176
Views
10
CrossRef citations to date
0
Altmetric
Original Articles

Variable NAT1 Enzyme Activity in Long-Term Cultured Human HaCaT Keratinocytes

, &
Pages 471-477 | Published online: 11 Jun 2012

REFERENCES

  • Adam , P. J. , Berry , J. , Loader , J. A. , Tyson , K. L. , Craggs , G. , Smith , P. , De Belin , J. , Steers , G. , Pezzella , F. , Sachsenmeir , K. F. , Stamps , A. C. , Herath , A. , Sim , E. , O'Hare , M. J. , Harris , A. L. and Terrett , J. A. 2003 . Arylamine N-acetyltransferase-1 is highly expressed in breast cancers and conveys enhanced growth and resistance to etoposide in vitro . Mol. Cancer Res. , 1 : 826 – 35 .
  • Balasubramanian , S. , Sturniolo , M. T. , Dubyak , G. R. and Eckert , R. L. 2005 . Human epidermal keratinocytes undergo (–)-epigallocatechin-3-gallate-dependent differentiation but not apoptosis . Carcinogenesis , 26 : 1100 – 8 .
  • Bikle , D. D. , Ratnam , A. , Mauro , T. , Harris , J. and Pillai , S. 1996 . Changes in calcium responsiveness and handling during keratinocyte differentiation. Potential role of the calcium receptor . J. Clin. Invest. , 97 : 1085 – 93 .
  • Bonifas , J. , Scheitza , S. , Clemens , J. and Blomeke , B. 2010a . Characterization of N-acetyltransferase 1 activity in human keratinocytes and modulation by para-phenylenediamine . J. Pharmacol. Exp. Ther. , 334 : 318 – 26 .
  • Bonifas , J. , Hennen , J. , Dierolf , D. , Kalmes , M. and Blömeke , B. 2010b . Evaluation of cytochrome p450 1 (CYP1) and N-acetyltransferase 1 (NAT1) activities in HaCaT cells: Implications for the development of in vitro techniques for predictive testing of contact sensitizers . Toxicol. In Vitro , 24 : 973 – 80 .
  • Boukamp , P. , Petrussevska , R. T. , Breitkreutz , D. , Hornung , J. , Markham , A. and Fusenig , N. E. 1988 . Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line . J. Cell. Biol. , 106 : 761 – 71 .
  • Bradford , M. M. 1976 . A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding . Anal. Biochem. , 72 : 248 – 54 .
  • Brooke , E. W. , Davies , S. G. , Mulvaney , A. W. , Pompeo , F. , Sim , E. and Vickers , R. J. 2003 . An approach to identifying novel substrates of bacterial arylamine N-acetyltransferases . Bioorg. Med. Chem. , 11 : 1227 – 34 .
  • Butcher , N. J. , Ilett , K. F. and Minchin , R. F. 2000 . Substrate-dependent regulation of human arylamine N-acetyltransferase-1 in cultured cells . Mol. Pharmacol. , 57 : 468 – 73 .
  • Foth , H. and Hayes , A. 2008 . Background of REACH in EU regulations on evaluation of chemicals . Hum. Exp. Toxicol. , 27 : 443 – 61 .
  • Ghahary , A. , Marcoux , Y. , Karimi-Busheri , F. and Tredget , E. E. 2001 . Keratinocyte differentiation inversely regulates the expression of involucrin and transforming growth factor beta1 . J. Cell. Biochem. , 83 : 239 – 48 .
  • Gilchrest , B. A. 1983 . In vitro assessment of keratinocyte aging . J. Invest. Dermatol. , 81 (1 suppl.) : 184s – 89s .
  • Goebel , C. , Hewitt , N. J. , Kunze , G. , Wenker , M. , Hein , D. W. , Beck , H. and Skare , J. 2009 . Skin metabolism of aminophenols: Human keratinocytes as a suitable in vitro model to qualitatively predict the dermal transformation of 4-amino-2-hydroxytoluene in vivo . Toxicol. Appl. Pharmacol. , 235 : 114 – 23 .
  • Hartung , T. and Daston , G. 2009 . Are in vitro tests suitable for regulatory use? . Toxicol. Sci. , 111 : 233 – 37 .
  • Hein , D. W. , Rustan , T. D. , Ferguson , R. J. , Doll , M. A. and Gray , K. 1994 . Metabolic activation of aromatic and heterocyclic N-hydroxyarylamines by wild-type and mutant recombinant human NAT1 and NAT2 acetyltransferases . Arch. Toxicol. , 68 : 129 – 33 .
  • Hennings , H. and Holbrook , K. A. 1983 . Calcium regulation of cell-cell contact and differentiation of epidermal cells in culture. An ultrastructural study . Exp. Cell. Res. , 143 : 127 – 42 .
  • Höfer , T. , Gerner , I. , Gundert-Remy , U. , Liebsch , M. , Schulte , A. , Spielmann , H. , Vogel , R. and Wettig , K. 2004 . Animal testing and alternative approaches for the human health risk assessment under the proposed new European chemicals regulation . Arch. Toxicol. , 78 : 549 – 64 .
  • Kim , S. Y. , Chung , S. I. , Yoneda , K. and Steinert , P. M. 1995 . Expression of transglutaminase 1 in human epidermis . J. Invest. Dermatol. , 104 : 211 – 17 .
  • Kirstein , S. L. , Atienza , J. M. , Xi , B. , Zhu , J. , Yu , N. , Wang , X. , Xu , X. and Abassi , Y. A. 2006 . Live cell quality control and utility of real-time cell electronic sensing for assay development . Assay Drug Dev. Technol. , 4 : 545 – 53 .
  • Matsui , M. , Miyasaka , J. , Hamada , K. , Ogawa , Y. , Hiramoto , M. , Fujimori , R. and Aioi , A. 2000 . Influence of aging and cell senescence on telomerase activity in keratinocytes . J. Dermatol. Sci. , 22 : 80 – 87 .
  • McKim , J. M. , Keller , D. J. and Gorski , J. R. 2010 . A new in vitro method for identifying chemical sensitizers combining peptide binding with ARE/EpRE-mediated gene expression in human skin cells . Cutan. Ocul. Toxicol. , 29 : 171 – 92 .
  • Micallef , L. , Battu , S. , Pinon , A. , Cook-Moreau , J. , Cardot , P. J. , Delage , C. and Simon , A. 2010 . Sedimentation field-flow fractionation separation of proliferative and differentiated subpopulations during Ca2+-induced differentiation in HaCaT cells . J. Chromatogr. B. Anal. Technol. Biomed. Life Sci. , 878 : 1051 – 58 .
  • Pillai , S. , Bikle , D. D. , Mancianti , M. L. , Cline , P. and Hincenbergs , M. 1990 . Calcium regulation of growth and differentiation of normal human keratinocytes: Modulation of differentiation competence by stages of growth and extracellular calcium . J. Cell. Physiol. , 143 : 294 – 302 .
  • Rea , M. A. and Rice , R. H. 2001 . Telomerase deregulation in immortalized human epidermal cells: Modulation by cellular microenvironment . Int. J. Cancer , 94 : 669 – 73 .
  • Riddle , B. and Jencks , W. P. 1971 . Acetyl-coenzyme A: Arylamine N-acetyltransferase. Role of the acetyl-enzyme intermediate and the effects of substituents on the rate . J. Biol. Chem. , 246 : 3250 – 58 .
  • Rovida , C. and Hartung , T. 2009 . Re-evaluation of animal numbers and costs for in vivo tests to accomplish REACH legislation requirements for chemicals—A report by the transatlantic think tank for toxicology (t(4)) . ALTEX , 26 : 187 – 208 .
  • Tiang , J. M. , Butcher , N. J. and Minchin , R. F. 2010 . Small molecule inhibition of arylamine N-acetyltransferase type I inhibits proliferation and invasiveness of MDA-MB-231 breast cancer cells . Biochem. Biophys. Res. Commun , 393 : 95 – 100 .
  • Vandebriel , R. J. , Pennings , J. L. , Baken , K. A. , Pronk , T. E. , Boorsma , A. , Gottschalk , R. and Van Loveren , H. 2010 . Keratinocyte gene expression profiles discriminate sensitizing and irritating compounds . Toxicol. Sci. , 117 : 81 – 89 .
  • Wilkening , S. and Bader , A. 2003 . Influence of culture time on the expression of drug-metabolizing enzymes in primary human hepatocytes and hepatoma cell line HepG2 . J. Biochem. Mol. Toxicol. , 17 : 207 – 13 .
  • Woodcock-Mitchell , J. , Eichner , R. , Nelson , W. G. and Sun , T. T. 1982 . Immunolocalization of keratin polypeptides in human epidermis using monoclonal antibodies . J. Cell. Biol. , 95 : 580 – 88 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.