If I Could Just Stop Loving You: Anti-Love Biotechnology and the Ethics of a Chemical Breakup

REFERENCES

• Alexander , D. A. and Klein , S. 2009 . Kidnapping and hostage-taking: A review of effects, coping and resilience . Journal of the Royal Society of Medicine , 102 ( 1 ) : 16 – 21 .
   PubMed Web of Science ®Google Scholar
• Amelung , T. , Kuhle , L. F. , Konrad , A. , Pauls , A. and Beier , K. M. 2012 . Androgen deprivation therapy of self-identifying, help-seeking pedophiles in the Dunkelfeld . International Journal of Law and Psychiatry , 35 ( 3 ) : 176 – 184 .
   PubMed Web of Science ®Google Scholar
• Aragona , B. J. and Wang , Z. 2004 . The prairie vole (Microtus ochrogaster): An animal model for behavioral neuroendocrine research on pair bonding . Institute for Laboratory Animal Research , 45 ( 1 ) : 35 – 45 .
   PubMed Web of Science ®Google Scholar
• Aragona , B. J. and Wang , Z. 2009 . Dopamine Regulation of Social Choice in a Monogamous Rodent Species . Frontiers in Behavioral Neuroscience , 3 doi: 10.3389/neuro.08.015.2009
   PubMed Web of Science ®Google Scholar
• Aragona , B. J. , Liu , Y. , Yu , Y. J. , Curtis , J. T. , Detwiler , J. M. , Insel , T. R. and Wang , Z. 2005 . Nucleus accumbens dopamine differentially mediates the formation and maintenance of monogamous pair bonds . Nature neuroscience , 9 ( 1 ) : 133 – 139 .
   PubMed Web of Science ®Google Scholar
• Babb , L. 1941 . The physiological conception of love in the Elizabethan and Early Stuart drama . PMLA [Modern Language Association] , 56 ( 4 ) : 1020 – 1035 .
   Google Scholar
• Baumeister , R. , Wotman , S. and Stillwell , A. 1993 . Unrequited love: On heartbreak, anger, guilt, scriptlessness, and humiliation . Journal of Personality and Social Psychology , 64 : 377 – 394 .
   Web of Science ®Google Scholar
• Bostwick , M. and Bucci , J. A. 2008 . Internet sex addiction treated with naltrexone . Mayo Clinic Proceedings , 83 ( 2 ) : 226 – 230 .
   PubMed Web of Science ®Google Scholar
• Buchheim , A. , Heinrichs , M. , George , C. , Koops , D. , Henningsen , P. and Gruendel , H. 2009 . Oxytocin enhances the experience of attachment security . Psychoneuroendocrinology , 34 ( 9 ) : 1417 – 1422 .
   PubMed Web of Science ®Google Scholar
• Burkett , J. and Young , L. J. 2012 . The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction . Psychopharmacology , 224 ( 1 ) : 1 – 26 .
   PubMed Web of Science ®Google Scholar
• Buss , D. M. 2006 . “ The evolution of love ” . In The new psychology of love , Edited by: Sternberg , R. and Weis , K. 65 – 86 . New Haven , CT : Yale University Press .
   Google Scholar
• Capgras , J. and Reboul-Lachaux , J. 1994 . L’illusion des ‘ sosies’ dans un delire systematise chronique . History of Psychiatry , 5 ( 17 ) : 119 – 133 . (1923)
   Google Scholar
• Carver , J. 2007 . Love and Stockholm syndrome: The mystery of loving an abuser Professional clinical website. Available at: http://drjoecarver.makeswebsites.com/clients/49355/File/love_and_stockholm_syndrome.html (accessed February 4, 2013)
   Google Scholar
• Cho , M. M. , DeVries , A. C. , Williams , J. R. and Carter , C. S. 1999 . The effects of oxytocin and vasopressin on partner preferences in male and female prairie voles (Microtus ochrogaster) . Behavioral Neuroscience , 113 ( 5 ) : 1071 – 1079 .
   PubMed Web of Science ®Google Scholar
• Cohen , S. 2009 . Nine drugs that can dampen your sex drive , Lifescript . Available at: www.lifescript.com/life/sex/libidio/9_drugs_that_can_dampen_your_sex_drive.aspx (accessed 9 February 9, 2009)
   Google Scholar
• Cunnngham , G. R. , Hirshkowitz , M. , Korenman , S. G. and Karacan , I. 1990 . Testosterone replacement therapy and sleep-related erections in hypogonadal men . Journal of Clinical Endocrinology & Metabolism , 70 ( 3 ) : 792 – 797 .
   PubMed Web of Science ®Google Scholar
• DeCamp , M. and Buchanan , A. 2007 . “ Pharmacogenomics, ethical and regulatory issues ” . In The Oxford handbook of bioethics , Edited by: Steinbock , B. 536 – 568 . Oxford , , UK : Oxford University Press .
   Google Scholar
• De Jongh , R. , Bolt , I. , Schermer , M. and Olivier , B. 2008 . Botox for the brain: Enhancement of cognition, mood and pro-social behavior and blunting of unwanted memories . Neuroscience & Biobehavioral Reviews , 32 ( 4 ) : 760 – 776 .
   PubMed Web of Science ®Google Scholar
• Donaldson , Z. R. and Young , L. J. 2008 . Oxytocin, vasopressin, and the neurogenetics of sociality . Science , 322 ( 5903 ) : 900 – 904 .
   PubMed Web of Science ®Google Scholar
• Earp , B. D. 2012 . Love and other drugs: On the chemical enhancement of human relationships . Philosophy Now , 91 : 14 – 17 .
   Google Scholar
• Earp , B. D. In press . Hymen ‘restoration’ in cultures of oppression: How can physicians promote individual patient welfare without becoming complicit in the perpetuation of unjust social norms? . Journal of Medical Ethics , doi: 10.1136/medethics-2013-101662
   Google Scholar
• Earp , B. D. , Sandberg , A. and Savulescu , J. 2012 . Natural selection, childrearing, and the ethics of marriage (and divorce): Building a case for the neuroenhancement of human relationships . Philosophy & Technology , 25 : 561 – 587 .
   PubMedGoogle Scholar
• Earp , B. D. , Sandberg , A. and Savulescu , J. Brave new love: The threat of high-tech “conversion” therapy and the bio-oppression of sexual minorities . AJOB Neuroscience ,
   Google Scholar
• Earp , B. D. , Savulescu , J. and Sandberg , A. 2012 . “ Should you take ecstasy to improve your marriage? Not so fast ” . In Practical Ethics. , University of Oxford . Available at: http://blog.practicalethics.ox.ac.uk/2012/06/should-you-take-ecstasy-to-improve-your-marriage-not-so-fast (accessed February 19, 2013)
   Google Scholar
• Earp , B. D. , Wudarczyk , O. A. , Foddy , B. and Savulescu , J. “ Unpublished ” . In Addicted to love: What is love addiction and when should it be treated? Prepublication draft available at: http://www.academia.edu/3393872/Addicted_to_love_What_is_love_addiction_and_when_should_it_be_treated
   Google Scholar
• Eastwick , P. W. 2009 . Beyond the pleistocene: Using phylogeny and constraint to inform the evolutionary psychology of human mating . Psychological Bulletin , 135 ( 5 ) : 794
   PubMed Web of Science ®Google Scholar
• Ellis , H. D. and Young , A. W. 1990 . Accounting for delusional misidentifications . British Journal of Psychiatry , 157 : 239 – 248 .
   PubMed Web of Science ®Google Scholar
• Ellis , H. D. , Young , A. W. , Quayle , A. H. and De Pauw , K. W. 1997 . Reduced autonomic responses to faces in Capgras delusion . Proceedings of the Royal Society of London. Series B: Biological Sciences , 264 ( 1384 ) : 1085 – 1092 .
   PubMed Web of Science ®Google Scholar
• Esch , T. and Stefano , G. B. 2005 . The neurobiology of love . Neuroendocrinology Letters , 3 ( 26 ) : 175 – 192 .
   Google Scholar
• Ettinger , Y. 2012 . Rabbi's little helper . Haaretz , Available at: http://www.haaretz.com/weekend/week-s-end/rabbi-s-little-helper-1.422985 (accessed April 6, 2012)
   Google Scholar
• Fisher , H. E. 1992 . Anatomy of love: The natural history of monogamy, adultery, and divorce , New York, NY : Norton .
   Google Scholar
• Fisher , H. E. 1998 . Lust, attraction, and attachment in mammalian reproduction . Human Nature , 9 ( 1 ) : 23 – 52 .
   PubMed Web of Science ®Google Scholar
• Fisher , H. E. 2000 . Lust, attraction, attachment: Biology and evolution of the three primary emotion systems for mating, reproduction, and parenting . Journal of Sex Education and Therapy , 25 ( 1 ) : 96 – 104 .
   Google Scholar
• Fisher , H. E. 2004 . Why we love: The nature and chemistry of romantic love. , New York , NY : Henry Holt .
   Google Scholar
• Fisher , H. E. , Aron , A. and Brown , L. L. 2006 . Romantic love: A mammalian brain system for mate choice . Philosophical Transactions of the Royal Society B , 361 ( 1476 ) : 2173 – 2186 .
   PubMed Web of Science ®Google Scholar
• Fisher , H. E. , Aron , A. , Mashek , D. , Li , H. and Brown , L. L. 2002 . Defining the brain systems of lust, romantic attraction, and attachment . Archives of Sexual Behavior , 31 ( 5 ) : 413 – 419 .
   PubMed Web of Science ®Google Scholar
• Fitzgerald , W. 1984 . “ Lucretius’ cure for love in the “De Rerum Natura”. ” . In The classical world , 73 – 86 . Charlottesville , VA : Classical Association of the Atlantic States .
   Google Scholar
• Glannon , W. 2006 . Psychopharmacology and memory . Journal of Medical Ethics , 32 ( 2 ) : 74 – 78 .
   PubMed Web of Science ®Google Scholar
• Gooren , L. J. 2011 . Ethical and medical considerations of androgen deprivation treatment of sex offenders . Journal of Clinical Endocrinology & Metabolism , 96 ( 12 ) : 3628 – 3637 .
   PubMed Web of Science ®Google Scholar
• Gottschall , J. and Nordlund , M. 2006 . Romantic love: A literary universal? . Philosophy and Literature , 30 ( 2 ) : 450 – 470 .
   Web of Science ®Google Scholar
• Graham , N. 2010 . Sex, love and serotonin . Health Intelligence: The Science of Health , 2 : 20 – 24 .
   Google Scholar
• Grau , C. 2006 . Eternal sunshine of the spotless mind and the morality of memory . Journal of Aesthetics and Art Criticism , 64 ( 1 ) : 119 – 133 .
   Web of Science ®Google Scholar
• Gupta , K. 2012 . Protecting sexual diversity: Rethinking the use of neurotechnological interventions to alter sexuality . AJOB Neuroscience , 3 ( 3 ) : 24 – 28 .
   Google Scholar
• Haldeman , D. 1994 . The practice and ethics of sexual orientation conversion therapy . Journal of Consulting and Clinical Psychology , 62 ( 2 ) : 221 – 227 .
   PubMed Web of Science ®Google Scholar
• Henry , M. , Fishman , J. R. and Younger , S. J. 2007 . Propranolol and the prevention of post-traumatic stress disorder: Is it wrong to erase the “sting” of bad memories? . AJOB Neuroscience , 7 ( 9 ) : 12 – 20 .
   PubMed Web of Science ®Google Scholar
• Hensch , T. K. and Bilimoria , P. M. 2012 . Re-opening windows: Manipulating critical periods for brain development. , The Dana Foundation . Available at: http://www.dana.org/news/cerebrum/detail.aspx?id=39360 (accessed August 29, 2012)
   Google Scholar
• Insel , T. R. and Hulihan , T. J. 1995 . A gender-specific mechanism for pair bonding: Oxytocin and partner preference formation in monogamous voles . Behavioral Neurosciences , 109 : 782 – 789 .
   PubMed Web of Science ®Google Scholar
• Insel , T. R. and Young , L. J. 2000 . The neurobiology of attachment . Nature Reviews Neuroscience , 2 ( 2 ) : 129 – 136 .
   Web of Science ®Google Scholar
• Insel , T. R. , Young , L. and Wang , Z. 1997 . Central oxytocin and reproductive behaviours . Reviews of Reproduction , 2 : 28 – 37 .
   PubMedGoogle Scholar
• Jankowiak , W. R. and Fischer , E. F. 1992 . A cross-cultural perspective on romantic love . Ethnology , 31 : 149 – 155 .
   Web of Science ®Google Scholar
• Juth , N. 2011 . “ Enhancement, autonomy, and authenticity ” . In Enhancing human capacities , Edited by: Savulescu , J. , Muelen , R. and Kahane , G. 34 – 48 . Oxford , , UK : Blackwell .
   Google Scholar
• Kasemset , C. 2009 . Should consensual incest between consanguine adults be restricted? . Intersect: The Stanford Journal of Science, Technology and Society , 2 ( 1 ) : 83 – 89 .
   Google Scholar
• Kennedy , N. , McDonough , M. , Kelly , B. and Berrios , G. E. 2002 . Erotomania revisited: Clinical course and treatment . Comprehensive Psychiatry , 43 ( 1 ) : 1 – 6 .
   PubMed Web of Science ®Google Scholar
• Kenrick , D. 2006 . “ A dynamical evolutionary view of love ” . In The new psychology of love , Edited by: Sternberg , R. , Weis , K. , Sternberg , R. and Weis , K. 15 – 34 . New Haven , CT : Yale University Press .
   Google Scholar
• Kreuger , R. and Kaplan , M. 2001 . Depot-leuprolide acetate for treatment of paraphilias: A report of twelve cases . Archives of Sexual Behavior , 30 ( 4 ) : 409 – 422 .
   PubMed Web of Science ®Google Scholar
• Leckman , J. F. , Hrdy , S. B. , Keverne , E. B. and Carter , C. S. 2006 . “ A biobehavioral model of attachment and bonding ” . In The new psychology of love , Edited by: Sternberg , R. and Weis , K. 116 – 145 . New Haven , CT : Yale University Press .
   Google Scholar
• Liao , S. M. and Sandberg , A. 2008 . The normativity of memory modification . Neuroethics , 1 ( 2 ) : 85 – 99 .
   Web of Science ®Google Scholar
• Liao , S. M. and Wasserman , D. T. 2007 . Neuroethical concerns about moderating traumatic memories . American Journal of Bioethics , 7 ( 9 ) : 38 – 40 .
   PubMed Web of Science ®Google Scholar
• Light , K. C. , Grewen , K. M. and Amico , J. A. 2005 . More frequent partner hugs and higher oxytocin levels are linked to lower blood pressure and heart rate in premenopausal women . Biological psychology , 69 ( 1 ) : 5 – 21 .
   PubMed Web of Science ®Google Scholar
• Liu , Y. and Wang , Z. X. 2003 . Nucleus accumbens oxytocin and dopamine interact to regulate pair bond formation in female prairie voles . Neuroscience , 121 ( 3 ) : 537 – 544 .
   PubMed Web of Science ®Google Scholar
• Luo , L. 2011 . Is there a sensitive period in human incest avoidance? . Evolutionary Psychology , 9 ( 2 ) : 285 – 295 .
   Web of Science ®Google Scholar
• Lynch , Z. 2004 . Neurotechnology and society (2010–2060) . Annals of the New York Academy of Science , 1013 : 229 – 233 .
   PubMed Web of Science ®Google Scholar
• Marazziti , D. , Aksiskal , H. S. , Rossi , A. and Cassano , G. B. 1999 . Alteration of the platelet serotonin transporter in romantic love . Psychological Medicine , 29 : 741 – 745 .
   PubMed Web of Science ®Google Scholar
• Markus , T. , Rantala , J. and Marcinkowska , U. M. 2011 . The role of sexual imprinting and the Westermarck effect in mate choice in humans . Behavioral Ecology and Sociobiology , 65 ( 5 ) : 859 – 873 .
   Web of Science ®Google Scholar
• May , S. 2011 . Love: A history. , New Haven , CT : Yale University Press .
   Google Scholar
• McClelland , S. 2006 . When love hurts: The story of an abused woman (as told by Bonnie Williamson). Canadian Living. . Available at: http://www.susanmcclelland.com/art_when_love_hurts.htm (accessed February 19, 2013)
   Google Scholar
• Mearns , J. 1991 . Coping with a breakup: Negative mood regulation expectancies and depression following the end of a romantic relationship . Journal of Personality and Social Psychology , 60 : 327 – 334 .
   PubMed Web of Science ®Google Scholar
• Meloy , J. R. and Fisher , H. 2005 . Some thoughts on the neurobiology of stalking . Journal of Forensic Sciences , 50 ( 6 ) : 1472 – 1480 .
   PubMed Web of Science ®Google Scholar
• Meyer , D. 2007 . Selective serotonin reuptake inhibitors and their effects on relationship satisfaction . Family Journal , 15 : 392 – 397 .
   Google Scholar
• Miura , H. , Qiao , H. , Kitagami , T. , Ohta , T. and Ozaki , N. 2005 . Effects of fluvoxamine on levels of dopamine, serotonin, and their metabolites in the hippocampus elicited by isolation housing and novelty stress in adult rats . International Journal of Neuroscience , 115 : 367 – 378 .
   PubMed Web of Science ®Google Scholar
• Montgomerry , S. A. 1994 . Long-term treatment of depression . British Journal of Psychiatry Supplement , 26 : 31 – 36 .
   PubMedGoogle Scholar
• Murray , T. H. 2007 . “ Enhancement ” . In The Oxford handbook of bioethics , Edited by: Steinbock , B. 491 – 516 . New York , NY : Oxford University Press .
   Google Scholar
• Nissen , E. , Uvnäs-Moberg , K. , Svensson , K. , Stock , S. , Widström , A. M. and Winberg , J. 1996 . Different patterns of oxytocin, prolactin but not cortisol release during breastfeeding in women delivered by Caesarean section or by the vaginal route . Early Human Development , 45 ( 1 ) : 103 – 118 .
   PubMed Web of Science ®Google Scholar
• Opbroek , A. , Delgado , P. Laukes , C. 2002 . Emotional blunting associated with SSRI-induced sexual dysfunction. Do SSRIs inhibit emotinoal responses? . International Journal of Neuropsychopharmacology , 5 : 147 – 151 .
   PubMed Web of Science ®Google Scholar
• Ovid and May , J. L. 2010 . The love books of Ovid Being the Amores, Ars Amatoria, Remedia Amoris and Medicamina Faciei Femineae of Publius Ovidius Naso. , Whitefish , MT : Kessinger Publishing .
   Google Scholar
• Parens , E. 2010 . The ethics of memory blunting and the narcissism of small differences . Neuroethics , 3 ( 2 ) : 99 – 107 .
   Web of Science ®Google Scholar
• Parens , E. 2013 . On good and bad forms of medicalization . Bioethics , 27 ( 1 ) : 28 – 35 .
   PubMed Web of Science ®Google Scholar
• Parker-Pope , T. 2006 . Where is the love? Antidepressants may inadvertently blunt feelings of romance . The Wall Street Journal , Available at: http://online.wsj.com/article/SB113987710213672933.html (accessed February 14, 2006)
   Google Scholar
• Peele , S. and Brodsky , A. 1974 . Love can be an addiction . Psychology Today , : 22 – 26 .
   Google Scholar
• Peele , S. and Brodsky , A. 1975 . Love and addiction. , New York , NY : Signet Books .
   Google Scholar
• Rimmele , U. , Hediger , K. , Heinrichs , M. and Klaver , P. 2009 . Oxytocin makes a face in memory familia . Journal of Neuroscience , 29 ( 1 ) : 38 – 42 .
   PubMed Web of Science ®Google Scholar
• Rösler , A. and Witztum , E. 1998 . Treatment of men with paraphilia with a long-acting analogue of gonadotropin-releasing hormone . New England Journal of Medicine , 338 : 416 – 422 .
   PubMed Web of Science ®Google Scholar
• Rowling , J. K. 2005 . Harry Potter and the half-blood prince. , New York , NY : Scholastic .
   Google Scholar
• Ruan , X. 2007 . Drug-related side effects of long-term intrathecal morphone therapy . Pain Physician , 10 : 357 – 365 .
   PubMedGoogle Scholar
• Savulescu , J. 2013 . A liberal consequentialist approach to regulation of cognitive enhancers . The American Journal of Bioethics , 13 ( 7 ) : 53 – 55 .
   PubMed Web of Science ®Google Scholar
• Savulescu , J. and Sandberg , A. 2008 . Neuroenhancement of love and marriage: The chemicals between us. . Neuroethics , 1 : 31 – 44 .
   Web of Science ®Google Scholar
• Savulescu , J. and Sandberg , A. 2012 . Love machine: Engineering lifelong romance . New Scientist , 2864 : 28 – 29 .
   Google Scholar
• Schneider , M. A. and Hendrix , L. 2000 . Olfactory sexual inhibition and the Westermarck effect . Human Nature , 11 : 65 – 92 .
   Web of Science ®Google Scholar
• Shakespeare , W. 1975 . As you like it , Edited by: Latham , A. London , , UK : Methuen . (1623)
   Google Scholar
• Shaver , P. R. and Mikulincer , M. 2006 . “ A behavioral systems approach to romantic love relationships: Attachment, caregiving, and sex ” . In The new psychology of love , Edited by: Sternberg , R. and Weis , K. 35 – 64 . New Haven , CT : Yale University Press .
   Google Scholar
• Shaw , G. B. 1911 . “ 1986. Getting married ” . In Getting married and press cuttings , Edited by: Shaw , G. B. 11 – 105 . Harmondsworth , , UK : Penguin Books .
   Google Scholar
• Sternberg , R. and Weis , K. 2006 . The new psychology of love. , New Haven , CT : Yale University Press .
   Google Scholar
• TEENADVOCATEDAN . 2009 . How do I stop loving the abuser? Feministing . Available at: http://community.feministing.com/2009/10/20/how-do-i-stop-loving-the-abuser
   Google Scholar
• Tierney , J. 2009 . Anti-love drug may be ticket to bliss . The New York Times , Available at: http://www.nytimes.com/2009/01/13/science/13tier.html?_r=0 (accessed January 12, 2009)
   Google Scholar
• Wang , Z. , Yu , G. , Cascio , C. , Liu , Y. , Gingrich , B. and Insel , T. R . 1999 . Dopamine D2 receptor-mediated regulation of partner preferences in female prairie voles (Microtus ochrogaster): A mechanism for pair bonding? . Behavioral Neuroscience , 113 ( 3 ) : 602 – 611 .
   PubMed Web of Science ®Google Scholar
• Weis , K. 2006 . “ Introduction ” . In The new psychology of love , Edited by: Sternberg , R. and Weis , K. 1 – 11 . New Haven , CT : Yale University Press .
   Google Scholar
• Weisfeld , G. E. , Czilli , T. , Phillips , K. A. , Gall , J. A. and Lichtman , C. M. 2003 . Possible olfaction-based mechanisms in human kin recognition and inbreeding avoidance . Journal of Experimental Child Psychology , 85 : 279 – 295 .
   PubMed Web of Science ®Google Scholar
• Westermarck , E. 1921 . The history of human marriage (5th ed.). , London , UK : Allerton . (1891)
   Google Scholar
• Williams , J. R. , Insel , T. R. , Harbaugh , C. R. and Carter , C. S. 1994 . Oxytocin administered centrally facilitates formation of a partner preference in female prairie voles (Microtus ochrogaster) . Journal of Neuroendocrinology , 6 : 247 – 250 .
   PubMed Web of Science ®Google Scholar
• Wilson , M. and Daly , M. 1992 . Who kills whom in spouse killings? On the exceptional sex ratio of spousal homicides in the United States . Criminology , 30 : 189 – 215 .
   Web of Science ®Google Scholar
• Winslow , J. T. , Hastings , N. , Carter , C. S. , Harbaugh , C. R. and Intel , T. R. 1993 . Pair bonding in the monogamous prairie vole: A role for central vasopressin . Nature , 365 : 545 – 548 .
   PubMed Web of Science ®Google Scholar
• Young , L. J. 2009 . Being human: Love: Neuroscience reveals all . Nature , 457 ( 7226 ) : 148
   PubMed Web of Science ®Google Scholar
• Young , L. and Wang , Z. 2004 . The neurology of pair bonding . Nature Neuroscience , 7 ( 10 ) : 1048 – 1054 .
   PubMed Web of Science ®Google Scholar
• Zohar , J. and Intel , T. R. 1987 . Drug treatment of obsessive-compulsive disorder . Journal of Affective Disorders , 13 ( 2 ) : 193 – 202 .
   PubMed Web of Science ®Google Scholar