178
Views
3
CrossRef citations to date
0
Altmetric
Research Article

Antitumoral activity of Caralluma europaea on colorectal and prostate cancer cell lines

, ORCID Icon, ORCID Icon, , ORCID Icon, ORCID Icon, ORCID Icon & ORCID Icon show all

References

  • Adnan, M., S. Jan, S. Mussarat, A. Tariq, S. Begum, A. Afroz, and Z. K. Shinwari. 2014. A review on ethnobotany, phytochemistry and pharmacology of plant genus Caralluma R. Br. J. Pharm. Pharmacol. 66 (10):1351–68. doi:10.1111/jphp.12265.
  • Ali, S. A., G. Singh, and A. K. Datusalia. 2021. Potential therapeutic applications of phytoconstituents as immunomodulators: Pre-clinical and clinical evidences. Phytother Res. 35:3702–31. doi:10.1002/ptr.7068.
  • Almehdar, H., H. M. Abdallah, A. M. Osman, and E. A. Abdel-Sattar. 2012. In vitro cytotoxic screening of selected Saudi medicinal plants. J. Nat. Med. 66:406–12. doi:10.1007/s11418-011-0589-8.
  • Amrati, F. E., M. Bourhia, H. Saghrouchni, M. Slighoua, A. Grafov, R. Ullah, E. Ezzeldin, G. A. Moustafa, A. Bari, S. Ibnemoussa, et al. 2021. Caralluma europaea (Guss.) N.E.Br.: Anti-Inflammatory, antifungal, and antibacterial activities against nosocomial antibiotic-resistant microbes of chemically characterized fractions. Molecules 26 (3):636. doi:10.3390/molecules26030636.
  • Amrati, F. E., M. Bourhia, M. Slighoua, S. Ibnemoussa, A. Bari, R. Ullah, A. Amaghnouje, F. Di Cristo, M. El Mzibri, A. Calarco, et al. 2020. Phytochemical study on antioxidant and antiproliferative activities of Moroccan Caralluma europaea extract and its bioactive compound classes. Evid. Based Complement Alternat. Med. 2020:8409718. doi:10.1155/2020/8409718.
  • Amrati, F. E., O. H. M. Elmadbouh, M. Chebaibi, B. Soufi, R. Conte, M. Slighoua, A. Saleh, O. Al Kamaly, A. Drioiche, T. Zair, et al. 2022. Evaluation of the toxicity of Caralluma europaea (C.E) extracts and their effects on apoptosis and chemoresistance in pancreatic cancer cells. J. Biomol. Struct. Dyn. 2022:1–18. doi:10.1080/07391102.2022.2135595.
  • Amri, Z., W. Kharroubi, C. Fidanzi-Dugas, D. Y. Leger, M. Hammami, and B. Liagre. 2020. Growth inhibitory and pro-apoptotic effects of ornamental pomegranate extracts in Du145 human prostate cancer cells. Nutr. Cancer 72 (6):932–38. doi:10.1080/01635581.2019.1660385.
  • Atanasov, A. G., B. Waltenberger, E. M. Pferschy-Wenzig, T. Linder, C. Wawrosch, P. Uhrin, V. Temml, L. Wang, S. Schwaiger, E. H. Heiss, et al. 2015. Discovery and resupply of pharmacologically active plant-derived natural products: A review. Biotechnol. Adv. 33(8):1582–614. doi:10.1016/j.biotechadv.2015.08.001.
  • Avtanski, D., and L. Poretsky. 2018. Phyto-polyphenols as potential inhibitors of breast cancer metastasis. Mol. Med. 24 (1):29. doi:10.1186/s10020-018-0032-7.
  • Benarba, B., and A. Pandiella. 2018. Colorectal cancer and medicinal plants: Principle findings from recent studies. Biomed. Pharmacother 107:408–23. doi:10.1016/j.biopha.2018.08.006.
  • Buyel, J. F. 2018. Plants as sources of natural and recombinant anti-cancer agents. Biotechnol. Adv. 36 (2):506–20. doi:10.1016/j.biotechadv.2018.02.002.
  • Chaitanya, G. V., A. J. Steven, and P. P. Babu. 2010. PARP-1 cleavage fragments: Signatures of cell-death proteases in neurodegeneration. Cell Commun. Signal 8 (1):31. doi:10.1186/1478-811X-8-31.
  • Ci, Y., J. Qiao, and M. Han. 2016. Molecular mechanisms and metabolomics of natural polyphenols interfering with breast cancer metastasis. Molecules 21:1634. doi:10.3390/molecules21121634.
  • Cock, I. E., and S. F. Van Vuuren. 2020. The traditional use of southern African medicinal plants for the treatment of bacterial respiratory diseases: A review of the ethnobotany and scientific evaluations. J. Ethnopharmacol. 263:113204. doi:10.1016/j.jep.2020.113204.
  • Cragg, G. M., and D. J. Newman. 2013. Natural products: A continuing source of novel drug leads. Biochim. Biophys. Acta 1830 (6):3670–95. doi:10.1016/j.bbagen.2013.02.008.
  • Dos Santos Freire, J., B. C. Dos Santos Fernandes, J. A. C. da Silvada Silvada Silva, J. R. da Silva Araújo, P. M. de Almeida, J. S. da Costa Júnior, J. N. da Silvada Silvada Silva, S. D. L. de Freitas, and F. A. Martins. 2020. Phytochemical and antioxidant characterization, cytogenotoxicity and antigenotoxicity of the fractions of the ethanolic extract of in Poincianella bracteosa (tul.) L.P. Queiroz. J. Toxicol. Environ. Health A 83 (23–24):730–47. doi:10.1080/15287394.2020.1824136.
  • Dra, L. A., S. Sellami, H. Rais, F. Aziz, A. Aghraz, K. Bekkouche, M. Markouk, and M. Larhsini. 2019. Antidiabetic potential of Caralluma europaea against alloxan-induced diabetes in mice. Saudi J. Biol. Sci. 26 (6):1171–78. doi:10.1016/j.sjbs.2018.05.028.
  • Dutt, H. C., S. Singh, B. Avula, I. A. Khan, and Y. S. Bedi. 2012. Pharmacological review of Caralluma R.Br. with special reference to appetite suppression and anti-obesity. J. Med. Food 15 (2):108–19. doi:10.1089/jmf.2010.1555.
  • Eddin, L. B., N. K. Jha, M. F. N. Meeran, K. K. Kesari, R. Beiram, and S. Ojha. 2021. Neuroprotective potential of limonene and limonene containing natural products. Mol. 26:4535. doi:10.3390/molecules26154535.
  • Ekor, M. 2014. The growing use of herbal medicines: Issues relating to adverse reactions and challenges in monitoring safety. Front Pharmacol. 4:177. doi:10.3389/fphar.2013.00177.
  • Figueiredo, C. C. M., A. C. Gomes, F. O. Granero, J. L. Bronzel Junior, L. P. Silva, A. L. T. G. Ruiz, and R. M. G. da Silva. 2021. Antiglycation and antitumoral activity of Tribulus terrestris dry extract. Avicenna J. Phytomed. 11 (3):224–37.
  • Fitzgerald, M., M. Heinrich, and A. Booker. 2019. Medicinal plant analysis: A historical and regional discussion of emergent complex techniques. Front Pharmacol. 10:1480. doi:10.3389/fphar.2019.01480.
  • Fridlender, M., Y. Kapulnik, and H. Koltai. 2015. Plant derived substances with anti-cancer activity: From folklore to practice. Front Plant Sci. 6:799. doi:10.3389/fpls.2015.00799.
  • Furtado, R. A., S. D. Ozelin, N. H. Ferreira, B. A. Miura, S. Almeida Junior, G. M. Magalhães, E. J. Nassar, M. A. Miranda, J. K. Bastos, and D. C. Tavares. 2022. Antitumor activity of solamargine in mouse melanoma model: Relevance to clinical safety. J. Toxicol. Environ. Health Part A 85 (4):131–42. doi:10.1080/15287394.2021.1984348.
  • Ghezali, L., D. Y. Leger, Y. Limami, J. Cook-Moreau, J. L. Beneytout, and B. Liagre. 2013. Cyclopamine and jervine induce COX-2 overexpression in human erythroleukemia cells but only cyclopamine has a pro-apoptotic effect. Exp. Cell Res. 319 (7):1043–53. doi:10.1016/j.yexcr.2013.01.014.
  • Ghezali, L., B. Liagre, Y. Limami, J. L. Beneytout, and D. Y. Leger. 2014. Sonic Hedgehog activation is implicated in diosgenin-induced megakaryocytic differentiation of human erythroleukemia cells. PLoS One 9 (4):e95016. doi:10.1371/journal.pone.0095016.
  • Hosseini, A., and A. Ghorbani. 2015. Cancer therapy with phytochemicals: Evidence from clinical studies. Avicenna J. Phytomed. 5 (2):84–97.
  • Idm’hand, E., F. Msanda, and K. Cherifi. 2020. Ethnopharmacological review of medicinal plants used to manage diabetes in Morocco. Clin. Phytosci. 6 (1):18. doi:10.1186/s40816-020-00166-z.
  • Ijaz, S., N. Akhtar, M. S. Khan, A. Hameed, M. Irfan, M. A. Arshad, S. Ali, and M. Asrar. 2018. Plant derived anticancer agents: A green approach towards skin cancers. Biomed. Pharmacother 103:1643–51. doi:10.1016/j.biopha.2018.04.113.
  • Ismail, B., C. Fagnere, Y. Limami, L. Ghezali, C. Pouget, C. Fidanzi, C. Ouk, R. Gueye, J. L. Beneytout, J. L. Duroux, et al. 2015. 2′-Hydroxy-4-methylsulfonylchalcone enhances TRAIL-induced apoptosis in prostate cancer cells. Anticancer Drugs 26(1):74–84. doi:10.1097/CAD.0000000000000163.
  • Issiki, Z., C. Moundir, F. Marnissi, N. Seddik, N. Benjelloun, Y. Zaid, and M. Oudghiri. 2017. Toxicological evaluation of the aqueous extract of Caralluma europaea and its immunomodulatory and inflammatory activities. Pharmacognosy Res. 9 (4):390–95. doi:10.4103/pr.pr_24_17.
  • Izzo, A. A., S. Hoon-Kim, R. Radhakrishnan, and E. M. Williamson. 2016. A critical approach to evaluating clinical efficacy, adverse events and drug interactions of herbal remedies. Phytother. Res. 30 (5):691–700. doi:10.1002/ptr.5591.
  • Kauroo, S., J. Govinden-Soulange, V. M. Ranghoo-Sanmukhiya, K. Miranda, W. E. Cotham, M. D. Walla, M. Nagarkatti, and P. Nagarkatti. 2021. Extracts of select endemic plants from the Republic of Mauritius exhibiting anti-cancer and immunomodulatory properties. Sci. Rep. 11 (1):4272. doi:10.1038/s41598-021-83461-0.
  • Kis, B., F. C. Ifrim, V. Buda, S. Avram, I. Z. Pavel, D. Antal, V. Paunescu, C. A. Dehelean, F. Ardelean, Z. Diaconeasa, et al. 2019. Cannabidiol—from plant to human body: a promising bioactive molecule with multi-target effects in cancer. Int. J. Mol. Sci. 20(23):5905. doi:10.3390/ijms20235905.
  • Laurent, V., J. Saillard, M. Thierry, A. Lepelletier, C. Fronteau, and J. F. Huon. 2021. Anticancer agents and phytotherapy: Interactions that are often unrecognized. J. Oncol. Pharm. Pract. 27 (2):322–28. doi:10.1177/1078155220920363.
  • Lepage, C., D. Y. Leger, J. Bertrand, F. Martin, J. L. Beneytout, and B. Liagre. 2011. Diosgenin induces death receptor-5 through activation of p38 pathway and promotes TRAIL-induced apoptosis in colon cancer cells. Cancer Lett. 301 (2):193–202. doi:10.1016/j.canlet.2010.12.003.
  • Limami, Y., D. Y. Leger, B. Liagre, N. Pecout, and M. Viana. 2021. Ibuprofen-loaded calcium phosphate granules: A new bone substitute for local relieving symptoms of osteoarthritis. Eur. J. Pharm. Sci. 158:105679. doi:10.1016/j.ejps.2020.105679.
  • Limami, Y., A. Pinon, D. Y. Leger, Y. Mousseau, J. Cook-Moreau, J. L. Beneytout, C. Delage, B. Liagre, and A. Simon. 2011. HT-29 colorectal cancer cells undergoing apoptosis overexpress COX-2 to delay ursolic acid-induced cell death. Biochimie. 93 (4):749–57. doi:10.1016/j.biochi.2011.01.003.
  • Lim, D. W., and J. H. Wang. 2022. Gut microbiome: The interplay of an “Invisible Organ” with herbal medicine and its derived compounds in chronic metabolic disorders. Int. J. Environ. Res. Public Health 19 (20):13076. doi:10.3390/ijerph192013076.
  • Maistro, E. L., P. M. Terrazzas, F. F. Perazzo, I. O. M. Gaivão, A. Sawaya, and P. C. P. Rosa. 2019. Salix alba (white willow) medicinal plant presents genotoxic effects in human cultured leukocytes. J. Toxicol. Environ. Health Part A 82 (23–24):1223–34. doi:10.1080/15287394.2019.1711476.
  • Ouassou, H., M. Bouhrim, L. Kharchoufa, H. Imtara, N. E. Daoudi, A. Benoutman, N. Bencheikh, S. Ouahhoud, A. Elbouzidi, and M. Bnouham. 2021. Caralluma europaea (Guss) N.E.Br.: A review on ethnomedicinal uses, phytochemistry, pharmacological activities, and toxicology. J. Ethnopharmacol. 273:113769. doi:10.1016/j.jep.2020.113769.
  • Pfeffer, C. M., and A. T. K. Singh. 2018. Apoptosis: A target for anticancer therapy. Int. J. Mol. Sci 19:448. doi:10.3390/ijms19020448.
  • Pricci, M., B. Girardi, F. Giorgio, G. Losurdo, E. Ierardi, and A. Di Leo. 2020. Curcumin and colorectal cancer: From basic to clinical evidences. Int. J. Mol. Sci. 21 (7):2364. doi:10.3390/ijms21072364.
  • Rahman, M. M., X. Wang, M. R. Islam, S. Akash, F. A. Supti, M. I. Mitu, M. Harun-Or-Rashid, M. N. Aktar, M. S. Khatun Kali, F. I. Jahan, et al. 2022. Multifunctional role of natural products for the treatment of Parkinson’s disease: At a glance. Front Pharmacol. 13:976385. doi:10.3389/fphar.2022.976385.
  • Rajendran, P., S. A. Abdelsalam, K. Renu, V. Veeraraghavan, R. Ben Ammar, and E. A. Ahmed. 2022. Polyphenols as potent epigenetics agents for cancer. Int. J. Mol. Sci. 23 (19):11712. doi:10.3390/ijms231911712.
  • Redza-Dutordoir, M., and D. A. Averill-Bates. 2016. Activation of apoptosis signalling pathways by reactive oxygen species. Biochim. Biophys. Acta 1863 (12):2977–92. doi:10.1016/j.bbamcr.2016.09.012.
  • Senapati, S., A. K. Mahanta, S. Kumar, and P. Maiti. 2018. Controlled drug delivery vehicles for cancer treatment and their performance. Signal. Transduct. Target Ther. 3 (1):7. doi:10.1038/s41392-017-0004-3.
  • Silva, J. D. N., N. B. N. Monção, R. R. S. de Farias, A. M. D. G. L. Citó, M. H. Chaves, M. R. S. Araújo, D. J. B. Lima, C. Pessoa, A. Lima, E. C. D. C. Araújo, et al. 2020. Toxicological, chemopreventive, and cytotoxic potentialities of rare vegetal species and supporting findings for the Brazilian Unified Health System (SUS). J. Toxicol. Environ. Health Part A. 83(13–14):525–45. doi:10.1080/15287394.2020.1780658.
  • Soltana, H., A. Pinon, Y. Limami, Y. Zaid, L. Khalki, N. Zaid, D. Salah, U. Y. Sabitaliyevich, A. Simon, B. Liagre, et al. 2019. Antitumoral activity of Ficus carica L. on colorectal cancer cell lines. Cell. Mol. Biol. (Noisy-le-Grand). 65(6):6–11. doi:10.14715/cmb/2019.65.6.2.
  • Sung, H., J. Ferlay, R. L. Siegel, M. Laversanne, I. Soerjomataram, A. Jemal, and F. Bray. 2021. Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 71 (3):209–49. doi:10.3322/caac.21660.
  • Talib, W. H., and A. M. Mahasneh. 2010. Antiproliferative activity of plant extracts used against cancer in traditional medicine. Sci. Pharm. 78 (1):33–45. doi:10.3797/scipharm.0912-11.
  • Tlili, H., A. Macovei, D. Buonocore, M. Lanzafame, H. Najjaa, A. Lombardi, A. Pagano, M. Dossena, M. Verri, A. B. Arfa, et al. 2021. The polyphenol/saponin-rich Rhus tripartita extract has an apoptotic effect on THP-1 cells through the PI3K/AKT/mTOR signaling pathway. BMC Complement Med. Ther. 21(1):153. doi:10.1186/s12906-021-03328-9.
  • Tsai, Y. T., S. T. Kao, and C. Y. Cheng. 2022. Medicinal herbs and their derived ingredients protect against cognitive decline in in vivo models of Alzheimer’s disease. Int. J. Mol. Sci 23 (19):11311. doi:10.3390/ijms231911311.
  • Véras, J. H., C. R. Do Vale, E. F. Luiz Cardoso Bailão, M. M. Dos Anjos, C. G. Cardoso, M. G. de Oliveirade Oliveira, J. R. de Paula, G. R. de Oliveirade Oliveira, C. R. E. Silva, and L. Chen-Chen. 2022. Protective effects and DNA repair induction of a coumarin-chalcone hybrid against genotoxicity induced by mutagens. J. Toxicol. Environ. Health Part A 85 (22):937–51. doi:10.1080/15287394.2022.2120585.
  • Wang, X., T. Wu, J. Zhang, G. Guo, X. He, Z. Pei, Z. Liu, C. F. Liu, C. A. Ross, and W. W. Smith. 2020. Transmembrane protein 230 mediates a poly(adp-ribose) polymerase-1-linked apoptosis. Front Aging. Neurosci. 12:235. doi:10.3389/fnagi.2020.00235.
  • Wu, H., L. Chen, F. Zhu, X. Han, L. Sun, and K. Chen. 2019. The cytotoxicity effect of resveratrol: Cell cycle arrest and induced apoptosis of breast cancer 4T1 cells. Toxins 11:731. doi:10.3390/toxins11120731.
  • Yang, H., and Q. P. Dou. 2010. Targeting apoptosis pathway with natural terpenoids: Implications for treatment of breast and prostate cancer. Curr. Drug Targets 11 (6):733–44. doi:10.2174/138945010791170842.
  • Yu, L., S. Li, L. Pu, C. Yang, Q. Shi, Q. Zhao, S. Meniga, Y. Liu, Y. Zhang, and X. Lai. 2022. Traditional Tibetan medicine: Therapeutic potential in rheumatoid arthritis. Front Pharmacol. 13:938915. doi:10.3389/fphar.2022.938915.
  • Zito, P., M. Sajeva, M. Bruno, A. Maggio, S. Rosselli, C. Formisano, and F. Senatore. 2010. Essential oil composition of stems and fruits of Caralluma europaea N.E.Br. (Apocynaceae). Mol. 15:627–38. doi:10.3390/molecules15020627.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.