332
Views
16
CrossRef citations to date
0
Altmetric
Articles

Evaluation of subchronic exposure to triclosan on hepatorenal and reproductive toxicities in prepubertal male rats

, , , , , , , , & show all

References

  • Amann, R. P., L. Johnson, D. L. Thompson, Jr, and B. W. Pickett. 1976. Daily spermatozoal production, epididymal spermatozoa reserves and transit time of spermatozoa through the epididymis of the rhesus monkey. Biology of Reproduction 15:586–92. doi:10.1095/biolreprod15.5.586.
  • Auletta, C. 1995. An 18-month oral oncogenicity study of tricolsan in the mouse via dietary administration. Pharmaco LSR. Colgate-Palmolive Company. Study No. 93e2260.
  • Bedoux, G., B. Roig, O. Thomas, V. Dupont, and B. Le Bot. 2012. Occurrence and toxicity ofantimicrobial triclosan and by-products in the environment. Environmental Science and Pollution Research 19:1044–65. doi:10.1007/s11356-011-0632-z.
  • Bentley, P., I. Calder, C. Elcombe, P. Grasso, D. Stringer, and H. J. Wiegand. 1993. Hepatic peroxisome proliferation in rodents and its significance for humans. Food and Chemical Toxicology 31:857–907. doi:10.1016/0278-6915(93)90225-N.
  • Bhargava, H. N., and P. A. Leonard. 1996. Triclosan: Applications and safety. American Journal of Infection Control 24:209–18. doi:10.1016/S0196-6553(96)90017-6.
  • Black, J. G., D. Howes, and T. Rutherford. 1975. Percutaneous absorption and metabolism of Irgasan DP300. Toxicology 3:33–47. doi:10.1016/0300-483X(75)90006-2.
  • Blazak, W. F., K. A. Trienen, and P. E. Juniewicz. 1993. Application of testicular sperm head counts in the assessment of male reproductive toxicity. In Methods in Toxicology, Vol. 3A, Male reproductive toxicology., editors R. E. Chapin and J. Heindel, 86–94. San. Diego:: Academic Press.
  • Calafat, A. M., X. Ye, L. Y. Wong, J. A. Reidy, and L. L. Needham. 2008. Urinary concentrations of triclosan in the U.S. population: 2003-2004. Environmental Health Perspectives 116:303–07. doi:10.1289/ehp.10768.
  • Chu, S., and C. D. Metcalfe. 2007. Simultaneous determination of triclocarban and triclosan in municipal biosolids by liquid chromatography tandem mass spectrometry. Journal of Chromatography A 1164:212–18. doi:10.1016/j.chroma.2007.07.024.
  • Cozad, A., and R. D. Jones. 2003. Disinfection and the prevention of infectious disease. American Journal of Infection Control 31:243–54. doi:10.1067/mic.2003.49.
  • Crofton, K. M., K. B. Paul, M. J. De Vito, and J. M. Hedge. 2007. Short-term in vivo exposure to the water contaminant triclosan: Evidence for disruption of thyroxine. Environmental Toxicology and Pharmacology 24:194–97. doi:10.1016/j.etap.2007.04.008.
  • Da Silva, R. F., C. D. S. Borges, C. De Almeida Lamas, V. H. A. Cagnon, and W. De Grava Kempinas. 2017. Arsenic trioxide exposure impairs testicular morphology in adult male mice and consequent fetus viability. Journal of Toxicology and Environmental Health, Part A 80:1166–79. doi:10.1080/15287394.2017.1376405.
  • Dann, A. B., and A. Hontela. 2011. Triclosan: Environmental exposure, toxicity and mechanisms of action. Journal Applied Toxicology 31:285–311. doi:10.1002/jat.1660.
  • DeSalva, S. J., B. M. Kong, and Y. J. Lin. 1989. Triclosan: A safety profile. Journal of the American Dental 2:185–96.
  • Etzel, T. M., A. M. Calafat, X. Ye, A. Chen, B. P. Lanphear, D. A. Savitz, K. Yolton, and J. M. Braun. 2017. Urinary triclosan concentrations during pregnancy and birth outcomes. Environmental Research 156:505–11. doi:10.1016/j.envres.2017.04.015.
  • Fang, J. L., R. L. Stingley, F. A. Beland, W. Harrouk, D. L. Lumpkins, and P. Howard. 2010. Occurrence, efficacy, metabolism, and toxicity of triclosan. Journal Environment Sciences Health C Environment Carcinogen Ecotoxicol Reviews 28:147–71. doi:10.1080/10590501.2010.504978.
  • Gee, R. H., A. Charles, N. Taylor, and P. D. Darbre. 2008. Oestrogenic and androgenic activity of triclosan in breast cancer cells. Journal Applied Toxicology 28:78–91. doi:10.1002/(ISSN)1099-1263.
  • Geens, T., H. Neels, and A. Covaci. 2012. Distribution of bisphenol-A, triclosan and n-nonylphenol in human adipose tissue, liver and brain. Chemosphere 87:796–802. doi:10.1016/j.chemosphere.2012.01.002.
  • Gilbert, P., and A. J. McBain. 2002. Literature-based evaluation of the potential risks associated with impregnation of medical devices and implants with triclosan. Surgery Infection (Larchmt) 3:S55–S63. doi:10.1089/sur.2002.3.s1-55.
  • Goodman, M., D. Q. Naiman, and J. S. Lakind. 2018. Systematic review of the literature on triclosan and health outcomes in humans. Critical Reviews in Toxicology 48:1–51. doi:10.1080/10408444.2017.1350138.
  • Hanioka, N., H. Jinno, T. Nishimura, and M. Ando. 1997. Effect of 2,4,4′‐trichloro‐2′‐ hydroxy diphenyl ether on cytochrome P450 enzymes in the rat liver. Chemosphere 34:719–30. doi:10.1016/S0045-6535(97)00464-5.
  • Hanioka, N., E. Omae, T. Nishimura, H. Jinno, S. Onodera, R. Yoda, and M. Ando. 1996. Interaction of 2,4,4′‐trichloro‐2′‐hydroxydiphenyl ether with microsomal cytochrome p450‐ dependent monooxygenases in rat liver. Chemosphere 33:265–76. doi:10.1016/0045-6535(96)00169-5.
  • Hassan, Z. A., M. R. Abd El-Haleem, and G. N. Mansour. 2014. Effect of triclosan on the renal cortex of adult male albino rats and the possible protective role of ellagic acid: Histological and biochemical study. Journal of Cytology & Histology 5:6. doi:10.4172/2157-7099.1000285.
  • Hays, T., I. Rusyn, A. M. Burns, M. J. Kennett, J. M. Ward, F. J. Gonzalez, and J. M. Peters. 2005. Role of peroxisome proliferator-activated receptor-alpha (PPAR-alpha) in bezafibrate-induced hepatocarcinogenesis and cholestasis. Carcinogenesis 26:219–27. doi:10.1093/carcin/bgh285.
  • Henry, N. D., and P. A. Fair. 2013. Comparison of in vitro cytotoxicity, estrogenicity and antiestrogenicity of triclosan, perfluorooctane sulfonate and perfluorooctanoic acid. Journal Applied Toxicology 3:265–72. doi:10.1002/jat.1736.
  • Juncker, J. C. 2016. Commission impementing decision not approving triclosan as an existing active substance for use in biocidal products for product-type 1. In 528/2012, edited by. European Union. Brussels: Jean-Claude Juncker.
  • Jung, E. M., B. S. An, K. C. Choi, and E. B. Jeung. 2012. Potential estrogenic activity of triclosan in the uterus of immature rats and rat pituitary GH3 cells. Toxicology Letters 208:142–48. doi:10.1016/j.toxlet.2011.10.017.
  • Kim, K. S., H. Y. Yang, H. Song, Y. R. Kang, J. Kwon, J. An, J. Y. Son, S. J. Kwack, Y. M. Kim, O. N. Bae, M. Y. Ahn, J. Lee, S. Yoon, B. M. Lee, and H. S. Kim. 2017. Identification of a sensitive urinary biomarker, selenium-binding protein 1, for early detection of acute kidney injury. Journal of Toxicology and Environmental Health, Part A 80:453–64. doi:10.1080/15287394.2017.1299655.
  • Kumar, V., A. Chakraborty, M. R. Kural, and P. Roy. 2009. Alteration of testicular steroidogenesis and histopathology of reproductive system in male rats treated with triclosan. Reproductive Toxicology 27:177–85. doi:10.1016/j.reprotox.2008.12.002.
  • Kux, L. 2016. Federal Register Vol. 81 No. 126. https://www.gpo.gov/fdsys/pkg/FR-2016-06-30/pdf/2016-15410.pdf.
  • Lassen, T. H., H. Frederiksen, H. B. Kyhl, S. H. Swan, K. M. Main, A. M. Andersson, D. V. Lind, S. Husby, C. Wohlfahrt-Veje, N. E. Skakkebæk, and T. K. Jensen. 2016. Prenatal triclosan exposure and anthropometric measures including anogenital distance in Danish infants. Environmental Health Perspectives 124:1261–68. doi:10.1289/ehp.1409637.
  • Lee, H. R., K. A. Hwang, K. H. Nam, H. C. Kim, and K. C. Choi. 2014. Progression of breast cancer cells was enhanced by endocrine-disrupting chemicals, triclosan and octylphenol: Via an estrogen receptor-dependent signaling pathway in cellular and mouse xenograft models. Chemical Research in Toxicology 27:834–42. doi:10.1021/tx5000156.
  • Li, J., Y. Zhang, J. Peng, X. Wu, S. Gao, and L. Mao. 2017. The effect of dissolved organic matter on soybean peroxidase-mediated removal of triclosan in water. Chemosphere 172:399–407. doi:10.1016/j.chemosphere.2017.01.013.
  • Louis, G. W., D. R. Hallinger, M. J. Braxton, A. Kamel, and T. E. Stoker. 2017. Effects of chronic exposure to triclosan on reproductive and thyroid endpoints in the adult Wistar female rat. Journal of Toxicology and Environmental Health, Part A 80:236–49. doi:10.1080/15287394.2017.1287029.
  • Lv, Y., C. Rui, Y. Dai, Q. Pang, Y. Li, R. Fan, and S. Lu. 2016. Exposure of children to BPA through dust and the association of urinary BPA and triclosan with oxidative stress in Guangzhou, China. Environmental Science: Processes & Impacts 18:1492–99. doi:10.1039/C6EM00472E.
  • Moss, T., D. Howes, and F. M. Williams. 2000. Percutaneous penetration and dermal metabolism of triclosan (2,4,4′-trichloro-2′-hydroxydiphenyl ether). Food and Chemical Toxicology 38:361–70. doi:10.1016/S0278-6915(99)00164-7.
  • Parrott, J. L., and D. T. Bennie. 2009. Life-cycle exposure of fathead minnows to a mixture of six common pharmaceuticals and triclosan. Journal of Toxicology and Environmental Health, Part A 72:633–41. doi:10.1080/15287390902769428.
  • Paul, K., J. Hedge, M. DeVito, and K. Crofton. 2010. Short-term exposure to triclosan decreases thyroxine in vivo via upregulation of hepatic catabolism in young Long-Evans rats. Toxicological Sciences 113:367–69. doi:10.1093/toxsci/kfp271.
  • Pernoncini, K. V., B. G. Montagnini, M. L. M. De Góes, P. C. Garcia, and D. C. C. Gerardin. 2018. Evaluation of reproductive toxicity in rats treated with triclosan. Reproductive Toxicology 75:65–72. doi:10.1016/j.reprotox.2017.11.010.
  • Peters, J. M., C. Cheung, and F. J. Gonzalez. 2005. Peroxisome proliferator-activated receptor-alpha and liver cancer: Where do we stand? Journal Molecular Medicine(Berl) 83:774–85. doi:10.1007/s00109-005-0678-9.
  • Philippat, C., J. Botton, A. M. Calafat, X. Ye, M. A. Charles, and R. Slama. 2014. EDEN Study Group. Prenatal exposure to phenols and growth in boys. Epidemiology 25:625–35. doi:10.1097/EDE.0000000000000132.
  • Pollock, T., L. J. Greville, B. Tang, and D. deCatanzaro. 2016. Triclosan elevates estradiol levels in serum and tissues of cycling and peri-implantation female mice. Reproductive Toxicology 65:394–401. doi:10.1016/j.reprotox.2016.09.004.
  • Provencher, G., R. Bérubé, P. Dumas, J. F. Bienvenu, E. Gaudreau, P. Bélanger, and P. Ayotte. 2014. Determination of bisphenol A, triclosan and their metabolites in human urine using isotope-dilution liquid chromatography-tandem mass spectrometry. Journal of Chromatography A 1348:97–249. doi:10.1016/j.chroma.2014.04.072.
  • Qing, X., M. Pitashny, D. B. Thomas, F. J. Barrat, M. P. Hogarth, and C. Putterman. 2008. Pathogenic anti-DNA antibodies modulate gene expression in mesangial cells: Involvement of HMGB1 in anti-DNA antibody-induced renal injury. Immunology Letters 121:61–73. doi:10.1016/j.imlet.2008.08.007.
  • Rodricks, J. V., J. A. Swenberg, J. F. Borzelleca, R. R. Maronpot, and A. M. Shipp. 2010. Triclosan: A critical review of the experimental data and development of margins of safety for consumer products. Critical Reviews in Toxicology 40:422–84. doi:10.3109/10408441003667514.
  • Rodríguez, P. E., and M. S. Sanchez. 2010. Maternal exposure to triclosan impairs thyroid homeostasis and female pubertal development in Wistar rat offspring. Journal of Toxicology and Environmental Health, Part A 73:1678–88. doi:10.1080/15287394.2010.516241.
  • Russell, A. D. 2004. Whither triclosan? Journal of Antimicrobial Chemotherapy 53:693–95. doi:10.1093/jac/dkh171.
  • Ruszkiewicz, J. A., S. Li, M. B. Rodriguez, and M. Aschner. 2017. Is triclosan a neurotoxic agent? Journal of Toxicology and Environmental Health, Part B 20:104–17. doi:10.1080/10937404.2017.1281181.
  • Sandborgh-Englund, G., M. Adolfsson-Erici, G. Odham, and J. Ekstrand. 2006. Pharmacokinetics of triclosan following oral ingestion in humans. Journal of Toxicology and Environmental Health, Part A 69:1861–73. doi:10.1080/15287390600631706.
  • Scaffidi, P., T. Misteli, and M. E. Bianchi. 2002. Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. Nature 418:191–95. doi:10.1038/nature00858.
  • SCF. 2000. Opinion of the Scientific Committee on Food on the 10th additional list of monomers and additives for food contact materials (adopted by the SCF on 22/6/2000) http://europa.eu.int/comm/food/fs/sc/scf/out62_en.pdf
  • Syberg, K., A. Nielsen, F. R. Khan, G. T. Banta, A. Palmqvist, and P. M. Jepsen. 2017. Microplastic potentiates triclosan toxicity to the marine copepod Acartia tonsa (Dana). Journal of Toxicology and Environmental Health, Part A 80:1369–71. doi:10.1080/15287394.2017.1385046.
  • Teplova, V. V., K. N. Belosludtsev, and A. G. Kruglov. 2017. Mechanism of triclosan toxicity: Mitochondrial dysfunction including complex II inhibition, superoxide release and uncoupling of oxidative phosphorylation. Toxicology Letters 275:108–17. doi:10.1016/j.toxlet.2017.05.004.
  • US EPA (US Environmental Protection Agency). 2008. Reregistration Eligibility Decision for Triclosan: List B. EPA 739/RO/8009, US Environmental Protection Agency, Washington.
  • US FDA (US Food and Drug Administration). 2008. Triclosan; supporting information for toxicological evaluation by the national toxicology program, July. 2008. US Food and Drug Administration. Department of Health and Human Services. https://ntp.niehs.nih.gov/ntp/htdocs/chem_background/exsumpdf/triclosan_508.pdf
  • Wang, C. F., and Y. Tian. 2015. Reproductive endocrine-disrupting effects of triclosan: Population exposure, present evidence and potential mechanisms. Environmental Pollution 206:195–201. doi:10.1016/j.envpol.2015.07.001.
  • Wang, Z., X. Li, and J. E. Klaunig. 2017. Investigation of the mechanism of triclosan induced mouse liver tumors. Regulatory Toxicology and Pharmacology 86:137–47. doi:10.1016/j.yrtph.2017.03.001.
  • Weatherly, L. M., and J. A. Gosse. 2017. Triclosan exposure, transformation, and human health effects. Journal of Toxicology and Environmental Health, Part B 20:447–69. doi:10.1080/10937404.2017.1399306.
  • Wu, H., J. Ma, P. Wang, T. M. Corpuz, U. Panchapakesan, K. R. Wyburn, and S. J. Chadban. 2010. HMGB1 contributes to kidney ischemia reperfusion injury. Journal of the American Society of Nephrology 21:1878–90. doi:10.1681/ASN.2009101048.
  • Yang, Y. S., J. T. Kwon, I. Shim, H. M. Kim, P. Kim, J. C. Kim, and K. Lee. 2015. Evaluation of toxicity to triclosan in rats following 28 days of exposure to aerosol inhalation. Regulatory Toxicology and Pharmacology 71:259–68. doi:10.1016/j.yrtph.2015.01.004.
  • Yin, J., L. Wei, Y. Shi, J. Zhang, Q. Wu, and B. Shao. 2016. Chinese population exposure to triclosan and triclocarban as measured via human urine and nails. Environment Geochem Health 38:1125–35. doi:10.1007/s10653-015-9777-x.
  • Yueh, M. F., K. Taniguchi, S. Chen, R. M. Evans, B. D. Hammock, M. Karin, and R. H. Tukey. 2014. The commonly used antimicrobial additive triclosan is a liver tumor promoter. Proceedings of National Academic Sciences U S A 111:17200–05. doi:10.1073/pnas.1419119111.
  • Yueh, M. F., and R. H. Tukey. 2016. Triclosan: A widespread environmental toxicant with many biological effects. Annual Review of Pharmacology and Toxicology 56:251–72. doi:10.1146/annurev-pharmtox-010715-103417.
  • Zorrilla, L. M., E. K. Gibson, S. C. Jeffay, K. M. Crofton, W. R. Setzer, R. L. Cooper, and T. E. Stoker. 2009. The effects of triclosan on puberty and thyroid hormones in male Wistar rats. Toxicological Sciences 107:56–64. doi:10.1093/toxsci/kfn225.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.