Association between TLR2, TLR4, and TLR5 genetic variants and the risk of hepatocellular carcinoma in Moroccan population

References

• Ge, X.-Y.; Sun, M.-C.; Wang, T.-Y.; Wang, X.-M.; Liu, G.; Yang, T.; Lu, Y.-M.; Wang, W. Analysis of Risk Factors of Hepatocellular Carcinoma and Establishment of a Clinical Prognosis Model. Front. Oncol 2023, 13, 1067353. DOI: 10.3389/fonc.2023.1067353.
   PubMed Web of Science ®Google Scholar
• Abounouh, K.; Aitraise, I.; Benabou, A.; Boussakri, I.; Doumir, M. A.; El Boussairi, C.; El Idrissi, S.; El Mahdaoui, C.; Qouar, D. E.; Ennahal, A.; et al. Virus-Associated Human Cancers in Moroccan Population: From Epidemiology to Prospective Research. Infect. Genet. Evol. 2019, 75, 103990. DOI: 10.1016/j.meegid.2019.103990.
   PubMed Web of Science ®Google Scholar
• https://gco.iarc.fr/today/data/factsheets/populations/504-morocco-fact-sheets.pdf.
   Google Scholar
• Sung, H.; Ferlay, J.; Siegel, R. L.; Laversanne, M.; Soerjomataram, I.; Jemal, A.; Bray, F. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J. Clin. 2021, 71, 209–249. DOI: 10.3322/caac.21660.
   PubMed Web of Science ®Google Scholar
• Bahri, O.; Ezzikouri, S.; Alaya-Bouafif, N. B.; Iguer, F.; Feydi, A. E.; Mestiri, H.; Benazzouz, M.; Khalfallah, T.; Afifi, R.; Elkihal, L.; et al. First Multicenter Study for Risk Factors for Hepatocellular Carcinoma Development in North Africa. World J. Hepatol. 2011, 3, 24–30. DOI: 10.4254/wjh.v3.i1.24.
   PubMedGoogle Scholar
• Llovet, J. M.; Zucman-Rossi, J.; Pikarsky, E.; Sangro, B.; Schwartz, M.; Sherman, M.; Gores, G. Hepatocellular Carcinoma. Nat. Rev. Dis. Primers 2016, 2, 16018. DOI: 10.1038/nrdp.2016.18.
   PubMed Web of Science ®Google Scholar
• Beutler, B. A. TLRs and Innate Immunity. Blood 2009, 113, 1399–1407. DOI: 10.1182/blood-2008-07-019307.
   PubMed Web of Science ®Google Scholar
• Aderem, A.; Ulevitch, R. J. Toll-like Receptors in the Induction of the Innate Immune Response. Nature 2000, 406, 782–787. DOI: 10.1038/35021228.
   PubMed Web of Science ®Google Scholar
• Du, B.; Jiang, Q.-L.; Cleveland, J.; Liu, B.-R.; Zhang, D. Targeting Toll-like Receptors against Cancer. JCMT 2016, 2, 463–470. DOI: 10.20517/2394-4722.2016.62.
   Google Scholar
• Kawasaki, T.; Kawai, T. Toll-like Receptor Signaling Pathways. Front. Immunol. 2014, 5, 461. DOI: 10.3389/fimmu.2014.00461.
   PubMed Web of Science ®Google Scholar
• Hayashi, F.; Smith, K. D.; Ozinsky, A.; Hawn, T. R.; Yi, E. C.; Goodlett, D. R.; Eng, J. K.; Akira, S.; Underhill, D. M.; Aderem, A. The Innate Immune Response to Bacterial Flagellin is Mediated by Toll-like Receptor 5. Nature 2001, 410, 1099–1103. DOI: 10.1038/35074106.
   PubMed Web of Science ®Google Scholar
• Oliveira-Nascimento, L.; Massari, P.; Wetzler, L. M. The Role of TLR2 in Infection and Immunity. Front. Immunol. 2012, 3, 79. DOI: 10.3389/fimmu.2012.00079.
   PubMed Web of Science ®Google Scholar
• Sepehri, Z.; Kiani, Z.; Kohan, F.; Alavian, S. M.; Ghavami, S. Toll like Receptor 4 and Hepatocellular Carcinoma; a Systematic Review. Life Sci 2017, 179, 80–87. DOI: 10.1016/j.lfs.2017.04.025.
   PubMed Web of Science ®Google Scholar
• Yang, J.; Yan, H. TLR5: Beyond the Recognition of Flagellin. Cell Mol. Immunol. 2017, 14, 1017–1019. DOI: 10.1038/cmi.2017.122.
   PubMed Web of Science ®Google Scholar
• Kim, H. M.; Park, B. S.; Kim, J. I.; Kim, S. E.; Lee, J.; Oh, S. C.; Enkhbayar, P.; Matsushima, N.; Lee, H.; Yoo, O. J.; Lee, J. O. Crystal Structure of the TLR4-MD-2 Complex with Bound Endotoxin Antagonist Eritoran. Cell 2007, 130, 906–917. DOI: 10.1016/j.cell.2007.08.002.
   PubMed Web of Science ®Google Scholar
• Piao, W.; Ru, L. W.; Piepenbrink, K. H.; Sundberg, E. J.; Vogel, S. N.; Toshchakov, V. Y. Recruitment of TLR Adapter TRIF to TLR4 Signaling Complex is Mediated by the Second Helical Region of TRIF TIR Domain. Proc. Natl. Acad. Sci. U S A 2013, 110, 19036–19041. DOI: 10.1073/pnas.1313575110.
   PubMed Web of Science ®Google Scholar
• Wang, Y.; Song, E.; Bai, B.; Vanhoutte, P. M. Toll-like Receptors Mediating Vascular Malfunction: Lessons from Receptor Subtypes. Pharmacol. Ther. 2016, 158, 91–100. DOI: 10.1016/j.pharmthera.2015.12.005.
   PubMed Web of Science ®Google Scholar
• Shen, Y.; Liu, Y.; Liu, S.; Zhang, A. Toll-like Receptor 4 Gene Polymorphisms and Susceptibility to Bladder Cancer. Pathol. Oncol. Res. 2013, 19, 275–280. DOI: 10.1007/s12253-012-9579-8.
   PubMed Web of Science ®Google Scholar
• Cheng, I.; Plummer, S. J.; Casey, G.; Witte, J. S. Toll-like Receptor 4 Genetic Variation and Advanced Prostate Cancer Risk. Cancer Epidemiol. Biomarkers Prev. 2007, 16, 352–355. DOI: 10.1158/1055-9965.EPI-06-0429.
   PubMed Web of Science ®Google Scholar
• Yang, C. X.; Li, C. Y.; Feng, W. Toll-like Receptor 4 Genetic Variants and Prognosis of Breast Cancer. Tissue Antigens 2013, 81, 221–226. DOI: 10.1111/tan.12096.
   PubMedGoogle Scholar
• Semlali, A.; Jalouli, M.; Parine, N. R.; Al Amri, A.; Arafah, M.; Al Naeem, A.; Abdullah Ajaj, S.; Rouabhia, M.; Alanazi, M. S. Toll-like Receptor 4 as a Predictor of Clinical Outcomes of Estrogen Receptor-Negative Breast Cancer in Saudi Women. Onco Targets Ther 2017, 10, 1207–1216. DOI: 10.2147/OTT.S112165.
   PubMed Web of Science ®Google Scholar
• Shi, D.; Zhao, S.; Jiang, W.; Zhang, C.; Liang, T.; Hou, G. TLR5: A Prognostic and Monitoring Indicator for Triple-Negative Breast Cancer. Cell Death Dis. 2019, 10, 954. DOI: 10.1038/s41419-019-2187-8.
   PubMed Web of Science ®Google Scholar
• Gast, A.; Bermejo, J. L.; Claus, R.; Brandt, A.; Weires, M.; Weber, A.; Plass, C.; Sucker, A.; Hemminki, K.; Schadendorf, D.; Kumar, R. Association of Inherited Variation in Toll-like Receptor Genes with Malignant Melanoma Susceptibility and Survival. PLoS One 2011, 6, e24370. DOI: 10.1371/journal.pone.0024370.
   PubMed Web of Science ®Google Scholar
• Doan, H. Q.; Bowen, K. A.; Jackson, L. A.; Evers, B. M. Toll-like Receptor 4 Activation Increases Akt Phosphorylation in Colon Cancer Cells. Anticancer Res. 2009, 29, 2473–2478.
   PubMed Web of Science ®Google Scholar
• Weber, A. N.; Försti, A. Toll-like Receptor Genetic Variants and Colorectal Cancer. Oncoimmunology 2014, 3, e27763. DOI: 10.4161/onci.27763.
   PubMed Web of Science ®Google Scholar
• He, B.; Xu, T.; Pan, B.; Pan, Y.; Wang, X.; Dong, J.; Sun, H.; Xu, X.; Liu, X.; Wang, S. Polymorphisms of TGFBR1, TLR4 Are Associated with Prognosis of Gastric Cancer in a Chinese Population. Cancer Cell Int. 2018, 18, 191. DOI: 10.1186/s12935-018-0682-0.
   PubMed Web of Science ®Google Scholar
• Huang, L.; Yuan, K.; Liu, J.; Ren, X.; Dong, X.; Tian, W.; Jia, Y. Polymorphisms of the TLR4 Gene and Risk of Gastric Cancer. Gene 2014, 537, 46–50. DOI: 10.1016/j.gene.2013.12.030.
   PubMed Web of Science ®Google Scholar
• Xiao, W.; Liu, Z.; Lin, J.; Xiong, C.; Li, J.; Wu, K.; Ma, Y.; Gong, Y.; Liu, Z. Association of TLR4 and TLR5 Gene Polymorphisms with Graves’ Disease in Chinese Cantonese Population. Hum. Immunol. 2014, 75, 609–613. DOI: 10.1016/j.humimm.2014.05.001.
   PubMed Web of Science ®Google Scholar
• Wen, S. J.; Wu, F. Y.; Fang, L.; Liu, H.; Zheng, W. J.; Lin, Y. K. Associations of Genetic Polymorphisms of TLR5, TLR9 and Transduction Molecules in MyD88 Signaling Pathway with Systemic Lupus Erythematosus in Zhuang and Han Ethnics of Guangxi Province, China. Int. J. Clin. Exp. Med. 2015, 8, 7872–7880.
   PubMed Web of Science ®Google Scholar
• Bank, S.; Andersen, P. S.; Burisch, J.; Pedersen, N.; Roug, S.; Galsgaard, J.; Turino, S. Y.; Brodersen, J. B.; Rashid, S.; Rasmussen, B. K.; et al. Genetically Determined High Activity of IL-12 and IL-18 in Ulcerative Colitis and TLR5 in Crohns Disease Were Associated with Non-Response to anti-TNF Therapy. Pharmacogenomics J. 2018, 18, 87–97. DOI: 10.1038/tpj.2016.84.
   PubMed Web of Science ®Google Scholar
• Agúndez, J. A.; García-Martín, E.; Devesa, M. J.; Carballo, M.; Martínez, C.; Lee-Brunner, A.; Fernández, C.; Díaz-Rubio, M.; Ladero, J. M. Polymorphism of the TLR4 Gene Reduces the Risk of Hepatitis C Virus-Induced Hepatocellular Carcinoma. Oncology 2012, 82, 35–40. DOI: 10.1159/000335606.
   PubMed Web of Science ®Google Scholar
• Salum, G. M.; Dawood, R. M.; Abd El-Meguid, M.; Ibrahim, N. E.; Abdel Aziz, A. O.; El Awady, M. K. Correlation between IL28B/TLR4 Genetic Variants and HCC Development with/without DAAs Treatment in Chronic HCV Patients. Genes Dis. 2020, 7, 392–400. DOI: 10.1016/j.gendis.2019.05.004.
   PubMed Web of Science ®Google Scholar
• Zhang, Y. Q.; Peng, L. J.; Cao, Y. R.; Zeng, Z. P.; Wu, Y. J.; Shi, H.; Cheng, S. Y.; Wang, J. Y.; Friedman, S. L.; Sninsky, J. J.; Guo, J. S. Risk Factors for Hepatocellular Carcinoma in Cirrhotic Patients with Chronic Hepatitis B. Genet Test Mol. Biomarkers 2016, 20, 535–543. DOI: 10.1089/gtmb.2016.0062.
   PubMed Web of Science ®Google Scholar
• Al-Qahtani, A. A.; Al-Anazi, M. R.; Al-Zoghaibi, F.; Abdo, A. A.; Sanai, F. M.; Khan, M. Q.; Albenmousa, A.; Al-Ashgar, H. I.; Al-Ahdal, M. N. The Association of Toll-like Receptor 4 Polymorphism with Hepatitis C Virus Infection in Saudi Arabian Patients. Biomed. Res. Int. 2014, 2014, 357062. DOI: 10.1155/2014/357062.
   PubMed Web of Science ®Google Scholar
• Bruix, J.; Sherman, M. American Association for the Study of Liver Diseases. Management of Hepatocellular Carcinoma: An Update. Hepatology 2011, 53, 1020–1022. DOI: 10.1002/hep.24199.
   PubMed Web of Science ®Google Scholar
• Ezzikouri, S.; El Feydi, A. E.; Chafik, A.; Afifi, R.; El Kihal, L.; Benazzouz, M.; Hassar, M.; Pineau, P.; Benjelloun, S. Genetic Polymorphism in the Manganese Superoxide Dismutase Gene is Associated with an Increased Risk for Hepatocellular Carcinoma in HCV-Infected Moroccan Patients. Mutat. Res. 2008, 649, 1–6. DOI: 10.1016/j.mrgentox.2007.05.019.
   PubMed Web of Science ®Google Scholar
• Solé, X.; Guinó, E.; Valls, J.; Iniesta, R.; Moreno, V. SNPStats: A Web Tool for the Analysis of Association Studies. Bioinformatics 2006, 22, 1928–1929. DOI: 10.1093/bioinformatics/btl268.
   PubMed Web of Science ®Google Scholar
• Ezzikouri, S.; El Feydi, A. E.; Chafik, A.; Benazzouz, M.; El Kihal, L.; Afifi, R.; Hassar, M.; Pineau, P.; Benjelloun, S. The Pro Variant of the p53 Codon 72 Polymorphism is Associated with Hepatocellular Carcinoma in Moroccan Population. Hepatol. Res. 2007, 37, 748–754. DOI: 10.1111/j.1872-034X.2007.00126.x.
   PubMed Web of Science ®Google Scholar
• Ezzikouri, S.; El Feydi, A. E.; Benazzouz, M.; Afifi, R.; El Kihal, L.; Hassar, M.; Akil, A.; Pineau, P.; Benjelloun, S. Single Nucleotide Polymorphism in DNMT3B Promoter and Its Association with Hepatocellular Carcinoma in a Moroccan Population. Infect. Genet. Evol. 2009, 9, 877–881. DOI: 10.1016/j.meegid.2009.05.012.
   PubMed Web of Science ®Google Scholar
• Ezzikouri, S.; El Feydi, A. E.; Afifi, R.; El Kihal, L.; Benazzouz, M.; Hassar, M.; Marchio, A.; Pineau, P.; Benjelloun, S. MDM2 SNP309T > G Polymorphism and Risk of Hepatocellular Carcinoma: A Case-Control Analysis in a Moroccan Population. Cancer Detect. Prev. 2009, 32, 380–385. DOI: 10.1016/j.cdp.2009.01.003.
   PubMedGoogle Scholar
• Rebbani, K.; Ezzikouri, S.; Marchio, A.; Kandil, M.; Pineau, P.; Benjelloun, S. MDM2 285G > C and 344T > a Gene Variants and Their Association with Hepatocellular Carcinoma: A Moroccan Case-Control Study. Infect Agent Cancer 2014, 9, 11.
   PubMed Web of Science ®Google Scholar
• Rebbani, K.; Marchio, A.; Ezzikouri, S.; Afifi, R.; Kandil, M.; Bahri, O.; Triki, H.; El Feydi, A. E.; Dejean, A.; Benjelloun, S.; Pineau, P. TP53 R72P Polymorphism Modulates DNA Methylation in Hepatocellular Carcinoma. Mol. Cancer 2015, 14, 74. DOI: 10.1186/s12943-015-0340-2.
   PubMed Web of Science ®Google Scholar
• Neamatallah, M.; El-Bendary, M.; Elalfy, H.; Besheer, T.; El-Maksoud, M. A.; Elhammady, D.; Abed, S.; Elegezy, M.; Kandeel, L.; Eldeib, D.; et al. Impact of Toll-like Receptors 2(TLR2) and TLR 4 Gene Variations on HCV Susceptibility, Response to Treatment and Development of Hepatocellular Carcinoma in Cirrhotic HCV Patients. Immunol. Invest. 2020, 49, 462–476. DOI: 10.1080/08820139.2019.1673772.
   PubMed Web of Science ®Google Scholar
• Semlali, A.; Almutairi, M.; Parine, N. R.; Al Amri, A.; Shaik, J. P.; Al Naeem, A.; Abdulla Ajaj, S.; Rouabhia, M.; Alanazi, M. S. No Genetic Relationship between TLR2 rs4696480, rs3804100, and rs3804099 Gene Polymorphisms and Female Breast Cancer in Saudi Populations. Onco Targets Ther. 2017, 10, 2325–2333. DOI: 10.2147/OTT.S121618.
   PubMed Web of Science ®Google Scholar
• Sghaier, I.; Zidi, S.; Mouelhi, L.; Ghazoueni, E.; Brochot, E.; Almawi, W. Y.; Loueslati, B. Y. TLR3 and TLR4 SNP Variants in the Liver Disease Resulting from Hepatitis B Virus and Hepatitis C Virus Infection. Br. J. Biomed. Sci. 2019, 76, 35–41. DOI: 10.1080/09674845.2018.1547179.
   PubMed Web of Science ®Google Scholar
• Zhou, L.; Wei, B.; Xing, C.; Xie, H.; Yu, X.; Wu, L.; Zheng, S. Polymorphism in 3'-Untranslated Region of Toll-like Receptor 4 Gene is Associated with Protection from Hepatitis B Virus Recurrence after Liver Transplantation. Transpl. Infect. Dis. 2011, 13, 250–258. DOI: 10.1111/j.1399-3062.2010.00574.x.
   PubMed Web of Science ®Google Scholar
• Duan, Z. X.; Zhu, P. F.; Dong, H.; Gu, W.; Yang, C.; Liu, Q.; Wang, Z. G.; Jiang, J. X. Functional Significance of the TLR4/11367 Polymorphism Identified in Chinese Han Population. Shock 2007, 28, 160–164. DOI: 10.1097/SHK.0b013e31803df782.
   PubMed Web of Science ®Google Scholar
• Katrinli, S.; Nigdelioglu, A.; Ozdil, K.; Dinler-Doganay, G.; Doganay, L. The Association of Variations in TLR Genes and Spontaneous Immune Control of Hepatitis B Virus. Clin. Res. Hepatol. Gastroenterol. 2018, 42, 139–144. DOI: 10.1016/j.clinre.2017.10.002.
   PubMed Web of Science ®Google Scholar
• Cao, L.; Zhang, T.; Zhu, J.; Li, A.; Zheng, K.; Zhang, N.; Su, B.; Xia, W.; Wu, H.; Li, N.; He, Q. Polymorphism of TLR5 rs5744174 is Associated with Disease Progression in Chinese Patients with Chronic HBV Infection. APMIS 2017, 125, 708–716. DOI: 10.1111/apm.12707.
   PubMed Web of Science ®Google Scholar