Synthesis of Quinazoline C-Nucleosides: A New Class of 6:6 Bicyclic Purine-Like Analogues.¹

References

• Support of this investigation by NIH grant CA24634 and the Cancer Center Support Grant CA13330 is gratefully aknowledged.
   Google Scholar
• Tam , S. Y-K. , Klein , R. S. , Wempen , I. and Fox , J. J. 1979 . Synthesis of Some New Pyrazolo[1,5-a]-1,3,5-triazines and their C-nucleosides. . J. Org. Chem. , 44 : 4547 – 4553 .
   Web of Science ®Google Scholar
• Lim , M-I. , Klein , R. S. and Fox , J. J. 1980 . Synthesis of the Pyrrolo-[3,2-d]pyrimidine C-Nucleoside Isostere of Inosine. . Tetrahedron Lett. , 21 : 1013 – 1016 .
   Web of Science ®Google Scholar
• Lim , M-I. and Klein , R. S. 1981 . Synthesis of 9-Deazaadenosine a New Cytotoxic C-Nucleoside Isostere of Adenosine. . Tetrahedron Lett. , 22 : 25 – 28 .
   Web of Science ®Google Scholar
• Battacharya , B. K. , Otter , B. A. , Berens , R. L. and Klein , R. S. 1990 . Studies on the Synthesis of Furo[3,2-d]Pyrimidine C-Nucleosides: New Inosine Analogues with Antiprotozoan Activity. . Nucleosides & Nucleotides , 9 ( 8 ) : 1021 – 1043 .
   Google Scholar
• Ren , W-Y. , Lim , M-I. , Otter , B. A. and Klein , R. S. 1982 . Synthetic Studies of the Thieno[3,2-d]pyrimidine C-Nucleoside Isostere of Inosine. . J. Org. Chem. , 47 : 4633 – 4637 .
   Web of Science ®Google Scholar
• Patil , S. A. , Otter , B. A. and Klein , R. S. 1993 . Synthesis of Some New Thieno[3,4-d]pyrimidines and their C-Nucleosides. . J. Heterocyclic Chem. , 30 : 509 – 515 .
   Google Scholar
• Patil , S. A. , Otter , B. A. and Klein , R. S. 4-Aza-7,9-Dideazaadenosine, a New Cytotoxic Synthetic C-Nucleoside Analogue of Adenosine. . Tetrahedron Lett. , In Press.
   Google Scholar
• Wamhoff , H. , Berressem , R. and Nieger , M. 1994 . Efficient Synthesis of Fused Isothiazole C-Nucleosides. 2. Synthesis of 8-Aza-7,9-deaza-7-thiaguanosine and 8-Aza-7,9-deaza-7-thiaadenosine. . J. Org. Chem. , 59 : 1912 – 1917 .
   Web of Science ®Google Scholar
• Rao , K. V. B. , Klein , R. S. , Sarma , M. S. P. and Otter , B. A. 1992 . Synthesis of the Pyrido[4,3-d]pyrimidine Congeners of Inosine and of Adenosine — A New Class of 6:6 Bicyclic C-Ribofuranoside. . Nucleosides & Nucleotides , 11 ( 1 ) : 61 – 83 .
   Web of Science ®Google Scholar
• Giese and Radicals , B. 1986 . Organic Synthesis: Formation of C-C Bonds. . Pergamon Press ,
   Google Scholar
• See 9 and references therein.
   Google Scholar