288
Views
33
CrossRef citations to date
0
Altmetric
Original Articles

Ceramide Produces Apoptosis Through Induction of p27kip1 by Protein Phosphatase 2A-dependent Akt Dephosphorylation in PC-3 Prostate Cancer Cells

, , &
Pages 1465-1476 | Published online: 13 Oct 2010

REFERENCES

  • Andreu , E. J. , Lledó , E. , Poch , E. , Ivorra , C. , Albero , M. P. , Martinez-Climent , J. A. , Montiel-Duarte , C. , Rifón , J. , Pérez-Calvo , J. , Arbona , C. , Prósper , F. and Pérez-Roger , I. 2005 . BCR-ABL induces the expression of Skp2 through the PI3K pathway to promote p27Kip1 degradation and proliferation of chronic myelogenous leukemia cells . Cancer Res. , 65 : 3264 – 3272 .
  • Ben-Izhak , O. , Lahav-Baratz , S. , Meretyk , S. , Ben-Eliezer , S. , Sabo , E. , Dirnfeld , M. , Cohen , S. and Ciechanover , A. 2003 . Inverse relationship between Skp2 ubiquitin ligase and the cyclin dependent kinase inhibitor p27Kip1 in prostate cancer . J. Urol. , 170 : 241 – 245 .
  • Brunet , A. , Bonni , A. , Zigmond , M. J. , Lin , M. Z. , Juo , P. , Hu , L. S. , Anderson , M. J. , Arden , K. C. , Blenis , J. and Greenberg , M. E. 1999 . Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor . Cell , 96 : 857 – 868 .
  • Carrano , A. C. , Eytan , R. E. , Hershko , A. and Pagano , M. 1999 . SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27 . Nat. Cell. Biol. , 1 : 193 – 199 .
  • Dawson , J. F. and Holmes , C. F. 1999 . Molecular mechanisms underlying inhibition of protein phosphatases by marine toxins . Front. Biosci. , 4 : D646 – D658 .
  • Ekholm , S. V. and Reed , S. I. 2000 . Regulation of G1 cyclin-dependent kinases in the mammalian cell cycle . Curr. Opin. Cell Biol. , 12 : 676 – 684 .
  • Fernández , J. J. , Candenas , M. L. , Souto , M. L. , Trujillo , M. M. and Norte , M. 2002 . Okadaic acid, useful tool for studying cellular processes . Curr. Med. Chem. , 9 : 229 – 262 .
  • Fujita , N. , Sato , S. , Katayama , K. and Tsuruo , T. 2002 . Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization . J. Biol. Chem. , 277 : 28706 – 28713 .
  • Graff , J. R. , Konicek , B. W. , McNulty , A. M. , Wqang , Z. , Houck , K. , Allen , S. , Paul , J. D. , Hbaiu , A. , Goode , R. G. , Sanduskey , G. E. , Vessella , R. L. and Neubauer , B. L. 2000 . Increased AKT activity contributes to prostate cancer progression by dramatically accelerating prostate tumor growth and diminishing p27Kip1 expression . J. Biol. Chem. , 275 : 24500 – 24505 .
  • Han , J. H. , Choi , C. S. , Kim , M. Y. and Chun , Y. J. 2007 . Differential gene expression by styrene in rat reproductive tissue . J. Toxicol. Environ. Health A , 70 : 1259 – 1263 .
  • Hannun , Y. A. 1996 . Functions of ceramide in coordinating cellular responses to stress . Science , 274 : 1855 – 1859 .
  • Janssens , V. and Goris , J. 2001 . Protein phosphatase 2A: A highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling . Biochem. J. , 353 : 417 – 439 .
  • Janssens , V. , Goris , J. and Van Hoof , C. 2005 . PP2A: The expected tumor suppressor . Curr. Opin. Genet. Dev. , 15 : 34 – 41 .
  • Kim , H. J. , Mun , J. Y. , Chun , Y. J. , Choi , K. H. and Kim , M. Y. 2001 . Bax-dependent apoptosis induced by ceramide in HL-60 cells . FEBS Lett. , 505 : 264 – 268 .
  • Kim , W. H. , Ghil , K. C. , Lee , J. H. , Yeo , S. H. , Chun , Y. J. , Choi , K. H. , Kim , D. K. and Kim , M. Y. 2000 . Involvement of p27kip1 in ceramide-mediated apoptosis in HL-60 cells . Cancer Lett. , 151 : 39 – 48 .
  • Law , B. and Rossie , S. 1995 . The dimeric and catalytic subunit forms of protein phosphatase 2A from rat brain are stimulated by C2-ceramide . J. Biol Chem. , 270 : 12808 – 12813 .
  • Lee , J. G. and Kay , E. P. 2007 . Two populations of p27 use differential kinetics to phosphorylate Ser-10 and Thr-187 via phosphatidylinositol 3-kinase in response to fibroblast growth factor-2 stimulation . J. Biol. Chem. , 282 : 6444 – 6454 .
  • Lee , S. K. , Kim , Y. , Kim , M. Y. , Chun , Y. J. and Kim , S. 2004 . Potent inhibition of recombinant human cytochrome P-450 1A1 by pentamethoxystilbene . J. Toxicol. Environ. Health A , 67 : 1987 – 2000 .
  • Lloyd , R. V. , Erickson , L. A. , Jin , L. , Kulig , E. , Qian , X. , Cheville , J. C. and Scheithauer , B. W. 1999 . p27kip1: A multifunctional cyclin-dependent kinase inhibitor with prognostic significance in human cancers . Am. J. Pathol. , 154 : 313 – 323 .
  • Matias , W. G. , Bonini , M. and Creppy , E. E. 1996 . Inhibition of protein synthesis in a cell-free system and Vero cells by okadaic acid, a diarrhetic shellfish toxin . J. Toxicol. Environ. Health A , 48 : 309 – 317 .
  • Medema , R. H. , Kops , G. J. , Bos , J. L. and Burgering , B. M. 2000 . AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1 . Nature , 404 : 782 – 787 .
  • Millward , T. A. , Zoinierowicz , S. and Hemmings , B. A. 1999 . Regulation of protein kinase cascades by protein phosphatase 2A . Trends Biochem. Sci. , 24 : 186 – 191 .
  • Montagnoli , A. , Fiore , F. , Eytan , E. , Carrano , A. C. , Draetta , G. F. , Hershko , A. and Pagano , M. 1999 . Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation . Genes Dev. , 13 : 1181 – 1189 .
  • Motti , M. L. , Califano , D. , Troncone , G. , De Marco , C. , Migliaccio , I. , Palmieri , E. , Pezzullo , L. , Palombini , L. , Fusco , A. and Viglietto , G. 2005 . Complex regulation of the cyclin-dependent kinase inhibitor p27kip1 in thyroid cancer cells by the PI3K/Akt pathway; Regulation of p27kip1 expression and localization . Am. J. Pathol. , 166 : 737 – 749 .
  • Obeid , L. M. , Linardic , C. M. , Karolak , L. A. and Hannun , Y. A. 1993 . Programmed cell death by ceramide . Science , 259 : 1769 – 1771 .
  • Oh , W. J. , Kim , W. H. , Kang , K. H. , Kim , T. Y. , Kim , M. Y. and Choi , K. H. 1998 . Induction of p21 during ceramide-mediated apoptosis in human hepatocarcinoma cells . Cancer Lett. , 129 : 215 – 222 .
  • Pagano , M. , Tam , S. W. , Theodoras , A. M. , Beer-Romero , P. , Del Sal , G. , Chau , V. , Yew , P. R. , Draetta , G. F. and Rolfe , M. 1995 . Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27 . Science , 269 : 682 – 685 .
  • Pettus , B. , Chalfant , C. E. and Hannun , Y. A. 2002 . Ceramide in apoptosis: An overview and current perspectives . Biochem. Biophys. Acta , 1585 : 114 – 125 .
  • Reichert , M. , Saur , D. , Hamacher , R. , Schmid , R. M. and Schneider , G. 2007 . Phosphoinositide-3-kinase signaling controls S-Phase Kinase-Associated protein 2 transcription via E2F-1 in pancreatic ductal adenocarcinoma cells . Cancer Res. , 67 : 4149 – 4156 .
  • Ruvolo , P. P. , Deng , X. , Ito , T. , Carr , B. K. and May , W. S. 1999 . Ceramide induces Bcl2 dephosphorylation via a mechanism involving mitochondrial PP2A . J. Biol. Chem. , 274 : 20296 – 20300 .
  • Shin , I. , Rotty , J. , Wu , F. Y. and Arteaga , C. L. 2005 . Phosphorylation of p27Kip1 at Thr-157 interferes with its association with importin α during G1 and prevents nuclear re-entry . J. Biol. Chem. , 280 : 6055 – 6063 .
  • Shin , I. , Yakes , F. M. , Rojo , F. , Shin , N. Y. , Bakin , A. V. , Baselga , J. and Arteaga , C. L. 2000 . PKB/Akt mediates cell-cycle progression by phosphorylation of p27Kip1 at threonine 157 and modulation of its cellular localization . Nat. Med. , 8 : 1145 – 1152 .
  • Slingerland , J. and Pagano , M. 2000 . Regulation of the cdk inhibitor p27 and its deregulation in cancer . J. Cell. Physiol. , 183 : 10 – 17 .
  • Son , J. H. , Yoo , H. H. and Kim , D. H. 2007 . Activation of de novo synthetic pathway of ceramides is responsible for the initiation of hydrogen peroxide-induced apoptosis in HL-60 cells . J. Toxicol. Environ. Health A , 70 : 1310 – 1318 .
  • Tsihlias , J. , Kapusta , L. R. , DeBoer , G. , Morava-Protzner , I. , Zbieranowski , I. , Bhattacharya , N. , Catzavelos , G. C. , Klotz , L. H. and Slingerland , J. M. 1998 . Loss of cyclin-dependent kinase inhibitor p27Kip1 is a novel prognostic factor in localized human prostate adenocarcinoma . Cancer Res. , 58 : 542 – 548 .
  • van Duijn , P. W. and Trapman , J. 2006 . PI3K/Akt signaling regulates p27kip1 expression via Skp2 in PC3 and DU145 prostate cancer cells, but is not a major factor in p27kip1 regulation in LNCaP and PC346 cells . Prostate , 66 : 749 – 760 .
  • Viglietto , G. , Motti , M. L. , Bruni , P. , Melillo , R. M. , D'Alessio , A. , Califano , D. , Vinci , F. , Chiappetta , G. , Tsichlis , P. , Bellacosa , A. , Fusco , A. and Santoro , M. 2002 . Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27kip by PKB/Akt-mediated phosphorylation in breast cancer . Nat. Med. , 8 : 1136 – 1144 .
  • Xin , M. and Deng , X. 2006 . Protein phosphatase 2A enhances the proapotpotic function of Bax through dephosphorylation . J. Biol. Chem. , 281 : 18859 – 18866 .
  • Yin , K. J. , Hsu , C. Y. , Hu , X. Y. , Chen , H. , Chen , S. W. , Xu , J. and Lee , J. M. 2006 . Protein phosphatase 2A regulates bim expression via the Akt/FKHRL1 signaling pathway in amyloid-beta peptide-induced cerebrovascular endothelial cell death . J. Neurosci. , 26 : 2290 – 2299 .
  • Zha , J. , Harada , H. , Yang , E. , Jockel , J. and Korsmeyer , S. J. 1996 . Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not Bcl-XL . Cell , 87 : 619 – 628 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.