357
Views
15
CrossRef citations to date
0
Altmetric
Original Articles

Fibrogenic and Redox-Related but not Proinflammatory Genes are Upregulated in Lewis Rat Model of Chronic Silicosis

, , , , , & show all
Pages 1261-1279 | Received 03 Mar 2011, Accepted 02 Jun 2011, Published online: 10 Aug 2011

REFERENCES

  • Arakawa , H. , Honma , K. , Saito , Y. , Morikubo , H. and Shida , H. 2005 . Delayed development of silicoproteinosis with diffuse interstitial fibrosis: 16-Year follow-up with autopsy correlation . Eur. Radiol , 15 : 2210 – 2211 .
  • Atkinson , J. J. and Senior , R. M. 2003 . Matrix metalloproteinase-9 in lung remodeling . Am. J. Respir. Cell Mol. Biol , 28 : 12 – 24 .
  • Barbarin , V. , Xing , Z. , Delos , M. , Lison , D. and Huaux , F. 2005 . Pulmonary overexpression of IL-10 augments lung fibrosis and Th2 responses induced by silica particles . Am. J. Physiol. Lung Cell. Mol. Physiol , 288 : L841 – L848 .
  • Barbaro , M. , Cutroneo , G. , Costa , C. , Sciorio , S. , Trimarchi , F. , Favaloro , A. , Fenga , C. , Barbaro Martino , L. , Spatari , G. , Abbate , C. and Bramanti , P. 2002 . Early events of experimental exposure to amorphous and crystalline silica in the rat: Time course of surfactant protein D . Ital. J. Anat. Embryol , 107 : 243 – 256 .
  • Berman , J. S. , Serlin , D. , Li , X. , Whitley , G. , Hayes , J. , Rishikof , D. C. , Ricupero , D. A. , Liaw , L. , Goetschkes , M. and O'Regan , A. W. 2004 . Altered bleomycin-induced lung fibrosis in osteopontin-deficient mice . Am. J. Physiol. Lung Cell. Mol. Physiol , 286 : L1311 – L1318 .
  • Borges , V. M. , Falcao , H. , Leite-Junior , J. H. , Alvim , L. , Teixeira , G. P. , Russo , M. , Nobrega , A. F. , Lopes , M. F. , Rocco , P. M. , Davidson , W. F. , Linden , R. , Yagita , H. , Zin , W. A. and DosReis , G. A. 2001 . Fas ligand triggers pulmonary silicosis . J. Exp. Med , 194 : 155 – 164 .
  • Borges , V. M. , Lopes , M. F. , Falcao , H. , Leite-Junior , J. H. , Rocco , P. R. , Davidson , W. F. , Linden , R. , Zin , W. A. and DosReis , G. A. 2002 . Apoptosis underlies immunopathogenic mechanisms in acute silicosis . Am. J. Respir. Cell Mol. Biol , 27 : 78 – 84 .
  • Castranova , V. 2004 . Signaling pathways controlling the production of inflammatory mediators in response to crystalline silica exposure: role of reactive oxygen/nitrogen species . Free Radical Biol. Med , 37 : 916 – 925 .
  • Castranova , V. , Porter , D. , Millecchia , L. , Ma , J. Y. , Hubbs , A. F. and Teass , A. 2002 . Effect of inhaled crystalline silica in a rat model: time course of pulmonary reactions . Mol. Cell. Biochem , : 234 – 235 . 177 – 184 .
  • Chensue , S. W. , Warmington , K. , Ruth , J. H. , Lukacs , N. and Kunkel , S. L. 1997 . Mycobacterial and schistosomal antigen-elicited granuloma formation in IFN-gamma and IL-4 knockout mice: analysis of local and regional cytokine and chemokine networks . J. Immunol , 159 : 3565 – 3573 .
  • Chong , S. , Lee , K. S. , Chung , M. J. , Han , J. , Kwon , O. J. and Kim , T. S. 2006 . Pneumoconiosis: comparison of imaging and pathologic findings . Radiographics , 26 : 59 – 77 .
  • Corbel , M. , Belleguic , C. , Boichot , E. and Lagente , V. 2002 . Involvement of gelatinases (MMP-2 and MMP-9) in the development of airway inflammation and pulmonary fibrosis . Cell Biol. Toxicol , 18 : 51 – 61 .
  • Davies , M. J. , Hawkins , C. L. , Pattison , D. I. and Rees , M. D. 2008 . Mammalian heme peroxidases: From molecular mechanisms to health implications . Antioxidant Redox Signal , 10 : 1199 – 1234 .
  • Edgar , R. , Domrachev , M. and Lash , A. E. 2002 . Gene Expression Omnibus: NCBI gene expression and hybridization array data repository . Nucleic Acids Res , 30 : 207 – 210 .
  • Fubini , B. and Hubbard , A. 2003 . Reactive oxygen species (ROS) and reactive nitrogen species (RNS) generation by silica in inflammation and fibrosis . Free Radical Biol. Med , 34 : 1507 – 1516 .
  • Giordano , G. , van den Brule , S. , Lo Re , S. , Triqueneaux , P. , Uwambayinema , F. , Yakoub , Y. , Couillin , I. , Ryffel , B. , Michiels , T. , Renauld , J. C. , Lison , D. and Huaux , F. 2010 . Type I interferon signaling contributes to chronic inflammation in a murine model of silicosis . Toxicol. Sci , 116 : 682 – 692 .
  • Helming , L. and Gordon , S. 2009 . Molecular mediators of macrophage fusion . Trends Cell. Biol , 19 : 514 – 522 .
  • Hnizdo , E. and Sluis-Cremer , G. K. 1993 . Risk of silicosis in a cohort of white South African gold miners . Am. J. Ind. Med , 24 : 447 – 457 .
  • Hnizdo , E. and Vallyathan , V. 2003 . Chronic obstructive pulmonary disease due to occupational exposure to silica dust: A review of epidemiological and pathological evidence . Occup. Environ. Med , 60 : 237 – 243 .
  • Ingersoll , S. A. , Martin , C. B. , Barnum , S. R. and Martin , B. K. 2010 . CNS-specific expression of C3a and C5a exacerbate demyelination severity in the cuprizone model . Mol. Immunol , 48 : 219 – 230 .
  • Langley , R. J. , Kalra , R. , Mishra , N. C. , Hahn , F. F. , Razani-Boroujerdi , S. , Singh , S. P. , Benson , J. M. , Pena-Philippides , J. C. , Barr , E. B. and Sopori , M. L. 2004 . A biphasic response to silica: I. Immunostimulation is restricted to the early stage of silicosis in Lewis rats . Am. J. Respir. Cell Mol. Biol , 30 : 823 – 829 .
  • Langley , R. J. , Mishra , N. C. , Pena-Philippides , J. C. , Hutt , J. A. and Sopori , M. L. 2010 . Granuloma formation induced by low-dose chronic silica inhalation is associated with an anti-apoptotic response in Lewis rats . J. Toxicol. Environ. Health A , 73 : 669 – 683 .
  • Li , C. , Yang , C. W. , Park , J. H. , Lim , S. W. , Sun , B. K. , Jung , J. Y. , Kim , S. B. , Kim , Y. S. , Kim , J. and Bang , B. K. 2004 . Pravastatin treatment attenuates interstitial inflammation and fibrosis in a rat model of chronic cyclosporine-induced nephropathy . Am. J. Physiol. Renal Physiol , 286 : F46 – F57 .
  • Lo Re , S. , Dumoutier , L. , Couillin , I. , Van Vyve , C. , Yakoub , Y. , Uwambayinema , F. , Marien , B. , van den Brule , S. , Van Snick , J. , Uyttenhove , C. , Ryffel , B. , Renauld , J. C. , Lison , D. and Huaux , F. 2010 . IL-17A-producing gammadelta T and Th17 lymphocytes mediate lung inflammation but not fibrosis in experimental silicosis . J. Immunol , 184 : 6367 – 6377 .
  • Mangum , J. , Bermudez , E. , Sar , M. and Everitt , J. 2004 . Osteopontin expression in particle-induced lung disease . Exp. Lung Res , 30 : 585 – 598 .
  • Martin , F. M. , Bydlon , G. and Friedman , J. S. 2006 . SOD2-deficiency sideroblastic anemia and red blood cell oxidative stress . Antioxidant Redox Signal , 8 : 1217 – 1225 .
  • Meyer-Hoffert , U. , Lezcano-Meza , D. , Bartels , J. , Montes-Vizuet , A. R. , Schroder , J. M. and Teran , L. M. 2003 . Th2- and to a lesser extent Th1-type cytokines upregulate the production of both CXC (IL-8 and gro-alpha) and CC (RANTES, eotaxin, eotaxin-2, MCP-3 and MCP-4) chemokines in human airway epithelial cells . Int. Arch. Allergy Immunol , 131 : 264 – 271 .
  • Nau , G. J. , Guilfoile , P. , Chupp , G. L. , Berman , J. S. , Kim , S. J. , Kornfeld , H. and Young , R. A. 1997 . A chemoattractant cytokine associated with granulomas in tuberculosis and silicosis . Proc. Natl. Acad. Sci. USA , 94 : 6414 – 6419 .
  • O'Regan , A. W. , Hayden , J. M. , Body , S. , Liaw , L. , Mulligan , N. , Goetschkes , M. and Berman , J. S. 2001 . Abnormal pulmonary granuloma formation in osteopontin-deficient mice . Am. J. Respir. Crit. Care Med , 164 : 2243 – 2247 .
  • Otsuki , T. , Maeda , M. , Murakami , S. , Hayashi , H. , Miura , Y. , Kusaka , M. , Nakano , T. , Fukuoka , K. , Kishimoto , T. , Hyodoh , F. , Ueki , A. and Nishimura , Y. 2007 . Immunological effects of silica and asbestos . Cell. Mol. Immunol , 4 : 261 – 268 .
  • Pardo , A. , Gibson , K. , Cisneros , J. , Richards , T. J. , Yang , Y. , Becerril , C. , Yousem , S. , Herrera , I. , Ruiz , V. , Selman , M. and Kaminski , N. 2005 . Up-regulation and profibrotic role of osteopontin in human idiopathic pulmonary fibrosis . PLoS Med , 2 : e251
  • Peng , Q. , Li , K. , Sacks , S. H. and Zhou , W. 2009 . The role of anaphylatoxins C3a and C5a in regulating innate and adaptive immune responses . Inflamm. Allergy Drug Targets , 8 : 236 – 246 .
  • Poljakovic , M. , Porter , D. W. , Millecchia , L. , Kepka-Lenhart , D. , Beighley , C. , Wolfarth , M. G. , Castranova , V. and Morris , S. M. Jr. 2007 . Cell- and isoform-specific increases in arginase expression in acute silica-induced pulmonary inflammation . J. Toxicol. Environ. Health A , 70 : 118 – 127 .
  • Porter , D. W. , Barger , M. , Robinson , V. A. , Leonard , S. S. , Landsittel , D. and Castranova , V. 2002a . Comparison of low doses of aged and freshly fractured silica on pulmonary inflammation and damage in the rat . Toxicology , 175 : 63 – 71 .
  • Porter , D. W. , Millecchia , L. L. , Willard , P. , Robinson , V. A. , Ramsey , D. , McLaurin , J. , Khan , A. , Brumbaugh , K. , Beighley , C. M. , Teass , A. and Castranova , V. 2006 . Nitric oxide and reactive oxygen species production causes progressive damage in rats after cessation of silica inhalation . Toxicol. Sci , 90 : 188 – 197 .
  • Porter , D. W. , Ramsey , D. , Hubbs , A. F. , Battelli , L. , Ma , J. , Barger , M. , Landsittel , D. , Robinson , V. A. , McLaurin , J. , Khan , A. , Jones , W. , Teass , A. and Castranova , V. 2001 . Time course of pulmonary response of rats to inhalation of crystalline silica: Histological results and biochemical indices of damage, lipidosis, and fibrosis . J. Environ. Pathol. Toxicol. Oncol , 20 ( 1 ) : 1 – 14 .
  • Porter , D. W. , Ye , J. , Ma , J. , Barger , M. , Robinson , V. A. , Ramsey , D. , McLaurin , J. , Khan , A. , Landsittel , D. , Teass , A. and Castranova , V. 2002b . Time course of pulmonary response of rats to inhalation of crystalline silica: NF-kappa B activation, inflammation, cytokine production, and damage . Inhal. Toxicol , 14 : 349 – 367 .
  • Pritchard , M. T. , McMullen , M. R. , Stavitsky , A. B. , Cohen , J. I. , Lin , F. , Medof , M. E. and Nagy , L. E. 2007 . Differential contributions of C3, C5, and decay-accelerating factor to ethanol-induced fatty liver in mice . Gastroenterology , 132 : 1117 – 1126 .
  • Razani-Boroujerdi , S. and Sopori , M. L. 2007 . Early manifestations of NNK-induced lung cancer: Role of lung immunity in tumor susceptibility . Am. J. Respir. Cell Mol. Biol , 36 : 13 – 19 .
  • Rimal , B. , Greenberg , A. K. and Rom , W. N. 2005 . Basic pathogenetic mechanisms in silicosis: Current understanding . Curr. Opin. Pulmon. Med , 11 : 169 – 173 .
  • Rushton , L. 2007 . Chronic obstructive pulmonary disease and occupational exposure to silica . Rev. Environ. Health , 22 : 255 – 272 .
  • Scabilloni , J. F. , Wang , L. , Antonini , J. M. , Roberts , J. R. , Castranova , V. and Mercer , R. R. 2005 . Matrix metalloproteinase induction in fibrosis and fibrotic nodule formation due to silica inhalation . Am. J. Physiol. Lung Cell. Mol. Physiol , 288 : L709 – L717 .
  • Seagrave , J. , Barr , E. B. , March , T. H. and Nikula , K. J. 2004 . Effects of cigarette smoke exposure and cessation on inflammatory cells and matrix metalloproteinase activity in mice . Exp. Lung Res , 30 : 1 – 15 .
  • Serlin , D. M. , Kuang , P. P. , Subramanian , M. , ’Regan , A. O , Li , X. , Berman , J. S. and Goldstein , R. H. 2006 . Interleukin-1beta induces osteopontin expression in pulmonary fibroblasts . J. Cell. Biochem , 97 : 519 – 529 .
  • Shang , X. Z. , Chiu , B. C. , Stolberg , V. , Lukacs , N. W. , Kunkel , S. L. , Murphy , H. S. and Chensue , S. W. 2002 . Eosinophil recruitment in type-2 hypersensitivity pulmonary granulomas: Source and contribution of monocyte chemotactic protein-3 (CCL7) . Am. J. Pathol , 161 : 257 – 266 .
  • Shen , H. M. , Zhang , Z. , Zhang , Q. F. and Ong , C. N. 2001 . Reactive oxygen species and caspase activation mediate silica-induced apoptosis in alveolar macrophages . Am. J. Physiol. Lung Cell. Mol. Physiol , 280 : L10 – L17 .
  • Shi , X. , Castranova , V. , Halliwell , B. and Vallyathan , V. 1998 . Reactive oxygen species and silica-induced carcinogenesis . J. Toxicol. Environ. Health B Crit. Rev , 1 : 181 – 197 .
  • Takabayashi , T. , Shimizu , S. , Clark , B. D. , Beinborn , M. , Burke , J. F. and Gelfand , J. A. 2004 . Interleukin-1 upregulates anaphylatoxin receptors on mononuclear cells . Surgery , 135 : 544 – 554 .
  • Zeidler , P. C. , Roberts , J. R. , Castranova , V. , Chen , F. , Butterworth , L. , Andrew , M. E. , Robinson , V. A. and Porter , D. W. 2003 . Response of alveolar macrophages from inducible nitric oxide synthase knockout or wild-type mice to an in vitro lipopolysaccharide or silica exposure . J. Toxicol. Environ. Health A , 66 : 995 – 1013 .
  • Zhang , D. D. , Hartsky , M. A. and Warheit , D. B. 2002 . Time course of quartz and TiO(2) particle-induced pulmonary inflammation and neutrophil apoptotic responses in rats . Exp. Lung Res , 28 : 641 – 670 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.