Surveillance Results of Depleted Uranium–Exposed Gulf War I Veterans: Sixteen Years of Follow-Up

REFERENCES

• Amin , S. , Zhang , Y. , Sawin , C. T. , Evans , S. R. , Hannan , M. T. , Kiel , D. P. , Wilson , P. W. and Felson , D. T. 2000 . Association of hypogonadism and estradiol levels with bone mineral density in elderly men from the Framingham study . Ann. Intern. Med. , 133 : 951 – 963 .
   PubMed Web of Science ®Google Scholar
• Army Environmental Policy Institute . 1995 . Health and environmental consequences of depleted uranium use in the U.S. Army Atlanta, GA
   Google Scholar
• Chia , S. E. , Chia , H. P. , Ong , C. N. and Jeyaratnam , J. 1997 . Cumulative blood lead levels and neurobehavioral test performance . Neurotoxicolog , 18 : 793 – 803 .
   PubMed Web of Science ®Google Scholar
• Consonni , D. , Pesatori , A. C. , Zocchetti , C. , Sindaco , R. , D'Oro , L. C. , Rubagotti , M. and Bertazzi , P. A. 2008 . Mortality in a population exposed to dioxin after the Seveso, Italy accident in 1976: 25 years of follow-up . Am. J. Epidemiol. , 167 : 847 – 858 .
   PubMed Web of Science ®Google Scholar
• Cross , F. T. , Palmer , R. F. , Busch , R. H. , Filipy , R. E. and Stuart , B. O. 1981 . Development of lesions in Syrian golden hamsters following exposure to radon daughters and uranium ore dust . Health Phys. , 41 : 135 – 153 .
   Google Scholar
• Diaz Sylvester , P. L. , Lopez , R. , Ubios , A. and Cabrini , R. 2002 . Exposure to subcutaneously implanted uranium dioxide impairs bone formation . Arch. Environ. Health , 57 : 320 – 325 .
   PubMedGoogle Scholar
• Donoghue , J. K. , Dyson , E. D. , Hislop , J. S. , Leach , A. M. and Spoor , L. N. 1972 . Human exposure to natural uranium. A case history and analytical results from some postmortem tissues . Br. J. Intern. Med. , 29 : 81 – 89 .
   Google Scholar
• Ejnik , J. W. , Todorov , T. , Mullick , F. G. , Squibb , K. S. , McDiarmid , M. A. and Centeno , J. A. 2005 . Uranium analysis in urine by inductively coupled plasma dynamic reaction cell mass spectrometry . Anal. Bioanal. Chem. , 382 : 73 – 79 .
   PubMed Web of Science ®Google Scholar
• Evans , H. J. and O'Riordan , M. L. 1975 . Human peripheral blood lymphocytes for the analysis of chromosome aberrations in mutagen tests . Mutat. Res. , 31 : 135 – 148 .
   PubMed Web of Science ®Google Scholar
• Fernald Environmental Management Project . Technical basis for internal dosimetry at the Fernald Environmental Management Project . FEMP Pub. SD 2008 . 1997 . Fernald, OH
   Google Scholar
• Finette , B. A. , Sullivan , L. M. , Oneill , J. P. , Nicklas , J. A. , Vacek , P. M. and Albertini , R. J. 1994 . Determination of HPRT mutant frequencies in t- lymphocytes in a healthy pediatric population—Statistical comparison between newborn, children and adult mutant frequencies, cloning efficiency and age . Mutat. Res. , 308 : 223 – 231 .
   Google Scholar
• Fisenne , I. M. and Perry , P.M. 1985 . Isotopic U concentration in human blood from New York donors . Health Phys. , 49 : 1272 – 1275 .
   PubMed Web of Science ®Google Scholar
• Guglielmotti , M. B. , Ubios , A. M. and Cabrini , R. L. 1985 . Alveolar wound healing alteration under uranyl nitrate intoxication . J. Oral Pathol. , 14 : 565 – 572 .
   PubMedGoogle Scholar
• Guglielmotti , M. B. , Ubios , A. M. , de Rey , B. M. and Cabrini , R. L. 1983 . Effects of acute intoxication with uranyl nitrate on bone formation . Experientia , 40 : 131 – 136 .
   Google Scholar
• Guilmette, R.A., Parkhurst, M. A., Miller, G., Hahn, E. F., Roszell, L. E., Daxon, E. G., Little, T. T., Whicker, J. J., Cheng, Y. S., Traub, R. J., Lodde, G. M., Szrom, F., Bihl, D. E., Creek, K. L., and McKee, C. B. 2004. Human health risk assessment of capstone depleted uranium aerosols. Attachment 3 of Depleted Uranium Aerosol Doses and Risks: Summary of U.S. Assessments. PNWD-3442. Prepared for the U.S. Army by Battelle. October 2004. http://fhp.osd.mil/du/du_capstone/index.pdf
   Google Scholar
• Hadjidakis , D. J. and Androulakis , I. I. 2006 . Bone remodeling . Ann. NY Acad. Sci. , 1092 : 385 – 396 .
   PubMed Web of Science ®Google Scholar
• Harley, N. H., Foulkes, E. C., Hilborne, L. H., Hudson, A., and Anthony, C. R. 1999. A review of the scientific literature as it pertains to Gulf War illnesses, Vol. 7, Depleted Uranium. RAND's National Defense Research Institute, Santa Monica, CA. http://www.rand.org/pubs/monograph_reports/2005/MR1018.7.pdf
   Google Scholar
• Heaton , R. K. , Miller , W. , Taylor , M. J. and Grant , I. 2004 . Revised comprehensive norms for an expanded Halstead–Reitan Battery: Demographically adjusted neuropsychological norms for African American and Caucasian adults—Professional Manual , Lutz, FL : Psychological Assessment Resources .
   Google Scholar
• Hodge , H. C. , Stannard , J. N. and Hursh , J. B. , eds. 1973 . Handbook of experimental pharmacology: Uranium, plutonium, transplutonic elements , Vol. 36 , New York : Springer-Verlag .
   Google Scholar
• Hooper , F. J. , Squibb , K. S. , Siegel , E. L. , McPhaul , K. and Keogh , J. P. 1999 . Elevated urine uranium excretion by soldiers with retained uranium shrapnel . Health Phys. , 77 : 512 – 519 .
   PubMed Web of Science ®Google Scholar
• International Commision on Radiologic Protection . 1974 . Report of the task groups on reference man , ICRP No. 23 Oxford : Pergamon Press .
   Google Scholar
• International Commision on Radiologic Protection . 1995 . Age-dependent dose to members of the public from intake of radionuclides: Part 3. Ingestion dose coefficients , ICRP No. 69. Ann. ICRP 25 Oxford : Pergamon Press .
   Google Scholar
• Institute of Medicine . 2000 . Gulf War and health , Vol. 1 , Washington, D.C : National Academy Press .
   Google Scholar
• Karpas , Z. , Kirber , A. , Eliah , E. , Marcus , P. , Roiz , Y. , Marko , R. , Kol , R. , Brikner , D. and Halicz , L. 1998 . Uranium in urine—Normalization to creatinine . Health Phys. , 74 : 86 – 90 .
   PubMed Web of Science ®Google Scholar
• Kathren , R. L. , McInroy , J. F. , Moore , R. H. and Dietert , S. E. 1989 . Uranium in the tissues of an occupationally exposed individual . Health Phys. , 57 : 17 – 21 .
   PubMed Web of Science ®Google Scholar
• Kuchuk , N. O. , van Schoor , N. M. , Pluijm , S. M. , Smit , J.H. , de Ronde , W. and Lips , P. 2007 . The association of sex hormone levels with quantitative ultrasound, bone mineral density, bone turnover and osteoporotic fractures in older men and women . Clin. Endocrinol. , 67 : 295 – 303 .
   Google Scholar
• Kurttio , P. , Komulainen , H. , Leino , A. , Salonen , L. , Auvinen , A. and Saha , H. 2005 . Bone as a possible target of chemical toxicity of natural uranium in drinking water . Environ. Health Perspect. , 113 : 68 – 72 .
   PubMed Web of Science ®Google Scholar
• Leach , L. J. , Maynard , E. A. , Hodge , H. C. , Scott , J. K. , Yuile , C. L. , Sylvester , G. E. and Wilson , H. B. 1970 . A five-year inhalation study with natural uranium dioxide (UO2) Dust—I. Retention and biologic effects in monkey, dog and rat . Health Phys. , 18 : 599 – 612 .
   PubMed Web of Science ®Google Scholar
• Leach , L. J. , Yuile , C. L. , Hodge , G. C. , Sylvester , G. E. and Wilson , H. B. 1973 . A five-year inhalation study with natural uranium dioxide (UO2) Dust—II. Postexposure retention and biologic effect in the monkey, dog and rat . Health Phys. , 25 : 239 – 258 .
   PubMed Web of Science ®Google Scholar
• Leggett , R. W. 1989 . The behavior and chemical toxicity of U in the kidney: A reassessment . Health Phys. , 57 : 365 – 383 .
   PubMed Web of Science ®Google Scholar
• Links , J. M. , Schwartz , B. S. , Simon , D. , Bandeen-Roche , K. and Stewart , W. F. 2001 . Characterization of toxicokinetics and toxicodynamics with linear systems theory: Application to lead-associated cognitive decline . Environ. Health Perspect. , 109 : 361 – 368 .
   PubMed Web of Science ®Google Scholar
• McDiarmid , M. A. , Engelhardt , S. E. , Oliver , M. , Gucer , P. , Wilson , P. D. , Kane , R. , Cernich , A. , Kaup , B. , Anderson , L. , Hoover , D. , Brown , L. , Albertini , R. , Gudi , R. , Jacobson-Kram , D. and Squibb , K. S. 2007 . Health surveillance of Gulf War I veterans exposed to depleted uranium: Updating the cohort . Health Phys. , 93 : 60 – 73 .
   PubMed Web of Science ®Google Scholar
• McDiarmid , M. A. , Engelhardt , S. M. , Oliver , M. , Gucer , P. , Wilson , P. D. , Kane , R. , Kabat , M. , Kaup , B. , Anderson , L. , Hoover , D. , Brown , L. , Handwerger , B. , Albertini , R. J. , Jacobson-Kram , D. , Thorne , C. D. and Squibb , K. S. 2004 . Health effects of depleted uranium on exposed Gulf War veterans: A 10-year follow-up . J. Toxicol. Environ. Health A , 67 : 277 – 296 .
   PubMed Web of Science ®Google Scholar
• McDiarmid , M. A. , Engelhardt , S. M. , Oliver , M. , Gucer , P. , Wilson , P. D. , Kane , R. , Kabat , M. , Kaup , B. , Anderson , L. , Hoover , D. , Brown , L. , Albertini , R. J. , Gudi , R. , Jacobson-Kram , D. , Thorne , C. D. and Squibb , K. S. 2006 . Biological monitoring and surveillance results of Gulf War I veterans exposed to depleted uranium . Int. Arch. Occup Environ Health , 79 : 11 – 21 .
   PubMed Web of Science ®Google Scholar
• McDiarmid , M. A. , Keogh , J. P. , Hooper , F. J. , McPhaul , K. , Squibb , K. S. , Kane , R. , DiPino , R. , Kabat , M. , Kaup , B. , Anderson , L. , Hoover , D. , Brown , L. , Hamilton , M. , Jacobson-Kram , D. , Burrows , B. and Walsh , M. 2000 . Health effects of depleted uranium on exposed Gulf War veterans . Environ. Res. , 82 : 168 – 180 .
   PubMed Web of Science ®Google Scholar
• McDiarmid , M. A. , Squibb , K. , Engelhardt , S. , Oliver , M. , Gucer , P. , Wilson , P. D. , Kane , R. , Kabat , M. , Kaup , B. , Anderson , L. , Hoover , D. , Brown , L. and Jacobson-Kram , D. 2001 . Surveillance of depleted uranium exposed Gulf War veterans: Health effects observed in an enlarged “friendly fire” cohort . J. Occup. Environ. Med. , 43 : 991 – 1000 .
   PubMed Web of Science ®Google Scholar
• McDiarmid , M. and Squibb , K. S. 2001 . “ Uranium and thorium ” . In Patty's industrial hygiene and toxicology , 5th , Edited by: Bingham , E. , Cohrssen , B. and Powell , C. 381 – 422 . New York : John Wiley & Sons .
   Google Scholar
• Mitchel , R. E. J. , Jackson , J. S. and Heinmeiller , B. 1999 . Inhaled uranium ore dust and lung cancer risk in rats . Health Phys. , 76 : 145 – 155 .
   PubMed Web of Science ®Google Scholar
• NHANES . Second National Report on Human Exposure to Environmental Chemicals . NCEH Publication No. 02–0716 . 2003 . Atlanta, GA: Centers for Disease Control and Prevention, National Health and Nutrition Examination Survey
   Google Scholar
• National Research Council . 2008 . Review of toxicologic and radiologic risks to military personnel from exposure to depleted uranium during and after combat , Washington, DC : National Academy Press .
   Google Scholar
• Office of the Special Assistant to the Deputy Secretary of Defense for Gulf War Illnesses. 2000. Environmental exposure report: Depleted uranium in the Gulf (II). U.S. Department of Defense, Washington, DC. http://www.gulflink.osd.mil/du_ii/
   Google Scholar
• Parkhurst , M. A. 2003 . Measuring aerosols generated inside armoured vehicles perforated by depleted uranium ammunition . Radiat. Prot. Dosim. , 105 : 167 – 170 .
   PubMed Web of Science ®Google Scholar
• Pellmar , T. C. , Fuciarelli , A. F. , Ejnik , J. W. , Hamilton , M. , Hogan , J. , Strocko , S. , Emond , C. , Mottaz , H. M. and Landauer , M. R. 1999a . Distribution of uranium in rats implanted with depleted uranium pellets . Toxicol. Sci. , 49 : 29 – 39 .
   PubMed Web of Science ®Google Scholar
• Pellmar , T.C. , Keyser , D. O. , Emery , C. and Hogan , J. B. 1999b . Electrophysiological changes in hippocampal slices isolated from rats embedded with depleted uranium fragments . Neurotoxicology. , 20 : 785 – 792 .
   PubMed Web of Science ®Google Scholar
• Reeves , D. L. , Winter , K. P. , Bleiberg , J. and Kane , R.L. 2007 . ANAM genogram: Historical perspectives, description, and current endeavors . Arch. Clin. Neuropsy. , 22 ( Suppl.1 ) : S15 – S38 .
   PubMed Web of Science ®Google Scholar
• Singh , N. P. , Bennett , D. B. and Wrenn , M. E. 1987 . Macro-distribution of naturally occurring alpha-emitting isotopes of U in the human skeleton . Health Phys. , 52 : 769 – 773 .
   Google Scholar
• Squibb , K. S. and McDiarmid , M. A. 2006 . Depleted uranium exposure and health effects in Gulf War veterans . Philos. Trans. R. Soc. B , 361 : 639 – 648 .
   PubMed Web of Science ®Google Scholar
• Squibb , K. S. , Todorov , T. , Centeno , J. A. and McDiarmid , M. A. 2008 . Blood uranium (U) isotopic analysis as a measure of DU exposure in U.S. soldiers . Toxicol. Sci. , 102 ( Suppl. ) : 356
   Google Scholar
• Squibb , K. S. , Leggett , R. W. and McDiarmid , M. A. 2005 . Prediction of renal concentrations of depleted uranium and radiation dose in Gulf War veterans with embedded shrapnel . Health Phys. , 89 : 267 – 273 .
   PubMed Web of Science ®Google Scholar
• Squibb , K. S. and McDiarmid , M. A. 2007 . “ Exposure and health surveillance in Gulf War veterans exposed to depleted uranium ” . In Depleted uranium. Properties, uses, and health consequences , Edited by: Miller , A. C. 105 – 119 . Boca Raton, FL : CRC Press .
   Google Scholar
• StataCorp . 2003 . Stata statistical software , College Station, TX : Stata .
   Google Scholar
• Statistical Products and Service Solutions . 2003 . SPSS statistical software [12.0] , Chicago : SPSS .
   Google Scholar
• Swierenga , S. H. , Heddle , J. A. , Sigal , E. A. , Gilman , J. P. , Brillinger , R. L. , Douglas , G. R. and Nestmann , E. R. 1991 . Recommended protocols based on a survey of current practice in genotoxicity testing laboratories, IV. Chromosome aberration and sister- chromatid exchange in Chinese hamster ovary, V79 Chinese hamster lung and human lymphocyte cultures . Mutat. Res. , 246 : 301 – 322 .
   PubMed Web of Science ®Google Scholar
• Tannenbaum , A. , ed. 1951 . Toxicology of uranium , National Nuclear Energy Series New York : McGraw-Hill .
   Google Scholar
• Tasat , D. R. , Orona , N. S. , Mandalunis , P. M. , Cabrini , R. L. and Ubios , A. M. 2007 . Ultrastructural and metabolic changes in osteoblasts exposed to uranyl nitrate . Arch. Toxicol. , 81 : 319 – 326 .
   PubMed Web of Science ®Google Scholar
• The Royal Society . 2001 . The health hazards of depleted uranium munitions part I , Policy document 6/01 London : Royal Society .
   Google Scholar
• The Royal Society . The health effects of depleted uranium munitions Summary . Policy document 6/02 . 2002 . London: Royal Society
   Google Scholar
• Thun , M. J. , Baker , D. B. , Steenland , K. , Smith , A. B. , Halperin , W. and Berl , T. 1985 . Renal toxicity in uranium mill workers . Scand. J. Work Environ. Health , 11 : 83 – 90 .
   PubMed Web of Science ®Google Scholar
• Tissandie , E. , Gueguen , Y. , Lobaccaro , J. M. A. , Grandcolas , L. , Voisin , P. , Aigueperse , J. , Gourmelon , P. and Souidi , M. 2007 . In vivo effects of chronic contamination with depleted uranium on vitamin D3 metabolism in rat . Biochim. Biophys. Acta , 1770 : 266 – 272 .
   PubMed Web of Science ®Google Scholar
• Tissandie , E. , Gueguen , Y. , Lobaccaro , J. M. A. , Paquet , F. , Aigueperse , J. and Soudi , M. 2006 . Effects of depleted uranium after short-term exposure on vitamin D metabolism in rat . Arch. Toxicol. , 80 : 473 – 480 .
   PubMed Web of Science ®Google Scholar
• Todorov , T. I. , Ejnik , J. W. , Squibb , K. , McDiarmid , M. and Centeno , J. A. Uranium analysis in blood by inductively coupled plasma mass spectrometry . Book of abstracts, 2007 European Winter Conference on Plasma Spectrochemistry . February 18–23 2007 . Palazzo dei Congressi, Taormina .
   Google Scholar
• Toohey , R. E. 2003 . Excretion of depleted uranium by Gulf war veterans . Radiat. Prot. Dosim. , 105 : 171 – 174 .
   PubMed Web of Science ®Google Scholar
• U.S. Department of Labor, Occupational Safety and Health Administration. 1978. 29 CFR 1910.1025 Lead standard.
   Google Scholar
• Ubios , A. M. , Guglielmotti , M. B. , Steinmetz , T. and Cabrini , R. L. 1991 . Uranium inhibits bone formation in physiologic alveolar bone modeling and remodeling . Environ. Res. , 54 : 17 – 23 .
   PubMed Web of Science ®Google Scholar
• Watanabe , N. , Kamel , S. , Ohkubo , A. , Yamanaka , N. , Ojsawa , S. , Makino , K. and Tokudo , K. 1986 . Urinary protein as measured with a pyrogallol red-molybdate complex, manually and in a Hitachi 726 automated analyzer . Clin. Chem. , 38 : 642 – 647 .
   Google Scholar
• World , Health Organization. 1987 . WHO laboratory manual for the examination of human semen and semen-cervical mucus interaction , Cambridge, , UK : Cambridge University Press .
   Google Scholar
• Woolson , R. F. 1987 . Statistical methods for the analysis of biomedical data , New York : John Wiley & Sons .
   Google Scholar
• Zhang , L. , Rothman , N. , Wang , Y. , Hayes , R. B. , Li , G. , Dosemeci , M. , Yin , S. , Kolachana , P. , Titenko-Holland , N. and Smith , M. T. 1998 . Increased aneusomy and long arm deletion of chromosomes 5 and 7 in the lymphocytes of Chinese workers exposed to benzene . Carcinogenesis , 9 : 1955 – 1961 .
   Google Scholar
• Zhang , L. , Rothman , N. , Wang , Y. , Hayes , R. B. , Yin , S. , Titenko-Holland , N. , Dosemeci , M. , Wang , Y. Z. , Kolachana , P. , Lu , W. , Xi , L. , Li , G. L. and Smith , M. T. 1999 . Benzene increases aneuploidy in the lymphocytes of exposed workers: A comparison of data obtained by fluorescence in situ hybridization in interphase and metaphase cells . Environ. Mol. Mutagen. , 34 : 260 – 268 .
   PubMedGoogle Scholar