DEPRENYL, A THERAPEUTIC AGENT FOR PARKINSON'S DISEASE, INHIBITS ARSENIC TOXICITY POTENTIATED BY GSH DEPLETION VIA INHIBITION OF JNK ACTIVATION

REFERENCES

• Bernstam , L. and Nriagu , J. 2000 . Molecular aspects of arsenic stress . J. Toxicol. Environ. Health B , 3 : 293 – 322 .
   PubMed Web of Science ®Google Scholar
• Brown , M. M. , Rhyne , B. C. , Goyer , R. A. and Fowler , B. A. 1976 . Intracellular effects of chronic arsenic administration on renal proximal tubule cells . J. Toxicol. Environ. Health , 1 : 505 – 514 .
   PubMed Web of Science ®Google Scholar
• Carlile , G. W. , Chalmers-Redman , R. M. , Tatton , N. A. , Pong , A. , Borden , K. E. and Tatton , W. G. 2000 . Reduced apoptosis after nerve growth factor and serum withdrawal: Conversion of tetrameric glyceraldehyde-3-phosphate dehydrogenase to a dimer . Mol. Pharmacol. , 57 : 2 – 12 .
   PubMed Web of Science ®Google Scholar
• Catherine , M. , Efthima , K. L. , Pheona , R. , Esa , H. H. , Shan-kuo , H. , Peter , W. , Gerald , C. and Warren , O. 1998 . Deprenyl and desmethylselegiline protect mesencephalic neurons from toxicity induced by glutathione depletion . J. Pharmacol. Exp. Ther. , 284 : 700 – 706 .
   PubMedGoogle Scholar
• Cho , M. K. , Kim , Y. G. , Lee , M. G. and Kim , S. G. 2001 . Prevention of c-Jun/activator protein-1 activation and microsomal epoxide hydrolase induction in the rat liver by cysteine during protein-calorie malnutrition . Biochem. Pharmacol. , 61 : 15 – 24 .
   PubMedGoogle Scholar
• Davis , R. J. 1993 . The mitogen-activated protein kinase signal transduction pathway . J. Biol. Chem. , 268 : 14553 – 14556 .
   PubMed Web of Science ®Google Scholar
• Ellis , R. E. , Yuan , J. Y. and Horvitz , H. R. 1991 . Mechanisms and functions of cell death . Annu. Rev. Cell Biol. , 7 : 663 – 698 .
   PubMed Web of Science ®Google Scholar
• Green , D. R. and Kroemer , G. 1998 . The central executioners of apoptosis: caspases or mitochondria? . Trends Cell. Biol. , 8 : 267 – 271 .
   PubMed Web of Science ®Google Scholar
• Hampton , M. B. , Fadeel , B. and Orrenius , S. 1998 . Redox regulation of the caspases during apoptosis . Ann. NY Acad. Sci. , 854 : 328 – 335 .
   PubMed Web of Science ®Google Scholar
• Hossain , K. , Akhand , A. A. , Kato , M. , Du , J. , Takeda , K. , Wu , J. , Takeuchi , K. , Liu , W. , Suzuki , H. and Nakashima , I. 2000 . Arsenite induces apoptosis of murine T lymphocytes through membrane raft-linked signaling for activation of c-Jun amino-terminal kinase . J. Immunol. , 165 : 4290 – 4297 .
   PubMed Web of Science ®Google Scholar
• Huang , C. , Ma , W. Y. , Li , J. and Dong , Z. 1999 . Arsenic induces apoptosis through a c-Jun NH2-terminal kinase-dependent, p53-independent pathway. . Cancer Res. , 59 : 3053 – 3058 .
   PubMed Web of Science ®Google Scholar
• Huang , C. , Bode , A. M. , Chen , N. Y. , Ma , W. Y. , Li , J. , Nomura , M. and Dong , Z. 2001 . Transactivation of AP-1 in AP-1-luciferase reporter transgenic mice by arsenite and arsenate . Anticancer Res. , 21 : 261 – 267 .
   PubMedGoogle Scholar
• Kang , K. W. , Ryu , J. H. and Kim , S. G. 2000 . The essential role of phosphatidylinositol 3-kinase and of p38 mitogen-activated protein kinase activation in the antioxidant response element-mediated rGSTA2 induction by decreased glutathione in H4IIE hepatoma cells . Mol. Pharmacol. , 58 : 1017 – 1025 .
   PubMed Web of Science ®Google Scholar
• Kim , S. G. , Nam , S. Y. , Kim , J. H. , Cho , C. K. and Yoo , S. Y. 1997 . Enhancement of radiation-inducible hepatic glutathione S-transferase Ya1, Yb1, Yb2, Yc1, and Yc2 expression by oltipraz: Possible role in radioprotection . Mol. Pharmacol. , 51 : 225 – 233 .
   PubMed Web of Science ®Google Scholar
• Kim , S. G. , Sung , M. A. , Kang , K. W. , Kim , S. H. , Son , M. H. and Kim , W. B. 2001 . DA-125, a novel anthracycline derivative with high affinity DNA binding and topoisomerase II inhibitory activities, exerts cytotoxicity via c-Jun N-terminal kinase pathway . Cancer Chemother. Pharmacol. , 47 : 511 – 518 .
   PubMed Web of Science ®Google Scholar
• Larochette , N. , Decaudin , D. , Jacotot , E. , Brenner , C. , Marzo , I. , Susin , S. A. , Zamzami , N. , Xie , Z. , Reed , J. and Kroemer , G. 1999 . Arsenite induces apoptosis via a direct effect on the mitochondrial permeability transition pore . Exp. Cell Res. , 249 : 413 – 421 .
   PubMed Web of Science ®Google Scholar
• Safaraz , A. , Kirk , T. K. and William , R. C. 2000 . Arsenic species that cause release of iron from ferritin and generation of activated oxygen . Arch. Biochem. Biophys. , 382 : 195 – 202 .
   PubMedGoogle Scholar
• Son , M. H. , Kang , K. W. , Lee , C. H. and Kim , S. G. 2001a . Potentiation of arsenic-induced cytotoxicity by sulfur amino acid deprivation (SAAD) through activation of ERK1/2, p38 kinase and JNK1: The distinct role of JNK1 in SAAD-potentiated mercury toxicity . Toxicol. Lett. , 121 : 45 – 55 .
   PubMedGoogle Scholar
• Son , M. H. , Kang , K. W. , Lee , C. H. and Kim , S. G. 2001b . Potentiation of cadmium-induced cytotoxicity by sulfur amino acid deprivation through activation of extracellular signal-regulated kinase1/2 (ERK1/2) in conjunction with p38 kinase or c-jun N-terminal kinase (JNK). Complete inhibition of the potentiated toxicity by U0126 an ERK1/2 and p38 kinase inhibitor . Biochem. Pharmacol. , 62 : 1379 – 1390 .
   PubMed Web of Science ®Google Scholar
• Standaert , D. G. and Young , A. B. 2001 . “ Treatment of central nervous system degenerative disorders ” . In The pharmacological basis of therapeutics , Edited by: Hardman , J. G. and Limbird , L. E. 549 – 568. . New York : McGraw-Hill .
   Google Scholar
• Susin , S. A. , Zamzami , N. and Kroemer , G. 1998 . Mitochondria as regulators of apoptosis: Doubt no more . Biochim. Biophys. Acta , 1366 : 151 – 165 .
   PubMed Web of Science ®Google Scholar
• Tatton , W. G. and Chalmers-Redman , R. M. 1996 . Modulation of gene expression rather than monoamine oxidase inhibition: (−)-Deprenyl-related compounds in controlling neurodegeneration . Neurology , 47 : 171 – 183 .
   Web of Science ®Google Scholar
• Thiffault , C. , Aumont , N. , Quirion , R. and Poirier , J. 1995 . Effect of MPTP and l-deprenyl on antioxidant enzymes and lipid peroxidation levels in mouse brain. . J. Neurochem. , 65 : 2725 – 2733 .
   PubMed Web of Science ®Google Scholar
• Waldmeier , P. C. , Boulton , A. A. , Cools , A. R. , Kato , A. C. and Tatton , W. G. 2000 . Neurorescuing effects of the GAPDH ligand CGP 3466B . J. Neural. Transm. Suppl. , 60 : 197 – 214 .
   PubMedGoogle Scholar
• Wei , M. C. , Lindsten , T. , Mootha , V. K. , Weiler , S. , Gross , A. , Ashiya , M. , Thompson , C. B. and Korsmeyer , S. J. 2000 . tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c . Genes Dev. , 14 : 2060 – 2071 .
   PubMed Web of Science ®Google Scholar
• Yang , C. F. , Shen , H. M. and Ong , C. N. 2000 . Intracellular thiol depletion causes mitochondrial permeability transition in ebselen-induced apoptosis . Arch Biochem. Biophys. , 380 : 319 – 330 .
   PubMedGoogle Scholar
• Yu , R. , Mandlekar , S. and Kong , A. N. T. 2000 . Molecular mechanisms of butylated hydroxylanisole-induced toxicity: Induction of apoptosis through direct release of cytochrome c . Mol. Pharmacol. , 58 : 431 – 437 .
   PubMed Web of Science ®Google Scholar
• Zanke , B. W. , Boudreau , K. , Rubie , E. , Winnett , E. , Tibbles , L. A. , Zon , L. , Kyriakis , J. , Liu , F. F. and Woodgett , J. R. 1996 . The stress-activated protein kinase pathway mediates cell death following injury induced by cisplatinium, UV irradiation, or heat . Curr. Biol. , 6 : 606 – 613 .
   PubMed Web of Science ®Google Scholar