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Original Articles

Biological Response to Nano-Scale Titanium Dioxide (TiO2): Role of Particle Dose, Shape, and Retention

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Pages 953-972 | Received 17 May 2013, Accepted 06 Jul 2013, Published online: 24 Oct 2013

REFERENCES

  • Bermudez , E. , Mangum , J. B. , Wong , B. A. , Asgharian , B. , Hext , P. M. , Warheit , D. B. and Everitt , J. I. 2004 . Pulmonary responses of mice, rats, and hamsters to subchronic inhalation of ultrafine titanium dioxide particles . Toxicol. Sci , 77 : 347 – 357 .
  • Bihari , P. , Vippola , M. , Schultes , S. , Praetner , M. , Khandoga , A. G. , Reichel , C. A. , Coester , C. , Tuomi , T. , Rehberg , M. and Krombach , F. 2008 . Optimized dispersion of nanoparticles for biological in vitro and in vivo studies . Part. Fibre Toxicol , 5 : 14
  • Bonner , J. C. 2010 . Nanoparticles as a potential cause of pleural and interstitial lung disease . Proc. Am. Thorac. Soc , 7 : 138 – 141 .
  • Bonner , J. C. , Silva , R. M. , Taylor , A. J. , Brown , J. M. , Hilderbrand , S. C. , Castranova , V. , Porter , D. , Elder , A. , Oberdorster , G. , Harkema , J. R. , Bramble , L. A. , Kavanagh , T. J. , Botta , D. , Nel , A. and Pinkerton , K. E. 2013 . Interlaboratory evaluation of rodent pulmonary responses to engineered nanomaterials: The NIEHS NanoGo Consortium . Environ. Health Perspect , 121 : 676 – 682 .
  • Cui , Y. L. , Liu , H. T. , Ze , Y. G. , Zhang , Z. L. , Hu , Y. Y. , Cheng , Z. , Cheng , J. , Hu , R. P. , Gao , G. D. , Wang , L. , Tang , M. and Hong , F. S. 2012 . Gene expression in liver injury caused by long-term exposure to titanium dioxide nanoparticles in mice . Toxicol. Sci , 128 : 171 – 185 .
  • Donaldson , K. , Murphy , F. , Schinwald , A. , Duffin , R. and Poland , C. A. 2011 . Identifying the pulmonary hazard of high aspect ratio nanoparticles to enable their safety-by-design . Nanomedicine , 6 : 143 – 156 .
  • Hamilton , R. F. , Wu , N. Q. , Porter , D. , Buford , M. , Wolfarth , M. and Holian , A. 2009 . Particle length-dependent titanium dioxide nanomaterials toxicity and bioactivity . Part. Fibre Toxicol , 6 : 35
  • Ho , M. , Wu , K. Y. , Chein , H. M. , Chen , L. C. and Cheng , T. J. 2011 . Pulmonary toxicity of inhaled nanoscale and fine zinc oxide particles: Mass and surface area as an exposure metric . Inhal. Toxicol , 23 : 947 – 956 .
  • Horie , M. , Fukui , H. , Endoh , S. , Maru , J. , Miyauchi , A. , Shichiri , M. , Fujita , K. , Niki , E. , Hagihara , Y. , Yoshida , Y. , Morimoto , Y. and Iwahashi , H. 2012 . Comparison of acute oxidative stress on rat lung induced by nano and fine-scale, soluble and insoluble metal oxide particles: NiO and TiO2 . Inhal. Toxicol , 24 : 391 – 400 .
  • Hougaard , K. S. , Jackson , P. , Jensen , K. A. , Sloth , J. J. , Loschner , K. , Larsen , E. H. , Birkedal , R. K. , Vibenholt , A. , Boisen , A. M. Z. , Wallin , H. and Vogel , U. 2010 . Effects of prenatal exposure to surface-coated nanosized titanium dioxide (UV-Titan). A study in mice . Part. Fibre Toxicol , 7 : 16
  • Hsiao , I. L. and Huang , Y. J. 2011 . Effects of various physicochemical characteristics on the toxicities of ZnO and TiO2 nanoparticles toward human lung epithelial cells . Sci. Total Environ , 409 : 1219 – 1228 .
  • Ji , Z. X. , Jin , X. , George , S. , Xia , T. A. , Meng , H. A. , Wang , X. , Suarez , E. , Zhang , H. Y. , Hoek , E. M. V. , Godwin , H. , Nel , A. E. and Zink , J. I. 2010 . Dispersion and stability optimization of TiO2 nanoparticles in cell culture media . Environ. Sci. Technol , 44 : 7309 – 7314 .
  • Kobayashi , N. , Naya , M. , Endoh , S. , Maru , J. , Yamamoto , K. and Nakanishi , J. 2009 . Comparative pulmonary toxicity study of nano-TiO2 particles of different sizes and agglomerations in rats: Different short- and long-term post-instillation results . Toxicology , 264 : 110 – 118 .
  • Kuhlbusch , T. A. J. , Asbach , C. , Fissan , H. , Gohler , D. and Stintz , M. 2011 . Nanoparticle exposure at nanotechnology workplaces: A review . Part. Fibre Toxicol , 8 : 22
  • LeBlanc , A. J. , Cumpston , J. L. , Chen , B. T. , Frazer , D. , Castranova , V. and Nurkiewicz , T. R. 2009 . Nanoparticle inhalation impairs endothelium-dependent vasodilation in subepicardial arterioles . J. Toxicol. Environ. Health A , 72 : 1576 – 1584 .
  • Ma-Hock , L. , Burkhardt , S. , Strauss , V. , Gamer , A. , Wiench , K. , van Ravenzwaay , B. and Landsiedel , R. 2009 . Development of a short-term inhalation test in the rat using nano-titanium dioxide as a model substance . Inhal. Toxicol , 21 : 102 – 118 .
  • McKinney , W. , Jackson , M. , Sager , T. M. , Reynolds , J. S. , Chen , B. T. , Afshari , A. , Krajnak , K. , Waugh , S. , Johnson , C. , Mercer , R. R. , Frazer , D. G. , Thomas , T. A. and Castranova , V. 2012 . Pulmonary and cardiovascular responses of rats to inhalation of a commercial antimicrobial spray containing titanium dioxide nanoparticles . Inhal. Toxicol , 24 : 447 – 457 .
  • Meena , R. , Rani , M. , Pal , R. and Rajamani , P. 2012 . Nano-TiO2-induced apoptosis by oxidative stress-mediated DNA damage and activation of p53 in human embryonic kidney cells . Appl. Biochem. Biotechnol , 167 : 791 – 808 .
  • Moon , C. , Park , H. J. , Choi , Y. H. , Park , E. M. , Castranova , V. and Kang , J. L. 2010 . Pulmonary inflammation after intraperitoneal administration of ultrafine titanium dioxide (TiO2) at rest or in lungs primed with lipopolysaccharide . J. Toxicol. Environ. Health A , 73 : 396 – 409 .
  • Nel , A. E. , Madler , L. , Velegol , D. , Xia , T. , Hoek , E. M. V. , Somasundaran , P. , Klaessig , F. , Castranova , V. and Thompson , M. 2009 . Understanding biophysicochemical interactions at the nano-bio interface . Nat. Mater , 8 : 543 – 557 .
  • Nemmar , A. , Melghit , K. , Al-Salam , S. , Zia , S. , Dhanasekaran , S. , Attoub , S. , Al-Amri , I. and Ali , B. H. 2011 . Acute respiratory and systemic toxicity of pulmonary exposure to rutile Fe-doped TiO2 nanorods . Toxicology , 279 : 167 – 175 .
  • Nemmar , A. , Melghit , K. and Ali , B. H. 2008 . The acute proinflammatory and prothrombotic effects of pulmonary exposure to rutile TiO2 nanorods in rats . Exp. Biol. Med , 233 : 610 – 619 .
  • Oberdorster , G. 2000 . Toxicology of ultrafine particles: In vivo studies . Philos. Trans. R. Soc. London Ser. A Math. Phys. Eng. Sci , 358 : 2719 – 2739 .
  • Oberdorster , G. , Ferin , J. , Gelein , R. , Soderholm , S. C. and Finkelstein , J. 1992 . Role of the alveolar macrophage in lung injury—Studies with ultrafine particles . Environ. Health Perspect , 97 : 193 – 199 .
  • Oberdorster , G. , Ferin , J. and Lehnert , B. E. 1994 . Correlation between particle size, in-vivo particle persistence, and lung injury . Environ. Health Perspect , 102 : 173 – 179 .
  • Ohtani , B. , Prieto-Mahaney , O. O. , Li , D. and Abe , R. 2010 . What is Degussa (Evonik) P25? Crystalline composition analysis, reconstruction from isolated pure particles and photocatalytic activity test . J. Photochem. Photobiol. A Chem , 216 : 179 – 182 .
  • Oosthuizen , M. A. , Oberholzer , H. M. , Scriba , M. R. , van der Spuy , W. J. and Pretorius , E. 2012 . Evaluation of the morphological changes in the lungs of BALB/c mice after inhalation of spherical and rod-shaped titanium nanoparticles . Micron , 43 : 863 – 869 .
  • Pegueroles , M. , Tonda-Turo , C. , Planell , J. A. , Gil , F. J. and Aparicio , C. 2012 . Adsorption of fibronectin, fibrinogen, and albumin on TiO2: Time-resolved kinetics, structural changes, and competition study . Biointerphases , 7 : 48 – 61 .
  • Porter , D. , Sriram , K. , Wolfarth , M. , Jefferson , A. , Schwegler-Berry , D. , Andrew , M. and Castranova , V. 2008 . A biocompatible medium for nanoparticle dispersion . Nanotoxicology , 2 : 144 – 154 .
  • Porter , D. W. , Wu , N. Q. , Hubbs , A. F. , Mercer , R. R. , Funk , K. , Meng , F. K. , Li , J. T. , Wolfarth , M. G. , Battelli , L. , Friend , S. , Andrew , M. , Hamilton , R. , Sriram , K. , Yang , F. , Castranova , V. and Holian , A. 2013 . Differential mouse pulmonary dose and time course responses to titanium dioxide nanospheres and nanobelts . Toxicol. Sci , 131 : 179 – 193 .
  • Rehn , B. , Seiler , F. , Rehn , S. , Bruch , J. and Maier , M. 2003 . Investigations on the inflammatory and genotoxic lung effects of two types of titanium dioxide: Untreated and surface treated . Toxicol. Appl. Pharmacol , 189 : 84 – 95 .
  • Renwick , L. C. , Brown , D. , Clouter , A. and Donaldson , K. 2004 . Increased inflammation and altered macrophage chemotactic responses caused by two ultrafine particle types . Occup. Environ. Med , 61 : 442 – 447 .
  • Robichaud , C. O. , Uyar , A. E. , Darby , M. R. , Zucker , L. G. and Wiesner , M. R. 2009 . Estimates of upper bounds and trends in nano-TiO2 production as a basis for exposure assessment . Environ. Sci. Technol , 43 : 4227 – 4233 .
  • Rothen-Rutishauser , B. , Brown , D. M. , Piallier-Boyles , M. , Kinloch , I. A. , Windle , A. H. , Gehr , P. and Stone , V. 2010 . Relating the physicochemical characteristics and dispersion of multiwalled carbon nanotubes in different suspension media to their oxidative reactivity in vitro and inflammation in vivo . Nanotoxicology , 4 : 331 – 342 .
  • Roulet , A. , Armand , L. , Dagouassat , M. , Rogerieux , F. , Simon-Deckers , A. , Belade , E. , Jeanne , T. V. N. , Lanone , S. , Pairon , J. C. , Lacroix , G. and Boczkowski , J. 2012 . Intratracheally administered titanium dioxide or carbon black nanoparticles do not aggravate elastase-induced pulmonary emphysema in rats . BMC Pulmon. Med , 12 : 38
  • Ruh , H. , Kuhl , B. , Brenner-Weiss , G. , Hopf , C. , Diabate , S. and Weiss , C. 2012 . Identification of serum proteins bound to industrial nanomaterials . Toxicol. Lett , 208 : 41 – 50 .
  • Saber , A. T. , Jacobsen , N. R. , Mortensen , A. , Szarek , J. , Jackson , P. , Madsen , A. M. , Jensen , K. A. , Koponen , I. K. , Brunborg , G. , Gutzkow , K. B. , Vogel , U. and Wallin , H. 2012a . “ Nanotitanium dioxide toxicity in mouse lung is reduced in sanding dust from paint ” . In Part. Fibre Toxicol Vol. 9 , 4
  • Saber , A. T. , Jensen , K. A. , Jacobsen , N. R. , Birkedal , R. , Mikkelsen , L. , Moller , P. , Loft , S. , Wallin , H. and Vogel , U. 2012b . Inflammatory and genotoxic effects of nanoparticles designed for inclusion in paints and lacquers . Nanotoxicology , 6 : 453 – 471 .
  • Sager , T. M. , Kommineni , C. and Castranova , V. 2008 . Pulmonary response to intratracheal instillation of ultrafine versus fine titanium dioxide: Role of particle surface area . Part. Fibre Toxicol , 5 : 17
  • Sager , T. M. , Porter , D. W. , Robinson , V. A. , Lindsley , W. G. , Schwegler-Berry , D. E. and Castranova , V. 2007 . Improved method to disperse nanoparticles for in vitro and in vivo investigation of toxicity . Nanotoxicology , 1 : 118 – 129 .
  • Scuri , M. , Chen , B. T. , Castranova , V. , Reynolds , J. S. , Johnson , V. J. , Samsell , L. , Walton , C. and Piedimonte , G. 2010 . Effects of titanium dioxide nanoparticle exposure on neuroimmune responses in rat airways . J. Toxicol. Environ. Health A , 73 : 1353 – 1369 .
  • Shi , J. , Feng , B. , Lu , X. and Weng , J. 2012 . Adsorption of bovine serum albumin onto titanium dioxide nanotube arrays . Int. J. Mater. Res , 103 : 889 – 896 .
  • Shimizu , M. , Tainaka , H. , Oba , T. , Mizuo , K. , Umezawa , M. and Takeda , K. 2009 . Maternal exposure to nanoparticulate titanium dioxide during the prenatal period alters gene expression related to brain development in the mouse . Part. Fibre Toxicol , 6 : 20
  • Srinivas , A. , Rao , P. J. , Selvam , G. , Goparaju , A. , Murthy , P. B. and Reddy , P. N. 2012 . Oxidative stress and inflammatory responses of rat following acute inhalation exposure to iron oxide nanoparticles . Hum. Exp.Toxicol , 31 : 1113 – 1131 .
  • Stoeger , T. , Reinhard , C. , Takenaka , S. , Schroeppel , A. , Karg , E. , Ritter , B. , Heyder , J. and Schulz , H. 2006 . Instillation of six different ultrafine carbon particles indicates a surface area threshold dose for acute lung inflammation in mice . Environ. Health Perspect , 114 : 328 – 333 .
  • Stone , K. C. , Mercer , R. R. , Gehr , P. , Stockstill , B. and Crapo , J. D. 1992 . Allometric relationships of cell numbers and size in the mammalian lung . Am. J. Respir. Cell Mol. Biol , 6 : 235 – 243 .
  • Takeda , K. , Suzuki , K. I. , Ishihara , A. , Kubo-Irie , M. , Fujimoto , R. , Tabata , M. , Oshio , S. , Nihei , Y. , Ihara , T. and Sugamata , M. 2009 . Nanoparticles transferred from pregnant mice to their offspring can damage the genital and cranial nerve systems . J. Health Sci , 55 : 95 – 102 .
  • Walczyk , D. , Bombelli , F. B. , Monopoli , M. P. , Lynch , I. and Dawson , K. A. 2010 . What the cell “sees” in bionanoscience . J. Am. Chem. Soc , 132 : 5761 – 5768 .
  • Warheit , D. B. , Webb , T. R. , Colvin , V. L. , Reed , K. L. and Sayes , C. R. 2007a . Pulmonary bioassay studies with nanoscale and fine-quartz particles in rats: Toxicity is not dependent upon particle size but on surface characteristics . Toxicol. Sci , 95 : 270 – 280 .
  • Warheit , D. B. , Webb , T. R. , Reed , K. L. , Frerichs , S. and Sayes , C. M. 2007b . Pulmonary toxicity study in rats with three forms of ultrafine-TiO2 particles: Differential responses related to surface properties . Toxicology , 230 : 90 – 104 .
  • Warheit , D. B. , Webb , T. R. , Sayes , C. M. , Colvin , V. L. and Reed , K. L. 2006 . Pulmonary instillation studies with nanoscale TiO2 rods and dots in rats: Toxicity is not dependent upon particle size and surface area . Toxicol. Sci , 91 : 227 – 236 .
  • Watanabe , M. , Okada , M. , Kudo , Y. , Tonori , Y. , Niitsuya , M. , Sato , T. , Aizawa , Y. and Kotani , M. 2002 . Differences in the effects of fibrous and particulate titanium dioxide on alveolar macrophages of Fischer 344 rats . J. Toxicol. Environ. Health A , 65 : 1047 – 1060 .
  • Weir , A. , Westerhoff , P. , Fabricius , L. , Hristovski , K. and von Goetz , N. 2012 . Titanium dioxide nanoparticles in food and personal care products . Environ. Sci. Technol , 46 : 2242 – 2250 .
  • Weir , A. 2011 . “ Master of science thesis ” . In TiO2 nanomaterials: Human exposure and environmental release , Phoenix , AZ. : Arizona State University .
  • Xia , T. , Malasarn , D. , Lin , S. , Ji , Z. , Zhang , H. , Miller , R. J. , Keller , A. A. , Nisbet , R. M. , Harthorn , B. H. , Godwin , H. A. , Lenihan , H. S. , Liu , R. , Gardea-Torresdey , J. , Cohen , Y. , Madler , L. , Holden , P. A. , Zink , J. I. and Nel , A. E. 2012 . Implementation of a multidisciplinary approach to solve complex nano EHS problems by the UC Center for the environmental implications of nanotechnology . Small , 9 : 1428 – 1443 .
  • Xia , T. , Hamilton , R. F. Jr. , Bonner , J. C. , Crandall , E. D. , Elder , A. , Fazlollahi , F. , Girtsman , T. A. , Kim , K. , Mitra , S. , Ntim , S. A. , Orr , G. , Tagmount , M. , Taylor , A. J. , Telesca , D. , Tolic , A. , Vulpe , C. D. , Walker , A. J. , Wang , X. , Witzmann , F. A. , Wu , N. , Xie , Y. , Zink , J. I. , Nel , A. and Holian , A. 2013 . Interlaboratory evaluation of in vitro cytotoxicity and inflammatory responses to engineered nanomaterials: The NIEHS Nano Go Consortium . Environ. Health Perspect , 121 : 683 – 690 .
  • Zhang , J. , Song , W. , Guo , J. , Zhang , J. , Sun , Z. , Li , L. , Ding , F. and Gao , M. 2012 . Cytotoxicity of different sized TiO2 nanoparticles in mouse macrophages . Toxicol. Ind. Health , [Epub ahead of print]

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