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Original Articles

METABOLISM OF TERRITREM A IN LIVER MICROSOMES FROM WISTAR RATS: 2. SEX DIFFERENCES AND REGULATION WITH GONADAL HORMONES AND PHENOBARBITAL

Pages 661-671 | Published online: 07 Jan 2011

References

  • Al-Turk , W. A. , Stohs , S. J. and Roche , E. B. 1980 . Effect of gonadectomy on hepatic, lung and intestinal mixed function mono-oxygenase enzymes in the rats . Harm. Met ab. Res. , 12 : 404 – 409 .
  • Al-Turk , W. A. , Stohs , S. J. and Roche , E. B. 1981 . Effect of hypophysectomy and castration on hepatic, pulmonary and intestinal aryl hydrocarbon hydroxylase activities in the rat . J. Pharmacol. Exp. Ther. , 216 : 492 – 495 .
  • Alvares , A. P. and Mannering , G. J. 1970 . Two substrate kinetics of drug-metabolizing enzyme systems of hepatic microsomes . MoI. Pharmacol. , 6 : 206 – 212 .
  • Bandiera , S. and Dworschak , C. 1992 . Effects of testosterone and estrogen on hepatic levels of cytochrome P450 2C7 and P450 2C11 in the rat . Arch. Biochem. Biophys. , 296 : 286 – 295 .
  • Chistiakov , V. V. and Prikod'ko , A. Z. 1979 . Induction of the microsomal monoxygenase system of rat liver by combined administration of testosterone and phenobarbital . Biokhimiia , 44 : 1630 – 1634 .
  • Chistiakov , V. V. and Prikod'ko , A. Z. 1981 . Effect of the long-term administration of testosterone on induction of cytochrome P-450 in female rat liver tissue using phenobarbital . Vopr. Med. Khim. , 27 : 340 – 342 .
  • Chung , C. H. , Ling , K. H. , Tung , S. S. and Tung , T. C. 1971 . Study on fungi of the stored unhulled rice of Taiwan. (2) Aflatoxin B-like compounds from the culture of Aspergillus genus . J. Formosan Med. Assoc. , 70 : 258 – 266 .
  • Dahms , R. and Gurtoo , H. L. 1976 . Metabolism of aflatoxin B1 to aflatoxin Q1, M1 and P1 by mouse and rat . Res. Commun. Chem. Pathol. Pharmacol. , 15 : 11 – 20 .
  • Dannan , G. A. , Guengerich , E. P. and Waxman , D. J. 1986 . Hormonal regulation of rat microsomal enzymes . J. Biol. Chem. , 261 : 10728 – 10735 .
  • Dowed , P. F. , Peng , F. C , Chen , J. W. and Ling , K. H. 1992 . Toxicity and anticholinesterase activity of the fungal metabolites territrems to the corn earworm, Helicoverpa zea . Entomol. Exp. Appl. , 65 : 57 – 64 .
  • Ellman , G. L. , Courtney , K. D. Jr , Anders , V. and featherstone , R. M. 1961 . A new and rapid colorimetric determination of acetylcholinesterase activity . Biochem. Pharmacol. , 7 : 88 – 95 .
  • Fumiyshi , K. , Otoguro , K. , Shiomi , K. , Iwai , Y. and Stoshi , O. 1996 . Arisugacins A and B, novel and selective acetylcholinesterase inhibitors from Penicillium sp . FO-4259 J. Antibiot. , 49 : 742 – 746 .
  • Gurtoo , H. L. and Motycka , L. E. 1976 . Effect of sex difference on the in vitro and in vivo metabolism of aflatoxin B1 by the rat . Cancer Res. , 36 : 4663 – 4671 .
  • Gurtoo , H. L. , Motycka , L. E. and Parker , N. (Bejba) . 1976 . Sex difference of the metabolic activation in vitro of the mycohepatocarcinogen aflatoxin B1 . J. Med. , 7 : 1 – 12 .
  • Hayes , J. R. , Mgbodile , M. U. K. and Campbell , T. C. 1973 . Effect of protein deficiency on the inducibility of the hepatic microsomal drug-metabolizing enzyme system--I. Effect on substrate interaction with cytochrome P-450 . Biochem. Pharmacol. , 22 : 1005 – 1014 .
  • lmaoka , S. , Terano , Y. and Funae , Y. 1988 . Constitutive testosterone 6 beta-hydroxylase in rat liver . J. Biochem. (Tokyo) , 104 : 481 – 487 .
  • Janeczko , R. , Waxman , D. J. , LeBlanc , G. A. , Morville , A. and Adesnik , M. 1990 . Hormonal regulation of levels of the messenger RNA encoding hepatic P450 2C (IIC11), a constitutive male-specific form of cytochrome P450 . MoI. Endocrinol. , 90 : 295 – 303 .
  • Jayarj , A. and Richardson , A. 1981 . Metabolic activation of aflatoxin B, by liver tissue from male Fischer F344 rats of various ages . Mech. Ageing Develop. , 17 : 163 – 171 .
  • Kamataki , T. , Maeda , K. , Shimada , M. , Kitani , K. , Nagai , T. and Kato , R. 1985 . Age-related alteration in the activities of drug-metabolizing enzymes and contents of sex-specific forms of cytochrome P-450 in liver microsomes from male and female rats . J. Pharmacol. Exp. Ther. , 233 : 222 – 228 .
  • Kato , R. 1974 . Sex-related difference in drug metabolism . Drug Metab. Rev. , 3 : 1 – 32 .
  • Kato , R. and Kamataki , T. 1982 . Cytochrome P450 as a determinant of sex difference of drug metabolism in the rat . Xenobiotica , 12 : 787 – 800 .
  • Kato , R. , Chiesara , E. and Frontino , G. 1962 . Influence of sex difference on the pharmacological action and metabolism of some drugs . Biochem. Pharmacol. , 11 : 221 – 227 .
  • Kato , R. , Taknaka , A. and Takayanagi , M. 1968 . Studies on the mechanism of sex differences in drug oxidizing activity of liver microsomes . Jpn. J. Pharmacol. , 18 : 482 – 489 .
  • Kobliakov , V. , Popova , N. and Rossi , L. 1991a . Regulation of the expression of the sex-specific isoforms of cytochrome P-450 in rat liver . J. Biochem. (Tokyo) , 195 : 585 – 591 .
  • Kobliakov , V. , Popova , N. and Rossi , L. 1991b . Regulation of the expression of the sex-specific isoforms of cytochrome P-450 in rat liver . Eur. J. Biochem. , 195 : 585 – 591 .
  • Larsen , M. C and Jefcoate , C. R. 1995 . Phenobarbital induction of CYP2B1, CYP2B2, and CYP3A1 in rat liver: Genetic differences in a common regulation mechanism . Arch. Biochem. Biophys. , 321 : 467 – 476 .
  • Ling , K. H. , Yang , C. K. and Peng , F. T. 1979 . Territrem, tremorgenic mycotoxins of Aspergillus terreus, Appl . Environ. Microbiol. , 37 : 355 – 357 .
  • Ling , K. H. , Liou , H. H. , Yang , C. M. and Yang , C. K. 1984 . Isolation, chemical structure, acute toxicity and some physicochemical properties of territrem C from Aspergillus terreus . Appl. Environ. Microbiol. , 47 : 98 – 100 .
  • Ling, K. H., Liou, H. H., Fu, T. C., Kuo, L., Tasi, M. C., and Lin, M. Y. 1985. Mechanism of action of the territrem, tremorgenic mycotoxin isolated from Aspergillus terreus. In Mycotoxins and phycotoxins, eds. P. S. Steyn and R. Vleggaar, 6th International IUPAC Symposium on Mycotoxins and Phycotoxins, pp. 387-398. Amsterdam: Elsevier.
  • Ling , K. H. , Chiou , C. M. and Tseng , Y. L. 1991 . Biotransformation of territrems by S9 fraction from rat liver . Drug Metab. Dispos. , 19 : 587 – 595 .
  • Lowry , O. H. , Rosebrough , N. J. , Farr , A. L. and Randall , R. J. 1951 . Protein measurement with the Folin phenol reagent . J. Biol. Chem. , 193 : 265 – 275 .
  • Mackinnon , M. , Sutherland , E. and Simon , F. R. 1977 . Effect of ethinylestradiol on hepatic microsomal proteins and the turn over of cytochrome P-450 . J. Lab. Clin. Med. , 90 : 1096 – 1106 .
  • Maeda , K. , Kamataki , R. , Nagai , T. and Kato , R. 1984 . Postnatal development of constitutive forms of cytochrome P-450 in liver microsomes of male and female rats . Biochem. Pharmacol. , 33 : 509 – 512 .
  • Malejika-Giganti , D. , Magat , W. J. and Decker , R. W. 1989 . Modification of hepatic microsomal Ooxidation of N-2-fluorenylacetamide in response to gonadectomy and treatment of rats with phenobarbital or diethylnitrosamine . Xenobiotica , 19 : 431 – 444 .
  • Michele , C. L. and Colin , R. J. 1995 . Phenobarbital induction of CYP2B1, CYP2B2, and CYP3A1 in rat liver: Genetic difference in a common regulatory mechanism . Arch. Biochem. Biophys. , 321 : 467 – 476 .
  • Peng , F. C , Lin-Wu , S. W. and Wang , B. L. 2001 . Metabolism of TRA in liver microsomes from male Wistar rats: 1. Identification of its metabolites and their metabolic sequence . J. Toxicol. Environ. Health A , 64 : 101 – 115 .
  • Shelnutt , S. R. , Badger , T. M. and Owens , S. M. 1996 . Phencycline metabolite irreversible binding in the rat: gonadal steroid regulation and CYP2C11 . J. Pharmacol. Exp. Ther. , 277 : 292 – 298 .
  • Tseng , Y. L. 1990 . Biotransformation of territrems in rats. Master's dissertation, Institute of Biochemistry , Taipei : National Taiwan University .
  • Tung , S. S. , Ling , K. H. , Tasi , S , Chung , E. , Wang , C. H. , Tung , J. J. and T. C. 1971 . Study on fungi of the stored unhulled rice of Taiwan. (1) Mycological survey of the stored unhulled rice . J. Formosan Med. Assoc. , 70 : 251 – 257 .
  • Waxman , D. J. and Azaroff , L. 1992 . Phenobarbital induction of cytochrome P450 gene expression . Biochem. J. (Tokyo) , 281 : 577 – 591 .
  • Waxman , D. J. , Dannan , G. A. and Guengerich , F. P. 1985 . Regulation of rat hepatic cytochrome P-450: Age-dependent expression, hormonal imprinting, and xenobiotic inducibility of sex-specific isoenzymes . Biochemistry , 24 : 4409 – 4417 .
  • Zaphiropoulos , P. G. , Mode , A. , Norstedt , G. and Gustatsson , J. A. 1989 . Regulation of sexual differentiation in drug and steroid metabolism . Trends Pharmacol. Sci. , 10 : 149 – 153 .

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