Antimutagenic and antioxidant properties of the aqueous extracts of organic and conventional grapevine Vitis labrusca cv. Isabella leaves in V79 cells

References

• Abarikwu, S. O., Otuechere, C. A., Ekor, M., Monwuba, K., and Osobu, D. 2012. Rutin ameliorates cyclophosphamide-induced reproductive toxicity in male rats. Toxicol. Int. 19: 207–214.
   PubMedGoogle Scholar
• Aebi, H. 1984. Catalase in vitro. Methods Enzymol. 105: 121–126.
   PubMed Web of Science ®Google Scholar
• Araujo, J. R., Goncalves, P., and Martel, F. 2011. Chemopreventive effect of dietary polyphenols in colorectal cancer cell lines. Nutr. Res. 31: 77–87.
   PubMed Web of Science ®Google Scholar
• Bass, D. A., Parce, J. W., Dechatelet, L. R., Szejda, P., Seeds, M. C., and Thomas, M. 1983. Flow cytometric studies of oxidative product formation by neutrophils: A graded response to membrane stimulation. J. Immunol. 130: 1910–1917.
   PubMed Web of Science ®Google Scholar
• Beutler, J. A. 2009. Natural products as a foundation for drug discovery. Curr. Protocols Pharmacol. 46: 9-11-11–19-11-21.
   PubMedGoogle Scholar
• Bouhlel, I., Kilani, S., Skandrani, I., Ben Amar, R., Nefatti, A., Laporte, F., Hininger-Favier, I., Ghedira, K., and Chekir-Ghedira, L. 2008. Acacia salicina extracts protect against DNA damage and mutagenesis in bacteria and human lymphoblast cell K562 cultures. Nutr. Res. 28: 190–197.
   PubMed Web of Science ®Google Scholar
• Celik, H., and Arinc, E. 2010. Evaluation of the protective effects of quercetin, rutin, naringenin, resveratrol and trolox against idarubicin-induced DNA damage. J. Pharm. Pharm. Sci. 13: 231–241.
   PubMed Web of Science ®Google Scholar
• Cho, J. H., Park, S. Y., Lee, H. S., Whang, W. K., and Sohn, U. D. 2011. The protective effect of quercetin-3-O-beta-D-glucuronopyranoside on ethanol-induced damage in cultured feline esophageal epithelial cells. Korean J. Physiol. Pharmacol. 15: 319–326.
   PubMed Web of Science ®Google Scholar
• Dani, C., Oliboni, L. S., Agostini, F., Funchal, C., Serafini, L., Henriques, J. A., and Salvador, M. 2010. Phenolic content of grapevine leaves (Vitis labrusca var. Bordo) and its neuroprotective effect against peroxide damage. Toxicol. In Vitro 24: 148–153.
   PubMed Web of Science ®Google Scholar
• Dani, C., Oliboni, L. S., Vanderlinde, R., Bonatto, D., Salvador, M., and Henriques, J. A. 2007. Phenolic content and antioxidant activities of white and purple juices manufactured with organically- or conventionally-produced grapes. Food Chem. Toxicol. 45: 2574–2580.
   PubMed Web of Science ®Google Scholar
• Denizot, F., and Lang, R. 1986. Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability. J. Immunol. Methods 89: 271–277.
   PubMed Web of Science ®Google Scholar
• Edenharder, R., Sager, J. W., Glatt, H., Muckel, E., and Platt, K. L. 2002. Protection by beverages, fruits, vegetables, herbs, and flavonoids against genotoxicity of 2-acetylaminofluorene and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in metabolically competent V79 cells. Mutat. Res. 521: 57–72.
   PubMed Web of Science ®Google Scholar
• Farrar, J. L., Hartle, D. K., Hargrove, J. L., and Greenspan, P. 2007. Inhibition of protein glycation by skins and seeds of the muscadine grape. Biofactors 30: 193–200.
   PubMed Web of Science ®Google Scholar
• Ferguson, LR., Bronzetti, G., and de Flora, S. 2005. Mechanistic approaches to chemoprevention of mutation and cancer. Mutat. Res. 591: 3–7.
   PubMed Web of Science ®Google Scholar
• Ferguson, L. R., Chen, H., Collins, A.R., Connell, M., Damia, G., Dasgupta, S., Malhotra, M., Meeker, A. K., Amedei, A., Amin, A., Ashraf, S. S., Aquilano, K., Azmi, A. S., Bhakta, D., Bilsland, A., Boosani, C. S., Chen, S., Ciriolo, M. R., Fujii, H., Guha, G., Halicka, D., Helferich, W. G., Keith, W. N., Mohammed, S. I., Niccolai, E., Yang, X., Honoki, K., Parslow, V. R., Prakash, S., Rezazadeh, S., Shackelford, R. E., Sidransky, D., Tran, P. T., Yang, E. S., and Maxwell, C. A. 2015. Genomic instability in human cancer: Molecular insights and opportunities for therapeutic attack and prevention through diet and nutrition. Semin. Cancer Biol. 35(Suppl.): S5–S24.
   PubMedGoogle Scholar
• Firuzi, O., Miri, R., Tavakkoli, M., and Saso, L. 2011. Antioxidant therapy: Current status and future prospects. Curr. Med. Chem. 18: 3871–3888.
   PubMed Web of Science ®Google Scholar
• Franke, S. I., Pra, D., Erdtmann, B., Henriques, J. A., and da Silva, J. 2005. Influence of orange juice over the genotoxicity induced by alkylating agents: An in vivo analysis. Mutagenesis 20: 279–283.
   PubMed Web of Science ®Google Scholar
• Galati, G., Sabzevari, O., Wilson, J. X., and O’Brien, P. J. 2002. Prooxidant activity and cellular effects of the phenoxyl radicals of dietary flavonoids and other polyphenolics. Toxicology 177: 91–104.
   PubMed Web of Science ®Google Scholar
• García-Rodríguez, M. del C., Nicolás-Méndez, T., Montaño-Rodríguez, A. R., and Altamirano-Lozano, M. A. 2014. Antigenotoxic effects of (–)-epigallocatechin-3-gallate (EGCG), quercetin, and rutin on chromium trioxide-induced micronuclei in the polychromatic erythrocytes of mouse peripheral blood. J. Toxicol. Environ. Health A 77: 324–336.
   PubMed Web of Science ®Google Scholar
• Granado-Serrano, A. B., Martin, M. A., Bravo, L., Goya, L., and Ramos, S. 2010. Quercetin modulates NF-kappa B and AP-1/JNK pathways to induce cell death in human hepatoma cells. Nutr. Cancer 62: 390–401.
   PubMed Web of Science ®Google Scholar
• Horwitz, W. 1990. Official methods of analysis, AOAC, 15th ed., Vol. II, pp. 1058–1059. Arlington, VA: Association of Official Analytical Chemists.
   Google Scholar
• Hu, M. L. 2011. Dietary polyphenols as antioxidants and anticancer agents: More questions than answers. Chang Gung Med. J. 34: 449–460.
   PubMedGoogle Scholar
• Juroszek, P., Lumpkin, H. M., Yang, R. Y., Ledesma, D. R., and Ma, C. H. 2009. Fruit quality and bioactive compounds with antioxidant activity of tomatoes grown on-farm: Comparison of organic and conventional management systems. J. Agric. Food Chem. 57: 1188–1194.
   PubMed Web of Science ®Google Scholar
• Keser, S., Celik, S., and Turkoglu, S. 2013. Total phenolic contents and free-radical scavenging activities of grape (Vitis vinifera L.) and grape products. Int. J. Food Sci. Nutr. 64: 210–216.
   PubMed Web of Science ®Google Scholar
• Khan, R. A., Khan, M. R., and Sahreen, S. 2012a. CCl4-induced hepatotoxicity: Protective effect of rutin on p53, CYP2E1 and the antioxidative status in rat. BMC Complement. Altern. Med. 12: 178.
   PubMed Web of Science ®Google Scholar
• Khan, R. A., Khan, M. R., and Sahreen, S. 2012b. Protective effects of rutin against potassium bromate induced nephrotoxicity in rats. BMC Complement. Altern. Med. 12: 204.
   PubMed Web of Science ®Google Scholar
• Kosar, M., Kupeli, E., Malyer, H., Uylaser, V., Turkben, C., and Baser, K. H. 2007. Effect of brining on biological activity of leaves of Vitis vinifera L. (Cv. Sultani Cekirdeksiz) from Turkey. J. Agric. Food Chem. 55: 4596–4603.
   PubMed Web of Science ®Google Scholar
• Krahn, D. F. 1983. Chinese hamster cell mutagenesis: A comparison of the CHO and V79 systems. Ann. NY Acad. Sci. 407: 231–238.
   PubMed Web of Science ®Google Scholar
• Lambert, J. D., and Elias, R. J. 2010. The antioxidant and pro-oxidant activities of green tea polyphenols: A role in cancer prevention. Arch. Biochem. Biophys. 501: 65–72.
   PubMed Web of Science ®Google Scholar
• Melo-Cavalcante, A. A., Dantas, S. M., Leite Ade, S., Matos, L. A., Sousa, J. M., Picada, J. N., and da Silva, J. 2011. In vivo antigenotoxic and anticlastogenic effects of fresh and processed cashew (Anacardium occidentale) apple juices. J. Med. Food 14: 792–798.
   PubMed Web of Science ®Google Scholar
• Min, K., and Ebeler, S. E. 2009. Quercetin inhibits hydrogen peroxide-induced DNA damage and enhances DNA repair in Caco-2 cells. Food Chem. Toxicol. 47: 2716–2722.
   PubMed Web of Science ®Google Scholar
• Mirabelli, C. K., Sung, C. M., McCabe, F. L., Faucette, L. F., Crooke, S. T., and Johnson, R. K. 1988. A murine model to evaluate the ability of in vitro clonogenic assays to predict the response to tumors in vivo. Cancer Res. 48: 5447–5454.
   PubMed Web of Science ®Google Scholar
• Neeha, V. S., and Kinth, P. 2013. Nutrigenomics research: A review. J. Food Sci. Technol. 50: 415–428.
   PubMed Web of Science ®Google Scholar
• Niture, S. K., Velu, C. S., Smith, Q. R., Bhat, G. J., and Srivenugopal, K. S. 2007. Increased expression of the MGMT repair protein mediated by cysteine prodrugs and chemopreventative natural products in human lymphocytes and tumor cell lines. Carcinogenesis 28: 378–389.
   PubMed Web of Science ®Google Scholar
• Oliboni, L. S., Dani, C., Funchal, C., Henriques, J. A., and Salvador, M. 2011. Hepatoprotective, cardioprotective, and renal-protective effects of organic and conventional grapevine leaf extracts on Wistar rat tissues. Ann. Acad. Bras. Cienc. 83: 1403–1411.
   PubMed Web of Science ®Google Scholar
• Orhan, N., Aslan, M., Orhan, D. D., Ergun, F., and Yesilada, E. 2006. In-vivo assessment of antidiabetic and antioxidant activities of grapevine leaves (Vitis vinifera) in diabetic rats. J. Ethnopharmacol. 108: 280–286.
   PubMed Web of Science ®Google Scholar
• Pacifico, S., D’Abrosca, B., Scognamiglio, M., Gallicchio, M., Potenza, N., Piccolella, S., Russo, A., Monaco, P., and Fiorentino, A. 2011. Metabolic profiling of strawberry grape (Vitis x labruscana cv. ‘Isabella’) components by nuclear magnetic resonance (NMR) and evaluation of their antioxidant and antiproliferative properties. J. Agric. Food Chem. 59: 7679–7687.
   PubMed Web of Science ®Google Scholar
• Rafehi, H., Orlowski, C., Georgiadis, G. T., Ververis, K., El-Osta, A., and Karagiannis, T. C. 2011. Clonogenic assay: Adherent cells. J. Vis. Exp. 49: 2573.
   PubMedGoogle Scholar
• Pastrana-Bonilla, E., Akoh, C. C., Sellappan, S., and Krewer, G. 2003. Phenolic content and antioxidant capacity of muscadine grapes. J. Agric. Food Chem. 51: 5497–5503.
   PubMed Web of Science ®Google Scholar
• Ramos, A. A., Marques, F., Fernandes-Ferreira, M., and Pereira-Wilson, C. 2013. Water extracts of tree Hypericum sps. protect DNA from oxidative and alkylating damage and enhance DNA repair in colon cells. Food Chem. Toxicol. 51: 80–86.
   PubMed Web of Science ®Google Scholar
• Rockenbach, I. I., Rodrigues, E., Gonzaga, L.V., Caliari, V., Genovese, M.I., Goncalves, A. E. S. S., and Fett, R. 2011. Phenolic compounds content and antioxidant activity in pomace from selected red grapes (Vitis vinifera L. and Vitis labrusca L.) widely produced in Brazil. Food Chem. 127: 174–179.
   Web of Science ®Google Scholar
• Santos, V. da Silva, Bisen-Hersh, E., Yu, Y., Cabral, I. S., Nardini, V., Culbreth, M., Teixeira, J. B. da Rocha, BarbosaF., Jr., and Aschner, M. 2014. Anthocyanin-rich açaí (Euterpe oleracea Mart.) extract attenuates manganese-induced oxidative stress in rat primary astrocyte cultures. J. Toxicol. Environ. Health A 77: 390–404.
   PubMed Web of Science ®Google Scholar
• Sato, M., Bagchi, D., Tosaki, A., and Das, D. K. 2001. Grape seed proanthocyanidin reduces cardiomyocyte apoptosis by inhibiting ischemia/reperfusion-induced activation of JNK-1 and C-JUN. Free Radical Biol. Med. 31: 729–737.
   PubMed Web of Science ®Google Scholar
• Scalbert, A., Manach, C., Morand, C., Rémésy, C., and Jiménez, L. 2005. Dietary polyphenols and the prevention of diseases. Crit. Rev. Food Sci. Nutr. 45: 287–306.
   PubMed Web of Science ®Google Scholar
• Singleton, V. L., and Rossi, J. A. 1965. Colorimetry of total phenolics with phosphomolybdic-phosphotungstic acid reagents. Am. J. Enol. Viticult. 16: 144–158.
   Google Scholar
• Singh, N. P., McCoy, M. T., Tice, R. R., and Schneider, E. L. 1988. A simple technique for quantitation of low levels of DNA damage in individual cells. Exp. Cell Res. 175: 184–191.
   PubMed Web of Science ®Google Scholar
• Soleas, G. J., Diamandis, E. P., and Goldberg, D. M. 1997. Resveratrol: A molecule whose time has come? And gone? Clin. Biochem 30: 91–113.
   PubMed Web of Science ®Google Scholar
• Thomas, P., and Fenech, M. 2011. Cytokinesis-block micronucleus cytome assay in lymphocytes. Methods Mol. Biol. 682: 217–234.
   PubMedGoogle Scholar
• Trindade, C., Juchem, A. L., de Albuquerque, N. R., de Oliveira, I. M., Rosa, R. M., Guecheva, T. N., Saffi, J., and Henriques, J. A. 2015. Antigenotoxic and antimutagenic effects of diphenyl ditelluride against several known mutagens in Chinese hamster lung fibroblasts. Mutagenesis 30: 799–809.
   PubMed Web of Science ®Google Scholar
• Wang, S. W., Wang, Y. J., Su, Y. J., Zhou, W. W., Yang, S. G., Zhang, R., Zhao, M., Li, Y. N., Zhang, Z. P., Zhan, D. W., and Liu, R. T. 2012. Rutin inhibits beta-amyloid aggregation and cytotoxicity, attenuates oxidative stress, and decreases the production of nitric oxide and proinflammatory cytokines. Neurotoxicology 33: 482–490.
   PubMed Web of Science ®Google Scholar
• Watjen, W., Michels, G., Steffan, B., Niering, P., Chovolou, Y., Kampkotter, A., Tran-Thi, Q. H., Proksch, P., and Kahl, R., 2005. Low concentrations of flavonoids are protective in rat H4IIE cells whereas high concentrations cause DNA damage and apoptosis. J. Nutr. 135: 525–531.
   PubMed Web of Science ®Google Scholar
• Xia, E. Q., Deng, G. F., Guo, Y. J., and Li, H. B., 2010. Biological activities of polyphenols from grapes. Int. J. Mol. Sci. 11: 622–646.
   PubMed Web of Science ®Google Scholar
• Yamaguchi, T., Takamura, H., Matoba, T., and Terao, J. 1998. HPLC method for evaluation of the free radical-scavenging activity of foods by using 1,1-diphenyl-2-picrylhydrazyl. Biosci. Biotechnol. Biochem. 62: 1201–1204.
   PubMed Web of Science ®Google Scholar
• Zhou, K., and Raffoul, J. J. 2012. Potential anticancer properties of grape antioxidants. J. Oncol. 2012: 803294.
   PubMedGoogle Scholar