Effects of Flaxseed Lignan and Oil on Bone Health of Breast-Tumor-Bearing Mice Treated With or Without Tamoxifen

REFERENCES

• Adlercreutz , H. 2007 . Lignans and human health . Crit. Rev. Clin. Lab. Sci. , 44 : 483 – 525 .
   PubMed Web of Science ®Google Scholar
• Albertazzi , P. and Coupland , K. 2002 . Polyunsaturated fatty acids. Is there a role in postmenopausal osteoporosis prevention? . Maturitas , 42 : 13 – 22 .
   PubMed Web of Science ®Google Scholar
• Almeida , M. , Ambrogini , E. , Han , L. , Manolagas , S. C. and Jilka , R. L. 2009 . Increased lipid oxidation causes oxidative stress, increased peroxisome proliferator-activated receptor-gamma expression, and diminished pro-osteogenic Wnt signaling in the skeleton . J. Biol. Chem. , 284 : 27438 – 27448 .
   PubMed Web of Science ®Google Scholar
• Baber , R. , Hickey , M. and Kwik , M. 2005 . Therapy for menopausal symptoms during and after treatment for breast cancer: Safety considerations . Drug. Safety , 28 : 1085 – 1100 .
   PubMed Web of Science ®Google Scholar
• Bitto , A. , Polito , F. , Squadrito , F. , Marini , H. , D'Anna , R. , Irrera , N. , Minutoli , L. , Granese , R. and Altavilla , D. 2010 . Genistein aglycone: A dual mode of action anti-osteoporotic soy isoflavone rebalancing bone turnover towards bone formation . Curr. Med. Chem. , 17 : 3007 – 3018 .
   PubMed Web of Science ®Google Scholar
• Boon , H. S. , Olatunde , F. and Zick , S. M. 2007 . Trends in complementary/alternative medicine use by breast cancer survivors: Comparing survey data from 1998 and 2005 . BMC Womens Health , 7 : 4 – 10 .
   PubMedGoogle Scholar
• Bougnoux , P. and Chajes , V. 2003 . “ Alpha-linolenic acid and cancer ” . In Flaxseed in human nutrition , 2nd , Edited by: Thompson , L. U. and Cunnane , S. C. 232 – 244 . Champaign, IL : AOCS Press .
   Google Scholar
• Brenna , J. T. , Salem , N. Jr. , Sinclair , A. J. and Cunnane , S. C. 2009 . α-Linolenic acid supplementation and conversion to n-3 long-chain polyunsaturated fatty acids in humans . Prostaglandins Leukotrienes Essential Fatty Acids , 80 : 85 – 91 .
   PubMed Web of Science ®Google Scholar
• Brooks , J. D. and Thompson , L. U. 2005 . Mammalian lignans and genistein decrease the activities of aromatase and 17β-hydroxysteroid dehydrogenase in MCF-7 cells . J. Steroid. Biochem. Mol. Biol. , 94 : 461 – 467 .
   PubMed Web of Science ®Google Scholar
• Brooks , J. D. , Ward , W. E. , Lewis , J. E. , Hilditch , J. , Nickell , L. , Wong , E. and Thompson , L. U. 2004 . Supplementation with flaxseed alters estrogen metabolism in postmenopausal women to a greater extent than does supplementation with an equal amount of soy . Am. J.Clin. Nutr. , 79 : 318 – 325 .
   PubMed Web of Science ®Google Scholar
• Burdge , G. C. and Calder , P. C. 2005 . Conversion of alpha-linolenic acid to longer-chain polyunsaturated fatty acids in human adults . Reprod. Nutr. Dev. , 45 : 581 – 597 .
   PubMedGoogle Scholar
• Canadian Council on Animal Care . 1993 . Guide to the care and use of experimental animals , 2nd , Vol. 1 , Ottawa : CCAC .
   Google Scholar
• Chen , J. , Hui , E. , Ip , T. and Thompson , L. U. 2004 . Dietary flaxseed enhances the inhibitory effect of tamoxifen on the growth of estrogen-dependent human breast cancer (MCF-7) in nude mice . Clin. Cancer. Res. , 10 : 7703 – 7711 .
   PubMed Web of Science ®Google Scholar
• Chen , J. , Power , K. A. , Mann , J. , Cheng , A. and Thompson , L. U. 2007a . Flaxseed alone or in combination with tamoxifen inhibits MCF-7 breast tumor growth in ovariectomized athymic mice with high circulating levels of estrogen . Exp. Biol. Med. , 232 : 1071 – 1080 .
   PubMed Web of Science ®Google Scholar
• Chen , J. , Power , K. A. , Mann , J. , Cheng , A. and Thompson , L. U. 2007b . Dietary flaxseed interaction with tamoxifen induced tumor regression in nude mice with MCF-7 xenografts by down-regulating the expression of estrogen related gene products and signal transduction pathways . Nutr. Cancer. , 58 : 162 – 170 .
   PubMed Web of Science ®Google Scholar
• Chien , A. J. and Goss , P. E. 2006 . Aromatase inhibitors and bone health in women with breast cancer . J. Clin. Oncol. , 24 : 5305 – 5312 .
   PubMed Web of Science ®Google Scholar
• Cornish , S. M. and Chilibeck , P. D. 2009 . Alpha-linolenic acid supplementation and resistance training in older adults . Appl. Physiol. Nutr. Metab. , 34 : 49 – 59 .
   PubMed Web of Science ®Google Scholar
• Cunnane , S.C. 2003 . “ Dietary sources and metabolism of α-linolenic acid ” . In Flaxseed in human nutrition , 2nd , Edited by: Thompson , L. U. and Cunnane , S. C. 63 – 91 . Champaign, IL : AOCS Press .
   Google Scholar
• Dodin , S. , Lemay , A. , Jacques , H. , Légaré , F. , Forest , J. C. and Mâsse , B. 2005 . The effects of flaxseed dietary supplement on lipid profile, bone mineral density, and symptoms in menopausal women: A randomized, double-blind, wheat germ placebo-controlled clinical trial . J. Clin. Endocrinol. Metab. , 90 : 1390 – 1397 .
   PubMed Web of Science ®Google Scholar
• Eastell , R. , Adams , J. E. , Coleman , R. E. , Howell , A. , Hannon , R. A. , Cuzick , J. , Mackey , J. R. , Beckmann , M. W. and Clack , G. 2008 . Effect of anastrozole on bone mineral density: 5-Year results from the anastrozole, tamoxifen, alone or in combination trial . J. Clin. Oncol. , 26 : 1051 – 1057 .
   PubMed Web of Science ®Google Scholar
• Gao , Q. and Horvath , T. L. 2008 . Cross-talk between estrogen and leptin signaling in the hypothalamus . Am. J. Physiol. Endocrinol. Metab. , 294 : E817 – E826 .
   PubMed Web of Science ®Google Scholar
• Gerster , H. 1998 . Can adults adequately convert α-linolenic acid (18:3n-3) to eicosapentaenoic acid (20:5n-3) and docosahexaenoic acid (22:6n-3)? . Int. J. Vit. Nutr. Res. , 68 : 159 – 173 .
   PubMed Web of Science ®Google Scholar
• Hardman , W. E. 2002 . Omega-3 fatty acids to augment cancer therapy . J. Nutr , 132 ( suppl ) : 3508S – 3512S .
   Google Scholar
• Jordan , V. C. 2001 . The past, present, and future of selective estrogen receptor modulation . Ann. NY Acad. Sci. , 949 : 72 – 79 .
   PubMed Web of Science ®Google Scholar
• Kaludjerovic , J. and Ward , W. E. 2009 . Neonatal exposure to daidzein, genistein, or the combination modulates bone development in female CD-1 mice . J. Nutr. , 139 : 467 – 473 .
   PubMed Web of Science ®Google Scholar
• Kaludjerovic , J. and Ward , W. E. 2010 . Neonatal administration of isoflavones attenuates deterioration of bone tissue in female but not male mice . J. Nutr. , 140 : 766 – 772 .
   PubMed Web of Science ®Google Scholar
• Kitts , D. D. , Yuan , Y. V. , Wijewickreme , A. N. and Thompson , L. U. 1999 . Antioxidant activity of the flaxseed lignan secoisolariciresinol diglycoside and its mammalian lignan metabolites enterodiol and enterolactone . Mol. Cel. Biochem. , 202 : 91 – 100 .
   PubMed Web of Science ®Google Scholar
• Kotake , S. , Nanke , Y. , Yago , T. , Kawamoto , M. and Yamanaka , H. 2009 . Human osteoclastogenic T cells and human osteoclastology . Arthritis. Rheum. , 60 : 3158 – 3163 .
   PubMed Web of Science ®Google Scholar
• Kristensen , B. , Ejlertsen , B. , Dalgaard , P. , Larsen , L. , Holmegaard , S. N. , Transbol , I. and Mouridsen , H. T. 1994 . Tamoxifen and bone metabolism in postmenopausal low-risk breast cancer patients: A randomized study . J. Clin. Oncol. , 12 : 992 – 997 .
   PubMed Web of Science ®Google Scholar
• Lau , B. Y. , Ward , W. E. , Kang , J. X. and Ma , D. W. 2009 . Femur EPA and DHA are correlated with femur biomechanical strength in young fat-1 mice . J. Nutr. Biochem. , 20 : 453 – 461 .
   PubMed Web of Science ®Google Scholar
• Li , Y. , Seifert , M.F. , Lim , S.Y. , Salem , N. Jr and Watkins , B.A. 2010 . Bone mineral content is positively correlated to n-3 fatty acids in the femur of growing rats . Br. J. Nutr. , 104 : 674 – 685 .
   PubMed Web of Science ®Google Scholar
• Lotinun , S. , Westerlind , K.C. , Kennedy , A.M. and Turner , R.T. 2003 . Comparative effects of long-term continuous release of 16 alpha-hydroxyestrone and 17 beta-estradiol on bone, uterus, and serum cholesterol in ovariectomized adult rats . Bone , 33 : 124 – 131 .
   PubMed Web of Science ®Google Scholar
• MacGregor , J. I. and Jordan , V. C. 1998 . Basic guide to the mechanisms of antiestrogen action . Pharmacol. Rev. , 50 : 151 – 196 .
   PubMed Web of Science ®Google Scholar
• Perez , E. A. 2007 . Safety profiles of tamoxifen and the aromatase inhibitors in adjuvant therapy of hormone-responsive early breast cancer . Ann. Oncol. , 18 ( suppl. 8 ) : viii26 – 35 .
   PubMed Web of Science ®Google Scholar
• Poulsen , R. C. and Kruger , M. C. 2006 . Detrimental effect of eicosapentaenoic acid supplementation on bone following ovariectomy in rats . Prostaglandins Leukotrienes Essential Fatty Acids , 75 : 419 – 427 .
   PubMed Web of Science ®Google Scholar
• Power , K. A. , Ward , W. E. , Chen , J. M. , Saarinen , N. M. and Thompson , L. U. 2007 . Flaxseed and soy protein isolate, alone and in combination, differ in their effect on bone mass, biomechanical strength, and uterus in ovariectomized nude mice with MCF-7 human breast tumor xenografts . J. Toxicol. Environ. Health A , 70 : 1888 – 1896 .
   PubMed Web of Science ®Google Scholar
• Powles , T.J. , Hickish , T. , Kanis , J.A. , Tidy , A. and Ashley , S. 1996 . Effect of tamoxifen on bone mineral density measured by dual-energy X-ray absorptiometry in healthy premenopausal and postmenopausal women . J. Clin. Oncol. , 14 : 78 – 84 .
   PubMed Web of Science ®Google Scholar
• Prasad , K. 1997 . Hydroxyradical-scavenging property of secoisolariciresinol diglucoside (SDG) isolated from flaxseed . Mol. Cell Biochem. , 168 : 117 – 123 .
   PubMed Web of Science ®Google Scholar
• Prasad , K. 2000a . Antioxidant activity of secoisolariciresinol diglucoside-derived metabolites, coisolariciresinol, enterodiol, and enterolactone . Int. J. Angiol. , 9 : 220 – 225 .
   PubMedGoogle Scholar
• Prasad , K. 2000b . Oxidative stress as a mechanism of diabetes in diabetic BB prone rats: effect of secoisolariciresinol diglucoside (SDG) . Mol. Cell Biochem. , 219 : 89 – 96 .
   Google Scholar
• Rausch , S. M. , Winegardner , F. , Kruk , K. M. , Phatak , V. , Wahner-Roedler , D. L. , Bauer , B. and Vincent , A. 2011 . Complementary and alternative medicine: Use and disclosure in radiation oncology community practice . Support Care Cancer , 19 : 521 – 529 .
   PubMed Web of Science ®Google Scholar
• Reeves , P. G. , Nielsen , F. H. and Fahey , G. C. Jr. 1993 . AIN-93 purified diets for laboratory rodents: Final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet . J. Nutr. , 123 : 1939 – 1951 .
   PubMed Web of Science ®Google Scholar
• Reid , D. M. 2009 . Prevention of osteoporosis after breast cancer . Maturitas , 64 : 4 – 8 .
   PubMed Web of Science ®Google Scholar
• Rickard , S. E. , Orcheson , L. J. , Seidl , M. M. , Luyengi , L. , Fong , H. H. and Thompson , L. U. 1996 . Dose-dependent production of mammalian lignans in rats and in vitro from the purified precursor secoisolariciresinol diglycoside in flaxseed . J. Nutr. , 126 : 2012 – 2019 .
   PubMed Web of Science ®Google Scholar
• Rickard , S. E. and Thompson , L. U. 1998 . Chronic exposure to SDG alters lignin disposition in rats . J. Nutr. , 128 : 615 – 623 .
   PubMed Web of Science ®Google Scholar
• Sacco , S. M. , Thompson , L. U. and Ward , W. E. 2010 . “ Combination of flaxseed and low dose estrogen therapy on bone healthin arat model of postmenopausal osteoporosis ” . In Proc. US Flax Institute , Edited by: Hammond , J. 16 – 21 . Fargo : North Dakota State University .
   Google Scholar
• Sacco , S. M. , Jiang , J. M. , Reza-Lopez , S. , Ma , D. W. , Thompson , L. U. and Ward , W. E. 2009a . Flaxseed does not antagonize the effect of ultra-low-dose estrogen therapy on bone mineral density and biomechanical bone strength in ovariectomized rats . J. Toxicol. Environ. Health A , 72 : 1209 – 1216 .
   PubMed Web of Science ®Google Scholar
• Sacco , S. M. , Jiang , J. M. , Reza-López , S. , Ma , D. W. , Thompson , L. U. and Ward , W. E. 2009b . Flaxseed combined with low-dose estrogen therapy preserves bone tissue in ovariectomized rats . Menopause , 16 : 545 – 554 .
   PubMed Web of Science ®Google Scholar
• Saggar , J. K. , Chen , J. , Corey , P. and Thompson , L. U. 2010a . Dietary flaxseed lignan or oil combined with tamoxifen treatment affects MCF-7 tumor growth through estrogen receptor- and growth factor-signaling pathways . Mol. Nutr. Food Res. , 54 : 415 – 425 .
   PubMed Web of Science ®Google Scholar
• Saggar , J. K. , Chen , J. , Corey , P. and Thompson , L. U. 2010b . The effect of secoisolariciresinol diglucoside and flaxseed oil, alone and in combination, on MCF-7 tumor growth and signaling pathways . Nutr. Cancer , 62 : 532 – 542 .
   Web of Science ®Google Scholar
• Salari , P. , Rezaie , A. , Larijani , B. and Abdollahi , M. 2008 . A systematic review of the impact of n-3 fatty acids in bone health and osteoporosis . Med. Sci. Monit. , 14 : RA37 – RA44 .
   PubMed Web of Science ®Google Scholar
• Shen , C. L. , Yeh , J. K. , Rasty , J. , Li , Y. and Watkins , B. A. 2006 . Protective effect of dietary long-chain n-3 polyunsaturated fatty acids on bone loss in gonad-intact middle-aged male rats . Br. J. Nutr. , 95 : 462 – 468 .
   PubMed Web of Science ®Google Scholar
• Suh , K. S. , Koh , G. , Park , C. Y. , Woo , J. T. , Kim , S. W. , Kim , J. W. , Park , I. K. and Kim , Y. S. 2003 . Soybean isoflavones inhibit tumor necrosis factor-alpha-induced apoptosis and the production of interleukin-6 and prostaglandin E2 in osteoblastic cells . Phytochemistry , 63 : 209 – 215 .
   PubMed Web of Science ®Google Scholar
• Sun , D. , Krishnan , A. , Zaman , K. , Lawrence , R. , Bhattacharya , A. and Fernandes , G. 2003 . Dietary n-3 fatty acids decrease osteoclastogenesis and loss of bone mass in ovariectomized mice . J. Bone Mineral Res. , 18 : 1206 – 1216 .
   PubMed Web of Science ®Google Scholar
• Thompson , L. U. , Boucher , B. A. , Liu , Z. , Cotterchio , M. and Kreiger , N. 2007 . Phytoestrogen content of foods consumed in Canada, including isoflavones, lignans, and coumestan . Nutr. Cancer , 54 : 184 – 201 .
   Web of Science ®Google Scholar
• Thompson , L. U. , Robb , P. , Serraino , M. and Cheung , F. 1991 . Mammalian lignan production from various foods . Nutr. Cancer , 16 : 43 – 52 .
   PubMed Web of Science ®Google Scholar
• Thompson , L. U. 2003 . “ Flaxseed, lignans, and cancer ” . In Flaxseed in human nutrition , 2nd , Edited by: Thompson , L. U. and Cunnane , S. C. 194 – 222 . Champaign, IL : AOCS Press .
   Google Scholar
• Truan , J. S. , Chen , J. M. and Thompson , L. U. 2010 . Flaxseed oil reduces the growth of human breast tumors (MCF-7) at high levels of circulating estrogen . Mol. Nutr. Food Res. , 54 : 1414 – 1421 .
   PubMed Web of Science ®Google Scholar
• Wang , L. , Chen , J. and Thompson , L. U. 2005 . The inhibitory effect of flaxseed on the growth and metastasis of estrogen receptor negative human breast cancer xenograftsis attributed to both its lignan and oil components . Int. J. Cancer , 116 : 793 – 798 .
   PubMed Web of Science ®Google Scholar
• Weiler , H. A. , Kovacs , H. , Nitschmann , E. , Bankovic-Calic , N. , Aukema , H. and Ogborn , M. 2007 . Feeding flaxseed oil but not secoisolariciresinol diglucoside results in higher bone mass in healthy rats and rats with kidney disease . Prostaglandins Leukotrienes Essential Fatty Acids , 76 : 269 – 275 .
   PubMed Web of Science ®Google Scholar
• Westerlind , K. C. , Gibson , K. J. , Malone , P. , Evans , G. L. and Turner , R. T. 1998 . Differential effects of estrogen metabolites on bone and reproductive tissues of ovariectomized rats . J. Bone Mineral Res. , 13 : 1023 – 1031 .
   PubMed Web of Science ®Google Scholar