Pharmacokinetics/Pharmacodynamics (PK/PD) Modeling of Risks of Kidney Toxicity from Exposure to Cadmium: Estimates of Dietary Risks in the U.S. Population

REFERENCES

• Aoshima, K., Kawanishi, Y., Fan, J., Cai, Y., Katoh, T., Teranishi, H., and Kasuya, M., 1995. Cross-sectional assessments of renal function in inhabitants of a cadmium-polluted area., Ann. Clin. Lab. Med. 25 (1995), pp. 493–501.
   Web of Science ®Google Scholar
• Arisawa, K., Nakano, A., Saito, H., Liu, X.-J., Yokoo, M., Soda, M., Koba, T., Takahashi, T., and Kinoshita, K., 2001. Mortality and cancer incidence among a population previously exposed to environmental cadmium., Int. Arch. Occup. Environ. Health 74 (2001), pp. 255–262.
   PubMed Web of Science ®Google Scholar
• Bannon, D. I., Abounader, R., Lees, P. S. J., and Bressler, J. P., 2003. Effect of DMT1 knockdown on iron, cadmium, and lead uptake in Caco-2 cell., Am. J. Cell Physiol. 284 (2003), pp. C44–C50.
   PubMed Web of Science ®Google Scholar
• Barregård, L., Svalander, C., Schütz, A., Westberg, G., Sällsten, G., Blohmé, J., Mölne, J., Attman, P.-O., and Haglind, P., 1999. Cadmium, mercury, and lead in kidney cortex of the general Swedish population: A study of biopsies from living kidney donors., Environ. Health Perspect. 107 (1999), pp. 867–871.
   PubMed Web of Science ®Google Scholar
• Benedetti, J.-L., Samuel, O., Dewailly, É, Gingras, S., and Lefebvre, M. A., 1999. Levels of cadmium in kidney and liver tissues among a Canadian population (province of Quebec)., J. Toxicol. Environ. Health A 56 (1999), pp. 145–163.
   PubMed Web of Science ®Google Scholar
• Bergagard, I., and Beam, A. G., 1968. Isolation and properties of a low-molecular-weight β2-globulin in human biological fluids., J. Biol. Chem. 243 (1968), pp. 4095–4103.
   PubMed Web of Science ®Google Scholar
• Bernard, A., Buchet, J. P., Roels, H., Masson, P., and Lauwerys, R., 1979. Renal excretion of proteins and enzymes in works exposed to cadmium., Eur. J. Clin. Invest. 9 (1979), pp. 11–22.
   PubMed Web of Science ®Google Scholar
• Bernard, A., Vyskocyl, A., Mahieu, P., and Lauwerys, R., 1988. Effect of renal insufficiency on the concentration of free retinol-binding protein in urine and serum., Clin. Chim. Acta 171 (1988), pp. 85–94.
   PubMed Web of Science ®Google Scholar
• Bernard, A. M., and Lauwerys, R. R., 1981. Retinol binding protein in urine: A more practical index than urinary β2-microglobulin for the routine screening of renal tubular function., Clin. Chem. 27 (1981), pp. 1781–1782.
   PubMed Web of Science ®Google Scholar
• Bernard, A. M., and Lauwerys, R. R., 1986. "Effects of cadmium exposure in humans.". In: Foulkes, E. C., ed. Handbook of experimental pharmacology. Berlin: Springer-Verlag; 1986. pp. 135–177.
   Google Scholar
• Börjesson, J., Bellander, T., Järup, L., Elinder, C. G., and Matteson, S., 1997. In vivo analysis of cadmium in battery workers versus measurements of blood, urine, and workplace air., Occup. Environ. Med. 54 (1997), pp. 424–431.
   PubMed Web of Science ®Google Scholar
• Börjesson, J., Gerhardsson, L., Schütz, A., Perfekt, R., Mattsson, S., and Skerfving, S., 2001. Kidney cadmium as compared to other markers of cadmium exposure in workers at a secondary metal smelter., Am. J. Ind. Med. 39 (2001), pp. 19–28.
   PubMed Web of Science ®Google Scholar
• Buchet, J.-P., Lauwerys, R., Roels, H., Bernard, A., Bruaux, P., Clayes, F., Ducoffre, G., De Plaen, P., Staessen, J., Amery, A., Lijnin, P., Thijs, L., Rondia, D., Sartor, F., Saint Remy, A., and Nick, L., 1990. Renal effects of cadmium body burden of the general population., Lancet 336 (1990), pp. 699–702.
   PubMed Web of Science ®Google Scholar
• Cai, S., Wang, J., Xue, J., Zhu, X., Wang, J., and Wang, Y., 1992. A judgement of attribution of increase in urine β2-microglobulin after cadmium exposure., Biomed. Envrion. Sci. 5 (1992), pp. 130–135.
   PubMedGoogle Scholar
• Cai, S., Yue, Y., Jin, T., and Nordberg, G., 1998. Renal dysfunction from cadmium contamination of irrigation water: Dose-response analysis in a Chinese population., Bull. WHO 76 (1998), pp. 153–159.
   PubMed Web of Science ®Google Scholar
• Cai, Y., Heranishi, H., Aoshima, K., Katoh, T., Arai, Y., and Kasuya, M., 2001. Development of the fluorometric ELISA method for determination of α1-microglobulinuria in a cadmium-polluted area in Japan., Int. Arch. Occup. Environ. Health 74 (2001), pp. 514–518.
   PubMed Web of Science ®Google Scholar
• Ceovic, S., Hrabar, A., and Radonic, M., 1985. An etiological approach to Balkan endemic nephropathy based on the investigation of two genetically different populations., Nephron 40 (1985), pp. 175–179.
   PubMed Web of Science ®Google Scholar
• Ceovic, S., Plestina, R., Miletic-Medved, M., Stavljenic, A., Mitar, J., and Vukelic, M., 1991. Epidemiological aspects of Balkan endemic nephropathy in a typical focus in Yugoslavia., IARC Sci. Publ. 115 (1991), pp. 5–10.
   PubMedGoogle Scholar
• Choudhury, D., Raj, D. S. C., Palmer, B. F., and Levi, M., 2000. "Effect of aging on renal function and disease.". In: Brenner, B. M., ed. Brenner and Rector's The kidney. Vol. II. Philadelphia: W. B. Saunders; 2000. pp. 2187–2215.
   Google Scholar
• Choudhury, H., Harvey, T., Thayer, W. C., Lockwood, T. F., Stiteler, W. M., Coodrum, P. E., Hassett, J. M., and Diamond, G. L., 2001. Urinary cadmium elimination as a biomarker of exposure for evaluating a cadmium dietary exposure-biokinetics model., J. Toxicol. Environ. Health Part A 63 (2001), pp. 101–130.
   PubMedGoogle Scholar
• Crump, K. S., 1984. A new method for determining allowable daily intakes., Fundam. Appl. Toxicol. 4 (1984), pp. 854–871.
   PubMedGoogle Scholar
• Diamond, C. L., Goodrum, P. E., Felter, S. P., and Ruoff, W. L., 1998. Gastrointestinal absorption of metals., Drug Chem. Toxicol. 21 (1998), pp. 223–251.
   PubMed Web of Science ®Google Scholar
• Efron, B., and Tibshirani, R. J., 1993. An introduction to the bootstrap.. Boca Raton, FL: Chapman and Hall.; 1993.
   Google Scholar
• Ellis, K. J., 1985. Dose-response analysis of heavy metal toxicants in man: Direct in vivo assessment of body burden., Trace Subst. Environ. Health 19 (1985), pp. 149–159.
   Google Scholar
• Ellis, K. J., Vartsky, D., Zanzi, I., Cohn, S. H., and Yasumura, S., 1979. Cadmium: In vivo measurement in smokers and nonsmokers., Science. 205 (1979), pp. 323–325.
   PubMed Web of Science ®Google Scholar
• Ellis, K. J., Yuen, K., Yasumura, S., and Cohn, S. H., 1984. Dose-response analysis of cadmium in man: Body burden vs. kidney dysfunction., Environ. Res. 33 (1984), pp. 216–226.
   PubMed Web of Science ®Google Scholar
• Falck, F. Y., Fine, L. J., Smith, R. G., McClatchey, K. D., Annesley, T., England, B., and Schork, A. M., 1983. Occupational cadmium exposure and renal status., Am. J. Ind. Med. 4 (1983), pp. 541–549.
   PubMed Web of Science ®Google Scholar
• Flanagan, P. R., McLellan, J. S., Haist, J., Cherian, G., Chamberlain, M. J., and Valberg, L. S., 1978. Increased dietary cadmium absorption in mice and human subjects with iron deficiency., Gastroenterology 7 (1978), pp. 841–846.
   Google Scholar
• Food and Drug Administration., 2000. Total diet survey.. U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition. Office of Plant and Dairy Foods and Beverages; 2000, October. (Data summaries from http://vm.cfsan.fda.gov/∼comm/tds-toc.html).
   Google Scholar
• Forbes, G. B., and Bruining, G. B., 1976. Urinary creatinine excretion and lean body mass., Am. J. Clin. Nutr. 29 (1976), pp. 1359–1366.
   PubMed Web of Science ®Google Scholar
• Friberg, L., 1950. Health hazards in the manufacture of alkaline accumulators with special reference to chronic cadmium poisoning.. Stockholm: Industrial Hygiene Department, Swedish Public Health Institute; 1950, and Department for Occupational Medicine at the Medical Clinic of Karolinska Sjukhuset, Stockholm.
   Google Scholar
• Friberg, L., Elinder, C.-G., Kjellström, T., and Nordberg, G. F., 1985. Cadmium and health: A toxicological and epidemiological appraisal. Boca Raton, FL: CRC Press; 1985. pp. 46–47.
   Google Scholar
• Friberg, L., Piscator, M., Nordberg, G. F., and Kjellström, T., 1974. Cadmium in the Environment. Cleveland, OH: CRC Press; 1974. pp. 79–89.
   Google Scholar
• Friis, L., Petersson, L., and Edling, C., 1998. Reduced cadmium levels in human kidney cortex in Sweden., Environ. Health Perspect. 106 (1998), pp. 175–178.
   PubMed Web of Science ®Google Scholar
• Furuse, A., Futagoishi, Y., Karashima, S., Hattori, S., and Matsuda, I., 1992. Familial progressive renal tubulopathy., Clin. Nephrol. 37 (1992), pp. 192–197.
   PubMed Web of Science ®Google Scholar
• Gaylor, D. W., Kodell, R. L., Chen, J. J., and Krewski, D., 1999. A unified approach to risk assessment for cancer and noncancer endpoints based on benchmark doses and uncertainty/safety factors., Regul. Toxicol. Pharmacol. 29 (1999), pp. 151–157.
   PubMed Web of Science ®Google Scholar
• Ginevri, F., Piccotti, E., Alinovi, R., DeToni, T., Biagini, C., Chiggeri, G. M., and Cusmano, R., 1993. Reversible tubular proteinuria precedes microalbuminuria and correlates with the metabolic status in diabetic children., Pediatr. Nephrol. 7 (1993), pp. 23–26.
   PubMed Web of Science ®Google Scholar
• Hayano, M., Nogawa, K., Kido, T., Kobayashi, E., Honda, R., and Turitani, I., 1996. Dose-response relationship between urinary cadmium concentration and β2-microglobulinuria using logistic regression analysis., Arch. Environ. Health 51 (1996), pp. 162–167.
   PubMed Web of Science ®Google Scholar
• Hellström, L., Elinder, C.-G., Dahlberg, B., Lundberg, M., Jarup, L., Persson, B., and Axelson, O., 2001. Cadmium exposure and end-stage renal disease., Am. J. Kidney Dis. 38 (2001), pp. 1001–1008.
   PubMed Web of Science ®Google Scholar
• Hochi, Y., Kido, T., Nogawa, K., Kito, H., and Shaikh, Z., 1995. Dose-response relationship between total cadmium intake and prevalence of renal dysfunction using general linear models., J. Appl. Toxicol. 15 (1995), pp. 109–116.
   PubMed Web of Science ®Google Scholar
• Hotz, P., Buchet, J. P., Bernard, A., Lison, D., and Lauwerys, R., 1999. Renal effects of low-level environmental cadmium exposure: 5-Year follow-up of a subcohort from the Cadmibel study., Lancet 354 (1999), pp. 1508–1513.
   PubMed Web of Science ®Google Scholar
• International Commission on Radiological Protection., 1981. Report of the Task Croup on Reference Man. ICRP Publication 23. New York: Pergamon; 1981. pp. 40–45, Press.
   Google Scholar
• Ishizaki, M., Kido, T., Honda, R., Tsuritaini, I., Yamada, Y., Nakagawa, H., and Nogawa, K., 1989. Dose-response relationship between urinary cadmium and β2-microglobulin in Japanese environmentally cadmium exposed population., Toxicology 58 (1989), pp. 121–131.
   PubMed Web of Science ®Google Scholar
• Iwata, K., Saito, H., Moriyama, M., and Nakano, A., 1991. Association between renal tubular dysfunction and mortality among residents in a cadmium-polluted area, Nagasaki, Japan., Tohoku J. Exp. Med. 164 (1991), pp. 93–102.
   PubMed Web of Science ®Google Scholar
• Iwata, K., Saito, H., and Nakano, A., 1991. Association between cadmium-induced renal dysfunction and mortality: Further evidence., Tohoku J. Exp. Med. 164 (1991), pp. 319–330.
   PubMed Web of Science ®Google Scholar
• Järup, L., and Elinder, C.-G., 1994. Dose-response relations between urinary cadmium and tubular proteinuria in cadmium-exposed workers., Am. J. Ind. Med. 26 (1994), pp. 759–769.
   PubMed Web of Science ®Google Scholar
• Jarup, L., Hellström, L., Alfvén, T., Carlsson, M. D., Crubb, A., Persson, B., Pettersson, C., Spang, G., Schutz, A., and Elinder, C.-G., 2000. Low level exposure to cadmium and early kidney damage: The OSCAR study., Occup. Environ. Med. 57 (2000), pp. 668–672.
   PubMed Web of Science ®Google Scholar
• Järup, L., Persson, B., and Elinder, C.-G., 1997. Blood cadmium as an indicator of dose in a long-term follow-up of workers previously exposed to cadmium., Scand. J. Work Environ. Health 23 (1997), pp. 31–36.
   PubMed Web of Science ®Google Scholar
• Kido, T., and Nogawa, K., 1993. Dose-response relationship between total cadmium intake and β2-microglobulinuria using logistic regression analysis., Toxicol. Lett. 69 (1993), pp. 113–120.
   PubMed Web of Science ®Google Scholar
• Kjellström, T., and Nordberg, G. F., 1978. A kinetic model of cadmium metabolism in the human being., Environ. Res. 16 (1978), pp. 248–269.
   PubMed Web of Science ®Google Scholar
• Kordonouri, O., Jorres, A., Muller, C., Enders, I., Gahl, G. M., and Weber, B., 1992. Quantitative assessment of urinary protein and enzyme excretion—A diagnostic programme for the detection of renal involvement in type I diabetes mellitus., Scand. J. Clin. Lab. Invest. 52 (1992), pp. 781–790.
   PubMed Web of Science ®Google Scholar
• Kowal, N. E., and Zirkes, N., 1983. Urinary cadmium and beta2-microglobulin: Normal values and concentration adjustment., J. Toxicol. Environ. Health 11 (1983), pp. 607–624.
   PubMed Web of Science ®Google Scholar
• Lapsley, M., Sansom, P. A., Marlow, C. T., Flynn, F. V., and Norden, A. G., 1991. Beta 2-glycoprotein-1 (apolipoprotein H) excretion in chronic renal tubular disorders: Comparison with other protein markers of tubular malfunction., J. Clin. Pathol. 44 (1991), pp. 812–816.
   PubMed Web of Science ®Google Scholar
• Lyon, T. D. B., Aughey, E., Scott, R., and Fell, G. S., 1999. Cadmium concentrations in human kidney in the UK: 1978–1993., J. Environ. Monitor. 1 (1999), pp. 227–231.
   PubMedGoogle Scholar
• McLellan, J. S., Flanagan, P. R., Chamberlain, M. J., and Valberg, L. S., 1978. Measurement of dietary cadmium absorption in humans., J. Toxicol. Environ. Health 4 (1978), pp. 131–138.
   PubMed Web of Science ®Google Scholar
• Morgan, M. G., and Henrion, M., 1990. "The propagation and analysis of uncertainty.". In: Uncertainty. A guide to dealing with uncertainty and quantitative risk and policy analysis. Cambridge, MA: Cambridge University; 1990. pp. 172–219, Press.
   Google Scholar
• Mueller, P. W., Paschal, D. C., Hammel, R. R., Klincewicz, S. L., MacNeil, M. L., Spierto, B., and Steinberg, K. K., 1992. Chronic renal effects in three studies of men and women occupationally exposed to cadmium., Arch. Environ. Contam. Toxicol. 23 (1992), pp. 125–136.
   PubMed Web of Science ®Google Scholar
• Mutti, A., 1989. Detection of renal diseases in humans: Developing markers and methods., Toxicol. Lett. 46 (1989), pp. 177–191.
   PubMed Web of Science ®Google Scholar
• Nakagawa, H., Nishijo, M., Morikawa, Y., Tabata, M., Senma, M., Kitagawa, Y., Kawano, S., Ishizaki, M., Sugita, N., and Nishi, M., 1993. Urinary beta 2-microglobulin concentration and mortality in a cadmium-polluted area., Arch. Environ. Health 48 (1993), pp. 428–435.
   PubMed Web of Science ®Google Scholar
• Newton, D., Johnson, P., Lally, A. E., Pentreath, R. J., and Swift, D. J., 1984. The uptake by man of cadmium ingested in crab meat., Human Toxicol. 3 (1984), pp. 23–28.
   PubMedGoogle Scholar
• Nilsson, U., Schutz, A., Skerfving, S., and Mattsson, S., 1995. Cadmium in kidneys in Swedes measured in vivo using x-ray fluorescence analysis., Int. Arch. Occup. Environ. Health 67 (1995), pp. 405–411.
   PubMed Web of Science ®Google Scholar
• Nishijo, M., Nakagawa, H., Morikawa, Y., Tabata, M., Senma, M., Kitagawa, Y., Kawano, S., Ishizaki, M., Sugita, N., Nishi, M., Kido, T., and Nogawa, K., 1994. Prognostic factors of renal dysfunction induced by environmental cadmium pollution., Environ. Res. 64 (1994), pp. 112–121.
   PubMed Web of Science ®Google Scholar
• Nogawa, K., Honda, R., Kido, T., Tsuritani, I., Yamada, Y., Ishizaki, M., and Yamaya, H., 1989. A dose-response analysis of cadmium in the general environment with special reference to total cadmium intake limit., Environ. Res. 48 (1989), pp. 7–16.
   PubMed Web of Science ®Google Scholar
• Noonan, C. W., Sarasua, S. M., Campagna, D., Kathman, S. J., Lybarger, J. A., and Mueller, P. W., 2002. Effects of exposure to low levels of environmental cadmium on renal biomarkers., Environ. Health Perspect. 110 (2002), pp. 151–155.
   PubMed Web of Science ®Google Scholar
• Nordberg, G. G., Kjellström, T., and Nordberg., M., 1985. "Kinetics and metabolism.". In: Friberg, L., C.-G., Elinder, Kjellström, T., and Nordberg, C., eds. Cadmium and health: A toxicologic and epidemiological appraisal. Vol. I. Boca Raton, FL: CRC Press; 1985. pp. 103–178.
   Google Scholar
• O'Flaherty, E. J., 1993. Physiologically based models for bone seeking elements: IV. Kinetics of lead disposition in humans., Toxicol. Appl. Pharmacol. 118 (1993), pp. 16–29.
   PubMed Web of Science ®Google Scholar
• Park, J. D., Cherrington, N. J., and Klaassen, C. D., 2002. Intestinal absorption of cadmium is associated with divalent metal transporter 1 in rats., Toxicol. Sci. 68 (2002), pp. 288–294.
   PubMed Web of Science ®Google Scholar
• Pesce, A. J., and First, M. J., 1979. Proteinuia: An integrated review. New York: Marcel Dekker; 1979. pp. 175–201.
   Google Scholar
• Pless-Mulloli, T., Boettcher, M., Steiner, M., and Berger, J., 1998. α-1-Microglobulin: Epidemiological indicator for tubular dysfunction induced by cadmium?, Occup. Environ. Med. 55 (1998), pp. 440–445.
   PubMed Web of Science ®Google Scholar
• Rahola, T., Aaran, R.-K., and Miettinen, J. K., 1972. "Half-time studies of mercury and cadmium by whole-body counting.". In: Assessment of radioactive contamination in man. IAEA-SM-150/13. New York: International Atomic Energy Agency; 1972. pp. 553–562.
   Google Scholar
• Reichert, L. J., Koene, R. A., and Wetzels, J. F., 1995. Urinary excretion of beta 2-microglobulin predicts renal outcome in patients with idiopathic membranous nephropathy., J. Am. Soc. Nephrol. 6 (1995), pp. 1666–1669.
   PubMed Web of Science ®Google Scholar
• Roels, H., Bernard, A. M., Cardenas, A., Buchet, J.-P., Lauwerys, R. R., Hotter, G., Ramis, I., Mutti, A., Franchini, I., Bundschuh, I., Stolte, H., De Broe, M. D., Nuyts, G. D., Taylor, S. A., and Price, R. G., 1993. Markers of early renal changes induced by industrial pollutants. III. Application to workers exposed to cadmium., Br. J. Ind. Med. 50 (1993), pp. 37–48.
   PubMedGoogle Scholar
• Roels, H. A., Lauwerys, R. R., Buchet, J.-P., Bernard, A., Chettle, D. R., Harvey, T. C., and Al-Hadda, I. K., 1981. In vivo measurement of liver and kidney cadmium in workers exposed to this metal: Its significance with respect to cadmium in blood and urine., Environ. Res. 26 (1981), pp. 217–240.
   PubMed Web of Science ®Google Scholar
• Roels, H., Lauwerys, R., and Dardenne, A. N., 1983. The critical level of cadmium in human renal cortex., Toxicol. Lett. 15 (1983), pp. 357–360.
   PubMed Web of Science ®Google Scholar
• Roels, H. A., Van Assche, F. J., Oversteyns, M., De Groof, M., Lauwerys, R. R., and Lison, D., 1997. Reversibility of microproteinuria in cadmium workers with incipient tubular dysfunction after reduction of exposure., Am. J. Ind. Med. 31 (5) (1997), pp. 645–652.
   PubMed Web of Science ®Google Scholar
• SAS Institute, Inc., 1999. SAS Version 8,1. Cary, NC: SAS Institute, Inc.; 1999.
   Google Scholar
• Schiavon, M., Di Landro, D., Baldo, M., De Silvestro, G., and Chiarelli, A., 1988. A study of renal damage in seriously burned patients., Burns Ind. Therm. Inj. 14 (1988), pp. 107–112.
   Web of Science ®Google Scholar
• Shah, B. V., Barnwell, B. G., and Bieler, C. S., 1997. SUDAAN user's manual, Release 7.5.. Research Triangle Park, NC: Research Triangle Institute.; 1997.
   Google Scholar
• Shaikh, Z. A., and Smith, J. C., 1980. "Metabolism of orally ingested cadmium in humans.". In: Holmstedt, B., Lauwerys, R., Mercier, M., and Roberfroid, M., eds. Mechanism of toxicity and hazard evaluation. Amsterdam: Elsevier/North-Holland Biomedical Press; 1980. pp. 569–574.
   Google Scholar
• Suwazono, Y., Kobayashi, E., Okubo, Y., Nogawa, K., Kido, T., and Nakagawa, H., 2000. Renal effects of cadmium exposure in cadmium nonpolluted areas in Japan., Environ. Res. 84 (2000), pp. 44–55.
   PubMed Web of Science ®Google Scholar
• Tanaka, G., Yoshiyuki, N., and Nakaima, Y., 1989. Japanese reference man., Nippon Igaku Hoshasen Cakkai Zasshi 49 (1989), pp. 344–364.
   PubMedGoogle Scholar
• Thun, M. J., Osorio, A. M., Schober, S., Hannon, W. H., Lewis, B., and Halperin, W., 1989. Nephropathy in cadmium workers: Assessment of risk from airborne occupational exposure to cadmium., Br. J. Ind. Med. 46 (1989), pp. 689–697.
   PubMedGoogle Scholar
• U.S. Department of Health and Human Services, National Center for Health Statistics., 1997. Third National Health and Nutrition Examination Survey, 1988–1994 (CD-ROM Series 11). Hyattsville, MD: Centers for Disease Control and Prevention, Department of Health and Human Services; 1997.
   Google Scholar
• World Health Organization., 1992. Environmental health criteria 134: Cadmium.. Geneva: International Programme on Chemical Safety, World Health Organization.; 1992.
   Google Scholar
• Wu, X., Jin, T., Wang, Z., Ye, T., Kong, Q., and Nordberg, C., 2001. Urinary calcium as a biomarker of renal dysfunction in a general population exposed to cadmium., J. Occup. Environ. Med. 43 (2001), pp. 898–904.
   PubMed Web of Science ®Google Scholar
• Yamanaka, O., Kobayashi, E., Nogawa, K., Suwazono, Y., Sakurada, I., and Kido, T., 1998. Association between renal effects and cadmium exposure in cadmium-nonpolluted area in Japan., Environ. Res. 77 (1998), pp. 1–8.
   PubMed Web of Science ®Google Scholar