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Proceedings of the 12th International Symposium on Purine and Pyrimidine Metabolism in Man (PP07)

5-Bromovinyl 2′-Deoxyuridine Phosphorylation by Mitochondrial and Cytosolic Thymidine Kinase (TK2 and TK1) and Its Use in Selective Measurement of TK2 Activity in Crude Extracts

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Pages 858-862 | Published online: 03 Jul 2008

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  • Wang , L. , Munch-Petersen , B. , Herrström Sjöberg , A. , Hellman , U. Bergman , T. 1999 . Human thymidine kinase 2: molecular cloning and characterisation of the enzyme activity with antiviral and cytostatic nucleoside substrates . FEBS Lett. , 443 : 170 – 174 .
  • Eriksson , S. , Wang , J. , Gronowitz , S. and Johansson , N. G. 1995 . Substrate specificities of mitochondrial thymidine kinase and cytosolic deoxycytidine kinase against 5-aryl substituted pyrimidine 2′-deoxyribose analogues . Nucleosides Nucleotides , 14 : 507 – 510 .
  • Desgranges , C. , Razaka , G. , Rabaud , M. , Bricaud , H. , Balzarini , J. and De Clercq , E. 1983 . Phosphorolysis of (E)-5-(2-bromovinyl)-2′-deoxyuridine (BVDU) and other 5-substituted-2′-deoxyuridines by purified human thymidine phosphorylase and intact blood platelets . Biochem. Pharmacol. , 32 : 3583 – 3590 .

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