and Obesity in Type 2 Diabetes Mellitus. Eur. J. Endocrinol. 2011, 164, 899–904. DOI: 10.1530/EJE-11-0053.
  • Vázquez-Meza, H.; Vilchis-Landeros, M. M.; Melissa Vázquez-Carrada, M.; Uribe-Ramírez, D.; Matuz-Mares, D. Cellular Compartmentalization, Glutathione Transport and Its Relevance in Some Pathologies. Antioxidants 2023, 12, 834. DOI: 10.3390/antiox12040834.
  • Castro, M. B.; Ferreira, B. K.; Cararo, J. H.; Chipindo, A. E.; Magenis, M. L.; Michels, M.; Danielski, L. G.; de Oliveira, M. R.; Ferreira, G. C.; Streck, E. L.; et al. Evidence of Oxidative Stress in Brain and Liver of Young Rats Submitted to Experimental Galactosemia. Metab. Brain Dis. 2016, 31, 1381–1390. DOI: 10.1007/s11011-016-9865-3.
  • Ng, Y.-C.; Akera, T.; Han, I. C.-S.; Braselton, W. E.; Kennedy, R. H.; Temma, K.; Brody, T. M.; Sato, P. H. Ascorbic Acid: An Endogenous Inhibitor of Isolated Na+,K+-ATPase. Biochem. Pharmacol. 1985, 34, 2525–2530. DOI: 10.1016/0006-2952(85)90537-4.
  • Tsakiris, S.; Schulpis, K. H.; Marinou, K.; Behrakis, P. Protective Effect of L-Cysteine and Glutathione on the Modulated Suckling Rat Brain Na+,K+-ATPase and Mg2+-ATPase Activities Induced by the in Vitro Galactosaemia. Pharmacol. Res. 2004, 49, 475–479. DOI: 10.1016/j.phrs.2003.11.006.

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