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Original Articles

Subchronic Thyroid Toxicity Evaluation of 4,4′-Methylenebis(N,N′-Dimethyl)Aniline in Fischer 344 Rats

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Pages 637-648 | Received 10 Feb 2012, Accepted 31 Mar 2012, Published online: 19 Jun 2012

REFERENCES

  • Botts , S. , Jokinen , M. P. , Isaacs , K. R. , Meuten , D. J. and Tanaka , N. 1991 . Proliferative lesions of the thyroid and parathyroid glands, E-3. Guides for Toxicologic Pathology , Washington , DC : STP/ARP/AFIP .
  • Capen , C. C. 1997 . Mechanistic data and risk assessment of selected toxic endpoints of the thyroid gland . Toxicol. Pathol. , 25 : 39 – 48 .
  • Dunkel , V. C. and Simmon , V. F. 1980 . “ Mutagenic activity of chemicals previously tested for carcinogenicity in the National Cancer Institute Bioassay Program ” . In Molecular and cellular aspects of carcinogen screening tests , Edited by: Montesano , R. , Bartsch , H. and Tomatis , L. 283 – 302 . International Agency for Research on Cancer, Scientific Publications Volume 27, Lyon, France .
  • Final rules: Animal welfare . 1989 . 9 CFR Parts 1 and 2 . Fed. Reg. , 54 ( 168 ) : 36112 – 63 .
  • Final rules: Animal welfare . 1991 . 9 CFR Part 3 . Fed. Reg. , 55 ( 32 ) : 6426 – 505 .
  • Fujimoto , N. , Onodera , H. , Mitsumori , K. , Tamura , T. , Maruyama , S. and Ito , A. 1999 . Changes in thyroid function during development of thyroid hyperplasia induced by kojic acid in F344 rats . Carcinogenesis , 20 : 1567 – 71 .
  • Greaves , P. 2007 . Histopathology of preclinical toxicity studies: Interpretation and relevance in drug safety evaluation , 3rd , 819 – 838 . New York : Elsevier .
  • Hooth , M. J. , DeAngelo , A. B. , George , M. H. , Gaillard , E. T. , Travlos , G. S. , Boorman , G. A. and Wolf , D. C. 2001 . Subchronic sodium chlorate exposure in drinking water results in a concentration-dependent increase in rat thyroid follicular cell hyperplasia . Toxicol. Pathol. , 29 : 250 – 59 .
  • Integrated Risk Information System (IRIS). 4,4′-Methylenebis(N,N′-dimethyl) aniline (CASRN 101-61-1). Carcinogenicity Assessment section. www.epa.gov/iris/subst/0386.htm (http://www.epa.gov/iris/subst/0386.htm)
  • Jennings , A. S. , Schwartz , S. L. , Balter , N. J. , Gardner , D. and Witorsch , R. J. 1990 . Effects of oral erythrosine (2′,4′,5′,7′-tetraiodofluorescein) on the pituitary–thyroid axis in rats . Toxicol. Appl. Phramcol. , 103 : 549 – 56 .
  • Kanno , J. , Onodera , H. , Furuta , K. , Maekawa , A. , Kasuga , T. and Hayashi , Y. 1992 . Tumor-promoting effects of both iodine deficiency and iodine excess in the rat thyroid . Toxicol. Pathol. , 20 : 226 – 35 .
  • Krishna Murthy , A. S. 1980 . Morphology of the neoplasms of the thyroid gland in Fischer 344 rats treated with 4,4′-methylene-bis-(N,N-dimethyl)-benzenamine . Toxicol Lett. , 6 : 391 – 97 .
  • McCarthy , D. J. , Struck , R. F. , Shih , T. , Suling , W. J. , Hill , D. L. and Enke , S. E. 1982 . Disposition and metabolism of the carcinogen reduced Michler's ketone in rats . Cancer Res. , 42 : 3475 – 79 .
  • McCarthy , D. J. , Suling , W. J. and Hill , D. L. 1983 . A comparison of the mutagenicity and macromolecular binding of the carcinogens Michler's ketone and reduced Michler's ketone . Mutat. Res. , 119 : 7 – 14 .
  • McClain , R. M. , Posch , R. C. , Bosakowski , T. and Armstrong , J. M. 1988 . Studies on the mode of action for thyroid gland tumor promotion in rats by phenobarbital . Toxicol. Appl. Pharmacol. , 94 : 254 – 65 .
  • National Cancer Institute . 1979 . “ 186. DHEW (NIH) publication no. 79–1742 ” . In Bioassay of 4,4′-methylenebis(N,N-dimethyl)benzenamine for possible carcinogenicity. NCI Carcinogenesis Technical Report Series No , Bethesda , MD : National Institutes of Health .
  • National Research Council . 1996 . Guide for the care and use of laboratory animals , Washington , DC : National Academies Press .
  • National Toxicology Program. 2011. Report on carcinogens, 12th edition (2010). U.S. Department of Health and Human Services http://ntp.niehs.nih.gov/go/roc12 (http://ntp.niehs.nih.gov/go/roc12)
  • New Jersey Department of Health and Senior Services. 2009. Hazardous substance fact sheet: 4,4′-Methylenebis(N,N-dimethyl)benzenamine http://nj.gov/health/eoh/rtkweb/documents/fs/1252.pdf (http://nj.gov/health/eoh/rtkweb/documents/fs/1252.pdf)
  • Sabbioni , G. and Schutze , D. 1998 . Hemoglobin binding of bicyclic aromatic amines . Chem. Res. Toxicol. , 11 : 471 – 83 .
  • Scribner , J. D. , Koponen , G. , Fisk , S. R. and Woodworth , B. 1980 . Binding of the dye intermediates Michler's ketone and methane base to rat liver nucleic acids and lack of mutagenicity . Salmonella typhimurium. Cancer Lett. , 9 : 117 – 21 .
  • Siglin , J. C. , Mattie , D. R. , Dodd , D. E. , Hildebrandt , P. K. and Baker , W. H. 2000 . A 90-day drinking water study in rats of the environmental contaminant ammonium perchlorate . Toxicol. Sci. , 57 : 61 – 74 .
  • Suzuki , K. , Kawashima , A. , Yoshihara , A. , Akama , T. , Sue , M. , Yoshida , A. and Kimura , H. J. 2011 . Role of thyroglobulin on negative feedback autoregulation of thyroid follicular function and growth . J. Endocrinol. , 209 : 169 – 74 .
  • U.S. Environmental Protection Agency . 1985 . Health and environmental effects profile for 4,4′-methylenebis(N,N-dimethyl)aniline , Washington , DC : U.S. Environmental Protection Agency, EPA/600/X-85/371 (NTIS PB88178769) .
  • U.S. Environmental Protection Agency. 2004. Non-confidential IUR production volume information. U.S. Environmental Protection Agency http://www.epa.gov/oppt/iur/tools/data/2002-vol.html (http://www.epa.gov/oppt/iur/tools/data/2002-vol.html)
  • Waalkens , D. H. , Joosten , H. F. P. , Yih , T. D. and Hoekstra , A. 1981 . Mutagenicity studies with o-tolidine and 4,4′-tetramethyldiaminodiphenylmethane . Mutat. Res. , 89 : 197 – 202 .
  • Weisburger , E. K. , Krishna Murthy , A. S. , Lilja , H. S. and Lamb , J. C. IV. 1984 . Neoplastic response of F344 rats and B6C3F1 mice to the polymer and dyestuff intermediates 4,4′-methylenebis(N,N-dimethyl)-benzenamine, 4,4′-oxydianiline, and 4,4′-methylenedianiline . J. Natl. Cancer Inst. , 72 : 1457 – 63 .
  • Williams , G. M. , Laspia , M. F. and Dunkel , V. C. 1982 . Reliability of the hepatocyte primary culture/DNA repair test in testing of coded carcinogens and noncarcinogens . Mutat. Res. , 97 : 359 – 70 .
  • Wolf, D. C. 2000. Report of the peer review of the thyroid histopathology from rodents and rabbits exposed to ammonium perchlorate in the drinking water. U.S. Environmental Protection Agency, National Health and Environmental Effects Research Laboratory, Environmental Carcinogenesis Division, Research Triangle Park, NC. Memorandum, 5 May http://www.epa.gov/ncea/perchlorate/references2/documents/wolf-peer-review-memo-2000.pdf (http://www.epa.gov/ncea/perchlorate/references2/documents/wolf-peer-review-memo-2000.pdf)
  • Wolf, D. C. 2001. Erratum to the report of the peer review of the thyroid histopathology from rodents and rabbits exposed to ammonium perchlorate in the drinking water. U.S. Environmental Protection Agency, National Health and Environmental Effects Research Laboratory, Environmental Carcinogenesis Division, Research Triangle Park, NC. Memorandum 26 October http://www.epa.gov/ncea/perchlorate/references2/documents/100514.pdf (http://www.epa.gov/ncea/perchlorate/references2/documents/100514.pdf)

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