Antimicrobial and antileukemic effects: in vitro activity of Calyptranthes grandifolia aqueous leaf extract

References

• Adebayo, S. A., J. P. Dzoyem, L. J. Shai, and J. N. Eloff. 2015. The anti-inflammatory and antioxidant activity of 25 plant species used traditionally to treat pain in Southern African. BMC Complement. Altern. Med. 15 (1):159. doi:10.1186/s12906-015-0669-5.
   PubMed Web of Science ®Google Scholar
• Alam, M., F. Zafar, and E. Sharmin. 2013. Polyetheramide-birth of a new coating material. In advanced functional polymers and composites: Materials, devices and allied applications, ed.. Inamuddin, India, 123–36. USA: Nova Publishers.
   Google Scholar
• Aldred, K. J., R. J. Kerns, and N. Osheroff. 2014. Mechanism of quinolone action and resistance. Biochemistry 53 (10):1565–74. doi:10.1021/bi5000564.
   PubMed Web of Science ®Google Scholar
• Alves-Silva, J. M., A. Romane, T. Efferth, and L. Salgueiro. 2017. North African medicinal plants traditionally used in cancer therapy. Front. Pharmacol. 8:383. doi:10.3389/fphar.2017.00383.
   PubMed Web of Science ®Google Scholar
• Anago, E., L. Lagnika, J. Gbenou, F. Loko, M. Moudachirou, and A. Sanni. 2011. Antibacterial activity and phytochemical study of six medicinal plants used in Benin. Pakistan J. Biol. Sci. 14 (7):449–55. doi:10.3923/pjbs.2011.449.455.
   PubMedGoogle Scholar
• Anastassiadis, T., S. W. Deacon, K. Devarajan, H. Ma, and J. R. Peterson. 2011. Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity. Nat. Biotechnol 29 (11):1039. doi:10.1038/nbt.2017.
   PubMed Web of Science ®Google Scholar
• Andriole, V. T. 2005. The quinolones: Past, present, and future. Clin. Infect. Dis. 41 (Supplement_2):S113–S119. doi:10.1086/428051.
   PubMedGoogle Scholar
• Araldi, R. P., T. C. de Melo, T. B. Mendes, P. L. de Sá Júnior, B. H. Nozima, E. T. Ito, R. F. de Carvalho, E. B. de Souza, and R. de Cassia Stocco. 2015. Using the comet and micronucleus assays for genotoxicity studies: A review. Biomed. Pharmacother. 72:74–82. doi:10.1016/j.biopha.2015.04.004.
   PubMed Web of Science ®Google Scholar
• Araújo, S. D. S., T. C. Fernandes, Y. T. Cardona, P. M. Almeida, M. A. Marin-Morales, A. V. Dos Santos, K. P. Randau, A. M. Benko-Iseppon, and A. C. Brasileiro-Vidal. 2015. Cytotoxic and genotoxic effects of ethanolic extract of Euphorbia hyssopifolia l. on HEPG2 cells. J. Ethnopharmacol. 170:16–19. doi:10.1016/j.jep.2015.04.044.
   PubMed Web of Science ®Google Scholar
• Avishai, N., C. Rabinowitz, and B. Rinkevich. 2003. Use of the comet assay for studying environmental genotoxicity: Comparisons between visual and image analyses. Environ. Mol. Mutagen 42 (3):155–65. doi:10.1002/em.10189.
   PubMed Web of Science ®Google Scholar
• Bonoli, M., V. Verardo, E. Marconi, and M. F. Caboni. 2004. Antioxidant phenols in Barley (Hordeum vulgare L.) flour: Comparative spectrophotometric study among extraction methods of free and bound phenolic compounds. J. Agric. Food Chem. 52 (16):5195–200. doi:10.1021/jf040075c.
   PubMed Web of Science ®Google Scholar
• Bordignon, N. F., G. C. Meier, F. J. C. Alves, A. Lunardelli, E. Caberlon, A. Peres, and J. Rodrigues De Oliveira. 2003. Immunomodulatory effect of fructose-1,6-bisphosphate on T-lymphocytes. Int. Immunopharmacol. 3 (2):267–72. doi:10.1016/S1567-5769(02)00295-3.
   PubMed Web of Science ®Google Scholar
• Brand-Williams, W., M. E. Cuvelier, and C. Berset. 1995. Use of a free radical method to evaluate antioxidant activity. LWT-Food Sci. Technol. 28 (1):25–30. doi:10.1016/S0023-6438(95)80008-5.
   Web of Science ®Google Scholar
• Cascaes, M. M., G. M. Guilhon, E. H. Andrade, M. Zoghbi, and L. S. Santos. 2015. Constituents and pharmacological activities of Myrcia (Myrtaceae): A review of an aromatic and medicinal group of plants. Int. J. Mol. Sci. 16 (10):23881–904. doi:10.3390/ijms161023881.
   PubMed Web of Science ®Google Scholar
• Catelan, T. B. S., J. A. Santos Radai, M. M. Leitão, L. S. Branquinho, P. C. P. Vasconcelos, S. C. Heredia-Vieira, C. A. L. Kassuya, and C. A. L. Cardoso. 2018. Evaluation of the toxicity and anti-inflammatory activities of the infusion of leaves of Campomanesia guazumifolia (Cambess.) O. Berg. J. Ethnopharmacol. 226:132–42. doi:10.1016/j.jep.2018.08.015.
   PubMed Web of Science ®Google Scholar
• Chiang, L. C., W. Chiang, M. Y. Chang, L. T. Ng, and C. C. Lin. 2003. Antileukemic activity of selected natural products in Taiwan. Am. J. Chin. Med. 31 (1):37–46. doi:10.1142/S0192415X03000825.
   PubMed Web of Science ®Google Scholar
• Comin, V. M., L. Q. Lopes, P. M. Quatrin, M. E. de Souza, P. C. Bonez, F. G. Pintos, R. P. Raffin, R. D. A. Vaucher, D. S. Martinez, and R. C. Santos. 2016. Influence of Melaleuca alternifolia oil nanoparticles on aspects of pseudomonas aeruginosa biofilm. Microb. Pathol. 93:120–25. doi:10.1016/j.micpath.2016.01.019.
   PubMed Web of Science ®Google Scholar
• Cordell, G. A., and M. D. Colvard. 2012. Natural products and traditional medicine: Turning on a paradigm. J. Nat. Prod. 75 (3):514–25. doi:10.1021/np200803m.
   PubMed Web of Science ®Google Scholar
• da Silva Brum, E., L. da Rosa Moreira, A. R. da Silva, A. A. Boligon, F. B. Carvalho, M. L. Athayde, R. Brandao, and S. M. Oliveira. 2016. Tabernaemontana catharinensis ethyl acetate fraction presents antinociceptive activity without causing toxicological effects in mice. J. Ethnopharmacol. 191:115–24. doi:10.1016/j.jep.2016.06.036.
   PubMed Web of Science ®Google Scholar
• de Souza Filho, O. C., M. R. Sagrillo, L. F. Garcia, A. K. Machado, F. Cadoná, E. E. Ribeiro, M. M. Duarte, A. F. Morel, and I. B. da Cruz. 2013. The in vitro genotoxic effect of Tucuma (Astrocaryum aculeatum), an Amazonian fruit rich in carotenoids. J. Med. Food 16 (11):1013–21. doi:10.1089/jmf.2012.0287.
   PubMed Web of Science ®Google Scholar
• Dexheimer, G. M., L. K. O. Becker Delving, H. S. de Oliveira, V. Biolchi, M. I. Goettert, and A. Pozzobon. 2017. Calyptranthes grandifolia O.Berg (Myrtaceae) ethanolic extract inhibits TNF-α gene expression and cytokine release in vitro. In Vitro. Mol. Med. Rep 15 (5):2873–80. doi:10.3892/mmr.2017.6319.
   PubMed Web of Science ®Google Scholar
• Dörr, J. A., S. Bitencourt, L. Bortoluzzi, C. Alves, J. Silva, S. Stoll, S. Pinteus, A. A. Boligon, R. C. V. Santos, S. Laufer, et al. 2018. In vitro activities of Ceiba speciosa (a.st.-hil) ravenna aqueous stem bark extract. Nat. Prod. Res. 24:1–4.
   Google Scholar
• Dymock, B. W., E. G. Yang, Y. Chu-Farseeva, and L. Yao. 2014. Selective JAK inhibitors. Future Med. Chem 6 (12):1439–71. doi:10.4155/fmc.14.92.
   PubMed Web of Science ®Google Scholar
• Faleiro, D., S. Immich, F. Majolo, L. Mayer, E. M. Ethur, and M. I. Goettert. 2017. GC/MS Analysis and potential cytotoxic activity of Calyptranthes grandifolia (O. BERG), Calyptranthes tricona (D. Legrand) and Myrciaria plinioides (D. Legrand) essential oil in RAW264.7 and CHO-K1 cells. Biomed. Pharmacother. 89:1431–41. doi:10.1016/j.biopha.2017.03.040.
   PubMed Web of Science ®Google Scholar
• Figueirôa Ede, O., L. C. Nascimento da Silva, C. M. de Melo, J. K. Neves, N. H. da Silva, V. R. Pereira, and M. T. Correia. 2013. Evaluation of antioxidant, immunomodulatory, and cytotoxic action of fractions from Eugenia uniflora l. and Eugenia malaccensis l.: Correlation with polyphenol and flavanoid content. Sci. World J. 2013:125027.
   Google Scholar
• Fridlender, M., Y. Kapulnik, and H. Koltai. 2015. Plant derived substances with anti-cancer activity: From folklore to practice. Front. Plant Sci. 6:799. doi:10.3389/fpls.2015.00799.
   PubMed Web of Science ®Google Scholar
• Goedken, E. R., M. A. Argiriadi, D. L. Banach, B. A. Fiamengo, S. E. Foley, K. E. Frank, J. S. George, C. M. Harris, A. D. Hobson, D. C. Ihle, et al. 2015. Tricyclic covalent inhibitors selectively target JAK3 through an active site thiol. J. Biol. Chem. 290 (8):4573–89. doi:10.1074/jbc.M114.595181.
   PubMed Web of Science ®Google Scholar
• Goettert, M., S. Luik, R. Graeser, and S. A. Laufer. 2011. A direct ELISA assay for quantitative determination of the inhibitory potency of small molecules inhibitors for JNK3. J. Pharm. Biomed. Anal. 55 (1):236–40. doi:10.1016/j.jpba.2011.01.014.
   PubMed Web of Science ®Google Scholar
• Goettert, M., S. Luik, R. Graeser, and S. A. Laufer. 2012. Development of a p38delta mitogen activated protein kinase ELISA assay for the quantitative determination of inhibitor activity. J. Pharm. Biomed. Anal. 66:349–51. doi:10.1016/j.jpba.2012.03.008.
   PubMed Web of Science ®Google Scholar
• Hao, N. B., M. H. Lü, Y. H. Fan, Y. L. Cao, Z. R. Zhang, and S. M. Yang. 2012. Macrophages in tumor microenvironments and the progression of tumors. Clin. Dev. Immunol. 2012:1–11. doi:10.1155/2012/948098.
   Google Scholar
• Haute, G. V., E. Caberlon, E. Squizani, F. C. de Mesquita, L. Pedrazza, B. A. Martha, D. A. da Silva Melo, E. Cassel, R. S. Czepielewski, S. Bitencourt, et al. 2015. Gallic acid reduces the effect of LPS on apoptosis and inhibits the formation of neutrophil extracellular traps. Toxicol. In Vitro 30 (1):309–17. doi:10.1016/j.tiv.2015.10.005.
   PubMed Web of Science ®Google Scholar
• Horta, A., S. Pinteus, C. Alves, N. Fino, J. Silva, S. Fernandez, A. Rodrigues, and R. Pedrosa. 2014. Antioxidant and antimicrobial potential of the Bifurcaria bifurcata epiphytic bacteria. Mar. Drugs 12 (3):1676–89. doi:10.3390/md12031676.
   PubMed Web of Science ®Google Scholar
• Kauffmann, C., E. M. Ethur, B. Buhl, T. Scheibel, G. M. C. Machado, and M. M. C. Cavalheiro. 2016. Potential antileishmanial activity of essential oils of native species from southern Brazil. Environ. Nat. Resour. J. 6:18–25.
   Google Scholar
• Kich, D. M., S. Bitencourt, C. Alves, J. Silva, S. Pinteus, R. Pedrosa, S. Laufer, C. F. V. de Souza, and M. I. Goettert. 2016. Neuromodulatory effects of Calyptranthes grandifolia extracts against 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y cells. Biomed. Pharmacother. 84:382–86. doi:10.1016/j.biopha.2016.09.063.
   PubMed Web of Science ®Google Scholar
• Kich, D. M., S. Bitencourt, B. Caye, D. Faleiro, C. Alves, J. Silva, S. Pinteus, M. Mergener, F. Majolo, A. A. Boligon, et al. 2017. Lymphocyte genotoxicity and protective effect of Calyptranthes tricona (Myrtaceae) against h2o2-induced cell death in MCF-7 cells. Mol. Cell Biochem. 424 (1–2):35–43. doi:10.1007/s11010-016-2840-9.
   PubMed Web of Science ®Google Scholar
• Kim, A. K., and C. S. Lee. 2018. Apigenin reduces the Toll-like receptor-4-dependent activation of NF-KAPPAB by suppressing the Akt, mTOR, JNK, and P38-MAPK. Naunyn-Schmiedeberg’s Arch. Pharmacol 391 (3):271–83. doi:10.1007/s00210-017-1454-4.
   Google Scholar
• Kim, G., C. Dasagrandhi, E. H. Kang, S. H. Eom, and Y. M. Kim. 2018. In vitro antibacterial and early stage biofilm inhibitory potential of an edible chitosan and its phenolic conjugates against Pseudomonas aeruginosa and Listeria monocytogenes. 3 Biotechnol. 8:439.
   PubMedGoogle Scholar
• Klusmann, J. H., D. Reinhardt, H. Hasle, G. J. Kaspers, U. Creutzig, K. Hahlen, M. M. van den Heuvel-eibrink, and C. M. Zwaan. 2007. Janus kinase mutations in the development of acute megakaryoblastic leukemia in children with and without Down’s syndrome. Leukemia 21 (7):1584–87. doi:10.1038/sj.leu.2404694.
   PubMed Web of Science ®Google Scholar
• Lavorgna, M., R. Iacovino, C. Russo, C. Di Donato, C. Piscitelli, and M. Isidori. 2019. A new approach for improving the antibacterial and tumor cytotoxic activities of pipemidic acid by including it in trimethyl-beta-cyclodextrin. Int. J. Mol. Sci. 20 (2):1–15. doi:10.3390/ijms20020416.
   Web of Science ®Google Scholar
• Lima, V. N., C. D. Oliveira-Tintino, E. S. Santos, L. P. Morais, S. R. Tintino, T. S. Freitas, Y. S. Geraldo, R. L. Pereira, R. P. Cruz, I. R. Menezes, et al. 2016. Antimicrobial and enhancement of the antibiotic activity by phenolic compounds: Gallic acid, caffeic acid and pyrogallol. Microb. Pathol. 99:56–61. doi:10.1016/j.micpath.2016.08.004.
   PubMed Web of Science ®Google Scholar
• Limberger, R. P., C. A. Simões-Pires, M. Sobral, C. Menut, J. M. Bessiere, and A. T. Henriques. 2002. Essential oils from Calyptranthes concinna, C. lucida and C. rubella (Myrtaceae). Rev. Bras. Cienc. Solo 38 (3):355–60. doi:10.1590/S1516-93322002000300011.
   Google Scholar
• Lindholm, P., J. Gullbo, P. Claeson, U. Göransson, S. Johansson, A. Backlund, R. Larsson, and L. Bohlin. 2002. Selective cytotoxicity evaluation in anticancer drug screening of fractionated plant extracts. J. Biomol. Screen 7 (4):333–40. doi:10.1177/108705710200700405.
   PubMedGoogle Scholar
• Liu, X., F. Ye, J. Wu, B. How, W. Li, and D. Y. Zhang. 2015. Signaling proteins and pathways affected by flavonoids in leukemia cells. Nutr. Cancer 67 (2):238–49. doi:10.1080/01635581.2015.989372.
   PubMed Web of Science ®Google Scholar
• Machado, M. M., L. F. S. Oliveira, L. De, Zuravski, R. O. Souza, P. De, Fischer, J. A. Duarte, M. O. Rocha, C. M. Güez, A. A. Boligon, M. L. R. Athayde et al. 2016. Evaluation of genotoxic and cytotoxic effects of hydroalcoholic extract of Euphorbia tirucalli (Euphorbiaceae) in cell cultures of human leukocytes. An. Acad Bras. Cienc 88 (1):17–28. doi:10.1590/0001-3765201520140076.
   PubMed Web of Science ®Google Scholar
• Mahbub, A. A., C. L. Le Maitre, S. L. Haywood-Small, G. J. McDougall, N. A. Cross, and N. Jordan-Mahy. 2013. Differential effects of polyphenols on proliferation and apoptosis in human myeloid and lymphoid leukemia cell lines. Anti-Cancer Agents Med. 13 (10):1601–13. doi:10.2174/18715206113139990303.
   PubMed Web of Science ®Google Scholar
• Maistro, E. L., P. M. Terrazzas, F. F. Perazzo, I. M. M. Gaivao, A. C. H. F. Sawaya, and P. C. P. Rosa. 2019. Salix alba (white willow) medicinal plant presents genotoxic effects in human cultured leukocytes. J. Toxicol. Environ. Health Part A 82 (23–24):1223–34. doi:10.1080/15287394.2019.1711476.
   PubMed Web of Science ®Google Scholar
• Majolo, F., L. K. O. B. Delwing, D. J. Marmitt, I. C. Bustamante-Filho, and M. I. Goettert. 2019. Medicinal plants and bioactive natural compounds for cancer treatment: Important advances for drug discovery. Phytochem. Lett. 31:196–207. doi:10.1016/j.phytol.2019.04.003.
   Web of Science ®Google Scholar
• Marjanovic, I., J. Kostic, B. Stanic, N. Pejanovic, B. Lucic, T. Karan-Djurasevic, D. Janic, L. Dokmanovic, S. Jankovic, N. S. Vukovic, et al. 2016. Parallel targeted next generation sequencing of childhood and adult acute myeloid leukemia patients reveals uniform genomic profile of the disease. Tumour Biol. 37 (10):13391–401. doi:10.1007/s13277-016-5142-7.
   PubMedGoogle Scholar
• Mosmann, T. 1983. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J. Immunol. Meth. 65 (1–2):55–63. doi:10.1016/0022-1759(83)90303-4.
   PubMed Web of Science ®Google Scholar
• Newman, D. J., and G. M. Cragg. 2016. Natural products as sources of new drugs from 1981 to 2014. J. Nat. Prod. 79 (3):629–61. doi:10.1021/acs.jnatprod.5b01055.
   PubMed Web of Science ®Google Scholar
• Pu, Y., T. Zhang, J. Wang, Z. Mao, B. Duan, Y. Long, F. Xue, D. Liu, S. Liu, and Z. Gao. 2018. Luteolin exerts an anticancer effect on gastric cancer cells through multiple signaling pathways and regulating miRNAs. J. Cancer 9 (20):3669–75. doi:10.7150/jca.27183.
   PubMed Web of Science ®Google Scholar
• Rayan, A., J. Raiyn, and M. Falah. 2017. Nature is the best source of anticancer drugs: Indexing natural products for their anticancer bioactivity. PLoS ONE 12 (11):e0187925. doi:10.1371/journal.pone.0187925.
   PubMed Web of Science ®Google Scholar
• Rodríguez-Chávez, J. L., E. Coballase-Urrutia, G. Sicilia-Argumedo, T. Ramírez-Apan, and G. Delgado. 2015. Toxicological evaluation of the natural products and some semisynthetic derivatives of Heterotheca inuloides Cass. (Asteraceae). J. Ethnopharmacol. 175:256–65. doi:10.1016/j.jep.2015.08.055.
   PubMed Web of Science ®Google Scholar
• Rody, H. V. S., D. C. Gontijo, V. P. M. Coelho, M. C. Ventrella, R. M. Padua, L. G. Fietto, and J. P. V. Leite. 2018. Mutagenic activity and chemical composition of phenolic-rich extracts of leaves from two species of Ficus medicinal plants. J. Toxicol. Environ. Health Part A 81 (17):861–72. doi:10.1080/15287394.2018.1498420.
   PubMed Web of Science ®Google Scholar
• Seca, A. M. L., and D. C. G. A. Pinto. 2018. Plant secondary metabolites as anticancer agents: Successes in clinical trials and therapeutic application. Int. J. Mol. Sci. 19 (1):263. doi:10.3390/ijms19010263.
   PubMed Web of Science ®Google Scholar
• Simões, C. M. O., E. P. Schenkel, G. Gosmann, J. C. P. Mello, L. A. Mentz, and P. R. Petrovick. 2003. Farmacognosia: Da planta ao medicamento. 5 ed. Porto Alegre/Florianópolis: Editora da UFRGS/Editora da UFSC.
   Google Scholar
• Singh, N. P., M. T. McCoy, R. R. Tice, and E. L. Schneider. 1988. A simple technique for quantitation of low levels of DNA damage in individual cells. Exp. Cell Res 175 (1):184–91. doi:10.1016/0014-4827(88)90265-0.
   PubMed Web of Science ®Google Scholar
• Sissi, C., and M. Palumbo. 2003. The quinolone family: From antibacterial to anticancer agents. Curr. Med. Chem. Anticancer Agents 3 (6):439–50. doi:10.2174/1568011033482279.
   PubMedGoogle Scholar
• Stefanello, M. É., A. C. Pascoal, and M. J. Salvador. 2011. Essential oils from neotropical Myrtaceae: Chemical diversity and biological properties. Chem. Biodivers. 8 (1):73–94. doi:10.1002/cbdv.201000098.
   PubMed Web of Science ®Google Scholar
• Szwed, M., A. Matusiak, A. Laroche-Clary, J. Robert, I. Marszalek, and Z. Jozwiak. 2014. Transferrin as a drug carrier: Cytotoxicity, cellular uptake and transport kinetics of doxorubicin transferrin conjugate in the human leukemia cells. Toxicol. In Vitro 28 (2):187–97. doi:10.1016/j.tiv.2013.09.013.
   PubMed Web of Science ®Google Scholar
• Takao, L. K., M. Imatomi, and S. C. J. Gualtieri. 2015. Antioxidant activity and phenolic content of leaf infusions of Myrtaceae species from cerrado (Brazilian savanna). Braz. J. Biol 75 (4):948–52. doi:10.1590/1519-6984.03314.
   PubMed Web of Science ®Google Scholar
• Tariq, A., S. Sadia, K. Pan, I. Ullah, S. Mussarat, F. Sun, O. O. Abiodun, A. Batbaatar, Z. Li, D. Song, et al. 2017. A systematic review on ethnomedicines of anti-cancer plants. Phytother. Res. 31 (2):202–64. doi:10.1002/ptr.5751.
   PubMed Web of Science ®Google Scholar
• Tuttis, K., D. L. M. G. da Costa, H. L. Nunes, A. F. L. Specian, J. M. Sepeloni, L. M. Dos Santos, E. A. Varanda, W. Vilegas, W. Martinez-Lopez, and I. M. S. Colus. 2018. Pouteria ramiflora (Mart.) Radlk. extract: Flavonoids quantification and chemopreventive effect on HepG2 cells. J. Toxicol. Environ. Health Part A 81 (16):792–804. doi:10.1080/15287394.2018.1491911.
   PubMed Web of Science ®Google Scholar
• Viktorsson, E. Ö., B. Melling Grøthe, R. Aesoy, M. Sabir, S. Snellingen, A. Prandina, O. A. Høgmoen Åstrand, T. Bonge-Hansen, S. O. Døskeland, L. Herfindal, et al. 2017. Total synthesis and antileukemic evaluations of the phenazine 5,10-dioxide natural products iodinin, myxin and their derivatives. Bioorg. Med. Chem. Lett. 25 (7):2285–93. doi:10.1016/j.bmc.2017.02.058.
   Google Scholar
• Wen-Hung, W., T. Yu-Chang, C. Zong-Shiow, L. Ching-Gong, Y. Ming-Hui, Y. Shyng-Shiou, and T. Wan-Chi. 2014. Evaluation of the antioxidant activity and antiproliferative effect of the jaboticaba (Myrciaria cauliflora) seed extracts in oral carcinoma cells. Biomed. Res. Int. United States: 185946. doi:10.1155/2014/185946
   Web of Science ®Google Scholar