Expression of N-Acetyltransferase in Monocyte-Derived Dendritic CellsFootnote∗

∗Jutta Lichter and Angela Heckelen contributed equally to this article.

REFERENCES

• Abdel-Razzak , Z. , Loyer , P. , Fautrel , A. , Gautier , J. C. , Corcos , L. , Turlin , B. , Beaune , P. and Guillouzo , A. 1993 . Cytokines down-regulate expression of major cytochrome P-450 enzymes in adult human hepatocytes in primary culture . Mol. Pharmacol. , 44 : 707 – 715 .
   PubMed Web of Science ®Google Scholar
• Atmane , N. , Dairou , J. , Paul , A. , Dupret , J. M. and Rodrigues-Lima , F. 2003 . Redox regulation of the human xenobiotic metabolizing enzyme arylamine N-acetyltransferase 1 (NAT1). Reversible inactivation by hydrogen peroxide . J Biol. Chem. , 278 : 35086 – 35092 .
   PubMed Web of Science ®Google Scholar
• Badawi , A. F. , Hirvonen , A. , Bell , D. A. , Lang , N. P. and Kadlubar , F. F. 1995 . Role of aromatic amine acetyltransferases, NAT1 and NAT2, in carcinogen–DNA adduct formation in the human urinary bladder . Cancer Res. , 55 : 5230 – 5237 .
   PubMed Web of Science ®Google Scholar
• Bhaiya , P. , Roychowdhury , S. , Vyas , P. M. , Doll , M. A. , Hein , D. W. and Svensson , C. K. 2006 . Bioactivation, protein haptenation, and toxicity of sulfamethoxazole and dapsone in normal human dermal fibroblasts . Toxicol. Appl. Pharmacol. , 215 : 158 – 167 .
   PubMed Web of Science ®Google Scholar
• Blum , M. , Grant , D. M. , McBride , W. , Heim , M. and Meyer , U. A. 1990 . Human arylamine N-acetyltransferase genes: Isolation, chromosomal localization, and functional expression . DNA Cell Biol. , 9 : 193 – 203 .
   PubMed Web of Science ®Google Scholar
• Bradford , M. M. 1976 . A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein–dye binding . Anal. Biochem. , 72 : 248 – 254 .
   PubMed Web of Science ®Google Scholar
• Bruhn , C. , Brockmöller , J. , Cascorbi , I. , Roots , I. and Borchert , H. H. 1999 . Correlation between genotype and phenotype of the human arylamine N‐ acetyltransferase type 1 (NAT1) . Biochem. Pharmacol. , 58 : 1759 – 1764 .
   PubMed Web of Science ®Google Scholar
• Butcher , N. J. , Ilett , K. F. and Minchin , R. F. 2000 . Substrate-dependent regulation of human arylamine N-acetyltransferase-1 in cultured cells . Mol. Pharmacol. , 57 : 468 – 473 .
   PubMed Web of Science ®Google Scholar
• Coroneos , E. and Sim , E. 1993 . Arylamine N-acetyltransferase activity in human cultured cell lines . Biochem. J. , 294 : 481 – 486 .
   PubMed Web of Science ®Google Scholar
• Cribb , A. E. , Grant , D. M. , Miller , M. A. and Spielberg , S. P. 1991 . Expression of monomorphic arylamine N-acetyltransferase (NAT1) in human leukocytes . J Pharmacol. Exp. Ther. , 259 : 1241 – 1246 .
   PubMed Web of Science ®Google Scholar
• Dairou , J. , Malecaze , F. , Dupret , J. M. and Rodrigues-Lima , F. 2005 . The xenobiotic-metabolizing enzymes arylamine N-acetyltransferases in human lens epithelial cells: inactivation by cellular oxidants and UVB-induced oxidative stress . Mol. Pharmacol. , 67 : 1299 – 1306 .
   PubMed Web of Science ®Google Scholar
• Deguchi , T. 1992 . Sequences and expression of alleles of polymorphic arylamine N- acetyltransferase of human liver . J. Biol. Chem. , 267 : 18140 – 18147 .
   PubMed Web of Science ®Google Scholar
• Hickman , D. , Pope , J. , Patil , S. D. , Fakis , G. , Smelt , V. , Stanley , L. A. , Payton , M. , Unadkat , J. D. and Sim , E. 1998 . Expression of arylamine N-acetyltransferase in human intestine . Gut , 42 : 402 – 409 .
   PubMed Web of Science ®Google Scholar
• Husain , A. , Barker , D. F. , States , J. C. , Doll , M. A. and Hein , D. W. 2004 . Identification of the major promoter and non-coding exons of the human arylamine N-acetyltransferase 1 gene (NAT1) . Pharmacogenetics , 14 : 397 – 406 .
   PubMedGoogle Scholar
• Kawakubo , Y. , Merk , H. F. , Masaoudi , T. A. , Sieben , S. and Blömeke , B. 2000 . N-Acetylation of paraphenylenediamine in human skin and keratinocytes . J. Pharmacol. Exp. Ther. , 292 : 150 – 155 .
   PubMed Web of Science ®Google Scholar
• Kloth , M. T. , Gee , R. L. , Messing , E. M. and Swaminathan , S. 1994 . Expression of N-acetyltransferase (NAT) in cultured human uroepithelial cells . Carcinogenesis , 15 : 2781 – 2787 .
   PubMed Web of Science ®Google Scholar
• Nohynek , G. J. , Duche , D. , Garrigues , A. , Meunier , P. A. , Toutain , H. and Leclaire , J. 2005 . Under the skin: Biotransformation of para-aminophenol and para-phenylenediamine in reconstructed human epidermis and human hepatocytes . Toxicol. Lett. , 158 : 196 – 212 .
   PubMed Web of Science ®Google Scholar
• Sadrieh , N. , Davis , C. D. and Snyderwine , E. G. 1996 . N-Acetyltransferase expression and metabolic activation of the food-derived heterocyclic amines in the human mammary gland . Cancer Res. , 56 : 2683 – 2687 .
   PubMed Web of Science ®Google Scholar
• Sanderson , J. P. , Naisbitt , D. J. , Farrell , J. , Ashby , C. A. , Tucker , M. J. , Rieder , M. J. , Pirmohamed , M. , Clarke , S. E. and Park , B. K. 2007 . Sulfamethoxazole and its metabolite nitroso sulfamethoxazole stimulate dendritic cell costimulatory signaling . J. Immunol. , 178 : 5533 – 5542 .
   PubMed Web of Science ®Google Scholar
• Sieben , S. , Baron , J. M. , Blomeke , B. and Merk , H. F. 1999 . Multiple cytochrome P450-isoenzymes mRNA are expressed in dendritic cells . Int. Arch. Allergy Immunol. , 118 : 358 – 361 .
   PubMed Web of Science ®Google Scholar
• Sinclair , J. C. , Delgoda , R. , Noble , M. E. , Jarmin , S. , Goh , N. K. and Sim , E. 1998 . Purification, characterization, and crystallization of an N-hydroxyarylamine O-acetyltransferase from Salmonella typhimurium . Protein Exp. Purification. , 12 : 371 – 380 .
   PubMedGoogle Scholar
• Smelt , V. A. , Mardon , H. J. and Sim , E. 1998 . Placental expression of arylamine N-acetyltransferases: Evidence for linkage disequilibrium between NAT1∗10 and NAT2∗4 alleles of the two human arylamine N-acetyltransferase loci NAT1 and NAT2 . Pharmacol. Toxicol. , 83 : 149 – 157 .
   PubMedGoogle Scholar
• Stanley , L. A. , Coroneos , E. , Cuff , R. , Hickman , D. , Ward , A. and Sim , E. 1996 . Immunochemical detection of arylamine N-acetyltransferase in normal and neoplastic bladder . J. Histochem. Cytochem. , 44 : 1059 – 1067 .
   PubMed Web of Science ®Google Scholar
• Stanley , L. A. , Skare , J. A. , Doyle , E. , Powrie , R. , D'Angelo , D. and Elcombe , C. R. 2005 . Lack of evidence for metabolism of p-phenylenediamine by human hepatic cytochrome P450 enzymes . Toxicology , 210 : 147 – 157 .
   PubMed Web of Science ®Google Scholar
• Ward , A. , Hickman , D. , Gordon , J. W. and Sim , E. 1992 . Arylamine N-acetyltransferase in human red blood cells . Biochem. Pharmacol. , 44 : 1099 – 1104 .
   PubMed Web of Science ®Google Scholar
• Windmill , K. F. , Gaedigk , A. , Hall , P. M. , Samaratunga , H. , Grant , D. M. and McManus , M. E. 2000 . Localization of N-acetyltransferases NAT1 and NAT2 in human tissues . Toxicol. Sci. , 54 : 19 – 29 .
   PubMed Web of Science ®Google Scholar
• Zhou , C. , Tabb , M. M. , Nelson , E. L. , Grun , F. , Verma , S. , Sadatrafiei , A. , Lin , M. , Mallick , S. , Forman , B. M. , Thummel , K. E. and Blumberg , B. 2006 . Mutual repression between steroid and xenobiotic receptor and NF-kappaB signaling pathways links xenobiotic metabolism and inflammation . J. Clin. Invest. , 116 : 2280 – 2289 .
   PubMed Web of Science ®Google Scholar