Synthesis of Modified Nucleosides for Incorporation of Formyletheno and Carboxyetheno Adducts of Adenine Nucleosides into Oligonucleotides

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• Compd. 2 1H NMR (CDCl3) 7.98 (H-5, s, 1H), 7.83 (H-2, s, 1H), 7.20–7.35 (DMTr, m, 9H), 6.85 (H-8, s, 1H), 6.69-6.77 (DMTr, m, 4H), 6.30 (H-1, dd, J = 8.0 and 5.6 Hz, 1H), 5.35 [-CH(OAc)-CH(OAc)Me, m, 1H], 4.27 [H-3 & -CH(OAc)-CH(OAc)Me, m, 2H), 3.99 (H-4, m, 1H), 3.71 (2 × OMe, s, 6H,), 2.88 (H-5′ & H-5″, m, 2H), 2.51 (H-2′ & H-2″, m, 2H), 2.04 & 2.00 (2 × Ac, s, 2 × 3H), 1.18 (s, 3H, Me)
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