Risk Assessment of an Essential Element: Manganese

REFERENCES

• Agency for Toxic Substances and Disease Registry . 2000 . Toxicological profile for manganese , Atlanta, GA : U.S. Department of Health and Human Services, Agency for Toxic Substances and Disease Registry .
   Google Scholar
• Agency for Toxic Substances and Disease Registry . 2008 . Draft toxicological profile for manganse , Atlanta, GA : U.S. Department of Health and Human Services, Agency for Toxic Substances and Disease Registry .
   Google Scholar
• Alessio , L. , Apostoli , P. , Ferioli , A. and Lombardi , S. 1989 . Interference of manganese on neuroendocrinal system in exposed workers. Preliminary report . Biol. Trace Elem. Res. , 21 : 249 – 253 .
   PubMed Web of Science ®Google Scholar
• Andersen , M. E. , Gearhart , J. M. and Clewell , H. J. 3rd . 1999 . Pharmacokinetic data needs to support risk assessments for inhaled and ingested manganese . Neurotoxicology , 20 : 161 – 171 .
   PubMed Web of Science ®Google Scholar
• Anger , W. K. 2003 . Neurobehavioural tests and systems to assess neurotoxic exposures in the workplace and community . Occup. Environ. Med. , 60 : 531 – 538 .
   PubMedGoogle Scholar
• Aschner , J. L. and Aschner , M. 2005 . Nutritional aspects of manganese homeostasis . Mol. Aspects Med. , 26 : 353 – 362 .
   PubMedGoogle Scholar
• Aschner , M. and Dorman , D. C. 2006 . Manganese: Pharmacokinetics and molecular mechanisms of brain uptake . Toxicol. Rev. , 25 : 147 – 154 .
   PubMedGoogle Scholar
• Aschner , M. , Erikson , K. M. and Dorman , D. C. 2005 . Manganese dosimetry: Species differences and implications for neurotoxicity . Crit. Rev. Toxicol. , 35 : 1 – 32 .
   PubMed Web of Science ®Google Scholar
• Aschner , M. , Guilarte , T. R. , Schneider , J. S. and Zheng , W. 2007 . Manganese: Recent advances in understanding its transport and neurotoxicity . Toxicol. Appl. Pharmacol. , 221 : 131 – 147 .
   PubMed Web of Science ®Google Scholar
• Barceloux , D. G. 1999 . Manganese . J. Toxicol. Clin. Toxicol. , 37 : 293 – 307 .
   PubMed Web of Science ®Google Scholar
• Bast-Pettersen , R. , Ellingsen , D. G. , Hetland , S. M. and Thomassen , Y. 2004 . Neuropsychological function in manganese alloy plant workers . Int. Arch. Occup. Environ. Health , 77 : 277 – 287 .
   PubMed Web of Science ®Google Scholar
• Bolte , S. , Normandin , L. , Kennedy , G. and Zayed , J. 2004 . Human exposure to respirable manganese in outdoor and indoor air in urban and rural areas . J. Toxicol. Environ. Health A , 67 : 459 – 467 .
   PubMed Web of Science ®Google Scholar
• Boojar , M. M. and Goodarzi , F. 2002 . A longitudinal follow-up of pulmonary function and respiratory symptoms in workers exposed to manganese . J. Occup. Environ. Med. , 44 : 282 – 290 .
   PubMed Web of Science ®Google Scholar
• Bouchard , M. , Laforest , F. , Vandelac , L. , Bellinger , D. and Mergler , D. 2007 . Hair manganese and hyperactive behaviors: Pilot study of school-age children exposed through tap water . Environ. Health Perspect. , 115 : 122 – 127 .
   PubMed Web of Science ®Google Scholar
• Bowler , R. M. , Gysens , S. , Diamond , E. , Booty , A. , Hartney , C. and Roels , H. A. 2003 . Neuropsychological sequelae of exposure to welding fumes in a group of occupationally exposed men . Int. J. Hyg. Environ. Health , 206 : 517 – 529 .
   PubMed Web of Science ®Google Scholar
• Bowler , R. M. , Roels , H. A. , Nakagawa , S. , Drezgic , M. , Diamond , E. , Park , R. , Koller , W. , Bowler , R. P. , Mergler , D. , Bouchard , M. , Smith , D. , Gwiazda , R. and Doty , R. L. 2007 . Dose-effect relations between manganese exposure and neurological, neuropsychological and pulmonary function in confined space bridge welders . Occup. Environ. Med. , 64 : 167 – 177 .
   PubMed Web of Science ®Google Scholar
• Cal EPA . 2007 . Air toxic hot spots risk assessment guidelines: Technical support document for the derivation of noncancer reference exposure levels , Sacramento, CA : Cal EPA .
   Google Scholar
• Calne , D. B. , Chu , N. S. , Huang , C. C. , Lu , C. S. and Olanow , W. 1994 . Manganism and idiopathic parkinsonism: similarities and differences . Neurology , 44 : 1583 – 1586 .
   PubMed Web of Science ®Google Scholar
• Chandra , S. V. , Srivastava , R. S. and Shukla , G. S . 1979 . Regional distribution of metals and biogenic amines in the brain of monkeys exposed to manganese . Toxicol. Lett. , 4 : 189 – 192 .
   Web of Science ®Google Scholar
• Clewell , H. J. , Lawrence , G. A. , Calne , D. B. and Crump , K. S. 2003 . Determination of an occupational exposure guideline for manganese using the benchmark method . Risk Anal. , 23 : 1031 – 1046 .
   PubMed Web of Science ®Google Scholar
• Couper , J. 1837 . On the effects of black oxide of manganese when inhaled into the lungs . Br. Ann. Med. Pharmacol. , : 41 – 42 .
   Google Scholar
• Crump , K. S. and Rousseau , P. 1999 . Results from eleven years of neurological health surveillance at a manganese oxide and salt producing plant . Neurotoxicology , 20 : 273 – 286 .
   PubMed Web of Science ®Google Scholar
• Davis , J. M. 1992 . Methylcyclopentadienyl manganese tricarbonyl: Health risk uncertainties and research directions . Environ. Health Perspect. , 106 ( suppl. 1 ) : 191 – 201 .
   Google Scholar
• Davis , C. D. and Greger , J. L. 1992 . Longitudinal changes of manganese-dependent superoxide dismutase and other indexes of manganese and iron status in women . Am. J. Clin. Nutr. , 55 : 747 – 752 .
   PubMed Web of Science ®Google Scholar
• Deschamps , F. J. , Guillaumot , M. and Raux , S. 2001 . Neurological effects in workers exposed to manganese . J. Occup. Environ. Med. , 43 : 127 – 132 .
   PubMed Web of Science ®Google Scholar
• Dobson , A. W. , Erikson , K. M. and Aschner , M. 2004 . Manganese neurotoxicity . Ann. NY Acad. Sci. , 1012 : 115 – 128 .
   PubMed Web of Science ®Google Scholar
• Dorman , D. C. , Struve , M. F. , James , R. A. , Marshall , M. W. , Parkinson , C. U. and Wong , B. A. 2001 . Influence of particle solubility on the delivery of inhaled manganese to the rat brain: Manganese sulfate and manganese tetroxide pharmacokinetics following repeated (14-day) exposure . Toxicol. Appl. Pharmacol. , 170 : 79 – 87 .
   PubMed Web of Science ®Google Scholar
• Dorman , D. C. , Brenneman , K. A. , McElveen , A. M. , Lynch , S. E. , Roberts , K. C. and Wong , B. A. 2002 . Olfactory transport: A direct route of delivery of inhaled manganese phosphate to the rat brain . J. Toxicol. Environ. Health A , 65 : 1493 – 1511 .
   PubMed Web of Science ®Google Scholar
• Dorman , D. C. , McManus , B. E. , Parkinson , C. U. , Manuel , C. A. , McElveen , A. M. and Everitt , J. I. 2004 . Nasal toxicity of manganese sulfate and manganese phosphate in young male rats following subchronic (13-week) inhalation exposure . Inhal. Toxicol. , 16 : 481 – 488 .
   PubMed Web of Science ®Google Scholar
• Dorman , D. C. , Struve , M. F. , Clewell , H. J. 3rd and Andersen , M. E. 2006a . Application of pharmacokinetic data to the risk assessment of inhaled manganese . Neurotoxicology , 27 : 752 – 764 .
   PubMed Web of Science ®Google Scholar
• Dorman , D. C. , Struve , M. F. , Wong , B. A. , Dye , J. A. and Robertson , I. D. 2006b . Correlation of brain magnetic resonance imaging changes with pallidal manganese concentrations in rhesus monkeys following subchronic manganese inhalation . Toxicol. Sci. , 92 : 219 – 227 .
   PubMed Web of Science ®Google Scholar
• Erikson , K. M. and Aschner , M. 2003 . Manganese neurotoxicity and glutamate-GABA interaction . Neurochem. Int. , 43 : 475 – 480 .
   PubMed Web of Science ®Google Scholar
• Eriksson , H. , Magiste , K. , Plantin , L. O. , Fonnum , F. , Hedstrom , K. G. , Theodorsson-Norheim , E. , Kristensson , K. , Stalberg , E. and Heilbronn , E. 1987 . Effects of manganese oxide on monkeys as revealed by a combined neurochemical, histological and neurophysiological evaluation . Arch. Toxicol. , 61 : 46 – 52 .
   PubMed Web of Science ®Google Scholar
• Fell , J. M. , Reynolds , A. P. , Meadows , N. , Khan , K. , Long , S. G. , Quaghebeur , G. , Taylor , W. J. and Milla , P. J. 1996 . Manganese toxicity in children receiving long-term parenteral nutrition . Lancet , 347 : 1218 – 1221 .
   PubMed Web of Science ®Google Scholar
• Finley , J. W. 2004 . Does environmental exposure to manganese pose a health risk to healthy adults? . Nutr. Rev. , 62 : 148 – 153 .
   PubMed Web of Science ®Google Scholar
• Finley , J. W. , Johnson , P. E. and Johnson , L. K. 1994 . Sex affects manganese absorption and retention by humans from a diet adequate in manganese . Am. J. Clin. Nutr. , 60 : 949 – 955 .
   PubMed Web of Science ®Google Scholar
• Finley , J. W. , Penland , J. G. , Pettit , R. E. and Davis , C. D. 2003 . Dietary manganese intake and type of lipid do not affect clinical or neuropsychological measures in healthy young women . J. Nutr. , 133 : 2849 – 2856 .
   PubMed Web of Science ®Google Scholar
• Fitzgerald , K. , Mikalunas , V. , Rubin , H. , McCarthey , R. , Vanagunas , A. and Craig , R. M. 1999 . Hypermanganesemia in patients receiving total parenteral nutrition . J. Parenteral Enteral Nutr. , 23 : 333 – 336 .
   PubMed Web of Science ®Google Scholar
• Fraga , C. G. 2005 . Relevance, essentiality and toxicity of trace elements in human health . Mol. Aspects Med. , 26 : 235 – 244 .
   PubMedGoogle Scholar
• Friedman , B. J. , Freeland-Graves , J. H. , Bales , C. W. , Behmardi , F. , Shorey-Kutschke , R. L. , Willis , R. A. , Crosby , J. B. , Trickett , P. C. and Houston , S. D. 1987 . Manganese balance and clinical observations in young men fed a manganese-deficient diet . J. Nutr. , 117 : 133 – 143 .
   PubMed Web of Science ®Google Scholar
• Gibbs , J. P. , Crump , K. S. , Houck , D. P. , Warren , P. A. and Mosley , W. S. 1999 . Focused medical surveillance: A search for subclinical movement disorders in a cohort of U.S. workers exposed to low levels of manganese dust . Neurotoxicology , 20 : 299 – 313 .
   PubMed Web of Science ®Google Scholar
• Goldhaber , S. B. 2003 . Trace element risk assessment: Essentiality vs. toxicity . Regul. Toxicol. Pharmacol. , 38 : 232 – 242 .
   PubMed Web of Science ®Google Scholar
• Greger , J. L. 1999 . Nutrition versus toxicology of manganese in humans: Evaluation of potential biomarkers . Neurotoxicology , 20 : 205 – 212 .
   PubMed Web of Science ®Google Scholar
• Greiffenstein , M. F. and Lees-Haley , P. R. 2007 . Neuropsychological correlates of manganese exposure: A meta-analysis . J. Clin. Exp. Neuropsychol. , 29 : 113 – 126 .
   PubMed Web of Science ®Google Scholar
• Hardy , I. J. , Gillanders , L. and Hardy , G. 2008 . Is manganese an essential supplement for parenteral nutrition? . Curr. Opin. Clin. Nutr. Metab. Care , 11 : 289 – 296 .
   PubMed Web of Science ®Google Scholar
• Health Canada . 1994 . Risk assessment for the combustion products of MMT in gasoline , Ottawa, Ontario : Environmental Health Directorate .
   Google Scholar
• Huang , C. C. , Lu , C. S. , Chu , N. S. , Hochberg , F. , Lilienfeld , D. , Olanow , W. and Calne , D. B. 1993 . Progression after chronic manganese exposure . Neurology , 43 : 1479 – 1483 .
   PubMed Web of Science ®Google Scholar
• Huang , Y. L. , Tseng , W. C. and Lin , T. H. 2001 . In vitro effects of metal ions (Fe2+, Mn2+, Pb2+) on sperm motility and lipid peroxidation in human semen . J. Toxicol. Environ. Health A , 62 : 259 – 267 .
   PubMed Web of Science ®Google Scholar
• Hurley , L. S. and Keen , C. L. 1987 . “ Manganese ” . In Trace elements in human and animal nutrition , Edited by: Mertz . Vol. 1 , 185 – 222 . Orlando, FL : Academic Press .
   Google Scholar
• Ikeda , S. , Yamaguchi , Y. , Sera , Y. , Ohshiro , H. , Uchino , S. , Yamashita , Y. and Ogawa , M. 2000 . Manganese deposition in the globus pallidus in patients with biliary atresia . Transplantation , 69 : 2339 – 2343 .
   PubMed Web of Science ®Google Scholar
• Institute of Medicine . 2001 . Dietary reference intakes: Vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc , Washington, DC : National Academy Press .
   Google Scholar
• Iregren , A. 1990 . Psychological test performance in foundry workers exposed to low levels of manganese . Neurotoxicol. Teratol. , 12 : 673 – 675 .
   PubMed Web of Science ®Google Scholar
• Jonderko , G. , Kujawska , A. and Langauer-Lewowicka , H. 1971 . Problems of chronic manganese poisoning on the basis of investigations of workers at a manganese alloy foundry . Int. Arch. Arbeitsmed. , 28 : 250 – 264 .
   PubMedGoogle Scholar
• Kaji , H. , Ohsaki , Y. , Rokujo , C. , Higashi , T. , Fujino , A. and Kamada , T. 1993 . Determination of blood and urine manganese (Mn) concentrations and the application of static sensography as the indices of Mn-exposure among Mn-refinery workers . J. UOEH , 15 : 287 – 296 .
   PubMedGoogle Scholar
• Kawamura , C. 1941 . Intoxication by manganese in well water . Kitasato Arch. Exp. Med. , 18 : 145 – 169 .
   Google Scholar
• Keen , C. 1994 . “ Nutritional and toxicological aspects of manganese intakes: An overview ” . In Risk assessment of essential elements , Edited by: Mertz , W. , Abernathy , C. O. and Olin , S. S. 221 – 235 . Washington, DC : ILSI Press .
   Google Scholar
• Keen , C. L. , Ensunsa , J. L. , Watson , M. H. , Baly , D. L. , Donovan , S. M. , Monaco , M. H. and Clegg , M. S. 1999 . Nutritional aspects of manganese from experimental studies . Neurotoxicology , 20 : 213 – 223 .
   PubMed Web of Science ®Google Scholar
• Kim , E. A. , Cheong , H. K. , Joo , K. D. , Shin , J. H. , Lee , J. S. , Choi , S. B. , Kim , M. O. , Lee , I. J. and Kang , D. M. 2007 . Effect of manganese exposure on the neuroendocrine system in welders . Neurotoxicology , 28 : 263 – 269 .
   PubMed Web of Science ®Google Scholar
• Kim , Y. , Kim , J. W. , Ito , K. , Lim , H. S. , Cheong , H. K. , Kim , J. Y. , Shin , Y. C. , Kim , K. S. and Moon , Y. 1999 . Idiopathic parkinsonism with superimposed manganese exposure: Utility of positron emission tomography . Neurotoxicology , 20 : 249 – 252 .
   PubMed Web of Science ®Google Scholar
• Kondakis , X. G. , Makris , N. , Leotsinidis , M. , Prinou , M. and Papapetropoulos , T. 1989 . Possible health effects of high manganese concentration in drinking water . Arch. Environ. Health , 44 : 175 – 178 .
   PubMed Web of Science ®Google Scholar
• Lander , F. , Kristiansen , J. and Lauritsen , J. M. 1999 . Manganese exposure in foundry furnacemen and scrap recycling workers . Int. Arch. Occup. Environ. Health , 72 : 546 – 550 .
   PubMed Web of Science ®Google Scholar
• Lauwerys , R. , Roels , H. , Genet , P. , Toussaint , G. , Bouckaert , A. and De Cooman , S. 1985 . Fertility of male workers exposed to mercury vapor or to manganese dust: A questionnaire study . Am. J. Ind. Med. , 7 : 171 – 176 .
   PubMed Web of Science ®Google Scholar
• Leavens , T. L. , Rao , D. , Andersen , M. E. and Dorman , D. C. 2007 . Evaluating transport of manganese from olfactory mucosa to striatum by pharmacokinetic modeling . Toxicol. Sci. , 97 : 265 – 278 .
   PubMed Web of Science ®Google Scholar
• Lees-Haley , P. R. , Rohling , M. L. and Langhinrichsen-Rohling , J. 2006 . A meta-analysis of the neuropsychological effects of occupational exposure to manganese . Clin. Neuropsychol. , 20 : 90 – 107 .
   PubMed Web of Science ®Google Scholar
• Levin , O. S. 2005 . [“Ephedron” encephalopathy] . Zh. Nevrol. Psikhiatr. Im S S Korsakova , 105 : 12 – 20 .
   PubMed Web of Science ®Google Scholar
• Levy , B. S. and Nassetta , W. J. 2003 . Neurologic effects of manganese in humans: A review . Int. J. Occup. Environ. Health , 9 : 153 – 163 .
   PubMed Web of Science ®Google Scholar
• Lewis , J. , Bench , G. , Myers , O. , Tinner , B. , Staines , W. , Barr , E. , Divine , K. K. , Barrington , W. and Karlsson , J. 2005 . Trigeminal uptake and clearance of inhaled manganese chloride in rats and mice . Neurotoxicology , 26 : 113 – 123 .
   PubMed Web of Science ®Google Scholar
• Lucchini , R. , Apostoli , P. , Perrone , C. , Placidi , D. , Albini , E. , Migliorati , P. , Mergler , D. , Sassine , M. P. , Palmi , S. and Alessio , L. 1999 . Long-term exposure to “low levels” of manganese oxides and neurofunctional changes in ferroalloy workers . Neurotoxicology , 20 : 287 – 297 .
   PubMed Web of Science ®Google Scholar
• McMillan , D. E. 1999 . A brief history of the neurobehavioral toxicity of manganese: Some unanswered questions . Neurotoxicology , 20 : 499 – 507 .
   PubMed Web of Science ®Google Scholar
• Meral , H. , Kutukcu , Y. , Atmaca , B. , Ozer , F. and Hamamcioglu , K. 2007 . Parkinsonism caused by chronic usage of intravenous potassium permanganate . Neurologist , 13 : 92 – 94 .
   PubMed Web of Science ®Google Scholar
• Mergler , D. , Huel , G. , Bowler , R. , Iregren , A. , Belanger , S. , Baldwin , M. , Tardif , R. , Smargiassi , A. and Martin , L. 1994 . Nervous system dysfunction among workers with long-term exposure to manganese . Environ. Res. , 64 : 151 – 180 .
   PubMed Web of Science ®Google Scholar
• Mergler , D. and Baldwin , M. 1997 . Early manifestations of manganese neurotoxicity in humans: An update . Environ. Res. , 73 : 92 – 100 .
   PubMed Web of Science ®Google Scholar
• Mertz , W. 1998 . A perspective on mineral standards . J. Nutr. , 128 : 375S – 378S .
   Web of Science ®Google Scholar
• Mirowitz , S. A. , Westrich , T. J. and Hirsch , J. D. 1991 . Hyperintense basal ganglia on T1-weighted MR images in patients receiving parenteral nutrition . Radiology , 181 : 117 – 120 .
   PubMed Web of Science ®Google Scholar
• Myers , J. E. , teWaterNaude , J , Fourie , M. , Zogoe , H. B. , Naik , I. , Theodorou , P. , Tassel , H. , Daya , A. and Thompson , M. L. 2003a . Nervous system effects of occupational manganese exposure on South African manganese mineworkers . Neurotoxicology , 24 : 649 – 656 .
   PubMed Web of Science ®Google Scholar
• Myers , J. E. , Thompson , M. L. , Naik , I. , Theodorou , P. , Esswein , E. , Tassell , H. , Daya , A. , Renton , K. , Spies , A. , Paicker , J. , Young , T. , Jeebhay , M. , Ramushu , S. , London , L. and Rees , D. J. 2003b . The utility of biological monitoring for manganese in ferroalloy smelter workers in South Africa . Neurotoxicology , 24 : 875 – 883 .
   PubMed Web of Science ®Google Scholar
• Myers , J. E. , Thompson , M. L. , Ramushu , S. , Young , T. , Jeebhay , M. F. , London , L. , Esswein , E. , Renton , K. , Spies , A. , Boulle , A. , Naik , I. , Iregren , A. and Rees , D. J. 2003c . The nervous system effects of occupational exposure on workers in a South African manganese smelter . Neurotoxicology , 24 : 885 – 894 .
   PubMed Web of Science ®Google Scholar
• Nagatomo , S. , Umehara , F. , Hanada , K. , Nobuhara , Y. , Takenaga , S. , Arimura , K. and Osame , M. 1999 . Manganese intoxication during total parenteral nutrition: Report of two cases and review of the literature . J. Neurol. Sci. , 162 : 102 – 105 .
   PubMed Web of Science ®Google Scholar
• National Research Council . 1989 . Recommended daily allowances , 1 – 9 . Washington, DC : National Academy Press .
   Google Scholar
• Neff , N. H. , Barrett , R. E. and Costa , E. 1969 . Selective depletion of caudate nucleus dopamine and serotonin during chronic manganese dioxide administration to squirrel monkeys . Experientia , 25 : 1140 – 1141 .
   PubMedGoogle Scholar
• Newland , M. C. 1999 . Animal models of manganese's neurotoxicity . Neurotoxicology , 20 : 415 – 432 .
   PubMed Web of Science ®Google Scholar
• Nielsen , F. H. 1996 . How should dietary guidance be given for mineral elements with beneficial actions or suspected of being essential? . J. Nutr. , 126 : 2377S – 2385S .
   PubMed Web of Science ®Google Scholar
• Nong , A. , Teeguarden , J. G. , Clewell , H. J. 3rd , Dorman , D. C. and Andersen , M. E. 2008 . Pharmacokinetic modeling of manganese in the rat IV: Assessing factors that contribute to brain accumulation during inhalation exposure . J. Toxicol. Environ. Health A , 71 : 413 – 426 .
   PubMed Web of Science ®Google Scholar
• Normandin , L. , Panisset , M. and Zayed , J. 2002 . Manganese neurotoxicity: Behavioral, pathological, and biochemical effects following various routes of exposure . Rev. Environ. Health , 17 : 189 – 217 .
   PubMedGoogle Scholar
• Olanow , C. W. 2004 . Manganese-induced parkinsonism and Parkinson's disease . Ann. NY Acad. Sci. , 1012 : 209 – 223 .
   PubMed Web of Science ®Google Scholar
• Olanow , C. W. , Good , P. F. , Shinotoh , H. , Hewitt , K. A. , Vingerhoets , F. , Snow , B. J. , Beal , M. F. , Calne , D. B. and Perl , D. P. 1996 . Manganese intoxication in the rhesus monkey: A clinical, imaging, pathologic, and biochemical study . Neurology , 46 : 492 – 498 .
   PubMed Web of Science ®Google Scholar
• Olin , S. S. 1998 . Between a rock and a hard place: Methods for setting dietary allowances and exposure limits for essential minerals . J. Nutr. , 128 : 364S – 367S .
   PubMed Web of Science ®Google Scholar
• Oskarsson , A. and Sandstrom , B. 1995 . A Nordic project–risk evaluation of essential trace elements: Essential versus toxic levels of intake . Analyst , 120 : 911 – 912 .
   PubMed Web of Science ®Google Scholar
• Pal , P. K. , Samii , A. and Calne , D. B. 1999 . Manganese neurotoxicity: A review of clinical features, imaging and pathology . Neurotoxicology , 20 : 227 – 238 .
   PubMed Web of Science ®Google Scholar
• Papavasiliou , P. S. , Miller , S. T. and Cotzias , G. C. 1966 . Role of liver in regulating distribution and excretion of manganese . Am. J. Physiol. , 211 : 211 – 216 .
   PubMed Web of Science ®Google Scholar
• Pennington , J. A. , Young , B. E. , Wilson , D. B. , Johnson , R. D. and Vanderveen , J. E. 1986 . Mineral content of foods and total diets: The Selected Minerals in Foods Survey, 1982 to 1984 . J. Am. Diet. Assoc. , 86 : 876 – 891 .
   PubMed Web of Science ®Google Scholar
• Roels , H. , Lauwerys , R. , Buchet , J. P. , Genet , P. , Sarhan , M. J. , Hanotiau , I. , de Fays , M. , Bernard , A. and Stanescu , D. 1987 . Epidemiological survey among workers exposed to manganese: Effects on lung, central nervous system, and some biological indices . Am. J. Ind. Med. , 11 : 307 – 327 .
   PubMed Web of Science ®Google Scholar
• Roels , H. A. , Ghyselen , P. , Buchet , J. P. , Ceulemans , E. and Lauwerys , R. R. 1992 . Assessment of the permissible exposure level to manganese in workers exposed to manganese dioxide dust . Br. J. Ind. Med. , 49 : 25 – 34 .
   PubMedGoogle Scholar
• Roels , H. A. , Ortega Eslava , M. I , Ceulemans , E. , Robert , A. and Lison , D. 1999 . Prospective study on the reversibility of neurobehavioral effects in workers exposed to manganese dioxide . Neurotoxicology , 20 : 255 – 271 .
   PubMed Web of Science ®Google Scholar
• Roth , J. A. 2006 . Homeostatic and toxic mechanisms regulating manganese uptake, retention, and elimination . Biol Res , 39 : 45 – 57 .
   PubMed Web of Science ®Google Scholar
• Sandstrom , B. 1998 . Toxicity considerations when revising the Nordic nutrition recommendations . J. Nutr. , 128 : 372S – 374S .
   Web of Science ®Google Scholar
• Sanotsky , Y. , Lesyk , R. , Fedoryshyn , L. , Komnatska , I. , Matviyenko , Y. and Fahn , S. 2007 . Manganic encephalopathy due to “ephedrone” abuse . Move. Disorders , 22 : 1337 – 1343 .
   PubMed Web of Science ®Google Scholar
• Santamaria , A. B. , Cushing , C. A. , Antonini , J. M. , Finley , B. L. and Mowat , F. S. 2007 . State-of-the-science review: Does manganese exposure during welding pose a neurological risk? . J. Toxicol. Environ. Health B , 10 : 417 – 465 .
   PubMed Web of Science ®Google Scholar
• Saric , M. 1986 . “ Manganese ” . In Handbook on the toxicology of metals, volume II: Specific metals , 354 – 386 . New York : Elsevier Science .
   Google Scholar
• Schneider , J. S. , Decamp , E. , Koser , A. J. , Fritz , S. , Gonczi , H. , Syversen , T. and Guilarte , T. R. 2006 . Effects of chronic manganese exposure on cognitive and motor functioning in non-human primates . Brain Res , 1118 : 222 – 231 .
   PubMed Web of Science ®Google Scholar
• Schroeder , H. A. , Balassa , J. J. and Tipton , I. H. 1966 . Essential trace metals in man: manganese. A study in homeostasis . J. Chron. Dis. , 19 : 545 – 571 .
   PubMedGoogle Scholar
• Selikhova , M. , Fedoryshyn , L. , Matviyenko , Y. , Komnatska , I. , Kyrylchuk , M. , Krolicki , L. , Friedman , A. , Taylor , A. , Jager , H. R. , Lees , A. and Sanotsky , Y. 2008 . Parkinsonism and dystonia caused by the illicit use of ephedrone—A longitudinal study . Move. Disorders , 23 : 2224 – 2231 .
   PubMed Web of Science ®Google Scholar
• Sikk , K. , Taba , P. , Haldre , S. , Bergquist , J. , Nyholm , D. , Zjablov , G. , Asser , T. and Aquilonius , S. M. 2007 . Irreversible motor impairment in young addicts—Ephedrone, manganism or both? . Acta Neurol. Scand. , 115 : 385 – 389 .
   PubMed Web of Science ®Google Scholar
• Sinczuk-Walczak , H. , Jakubowski , M. and Matczak , W. 2001 . Neurological and neurophysiological examinations of workers occupationally exposed to manganese . Int. J. Occup. Med. Environ. Health , 14 : 329 – 337 .
   PubMedGoogle Scholar
• Sjogren , B. , Gustavsson , P. and Hogstedt , C. 1990 . Neuropsychiatric symptoms among welders exposed to neurotoxic metals . Br. J. Ind. Med. , 47 : 704 – 707 .
   PubMedGoogle Scholar
• Sjogren , B. , Iregren , A. , Frech , W. , Hagman , M. , Johansson , L. , Tesarz , M. and Wennberg , A. 1996 . Effects on the nervous system among welders exposed to aluminium and manganese . Occup. Environ. Med. , 53 : 32 – 40 .
   PubMed Web of Science ®Google Scholar
• Smargiassi , A. and Mutti , A. 1999 . Peripheral biomarkers and exposure to manganese . Neurotoxicology , 20 : 401 – 406 .
   PubMed Web of Science ®Google Scholar
• Solomou , E. , Velissaris , D. , Polychronopoulos , P. , Kalogeropoulos , A. , Kiriakopoulo , M. , Mpadra , F. , Kordonouri , T. and Karantza , C. 2005 . Quantitative evaluation of magnetic resonance imaging (MRI) abnormalities in subclinical hepatic encephalopathy . Hepatogastroenterology , 52 : 203 – 207 .
   PubMedGoogle Scholar
• Spahr , L. , Butterworth , R. F. , Fontaine , S. , Bui , L. , Therrien , G. , Milette , P. C. , Lebrun , L. H. , Zayed , J. , Leblanc , A. and Pomier-Layrargues , G. 1996 . Increased blood manganese in cirrhotic patients: Relationship to pallidal magnetic resonance signal hyperintensity and neurological symptoms . Hepatology , 24 : 1116 – 1120 .
   PubMed Web of Science ®Google Scholar
• Stepens , A. , Logina , I. , Liguts , V. , Aldins , P. , Eksteina , I. , Platkajis , A. , Martinsone , I. , Terauds , E. , Rozentale , B. and Donaghy , M. 2008 . A Parkinsonian syndrome in methcathinone users and the role of manganese . N. Engl. J. Med. , 358 : 1009 – 1017 .
   PubMed Web of Science ®Google Scholar
• Tanner , C. M. 2003 . Is the cause of Parkinson's disease environmental or hereditary? Evidence from twin studies . Adv. Neurol. , 91 : 133 – 142 .
   PubMed Web of Science ®Google Scholar
• Teeguarden , J. G. , Dorman , D. C. , Covington , T. R. , Clewell , H. J. 3rd and Andersen , M. E. 2007 . Pharmacokinetic modeling of manganese. I. Dose dependencies of uptake and elimination . J. Toxicol. Environ. Health A , 70 : 1493 – 1504 .
   PubMed Web of Science ®Google Scholar
• Underwood , E. 1977 . Manganese , New York : Academic Press .
   Google Scholar
• U.S. Environmental Protection Agency. 1996. Integrated Risk Information System (IRIS) [online electronic data files]. U.S. Environmental Protection Agency, Office of Research and Development, National Center for Environmental Assessment. Last updated December 1, 1996 http://toxnet.nlm.nih.gov (Accessed: June 2006 ).
   Google Scholar
• U.S. Environmental Protection Agency. 2006. Approaches for the application of physiologically based pharmacokinetic (PBPK) models and supporting data in risk assessment. National Center for Environmental Assessment, Washington, DC; EPA/600/R-05/043F http://epa.gov/ncea
   Google Scholar
• Varlibas , F. M. D. , Delipoyraz , I. , Yuksel , G. , Filiz , G. , Tireli , H. and Gecim , N. O. 2008 . Neurotoxicity following chronic intravenous use of “Russian Cocktail.” . Clin. Toxicol. , 14 : 1 – 4 .
   Google Scholar
• Wang , J. D. , Huang , C. C. , Hwang , Y. H. , Chiang , J. R. , Lin , J. M. and Chen , J. S. 1989 . Manganese induced parkinsonism: An outbreak due to an unrepaired ventilation control system in a ferromanganese smelter . Br. J. Ind. Med. , 46 : 856 – 859 .
   PubMedGoogle Scholar
• Wasserman , G. A. , Liu , X. , Parvez , F. , Ahsan , H. , Levy , D. , Factor-Litvak , P. , Kline , J. , van Geen , A. , Slavkovich , V. , LoIacono , N. J. , Cheng , Z. , Zheng , Y. and Graziano , J. H. 2006 . Water manganese exposure and children's intellectual function in Araihazar, Bangladesh . Environ. Health Perspect. , 114 : 124 – 129 .
   PubMed Web of Science ®Google Scholar
• World Health Organization . 2004a . Manganese and its compounds: Environmental aspects , Geneva : WHO .
   Google Scholar
• World Health Organization . 2004b . “ Manganese in drinking water ” . In Background document for development of WHO guidelines for drinking-water quality , 1 – 29 . Geneva : WHO .
   Google Scholar
• World Health Organization. 2005. Chemical-Specific adjustment factors for interspecies differences and human variability: Guidance document for use of data in dose/concentration–response assessment http://whqlibdoc.who.int/publications/2005/ 9241546786_eng.pdf
   Google Scholar
• Yiin , S. J. , Lin , T. H. and Shih , T. S. 1996 . Lipid peroxidation in workers exposed to manganese . Scand. J. Work Environ. Health , 22 : 381 – 386 .
   PubMed Web of Science ®Google Scholar
• Young , T. , Myers , J. E. and Thompson , M. L. 2005 . The nervous system effects of occupational exposure to manganese—measured as respirable dust—in a South African manganese smelter . Neurotoxicology , 26 : 993 – 1000 .
   PubMed Web of Science ®Google Scholar
• Zlotkin , S. H. , Atkinson , S. and Lockitch , G. 1995 . Trace elements in nutrition for premature infants . Clin. Perinatol. , 22 : 223 – 240 .
   PubMed Web of Science ®Google Scholar
• Zoni , S. , Albini , E. and Lucchini , R. 2007 . Neuropsychological testing for the assessment of manganese neurotoxicity: A review and a proposal . Am. J. Ind. Med. , 50 : 812 – 830 .
   PubMed Web of Science ®Google Scholar