The protective mechanisms underlying Ginsenoside Rg1 effects on rat sciatic nerve injury

References

• Allodi, I., E. Udina, and X. Navarro. 2012. Specificity of peripheral nerve regeneration: Interactions at the axon level. Prog. Neurobiol. 98:16–37.
   PubMed Web of Science ®Google Scholar
• Catrina, S., B. Gander, and S. Madduri. 2013. Nerve conduit scaffolds for discrete delivery of two neurotrophic factors. Eur. J. Pharm. Biopharm. 85:139–42. doi:10.1016/j.ejpb.2013.03.030.
   PubMed Web of Science ®Google Scholar
• Chen, L., H. Yao, X. Chen, Z. Wang, Y. Xiang, J. Xia, Y. Liu, and Y. Wang. 2018. Ginsenoside Rg1 decreases oxidative stress and down-regulates Akt/mTOR signalling to attenuate cognitive impairment in mice and senescence of neural stem cells induced by D-galactose. Neurochem. Res. 43:430–40. doi:10.1007/s11064-017-2438-y.
   PubMed Web of Science ®Google Scholar
• Chen, X. D., and Y. D. Gu. 2000. Study progresses in peripheral nerve injury and motor neural cell death. Chin. J. Microsurg. 23:238–40.
   Google Scholar
• Chen, Y. S., F. Y. Tseng, C. T. Tan, S. Y. Lin-Shiauc and C. J. Hsu. 2008. Effects of methylprednisolone on nitric oxide formation and survival of facial motor neurons after axotomy. Brain Res. 1197:23–31. doi:10.1016/j.brainres.2007.12.046.
   PubMed Web of Science ®Google Scholar
• Chiarotto, G. B., L. Drummond, and G. Cavarretto. 2014. Neuroprotective effect of tempol (4 hydroxy-tempo) on neuronal death induced by sciatic nerve transection in neonatal rats. Brain Res. Bull. 106:1–8. doi:10.1016/j.brainresbull.2014.04.010.
   PubMed Web of Science ®Google Scholar
• Deveraux, Q. L., R. Takahashi, G. S. Salvesen, and J. C. Reed. 1997. X-linked IAP is a direct inhibitor of cell-death proteases. Nature 388:300–04. doi:10.1038/40901.
   PubMed Web of Science ®Google Scholar
• Eckelman, B. P., G. S. Salvesen, and F. L. Scott. 2006. Human inhibitor of apoptosis proteins: Why XIAP is the black sheep of the family. EMBO Rep. 7:988–94. doi:10.1038/sj.embor.7400795.
   PubMed Web of Science ®Google Scholar
• Fernandez-Moriano, C., E. Gonzalez-Burgos, I. Iglesias, R. Lozano, and M. P. Gómez-Serranillos. 2017. Evaluation of the adaptogenic potential exerted by ginsenosides Rb1 and Rg1 against oxidative stress-mediated neurotoxicity in an in vitro neuronal model. PLoS One 12:e0182933. doi:10.1371/journal.pone.0182933.
   PubMed Web of Science ®Google Scholar
• Gu, L. Q., and G. X. Fei. 2001. Basic and clinical medicine of peripheral nerve injuries. Beijing, China: People’s Military Medicine Press.
   Google Scholar
• Huang, S. L., X. J. He, Z. F. Li, L. Lin, and B. Cheng. 2014. Neuroprotective effects of ginsenoside Rg1 on oxygen-glucose deprivation reperfusion in PC12 cells. Pharmazie 69:208–11.
   PubMed Web of Science ®Google Scholar
• Huo, D. S., J. F. Sun, B. Zhang, X. S. Yan, H. Wang, J. X. Jia, and Z. J. Yang. 2016. Protective effects of testosterone on cognitive dysfunction in Alzheimer’s disease model rats induced by oligomeric beta amyloid peptide 1-42. J. Toxicol. Environ. Health Part A 79:856–63. doi:10.1080/15287394.2016.1193114.
   PubMed Web of Science ®Google Scholar
• Huo, D. S., M. Zhang, Z. P. Cai, C. X. Dong, H. Wang, and Z. J. Yang. 2015. The role of nerve growth factor in ginsenoside Rg1-induced regeneration of injured rat sciatic nerve. J. Toxicol. Environ. Health Part A 78:1328–37. doi:10.1080/15287394.2015.1085943.
   PubMed Web of Science ®Google Scholar
• Korhonen, L., U. Näpänkangas, H. Steen, Y. Chen, R. Martinez, and D. Lindholm. 2004. Differential regulation of X-chromosome-linked inhibitor of apoptosis protein (XIAP) and caspase-3 by NMDA in developing hippocampal neurons; involvement of the mitochondrial pathway in NMDA-mediated neuronal survival. Exp. Cell Res. 295:290–99. doi:10.1016/j.yexcr.2003.12.026.
   PubMed Web of Science ®Google Scholar
• Lee, S. K., and S. W. Wolfe. 2000. Peripheral nerve injury and repair. J Am. Acad. Orthop. Surg. 8:243–52. doi:10.5435/00124635-200007000-00005.
   PubMedGoogle Scholar
• Li, H. Y., Y. W. Ruan, C. R. Ren, Q. Cui and K. F. So. 2014. Mechanisms of secondary degeneration after partial optic nerve transection. Neural Regen. Res. 9:565–74. doi:10.4103/1673-5374.130093.
   PubMed Web of Science ®Google Scholar
• Li, Y., Y. Guan, Y. Wang, C. L. Yu, F. G. Zhai, and L. X. Guan. 2017. Neuroprotective effect of the ginsenoside Rg1 on cerebral ischemic injury in vivo and in vitro is mediated by PPARγ-regulated anti-oxidative and anti-inflammatory pathways. Evid. Based Complement Altern. Med. 2017:7842082.
   PubMedGoogle Scholar
• Li, Y. B., Y. Wang, J. P. Tang, D. Chen, and S. L. Wang. 2015. Neuroprotective effects of ginsenoside Rg1-induced neural stem cell transplantation on hypoxic-ischemic encephalopathy. Neural Regen. Res. 10:753–59. doi:10.4103/1673-5374.156971.
   PubMed Web of Science ®Google Scholar
• Ma, J., J. Liu, Q. Wang, H. Yu, Y. Chen, and L. Xiang. 2013. The beneficial effect of ginsenoside Rg1 on Schwann cells subjected to hydrogen peroxide induced oxidative injury. Int. J. Biol. Sci. 9:624–36. doi:10.7150/ijbs.5885.
   PubMed Web of Science ®Google Scholar
• Martin, L. J., A. Kaiser, and A. C. Price. 1999. Motor neuron degeneration after sciatic nerve avulsion in adult rat evolves with oxidative stress and is apoptosis. J. Neurobiol. 40:185–201.
   PubMedGoogle Scholar
• Martin, L. J., and Z. Liu. 2002. Injury-induced spinal motor neuron apoptosis is preceded by DNA single-strand breaks and is p53- and Bax-dependent. J. Neurobiol. 50:181–97. doi:10.1002/(ISSN)1097-4695.
   PubMedGoogle Scholar
• Praznikar, Z. J., T. Petan, and J. Pungerc. 2009. A neurotoxic secretory phospholipase A2 induces apoptosis in motoneuron-like cells. Ann. N. Y. Acad. Sci. 1152:215–24. doi:10.1111/j.1749-6632.2008.03999.x.
   PubMed Web of Science ®Google Scholar
• Shams, Z., A. R. Khalatbary, H. Ahmadvand, Z. Zare, and K. Kian. 2017. Neuroprotective effects of hyperbaric oxygen (HBO) therapy on neuronal death induced by sciatic nerve transection in rat. BMC Neurol. 17:220. doi:10.1186/s12883-017-1004-1.
   PubMed Web of Science ®Google Scholar
• Tiret, L., L. M H, M. Maury, and P. Brulet. 1998. Increased apoptosis of motoneurons and altered somatotopic maps in the brachial spinal cord of Hoxc-8-deficient mice. Development 125:279–91.
   PubMed Web of Science ®Google Scholar
• Unsain, N., J. M. Higgins, K. N. Parker, A. D. Johnstone, and P. A. Barker. 2013. XIAP regulates caspase activity in degenerating axons. Cell Rep. 4:751–63. doi:10.1016/j.celrep.2013.07.015.
   PubMed Web of Science ®Google Scholar
• Uslusoy, F., M. Nazıroğlu, and B. Çiğ. 2017. Inhibition of the TRPM2 and TRPV1 channels through Hypericum perforatum in sciatic nerve injury-induced rats demonstrates their key role in apoptosis and mitochondrial oxidative stress of sciatic nerve and dorsal root ganglion. Front. Physiol. 31:335.
   Google Scholar
• Wang, B., L. He, B. Cui, and H. Lv. 2014. Protection of ginsenoside Rg1 on central nerve cell damage and the influence on neuron apoptosis. Pak. J. Pharm. Sci. 27:2035–40.
   PubMed Web of Science ®Google Scholar
• Wang, Y., Q. Liu, Y. Xu, Y. Zhang, Y. Lv, Y. Tan, N. Jiang, G. Cao, X. Ma, J. Wang, et al. 2016. Ginsenoside Rg1 protects against oxidative stress-induced neuronal apoptosis through myosin IIA-actin related cytoskeletal reorganization. Int. J. Biol. Sci. 12:1341–56. doi:10.7150/ijbs.15992.
   PubMed Web of Science ®Google Scholar
• Wu, J., Z. Pan, Z. Wang, W. Zhu, Y. Shen, R. Cui, J. Lin, H. Yu, Q. Wang, J. Qian, et al. 2012. Ginsenoside Rg1 protection against β-amyloid peptide-induced neuronal apoptosis via estrogen receptor α and glucocorticoid receptor-dependent anti-protein nitration pathway. Neuropharmacology 63:349–61. doi:10.1016/j.neuropharm.2012.04.005.
   PubMed Web of Science ®Google Scholar
• Yang, Y., X. Li, L. Zhang, L. Liu, G. Jing, and H. Cai. 2015. Ginsenoside Rg1 suppressed inflammation and neuron apoptosis by activating PPARγ/HO-1 in hippocampus in rat model of cerebral ischemia-reperfusion injury. Int J Clin Exp Pathol 8:2484–94.
   PubMed Web of Science ®Google Scholar
• Yin, F. M., G. H. Yu, Y. M. Hu, and D. Y. Liu. 1998. The dead character of spine cord motoneurons after sciatic nerve injury. J. Guangzhou Med. Coll. 21:85–86.
   Google Scholar
• Yu, W. R., T. Liu, and T. K. Fehlings. 2009. Involvement of mitochondrial signaling pathways in the mechanism of Fas-mediated apoptosis after spinal cord injury. Eur. J. Neurosci. 29:114–31. doi:10.1111/j.1460-9568.2008.06555.x.
   PubMed Web of Science ®Google Scholar
• Zhou, P., L. L. Dong, Z. J. Yang, and X. Fang. 2011. A study of effects of ginsenoside Rg1 on regeneration of rat sciatic nerves. Inner Mongolia Med. J. 43:413–15.
   Google Scholar
• Zhou, T., G. Zu, X. Zhang, X. Wang, S. Li, X. Gong, Z. Liang, and J. Zhao. 2016. Neuroprotective effects of ginsenoside Rg1 through the Wnt/β-catenin signaling pathway in both in vivo and in vitro models of Parkinson’s disease. Neuropharmacology 101:480–89. doi:10.1016/j.neuropharm.2015.10.024.
   PubMed Web of Science ®Google Scholar