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Original Articles

Acid-Mediated Cleavage oF Oligonucleotide P3′ → N5′ Phosphoramidates Triggered by Sequence-Specific Triplex Formation

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Pages 893-896 | Published online: 10 Dec 2007

REFERENCES

  • Bannwarth , W. 1988 . Solid-phase synthesis of oligodeoxynucleotides containing phosphoramidate internucleotide linkages and their specific chemical cleavage . Helv. Chim. Acta , 71 : 1517 – 1527 .
  • Shchepinov , M. S. , Denissenko , M. F. , Smylie , K. J. , Wörl , R. J. , Leppin , A. L. , Cantor , C. R. and Rodi , C. P. 2001 . Matrix-induced fragmentation of P3′ -N5′ phosphoramidate-containing DNA: high-throughput MALDI-TOF analysis of genomic sequence polymorphisms . Nucleic Acids Res. , 29 : 3864 – 3872 .
  • Wolfe , J. L. , Wang , B. H. , Kawate , T. and Stanton , V. P. Jr. 2003 . Sequence-specific dinucleotide cleavage promoted by synergistic interactions between neighboring modified nucleotides in DNA . J. Am. Chem. Soc. , 125 : 10500 – 10501 .
  • Gryaznov , S. M. and Letsinger , R. L. 1992 . Synthesis and properties of oligonucleotides containing aminodeoxythymidine units . Nucleic Acids Res. , 20 : 3403 – 3409 .
  • Obika , S. , Nakagawa , O. , Hiroto , A. , Hari , Y. and Imanishi , T. 2003 . Synthesis and properties of a novel bridged nucleic acid with a P3′ →N5′ phosphoramidate linkage, 5′ -amino-2′, 4′ -BNA . Chem. Commun. , : 2202 – 2203 .
  • Benkovic , S. J. and Sampson , E. J. 1971 . Structure—reactivity correlation for the hydrolysis of phosphoramidate monoanions . J. Am. Chem. Soc. , 93 : 4009 – 4016 .
  • Synthesis of these nucleoside and oligonucleotide derivatives will be published elsewhere

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