449
Views
167
CrossRef citations to date
0
Altmetric
Original Articles

Cylindrospermopsin Genotoxicity and Cytotoxicity: Role Of Cytochrome P-450 and Oxidative Stress

, , , &
Pages 739-753 | Received 18 Aug 2004, Accepted 04 Nov 2004, Published online: 24 Feb 2007

References

  • Adamson , G. M. and Harman , A. W. 1989 . A role for the glutathione peroxidase reductase enzyme system in the protection from paracetamol toxicity in isolated mouse hepatocytes . Biochem. Pharmacol. , 38 : 3323 – 3330 . [PUBMED] [INFOTRIEVE] [CSA]
  • Berry , M. N. , Edwards , A. M. and Barritt , G. J. 1991 . “ Utilization of hepatocytes for drug studies ” . In Isolated hepatocytes: Preparation, properties and applications , Edited by: Berry , M. , Edwards , A. and Barritt , G. 179 – 200 . Amsterdam : Elsevier Science .
  • Bogaards , J. J. P. , Bertrand , M. , Jackson , P. , Oudshoorn , M. J. , Weaver , R. J. , van Bladeren , P. J and Walther , B. 2000 . Determining the best animal model for human cytochrome P450 activities: A comparison of mouse, rat, rabbit, dog, micropig, monkey and man . Xenobiotica , 30 : 1131 – 1152 . [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
  • Byth , S. 1980 . Palm Island mystery disease . Med. J. Aust. , 2 : 40 – 42 . [PUBMED] [INFOTRIEVE]
  • Carmichael , W. W. , Azevedo , S. M. , An , J. S. , Molica , R. J. , Jochimsen , E. M. , Lau , S. , Rinehart , K. L. , Shaw , G. R. and Eaglesham , G. K. 2001 . Human fatalities from cyanobacteria: Chemical and biological evidence for cyanotoxins . Environ. Health Perspect. , 109 : 663 – 668 . [PUBMED] [INFOTRIEVE] [CSA]
  • Falconer , I. R. and Humpage , A. R. 2001 . Preliminary evidence for in vivo tumour initiation by oral administration of extracts of the blue-green alga Cylindrospermopsis raciborskii containing the toxin cylindrospermopsin . Environ. Toxicol. , 16 : 192 – 195 . [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
  • Fessard , V. and Bernard , C. 2003 . Cell alterations but no DNA strand breaks induced in vitro by cylindrospermopsin in CHOK1 cells . Environ. Toxicol. , 18 : 353 – 359 . [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
  • Fontaine , F. R. , DeGraaf , Y. C. , Ghaoui , R. , Sallustio , B. C. , Edwards , J. and Burcham , P. C. 2004 . Optimisation of the comet genotoxicity assay in freshly isolated murine hepatocytes: Detection of strong in vitro DNA damaging properties for styrene . Toxicol. In Vitro , 18 : 343 – 350 . [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
  • Froscio , S. M. , Humpage , A. R. , Burcham , P. C. and Falconer , I. R. 2001 . Cell-free protein synthesis inhibition assay for the cyanobacterial toxin cylindrospermopsin . Environ. Toxicol. , 16 : 408 – 412 . [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
  • Froscio , S. M. , Humpage , A. R. , Burcham , P. C. and Falconer , I. R. 2003 . Cylindrospermopsin-induced protein synthesis inhibition and its dissociation from acute toxicity in mouse hepatocytes . Environ. Toxicol. , 18 : 243 – 251 . [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
  • Gérard-Monnier, D., Erdelmeier , I. , Régnard , K. , Moze-Henry , N. , Yadan , J.-C. and Chaudière , J. 1998 . Reactions of 1-methyl-2-phenylindole with malondialdehyde and 4-hydroxyalkenals. Analytical applications to a colorimetric assay of lipid peroxidation . Chem. Res. Toxicol. , 11 : 1176 – 1183 . [CSA] [CROSSREF]
  • Ghaoui , R. , Sallustio , B. C. , Burcham , P. C. and Fontaine , F. R. 2003 . UDP-glucuronosyltransferase-dependent bioactivation of clofibric acid to a DNA-damaging intermediate in mouse hepatocytes . Chem. Biol. Interact. , 145 : 201 – 211 . [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
  • Harman , A. W. , McCamish , L. E. and Henry , C. A. 1987 . Isolation of hepatocytes from postnatal mice . J. Pharmacol. Methods. , 17 : 157 – 163 . [PUBMED] [INFOTRIEVE] [CROSSREF]
  • Hawkins , P. R. , Runnegar , M. T. C. , Jackson , A. R. B. and Falconer , I. R. 1985 . Severe hepatotoxicity caused by the tropical cyanobacterium (blue-green alga) Cylindrospermopsis raciborskii (Woloszynska) Seenaya and Subba Raju isolated from a domestic supply reservoir . Appl. Environ. Microbiol. , 50 : 1292 – 1295 . [PUBMED] [INFOTRIEVE] [CSA]
  • Henderson , L. , Wolfreys , A. , Fedyk , J. , Bourner , C. and Windebank , S. 1998 . The ability of the Comet assay to discriminate between genotoxins and cytotoxins . Mutagenesis , 13 : 89 – 94 . [PUBMED] [INFOTRIEVE] [CSA]
  • Hissin , P. J. and Hilf , R. 1976 . A fluorometric method for determination of oxidized and reduced glutathione in tissues . Anal. Biochem. , 71 : 214 – 226 . [CROSSREF]
  • Humpage , A. R. , Fenech , M. , Thomas , P. and Falconer , I. R. 2000 . Micronucleus induction and chromosome loss in transformed human white cells indicate clastogenic and aneugenic action of the cyanobacterial toxin, cylindrospermopsin . Mutat. Res. , 472 : 155 – 161 . [PUBMED] [INFOTRIEVE]
  • Kuiper-Goodman , T., Falconer , I. and Fitzgerald , J. 1999 . “ Human health aspects ” . In Toxic cyanobacteria in water. A guide to their public health consequences, monitoring and management , Edited by: Chorus and Bartram , J. 113 – 153 . London : E & FN Spon on behalf of WHO. .
  • Kuo , C. H. , Tune , B. M. and Hook , J. B. 1983 . Effect of piperonyl butoxide on organic anion and cation transport in rabbit kidneys . Proc. Soc. Exp. Biol. Med. , 174 : 165 – 171 . [PUBMED] [INFOTRIEVE] [CSA]
  • Labarca , C. and Paigen , K. 1980 . A simple, rapid, and sensitive DNA assay procedure . Anal. Chem. , 102 : 344 – 352 .
  • Norris , R. L. , Seawright , A. A. , Shaw , G. R. , Senogles , P. , Eaglesham , G. K. , Smith , M. J. , Chiswell , R. K. and Moore , M. R. 2002 . Hepatic xenobiotic metabolism of cylindrospermopsin in vivo in the mouse . Toxicon , 40 : 471 – 476 . [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
  • Norris , R. L. , Seawright , A. A. , Shaw , G. R. , Smith , M. J. , Chiswell , R. K. and Moore , M. R. 2001 . Distribution of 14C cylindrospermopsin in vivo in the mouse . Environ. Toxicol. , 16 : 498 – 505 . [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
  • Ohtani , I. , Moore , R. E. and Runnegar , M. T. C. 1992 . Cylindrospermopsin: A potent hepatotoxin from the blue-green alga Cylindrospermopsis raciborskii . J. Am. Chem. Soc. , 114 : 7941 – 7942 . [CROSSREF]
  • Park , J. G. , Kramer , B. S. , Steinberg , S. M. , Carmichael , J. , Collins , J. M. , Minna , J. D. and Gazdar , A. F. 1987 . Chemosensitivity testing of human colorectal carcinoma cell lines using a tetrazolium-based colorimetric assay . Cancer Res. , 47 : 5875 – 5879 . [PUBMED] [INFOTRIEVE]
  • Plewa , M. J. , Wagner , E. D. , Jazwierska , P. , Richardson , S. D. , Chen , P. H. and McKague , A. 2004 . Halonitromethane drinking water disinfection byproducts: Chemical characterization and mammalian cell cytotoxicity and genotoxicity . 38 : 62 – 68 .
  • Richards , A. H. , Lubinski , R. M. and Vanderlinde , R. E. 1975 . Studies on the kinetic assay of lactate dehydrogenase activity . Clin. Chem. , 21 : 1018 – 1023 .
  • Runnegar , M. T. , Kong , S. M. , Zhong , Y. Z. , Ge , J. L. and Lu , S. C. 1994 . The role of glutathione in the toxicity of a novel cyanobacterial alkaloid cylindrospermopsin in cultured rat hepatocytes . Biochem. Biophys. Res. Commun. , 201 : 235 – 241 . [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
  • Runnegar , M. T. , Kong , S. M. , Zhong , Y. Z. and Lu , S. C. 1995 . Inhibition of reduced glutathione synthesis by cyanobacterial alkaloid cylindrospermopsin in cultured rat hepatocytes . Biochem. Pharmacol. , 49 : 219 – 225 . [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
  • Sallustio , B. C. , Harkin , L. A. and Burcham , P. C. 1997 . Genotoxicity of acyl glucuronide metabolites formed from clofibric acid and gemfibrozil: A novel role for Phase II-mediated bioactivation in the hepatocarcinogenicity of the parent aglycones? . Toxicol. Appl. Pharmacol. , 147 : 459 – 464 . [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
  • Shaw , G. R. , Seawright , A. A. , Moore , M. R. and Lam , P. K. 2000 . Cylindrospermopsin, a cyanobacterial alkaloid: Evaluation of its toxicologic activity . Ther. Drug. Monit. , 22 : 89 – 92 . [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
  • Shen , X. Y. , Lam , P. K. S. , Shaw , G. R. and Wickramasinghe , W. 2002 . Genotoxicity investigation of a cyanobacterial toxin, cylindrospermopsin . Toxicon , 40 : 1499 – 1501 . [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
  • Singh , N. P. , McCoy , M. T. , Tice , R. R. and Schneider , E. L. 1988 . A simple technique for quantitation of low levels of DNA damage in individual cells . Exp. Cell. Res. , 175 : 184 – 191 . [PUBMED] [INFOTRIEVE]
  • Sriram , K. , Pai , K. S. and Ravindranath , V. 1995 . Protection and potentiation of 1-methyl-4-phenylpyridinium-induced toxicity by cytochrome P450 inhibitors and inducer may be due to the altered uptake of the toxin . J. Neurochem. , 64 : 1203 – 1208 . [PUBMED] [INFOTRIEVE]
  • Terao , K. , Ohmori , S. , Igarashi , K. , Ohtani , I. , Watanabe , M. F. , Harada , K. I. , Ito , E. and Watanabe , M. 1994 . Electron microscopic studies on experimental poisoning in mice induced by cylindrospermopsin isolated from blue-green algaUmezakia natans . Toxicon , 32 : 833 – 843 . [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.