166
Views
14
CrossRef citations to date
0
Altmetric
Original Articles

Uptake, Tissue Distribution, and Excretion of 14C-Sulfur Mustard Vapor Following Inhalation in F344 Rats and Cutaneous Exposure in Hairless Guinea Pigs

, , &
Pages 875-885 | Received 13 Nov 2010, Accepted 12 Jan 2011, Published online: 18 May 2011

REFERENCES

  • Altshuler , B. and Pasternack , B. 1963 . Statistical measures of the lower limit of detection of a radioactivity counter . Health Phys. , 9 : 293 – 298 .
  • Benson , J. M. , Seagrave , J. C. , Weber , W. M. , Santistevan , C. D. , Grotendorst , G. R. , Schultz , G. S. and March , T. H. In press . Time course of lesion development in the hairless guinea pig model of sulfur mustard induced cutaneous injury . Wound Repair Regeneration , 2011 Mar 16 doi: 10.1111/j.1524-475X.2011.00675.x. [Epub ahead of print]
  • Black , R. M. , Brewster , K. , Clarke , R. J. , Hambrook , J. L. , Harrison , J. M. and Howells , D. J. 1992a . Biological fate of sulphur mustard, 1,1′-thiobis(2-chloroethane): Isolation and identification of urinary metabolites following intraperitoneal administration to rat . Xenobiotica , 22 : 405 – 418 .
  • Black , R. M. , Hambrook , J. L. , Howells , D. J. and Read , R. W. 1992b . Biological fate of sulfur mustard, 1,1′-thiobis(2-chloroethane). Urinary excretion profiles of hydrolysis products and β-lyase metabolites of sulfur mustard after cutaneous application in rats . J. Anal. Toxicol. , 16 : 79 – 84 .
  • Black , R. M. and Read , R. W. 1995 . Biological fate of sulphur mustard, 1,1′-thiobis(2-chloroethane): Identification of β-lyase metabolites and hydrolysis products in human urine . Xenobiotica , 25 : 167 – 173 .
  • Dachir , S. , Cohen , M. , Fishbeine , E. , Sahar , R. , Brandies , R. , Horwitz , V. and Kadar , T. 2010 . Characterization of acute and long-term sulfur mustard-induced skin injuries in hairless guinea-pigs using non-invasive methods . Skin Res. Technol. , 16 : 114 – 124 .
  • Dalton , C. H. , Maidment , M. P. , Jenner , J. and Chilcott , R. P. 2006 . Closed cup vapor systems in percutaneous exposure studies: What is the dose? . J. Anal. Toxicol. , 30 : 165 – 170 .
  • Hambrook , J. L. , Harrison , J. M. , Howells , D. J. and Schock , C. 1992 . Biological fate of sulphur mustard (1,1′-thio-bis(2-chloroethane)): urinary and faecal excretion of 35S by rat after injection or cutaneous application of 35S-labelled sulphur mustard . Xenobiotica , 22 : 65 – 75 .
  • Hattersley , I. J. , Jenner , J. , Dalton , C. , Chilcott , R. P. and Graham , J. S. 2008 . The skin reservoir of sulphur mustard . Toxicol. In Vitro , 22 : 1539 – 1546 .
  • Hayes , A. W. 2007 . Principle and methods of toxicology , 5th , 154 – 156 . New York : Informa Healthcare .
  • Langenberg , J. P. , van der Schans , G. P. , Spruit , H. E. , Kuijpers , W. C. , Mars-Groenendijk , R. H. , van Dijk-Knijnenburg , H. C. , Trap , H. C. , van Helden , H. P. and Benschop , H. P. 1998 . Toxicokinetics of sulfur mustard and its DNA-adducts in the hairless guinea pig . Drug Chem. Toxicol. , 21 ( suppl. 1 ) : 131 – 147 .
  • Maisonneuve , A. , Callebat , I. , Debordes , L. and Coppet , L. 1994 . Distribution of [14C]sulfur mustard in rats after intravenous exposure . Toxicol. Appl. Pharmacol. , 125 : 281 – 287 .
  • March , T. , Benson , J. , Grotendorst , G. , Seagrave , JC. and Weber , W. 2009 . Comparison of the acute effects of inhaled sulfur mustard and its surrogate, CEES, in F344 rats . Toxicol. Pathol. , 38 : E1 – E6 .
  • March , T. H. , Weber , W. M. and Grotendorst , G. R. June 20–24, 2010 2010 . Acute systemic effects of the inhaled chemical warfare agent, sulfur mustard, in rats , June 20–24, 2010 , Chicago : 29th Annual Meeting of the Society of Toxicologic Pathology .
  • Mershon , M. M. , Mitcheltree , L. W. , Petrali , J. P. , Braue , E. H. and Wade , J. V. 1990 . Hairless guinea pig bioassay model for vesicant vapor exposures . Fundam. Appl. Toxicol. , 15 : 622 – 630 .
  • Mishra , N. C. , Rir-sima-ah , J. , March , T. , Weber , W. , Benson , J. , Jaramillo , R. , Seagrave , JC. , Schultz , G. , Grotendorst , G. and Sopori , M. 2010 . Sulfur mustard induces immune sensitization in hairless guinea pigs . Int. Immunopharmacol. , 10 : 193 – 199 .
  • Snider , T. H. , Matthews , M. C. and Braue , E. H. 1999 . Model for assessing efficacy of topical skin protectants against sulfur mustard vapor using hairless guinea pigs . J. Appl. Toxicol. , 19 ( suppl. 1 ) : S55 – S58 .
  • Sueki , H. , Gammal , C. , Kudoh , K. and Kligman , A. M. 2000 . Hairless guinea pig skin: Anatomical basis for studies of cutaneous biology . Eur. J. Dermatol. , 10 : 357 – 364 .
  • Wattana , M. and Bey , T. 2009 . Mustard gas or sulfur mustard: An old chemical agent as a new terrorist threat . Prehosp. Disaster Med. , 24 : 19 – 29 . discussion 30–31
  • Weber , W. M. , Kracko , D. A. , Lehman , M. R. , Irvin , C. M. , Blair , L. F. , White , R. K. , Benson , J. M. , Grotendorst , G. R. , Cheng , Y. S. and McDonald , J. D. 2010 . Inhalation exposure systems for the development of rodent models of sulfur mustard-induced pulmonary injury . Toxicol. Mech. Methods , 20 : 14 – 24 .
  • Wormser , U. , Brodsky , B. and Sintov , A. 2002 . Skin toxicokinetics of mustard gas in the guinea pig: effect of hypochlorite and safety aspects . Arch. Toxicol. , 76 : 517 – 522 .
  • Yourick , J. J. , Dawson , J. S. , Benton , C. D. , Craig , M. E. and Mitcheltree , L. W. 1993 . Pathogenesis of 2,2′-dichlorodiethyl sulfide in hairless guinea pigs . Toxicology , 84 : 185 – 197 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.