231
Views
13
CrossRef citations to date
0
Altmetric
Original Articles

Determination of the Effects of eNOS Gene Polymorphisms (T-786C and Glu298Asp) on Nitric Oxide Levels in a Methylmercury-Exposed Population

, &
Pages 1323-1333 | Received 08 May 2011, Accepted 09 Jun 2011, Published online: 07 Sep 2011

REFERENCES

  • Barbosa , F. Jr. , Sertorio , J. T. C. , Gerlach , R. F. and Tanus-Santos , J. E. 2006a . Clinical evidence for lead-induced inhibition of nitric oxide formation . Arch. Toxicol. , 80 : 811 – 16 .
  • Barbosa Jr , F. , Sandrim , V. C. , Uzuelli , J. A. , Gerlach , R. F. and Tanus-Santos , J. E. 2006b . eNOS genotype-dependent correlation between whole blood lead and plasma nitric oxide products concentrations . Nitric Oxide , 14 : 58 – 64 .
  • Baylis , C. and Vallance , P. 1998 . Measurement of nitrite and nitrate levels in plasma and urine—What does this measure tell us about the activity of the endogenous nitric oxide system? . Curr. Opin. Nephrol. Hypertens. , 7 : 59 – 62 .
  • Berdeli , A. , Sekuri , C. , Sirri Cam , F. , Ercan , E. , Sagcan , A. , Tengiz , I. , Eser , E. and Akin , M. 2005 . Association between the eNOS (Glu298Asp) and the RAS genes polymorphisms and premature coronary artery diseases in a Turkish population . Clin. Chim. Acta , 351 : 87 – 94 .
  • Bernard , A. 2008 . Biomarkers of metal toxicity in population studies: Research potential and interpretation issues . J. Toxicol. Environ. Health A , 71 : 1259 – 65 .
  • Bridges , C. C. and Zalups , K. R. 2010 . Transport of inorganic mercury and methylmercury in target tissues and organs . J. Toxicol. Environ. Health B , 13 : 385 – 410 .
  • Burger , J. , Jeitner , C. and Gochfeld , M. 2011 . Locational differences in mercury and selenium levels in 19 species of saltwater fish from New Jersey . J. Toxicol. Environ. Health A , 74 : 863 – 74 .
  • Casas , J. P. , Cavalleri , G. L. , Bautista , L. E. , Smeeth , L. , Humphries , S. E. and Hingorani , A. D. 2006 . Endothelial nitric oxide synthase gene polymorphisms and cardiovascular disease: A HuGE review . Am. J. Epidemiol. , 164 : 921 – 35 .
  • Cattaruzza , M. , Guzik , T. J. , Stodowski , W. , Pelvan , A. , Becker , J. , Halle , M. , Buchwald , A. B. , Channon , K. M. and Hecker , M. 2004 . Shear stress insensitivity of endothelial nitric oxide synthase expression as a genetic risk factor for coronary heart disease . Circ. Res. , 95 : 841 – 47 .
  • Çengel , A. and Sahinarslan , A. 2006 . Nitric oxide and cardiovascular system . Anadolu Kardiyol. Derg. , 6 : 364 – 68 .
  • Chatterjee , A. and Catravas , J. D. 2008 . Endothelial nitric oxide (NO) and its pathophysiologic regulation . Vasc. Pharmacol. , 49 : 134 – 40 .
  • Choi , A. L. , Weihe , P. , Budtz-Jørgensen , E. , Jørgensen , P. J. , Salonen , J.T. , Tuomainen , T. P. , Murata , K. , Nielsen , H. P. , Petersen , M. S. , Askham , J. and Grandjean , P. 2009 . Methylmercury exposure and adverse cardiovascular effects in Faroese whaling men . Environ. Health Perspect. , 17 : 367 – 72 .
  • Colomba , D. , Duro , G. , Corrao , S. , Argano , C. , Di Chiara , T. , Nuzzo , D. , Pizzo , F. , Parrinello , G. , Scaglione , R. and Licata , G. 2008 . Endothelial nitric oxide synthase gene polymorphisms and cardiovascular damage in hypertensive subjects: an Italian case-control study . Immun. Ageing , 5 : 4 – 10 .
  • Colombo , M. G. , Andreassi , M. G. , Paradossi , U. , Botto , N. , Manfredi , S. , Masetti , S. , Rossi , G. , Clerico , A. and Biagini , A. 2002 . Evidence for association of a common variant of the endothelial nitric oxide synthase gene (Glu298→Asp polymorphism) to the presence, extent and severity of coronary artery disease . Heart , 87 : 525 – 28 .
  • Cooke , G. E. , Doshi , A. and Binkley , P. F. 2007 . Endothelial nitric oxide synthase gene: prospects for treatment of heart disease . Pharmacogenomics , 8 : 1723 – 34 .
  • Ghilardi , G. , Biondi , M. L. , DeMonti , M. , Bernini , M. , Turri , O. , Massaro , F. , Guagnellini , E. and Scorza , R. 2002 . Independent risk factor for moderate to severe internal carotid artery stenosis: T786C mutation of the endothelial nitric oxide synthase gene . Clin. Chem. , 48 : 989 – 93 .
  • Grotto , D. , Castro , M. M. , Barcelos , G. R. M. , Garcia , S. C. and Barbosa , F. Jr. 2009 . Low level and sub-chronic exposure to methylmercury induces hypertension in rats: nitric oxide depletion and oxidative damage as possible mechanisms . Arch. Toxicol. , 83 : 653 – 62 .
  • Guallar , E. , Sanz-Gallardo , M. I. , Van't Veer , P. , Bode , P. , Aro , A. , Gómez-Aracena , J. , Kark , J. D. , Riemersma , R. A. , Martín-Moreno , J. M. and Kok , F. J. 2002 . Mercury, fish oils, and the risk of myocardial infarction . N. Engl. J Med. , 347 : 1747 – 54 .
  • Guldiken , B. , Sipahi , T. , Guldiken , S. , Ustundag , S. , Budak , M. , Turgut , N. and Ozkan , H. 2009 . Glu298Asp polymorphism of the endothelial nitric oxide synthase gene in Turkish patients with ischemic stroke . Mol. Biol. Rep. , 36 : 1539 – 43 .
  • Hibbs , J. B. Jr. , Westenfelder , C. , Taintor , R. , Vavrin , Z. , Kablitz , C. , Baranowski , R. L. , Ward , J. H. , Menlove , R. L. , McMurry , M. P. and Kushner , J. P. 1992 . Evidence for cytokine-inducible nitric oxide synthesis from L-arginine in patients receiving interleukin-2 therapy . J. Clin. Invest. , 89 : 867 – 77 .
  • Hingorani , A. D. 2001 . Polymorphisms in endothelial nitric oxide synthase and atherogenesis: John French Lecture 2000 . Atherosclerosis , 154 : 521 – 27 .
  • Kishimoto , T. , Oguri , T. and Tada , M. 1995 . Effect of methylmercury (CH3HgCl) injury on nitric oxide synthase (NOS) activity in cultured human umbilical vascular endothelial cells . Toxicology , 103 : 1 – 7 .
  • Kleinbongard , P. , Dejam , A. , Lauer , T. , Jax , T. , Kerber , S. , Gharini , P. , Balzer , J. , Zotz , R. B. , Scharf , R. E. , Willers , R. , Schechter , A. N. , Feelisch , M. and Kelm , M. 2006 . Plasma nitrite concentrations reflect the degree of endotelial dysfunction in humans . Free Radical Biol. Med. , 40 : 295 – 302 .
  • Kleinbongard , P. , Dejam , A. , Lauer , T. , Rassaf , T. , Schindler , A. , Picker , O. , Sheeren , T. , Gödecke , A. , Schrader , J. , Schulz , R. , Heusch , G. , Schaub , G. A. , Bryan , N. S. , Feelisch , M. and Kelm , M. 2003 . Plasma nitrite reflects constitutive nitric oxide synthase activity in mammals . Free Radical Biol. Med. , 35 : 790 – 96 .
  • Kleinbongard , P. , Keymel , S. and Kelm , M. 2007 . New functional aspects of the L-arginine-nitric oxide metabolism within the circulating blood . Thromb. Haemost. , 98 : 970 – 74 .
  • Kuo , T. C. , Huang , C. I. and Lin-Shiau , S. Y. 2002 . Methylmercury inhibits nitric oxide production mediated by Ca(2+) overload and protein kinase A activation . Toxicology , 176 : 113 – 22 .
  • Leeson , C. P. M. , Hingorani , A. D. , Mullen , M. J. , Jeerooburkhan , N. , Kattenhorn , M. , Cole , T. J. , Muller , D. P. R. , Lucas , A. , Humphries , S. E. and Deanfield , J. E. 2002 . Glu298Asp endothelial nitric oxide synthase gene polymorphism interacts with environmental and dietary factors to influence endothelial function . Clin. Res. , 90 : 1153 – 58 .
  • Marco , K. C. , Passos , C. J. S. , Sertorio , J. T. , Tanus-Santos , J. E. and Barbosa , F. Jr. 2009 . Environmental exposure to methylmercury is associated with a decrease in nitric oxide production . Basic Clin. Pharmacol. Toxicol. , 106 : 411 – 15 .
  • McDonald , D. M. , Alp , N. J. and Channon , K. M. 2004 . Functional comparison of the endothelial nitric oxide synthase Glu298Asp polymorphic variants in human endothelial cells . Pharmacogenetics , 14 : 831 – 39 .
  • Metzger , I. F. , Souza-Costa , D. C. , Marroni , A. S. , Nagassaki , S. , Destac , Z. , Flockhart , D. A. and Tanus-Santos , J. E. 2005 . Endothelial nitric oxide synthase gene haplotypes associated with circulating concentrations of nitric oxide products in healthy men . Pharmacogenomics , 15 : 565 – 70 .
  • Metzger , I. F. , Sertorio , J. T. and Tanus-Santos , J. E. 2007 . Modulation of nitric oxide formation by endothelial nitric oxide synthase gene haplotypes . Free Radical Biol. Med. , 43 : 987 – 92 .
  • Mozaffarian , D. 2009 . Fish, mercury, selenium and cardiovascular risk: Current evidence and unanswered questions . Int. J. Environ. Res. Public Health , 6 : 1894 – 916 .
  • Nakayama , M. , Yasue , H. , Yoshimura , M. , Shimasaki , Y. , Kugiyama , K. , Ogawa , H. , Motoyama , T. , Saito , Y. , Ogawa , Y. , Miyamoto , Y. and Nakao , K. 1999 . T-786-C mutation in the 5-flanking region of the endothelial nitric oxide synthase gene is associated with coronary spasm . Circulation , 99 : 2864 – 70 .
  • Nakayama , M. , Yasue , H. , Yoshimura , M. , Shimasaki , Y. , Ogawa , H. , Kugiyama , K. , Mizuno , Y. , Harada , E. , Nakamura , S. , Ito , T. , Saito , Y. , Miyamoto , Y. , Ogawa , Y. and Nakao , K. 2000 . T(-786)C mutation in the 5-Flanking region of the endothelial nitric oxide synthase gene is associated with myocardial infarction, especially without coronary organic stenosis . Am. J. Cardiol. , 86 : 628 – 34 .
  • NIST, 2011. https://www-s.nist.gov/srmors/view_cert.cfm?srm=966 (https://www-s.nist.gov/srmors/view_cert.cfm?srm=966) (Accessed: 27 July 2011 ).
  • Palmer , C. D. , Lewis , M. E. Jr. , Geraghtya , C. M. , Barbosa , F. Jr. and Parsons , P. J. 2006 . Determination of lead, cadmium and mercury in blood for assessment of environmental exposure: A comparison between inductively coupled plasma–mass spectrometry and atomic absorption spectrometry . Spectrochim. Acta B , 61 : 980 – 90 .
  • Persu , A. , Stoenoiu , M. S. , Messiaen , T. , Davila , S. , Robino , C. , El-Khattabi , O. , Mourad , M. , Horie , S. , Feron , O. , Balligand , J. L. , Wattiez , R. , Pirson , Y. , Chauveau , D. , Lens , X. M. and Devuyst , O. 2002 . Modifier effect of ENOS in autosomal dominant polycystic kidney disease . Hum. Mol. Genet. , 11 : 229 – 41 .
  • Rosselli , M. , Imthurn , B. , Keller , P. J. , Jackson , E. K. and Dubey , R. K. 1995 . Circulating nitric oxide (nitrite/nitrate) levels in postmenopausal women substituted with 17 beta-estradiol and norethisterone acetate. A two-year follow-up study . Hypertension , 25 : 848 – 53 .
  • Rubio , A. R. and Morales-Segura , M. A. 2004 . Nitric oxide, an iceberg in cardiovascular physiology: Far beyond vessel tone control . Arch. Med. Res. , 35 : 1 – 11 .
  • Salonen , J. T. , Seppänen , K. , Nyyssönen , K. , Korpela , H. , Kauhanen , J. , Kantola , M. , Tuomilehto , J. , Esterbauer , H. , Tatzber , F. and Salonen , R. 1995 . Intake of mercury from fish, lipid peroxidation, and the risk of myocardial infarction and coronary, cardiovascular, and any death in eastern Finnish men . Circulation , 91 : 645 – 55 .
  • Salonen , J. T. , Seppänen , K. , Lakka , T. A. , Salonen , R. and Kaplan , G. A. 2000 . Mercury accumulation and accelerated progression of carotid atherosclerosis: A population based prospective 4-year follow-up study in men in eastern Finland . Atherosclerosis , 148 : 265 – 73 .
  • Savvidou , M. D. , Vallance , P. J. , Nicolaides , K. H. and Hingorani , A. D. 2001 . Endothelial nitric oxide synthase gene polymorphism and maternal vascularadaptation to pregnancy . Hypertension , 38 : 1289 – 93 .
  • Srivastava , K. , Narang , R. , Sreenivas , V. , Das , S. and Das , N. 2008 . Association of eNOS Glu298Asp gene polymorphism with essential hypertension in Asian Indians . Clin. Chim. Acta , 387 : 80 – 83 .
  • Stern , A. H. 2005 . A review of the studies of the cardiovascular health effects of methylmercury with consideration of their suitability for risk assessment . Environ. Res. , 98 : 133 – 42 .
  • Tamemoto , H. , Ishikawa , S. and Kawakami , M. 2008 . Association of the Glu298Asp polymorphism of the eNOS Gene with ischemic heart disease in Japanese diabetic subjects . Diabetes Res. Clin. Pract. , 80 : 275 – 79 .
  • Tanus-Santos , J. E. , Desai , M. and Flockhart , D. A. 2001 . Effects of ethnicity on the distribution of clinically relevant endothelial nitric oxide variants . Pharmacogenetics , 11 : 719 – 25 .
  • Tesauro , M. , Thompson , W. C. , Rogliani , P. , Qi , L. , Chaudhary , P. P. and Moss , J. 2000 . Intracellular processing of endothelial nitric oxide synthase isoforms associated with differences in severity of cardiopulmonary diseases: Cleavage of proteins with aspartate vs. glutamate at position 298 . Proc. Natl. Acad. Sci. USA , 97 : 2832 – 35 .
  • Tsuchiya , A. , Hinners , T.A. , Burbacher , T. M. , Faustman , E. M. and Mariën , K. 2008 . Mercury exposure from fish consumption within the Japanese and Korean communities . J. Toxicol. Environ. Health A , 71 : 1019 – 31 .
  • Virtanen , J. K. , Voutilainen , S. , Rissanen , T. H. , Mursu , J. , Tuomainen , T. P. , Korhonen , M. J. , Valkonen , V. P. , Seppänen , K. , Laukkanen , J. A. and Salonen , J. T. 2005 . Mercury, fish oils, and risk of acute coronary events and cardiovascular disease, coronary heart disease, and all-cause mortality in men in eastern Finland . Arteriosclerosis Thrombosis Vasc. Biol. , 25 : 228 – 33 .
  • Virtanen , J. K , Rissanen , T. H. , Voutilainen , S. and Tuomainen , T. P. 2007 . Mercury as a risk factor for cardiovascular diseases . J. Nutr. Biochem. , 18 : 75 – 85 .
  • Walkuska , G. , Chalabis-Mazurek , A. and Szkoda , J. 2010 . Mercury content in the trophic chain of the Tanew River, Poland, ecosystem . J. Toxicol. Environ. Health A , 73 : 1180 – 85 .
  • Wang , X. L. , Mahaney , M. C. , Sim , A. S. , Wang , J. , Wang , J. , Blangero , J. , Almasy , L. , Badenhop , R. B. and Wilcken , D. E. 1997 . Genetic contribution of the endothelial constitutive nitric oxide synthase gene to plasma nitric oxide levels . Arteriosclerosis Thrombosis Vasc. Biol. , 17 : 3147 – 53 .
  • Wang , X. L. and Wang , J. 2000 . Endothelial nitric oxide synthase gene sequence variations and vascular disease . Mol. Genet. Metab. , 70 : 241 – 51 .
  • Yemişçi , M. , Sinici , I. , Ozkara , H. A. , Hayran , M. , Ay , H. , Celtikçi , B. , Onder , E. , Büyükşerbetci , G. , Kaya , E. B. , Tokgözoglu , L. and Dalkara , T. 2009 . Protective role of 27bp repeat polymorphism in intron 4 of eNOS gene in lacunar infarction . Free Radical Res. , 43 : 272 – 79 .
  • Yoshimura , M. , Yasue , H. , Nakayama , M. , Shimasaki , Y. , Ogawa , H. , Kugiyama , K. , Saito , Y. , Miyamoto , Y. , Ogawa , Y. , Kaneshige , T. , Hiramatsu , H. , Yoshioka , T. , Kamitani , S. , Teraoka , H. and Nakao , K. 2000 . Genetic risk factors for coronary artery spasm: Significance of endothelial nitric oxide synthase gene T-786-->C and missense Glu298Asp variants . J. Invest. Med. , 48 : 367 – 74 .
  • Zhang , C. , Lopez-Ridaura , R. , Hunter , D. J. , Rifai , N. and Hu , F. B. 2006 . Common variants of the endothelial nitric oxide synthase gene and the risk of coronary heart disease among U.S. diabetic men . Diabetes , 55 : 2140 – 47 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.