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Original Articles

Malondialdehyde-Protein Adducts in the Spleens of Aniline-Treated Rats: Immunochemical Detection and Localization

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Pages 93-102 | Published online: 07 Jan 2011

References

  • Anania , F. A. , Womack , L. , Jiang , M. and saxena , N. K. 2001 . Aldehydes potentiate a2(1) collagen gene activity by JNK in hepatic stellate cells . Free Radical Biol. Med. , 30 : 846 – 857 .
  • Bacon , B. R. , Park , C. H. , Brittenham , G. M. , O'Neil , R. and Tavil , A. S. 1985 . Hepatic mitochondrial oxidative metabolism in rats with chronic dietary iron overload . Hepatology , 5 : 789 – 797 .
  • Bacon , B. R. , Healey , J. F. , Brittenham , G. M. , Park , C. H. , Nunnari , J. , Tavill , A. S. and Bonkovsky , H. L. 1986 . Hepatic microsomal function in rats with chronic dietary overload . Gastroenterology , 90 : 1844 – 1853 .
  • Bonkovsky , H. L. , Healey , J. F. , Sinclair , P. R. , Sinclair , J. F. and Pomeroy , J. S. 1981 . Iron and the liver: Acute and long-term effects of iron-loading on hepatic haem metabolism . Biochem. J. , 196 : 57 – 64 .
  • Britton , R. S. 1996 . Metal-induced heptotoxicity . Semin. Liver Dis. , 16 : 3 – 12 .
  • Bus , J. S. and Popp , J. A. 1987 . Perspectives on the mechanism of action of the splenic toxicity of aniline and structurally-related compounds . Food Chem. Toxicol. , 25 : 619 – 626 .
  • Chaudhary , A. K. , Nokubo , M. , Reddy , G. R. , Yeola , S. N. , Morrow , J. D. , Blair , I. A. and Marnett , L. J. 1994 . Detection of endogenous malondialdehyde-deoxyguanosine adducts in human liver . Science , 265 : 1580 – 1582 .
  • Chen , J. , Schenker , S. , Frosto , T. A. and Henderson , G. I. 1998 . Inhibition of cytochrome C oxidase activity by 4-hydroxynonenal (HNE). Role of HNE adduct formation with the enzyme subunits . Biochim. Biophys. Acta , 1380 : 336 – 344 .
  • Chojkier , M. , Houglum , K. , Solis-Herruzo , J. and Brenner , D. A. 1989 . Stimulation of collagen gene expression by ascorbic acid in cultured human fibroblasts. A role for lipid peroxidation . J. Biol. Chem. , 264 : 16957 – 16962 .
  • Esterbauer , H. , Schus , R. J. and Zollner , H. 1991 . Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes . Free Radical Biol. Med. , 11 : 81 – 128 .
  • Goodman , D. G. , Ward , J. M. and Reichardt , W. D. 1984 . Splenic fibrosis and sarcomas in F344 rats fed diets containing aniline hydrochloride, P-chloroaniline, azobenzene, o-toluidine hydrochloride, 4,4'-sulfonylydianiline, or D&C Red No . 9. JNCI , 73 : 265 – 273 .
  • Hartley , D. P. , Kolaja , K. L. , Reichar , J. and Petersen , D. R. 1999 . 4-Hydroxynonenal and malondialdehyde hepatic protein adducts in rats treated with carbon tetrachloride: Immunochemical detection and lobular localization . Toxicol. Appl. Pharmacol. , 161 : 23 – 33 .
  • Houglum , K. , Filip , M. , Witztum , J. L. and Chojkier , M. 1990 . Malondialdehyde and 4-hydroxynonenal protein adducts in plasma and liver of rats with iron overload . J. Clin. Invest. , 86 : 1991 – 1998 .
  • Khan , M. F. , Kaphalia , B. S. , Boor , P. J. and Ansari , G. A. S. 1993 . Subchronic toxicity of aniline hydrochloride in rats . Arch. Environ. Contam. Toxicol. , 24 : 368 – 374 .
  • Khan , M. F. , Boor , P. J. , Gu , Y. , Alcock , N. W. and Ansari , G. A. S. 1997a . Oxidative stress in the splenotoxicity of aniline . Fundam. Appl. Toxicol. , 35 : 22 – 30 .
  • Khan , M. F. , Wu , X. , Kaphalia , B. S. , Boor , P. J. and Ansari , G. A. S. 1997b . Acute hematopoietic toxicity of aniline . Toxicol. Lett. , 92 : 31 – 37 .
  • Khan , M. F. , Green , S. M. , Ansari , G. A. S. and Boor , P. J. 1998 . Phenylhydroxylamine: Role in aniline-associated splenic oxidative stress and induction of subendocardial necrosis . Toxicol. Sci. , 42 : 64 – 71 .
  • Khan , M. F. , Wu , X. , Alcock , N. W. , Boor , P. J. and Ansari , G. A. S. 1999b . Oxidative modification of lipids and proteins in aniline-induced spenic toxicity . Toxicol. Sci. , 48 : 134 – 140 .
  • Khan , M. F. , Wu , X. , Alcock , N. W. , Boor , P. J. and Ansari , G. A. S. 1999b . Iron exacerbates aniline-associated splenic toxicity . J. Toxicol. Environ. Health A , 57 : 173 – 184 .
  • Khan , M. F. , Wu , X. and Ansari , G. A. S. 2000 . Contribution of nitrosobenzene to splenic toxicity of aniline . J. Toxicol. Environ. Health A , 60 : 263 – 273 .
  • Khan , M. F. , Wu , X. and Ansari , G. A. S. 2001 . Anti-malondialdehyde antibodies in MRL+/+ mice treated with trichloroethene and dichloroacetyl chloride: Possible role of lipid peroxidation in autoimmunity . Toxicol. Appl. Pharmacol. , 170 : 88 – 92 .
  • Laemmli , U. K. 1970 . Cleavage of structural proteins during the assembly of the head of bacteriophage T4 . Nature , 227 : 680 – 685 .
  • Linpisarn , S. , Satoh , K. , Mikami , T. , Orimo , H. , Shinjo , S. and Yoshino , Y. 1991 . Effects of iron on lipid peroxidation . Int. J. Hematol. , 54 : 181 – 188 .
  • Lung , C. C. , Fleisher , J. H. , Meinke , G. and Pinnas , J. L. 1990 . Immunochemical properties of malondialdehyde-protein adducts . J. Immunol. Methods , 128 : 127 – 132 .
  • Mahmoodi , H. , Hadley , M. , Chang , Y.-X. and Draper , H. H. 1995 . Increased formation and degradation of malondialdehyde-modified proteins under conditions of peroxidative stress . Lipids , 30 : 963 – 966 .
  • McGirr , L. G. , Hadley , M. and Draper , H. H. 1985 . Identification of Na-acetyl-Ne (2-propenol) lysine as an urinary metabolite of malondialdehyde . J. Biol. Chem. , 260 : 15427 – 15431 .
  • Minotti , G. 1993 . Sources and role of iron in lipid peroxidation . Chem. Res. Toxicol. , 6 : 134 – 146 .
  • Peters , T. J. , O'Connell , M. J. and Ward , R. J. 1985 . “ Role of free-radical mediated lipid peroxidation in the pathogenesis of hepatic damage by lysosomal disruption ” . In Free redicals in liver injury , Edited by: Poli , G. , Cheesman , H. H. , Dianzani , M. U. and Slater , T. F. 107 – 115 . Oxford, UK : I.R.L. Press .
  • Stone , K. , Ksebati , M. B. and Marnett , L. J. 1990 . Investigation of the adducts formed by reaction of malondialdehyde with adenosine . Chem. Res. Toxicol. , 3 : 33 – 38 .
  • Towbin , H. , Staehelin , T. and Gordon , J. 1979 . Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications . Proc. Natl. Acad. Sci. USA , 76 : 4350 – 4354 .
  • Weinberger , M. A. , Albert , R. H. and Montgomery , S. B. 1985 . Splenotoxicity associated with splenic sarcomas in rats fed high doses of D&C red no. 9 or aniline hydrochloride . JNCI , 75 : 681 – 690 .

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