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Original Articles

Kinetic Factors Involved in the Metabolism of Benzene in Mouse Lung and Liver

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Pages 421-430 | Accepted 01 Sep 2003, Published online: 12 Aug 2010

REFERENCES

  • Aksoy , M. 1980 . Different types of malignancies due to occupational exposure to benzene: A review of recent observations in Turkey . Environ. Res. , 23 : 181 – 190 .
  • Aksoy , M. 1981 . Problems with benzene in Turkey . Regul. Toxicol. Pharmacol. , 1 : 147 – 155 .
  • Aksoy , M. 1985 . Benzene as a leukemogenic and carcinogenic agent . Am. J. Ind. Med. , 8 : 9 – 20 .
  • Bauer , A. K. , Faiola , B. , Abernethy , D. J. , Marchan , R. , Pluta , L. J. , Wong , V. A. , Roberts , K. , Jaiswal , A. K. , Gonzalez , F. J. , Butterworth , B. E. , Borghoff , S. J. , Parkinson , H. , Everitt , J. I. and Recio , L. 2003 . Genetic susceptibility to benzene-induced toxicity: Role of NADPH:quinone oxidoreductase-1 . Cancer Res. , 63 : 929 – 935 .
  • Chaney , A. M. and Carlson , G. P. 1995 . Comparison of rat hepatic and pulmonary microsomal metabolism of benzene and the lack of benzene-induced pneumotoxicity and hepatotoxicity . Toxicology , 104 : 53 – 62 .
  • Choudhary , D. , Jansson , I. , Schenkman , J. B. , Sarfarazi , M. and Stoiov , I. 2003 . Comparative expression profiling of 40 mouse cytochrome P450 genes in embryonic and adult tissues . Arch. Biochem. Biophys. , 414 : 91 – 100 .
  • Ghanayem , B. I. , Wang , S. and Sumner , S. 2000 . Using cytochrome P450 gene knockout mice to study chemical metabolism, toxicity, and carcinogenicity . Toxicol. Pathol. , 6 : 839 – 850 .
  • Gut , I. , Nedelcheva , V. , Soucek , P. , Stopka , P. , Vodicka , P. , Gelboin , H. V. and Ingelman-Sundberg , M. 1996 . The role of CYP2E1 and 2B1 in metabolic activation of benzene derivatives . Arch. Toxicol. , 71 : 45 – 56 .
  • Haddad , S. , Tardif , R. , Charest-Tardif , G. and Krishnan , K. 1999 . Physiological modeling of the toxicokinetic interactions in a quaternary mixture of aromatic hydrocarbons . Toxicol. Appl. Pharmacol. , 161 : 249 – 257 .
  • Hoffler , U. , El-Masri , H. A. and Ghanayem , B. I. 2003 . Cytochrome P450 2E1 (CYP2E1) is the principal enzyme responsible for urethane metabolism: Comparative studies Using CYP2E1-null and wild-type mice . J. Pharmacol. Exp. Ther. , 305 : 557 – 564 .
  • Huff , J. E. , Haseman , J. K. , Demarini , D. M. , Eustis , S. , Maronpot , R. R. , Peters , A. C. , Persing , R. L. , Chrisp , C. E. and Jacobs , A. C. 1989 . Multiple-site carcinogenicity of benzene in Fischer 344 rats and B6C3F1 mice . Environ. Health Perspect. , 82 : 125 – 163 .
  • Infante , P. F. , Rinsky , R. A. , Wagoner , J. K. and Young , R. J. 1977 . Leukemia in benzene workers . Lancet , 19 : 407 – 421 .
  • Jerina , A. , Daly , J. , Witkop , B. , Zaltzman-Nirenberg , P. and Udenfriend , S. 1968 . Role of the arene oxide–oxepin system in the metabolism of aromatic substances. I. In-vitro conversion of benzene oxide to a premercapturic acid and dihydrodiol . Arch. Biochem. Biophys. , 128 : 176 – 193 .
  • Kacew , S. and Lemaire , I. 2000 . Recent developments in benzene risk assessment . J. Toxicol. Environ. Health A , 61 : 485 – 498 .
  • Koop , D. R. , Laethem , C. L. and Schnier , G. G. 1989 . Identification of ethanol-inducible P450 isoenzyme 3a (P450 IIE1) as a benzene and phenol hydroxylase . Toxicol. Appl. Pharmacol. , 98 : 278 – 288 .
  • Krewski , D. , Snyder , R. , Beatty , P. , Granville , G. , Meek , B. and Sonawane , B. 2000 . Assessing the health risks of benzene: A report on the benzene state-of-the-art workshop . J. Toxicol. Environ. Health A , 61 : 307 – 338 .
  • Masuda , Y. , Nakayama , N. , Yamaguchi , A. and Murohashi , M. 1984 . The effects of diethyldithiocarbamate and carbon disulfide on acute nephrotoxicity induced by furan, bromobenzene, and cephaloridine in mice . Jpn. J. Pharmacol. , 34 : 221 – 229 .
  • Nedelcheva , V. , Gut , I. , Soucek , P. , Tichavska , B. , Tynkova , L. , Mraz , J. , Guengerich , F. P. and Ingelman-Sundberg , M. 1999 . Metabolism of benzene in human liver microsomes: Individual variations in relation to CYP2E1 expression . Arch. Toxicol. , 73 : 33 – 40 .
  • Ono , S. , Hatanaka , T. , Hotta , H. , Satoh , T. , Gonzalez , F. J. and Tsutsui , M. 1996 . Specificity of substrate and inhibitor probes for cytochromes P450: Evaluation of in vitro metabolism using cDNA-expressed human P450s and human liver microsomes . Xenobiotica , 26 : 681 – 693 .
  • Phillips , S. C. and Johnson , C. E. 2001 . Lympho-haematopoietic cancer and exposure to benzene in the Australian petroleum industry: Technical report and appendices. , Washington, DC : Exxon Mobil Corporation. . 8EHQ-0901-15006.
  • Powley , M. W. and Carlson , G. P. 1999 . Species comparison of hepatic and pulmonary metabolism of benzene . Toxicology , 139 : 207 – 217 .
  • Powley , M. W. and Carlson , G. P. 2000 . Cytochromes P450 involved with benzene metabolism in hepatic and pulmonary microsomes . J. Biochem. Mol. Toxicol. , 14 : 303 – 309 .
  • Powley , M. W. and Carlson , G. P. 2001a . Cytochrome P450 isoenzymes involved in the metabolism of phenol, a benzene metabolite . Toxicol. Lett. , 125 : 117 – 123 .
  • Powley , M. W. and Carlson , G. P. 2001b . Hepatic and pulmonary microsomal benzene metabolism in CYP2E1 knockout mice . Toxicology , 169 : 187 – 194 .
  • Ross , D. 2000 . The role of metabolism and specific metabolites in benzene-induced toxicity: Evidence and issues . J. Toxicol Environ. Health A , 61 : 357 – 372 .
  • Runion , H. E. and Scott , L. M. 1985 . Benzene exposure in the United States 1978–1983: An overview . Am. J. Ind. Med. , 7 : 385 – 393 .
  • Sawahata , T. and Neal , R. A. 1983 . Biotransformation of phenol to hydroquinone and catechol by rat liver microsomes . Mol. Pharmacol , 23 : 453 – 460 .
  • Schlosser , P. M. , Bond , J. A. and Medinsky , M. A. 1993 . Benzene and phenol metabolism by mouse and rat liver microsomes . Carcinogenesis , 14 : 2477 – 2486 .
  • Snyder , R. , Chepiga , T. , Yang , C. S. , Thomas , H. , Platt , K. and Oesch , F. 1993 . Benzene metabolism by reconstituted cytochromes P450 2B1 and 2E1 and its modulation by cytochrome b5, microsomal epoxide hydrolase, and glutathione transferases: Evidence for an important role of microsomal epoxide hydrolase in the formation of hydroquinone . Toxicol. Appl. Pharmacol. , 122 : 172 – 181 .
  • Travis , C. C. , Quillen , J. L. and Arms , A. D. 1990 . Pharmacokinetics of benzene . Toxicol. Appl. Pharmacol. , 102 : 400 – 420 .
  • Valentine , J. L. , Lee , S. S.-T. , Seaton , M. J. , Asgharian , B. , Farris , G. , Corton , J. C. , Gonzalez , F. J. and Medinsky , M. A. 1996 . Reduction of benzene metabolism and toxicity in mice that lack CYP2E1 expression . Toxicol. Appl. Pharmacol. , 141 : 205 – 213 .

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