Effect of total flavonoids of Dracocephalum moldavica L. On neuroinflammation in Alzheimer's disease model amyloid-β (Aβ1-42)-peptide-induced astrocyte activation

References

• 2023 Alzheimer’s disease facts and figures. 2023. Alzheimer’s Dement 19 (4): 1598–1695. https://doi.org/10.1002/alz.13016.
   PubMed Web of Science ®Google Scholar
• Asimakidou, E., R. Reynolds, A. M. Barron, and C. H. Lo. 2024. “Autolysosomal Acidification Impairment as a Mediator for TNFR1 Induced Neuronal Necroptosis in Alzheimer’s Disease.” Neural Regeneration Research 19:1869–1870. https://doi.org/10.4103/1673-5374.390979.
   PubMed Web of Science ®Google Scholar
• Chang, J., Z. Qian, B. Wang, J. Cao, S. Zhang, F. Jiang, R. Kong, et al. 2023. “Transplantation of A2 Type Astrocytes Promotes Neural Repair and Remyelination After Spinal Cord Injury.” Cell Communication and Signaling 21 (1): 37. https://doi.org/10.1186/s12964-022-01036-6.
   PubMed Web of Science ®Google Scholar
• Daneman, R., and A. Prat. 2015. “The Blood–Brain Barrier.” Cold Spring Harbor Perspectives in Biology 7 (1): a020412. https://doi.org/10.1101/cshperspect.a020412.
   PubMed Web of Science ®Google Scholar
• Decourt, B., D. K. Lahiri, and M. N. Sabbagh. 2017. “Targeting Tumor Necrosis Factor Alpha for Alzheimer’s Disease.” Current Alzheimer Research 14 (4): 412–425. https://doi.org/10.2174/1567205013666160930110551.
   PubMed Web of Science ®Google Scholar
• Escartin, C., E. Galea, A. Lakatos, J. P. O’Callaghan, G. C. Petzold, A. Serrano-Pozo, C. Steinhäuser, et al. 2021. “Reactive Astrocyte Nomenclature, Definitions, and Future Directions.” Nature Neuroscience 24 (3): 312–325. https://doi.org/10.1038/s41593-020-00783-4.
   PubMed Web of Science ®Google Scholar
• Fan, Y. Y., and J. Huo. 2021. “A1/A2 Astrocytes in Central Nervous System Injuries and Diseases: Angels or Devils?” Neurochemistry International 148:105080. https://doi.org/10.1016/j.neuint.2021.105080.
   PubMed Web of Science ®Google Scholar
• Figley, C. R., and P. W. Stroman. 2011. “The Role (S) of Astrocytes and Astrocyte Activity in Neurometabolism, Neurovascular Coupling, and the Production of Functional Neuroimaging Signals.” The European Journal of Neuroscience 33 (4): 577–588. https://doi.org/10.1111/j.1460-9568.2010.07584.x.
   PubMed Web of Science ®Google Scholar
• Fotuhi, S. N., M. Kondori-Khalaj, M. A. H. Feizi, and M. Talebi. 2020. “Memory-Related Process in Physiological Status and Alzheimer’s Disease.” Molecular Biology Reports 47 (6): 4651–4657. https://doi.org/10.1007/s11033-020-05438-y.
   PubMed Web of Science ®Google Scholar
• Gorlovoy, P., S. Larionov, T. T. H. Pham, and H. Neumann. 2009. “Accumulation of Tau Induced in Neurites by Microglial Proinflammatory Mediators.” Federation of American Societies for Experimental Biology Journal 23 (8): 2502–2513. https://doi.org/10.1096/fj.08-123877.
   PubMed Web of Science ®Google Scholar
• Guo, M. F., H. Y. Zhang, Y. H. Li, Q. F. Gu, W. Y. Wei, Y. Y. Wang, X. J. Zhang, et al. 2020. “Fasudil Inhibits the Activation of Microglia and Astrocytes of Transgenic Alzheimer’s Disease Mice via the Downregulation of TLR4/Myd88/NF-Κb Pathway.” Journal of neuroimmunology 346:577284. https://doi.org/10.1016/j.jneuroim.2020.577284.
   PubMed Web of Science ®Google Scholar
• Gustavsson, A., N. Norton, T. Fast, L. Frölich, J. Georges, D. Holzapfel, T. Kirabali, et al. 2023. “Global Estimates on the Number of Persons Across the Alzheimer’s Disease Continuum.” Alzheimer’s Dement 19:658–670. https://doi.org/10.1002/alz.12694.
   PubMed Web of Science ®Google Scholar
• Guzman-Martinez, L., R. B. Maccioni, V. Andrade, L. P. Navarrete, M. G. Pastor, and E. N. Ramos. 2019. “Neuroinflammation as a Common Feature of Neurodegenerative Disorders.” Frontiers in Pharmacology 10. https://doi.org/10.3389/fphar.2019.01008.
   PubMed Web of Science ®Google Scholar
• Guzman-Martinez, L., R. B. Maccioni, V. Andrade, L. P. Navarrete, M. G. Pastor, and N. Ramos-Escobar. 2019. “Neuroinflammation As a Common Feature of Neurodegenerative Disorders.” Frontiers in Pharmacology 10:1008. https://doi.org/10.3389/fphar.2019.01008.
   PubMed Web of Science ®Google Scholar
• Hashimoto, M., Y. Yatabe, K. Kaneda, K. Honda, and M. Ikeda. 2009. “Impact of Donepezil Hydrochloride on the Care Burden of Family Caregivers of Patients with Alzheimer’s Disease.” Psychogeriatrics 9:196–203. https://doi.org/10.1111/j.1479-8301.2009.00302.x.
   PubMed Web of Science ®Google Scholar
• He, C. H., J. M. Lv, G. J. Khan, H. Duan, W. Wang, K. F. Zhai, G. A. Zou, and H. A. Aisa. 2023. “Total Flavonoid Extract from Dracocephalum Moldavica L. Improves Pulmonary Fibrosis by Reducing Inflammation and Inhibiting the Hedgehog Signaling Pathway.” Phytotherapy Research: PTR 37 (7): 2745–2758. https://doi.org/10.1002/ptr.7771.
   PubMed Web of Science ®Google Scholar
• Hol, E. M., and M. Pekny. 2015. “Glial Fibrillary Acidic Protein (GFAP) and the Astrocyte Intermediate Filament System in Diseases of the Central Nervous System.” Current Opinion in Cell Biology 32:121–130. https://doi.org/10.1016/j.ceb.2015.02.004.
   PubMed Web of Science ®Google Scholar
• Kashon, M. L., G. W. Ross, J. P. O’Callaghan, D. B. Miller, H. Petrovitch, C. M. Burchfiel, D. S. Sharp, et al. 2004. “Associations of Cortical Astrogliosis with Cognitive Performance and Dementia Status.” Journal of Alzheimer’s Disease 6 (6): 595–604. discussion 673-81. https://doi.org/10.3233/JAD-2004-6604.
   PubMed Web of Science ®Google Scholar
• Kelley, B. J., and R. C. Petersen. 2007. “Alzheimer’s Disease and Mild Cognitive Impairment.” Neurologic Clinics 25:577–609. https://doi.org/10.1016/j.ncl.2007.03.008. 3
   PubMed Web of Science ®Google Scholar
• Kim, K. M., S. Y. Kim, T. J. Mony, H. J. Bae, S. D. Han, E. S. Lee, S. H. Choi, S. H. Hong, S. D. Lee, and S. J. Park. 2021. “Dracocephalum Moldavica Ethanol Extract Suppresses LPS-Induced Inflammatory Responses Through Inhibition of the JNK/ERK/NF-Κb Signaling Pathway and IL-6 Production in RAW 264.7 Macrophages and in Endotoxic-Treated Mice.” Nutrients 16 (13): 4501. https://doi.org/10.3390/nu13124501.
   Google Scholar
• Kumar, A., and A. Singh 2015. “A Review on Alzheimer’s Disease Pathophysiology and Its Management: An Update.” Pharmacological Reports 67 (2): 195–203. https://doi.org/10.1016/j.pharep.2014.09.004.
   PubMed Web of Science ®Google Scholar
• Lagarde, J., M. Sarazin, and M. Bottlaender. 2017. “In vivo Pet Imaging of Neuroinflammation in Alzheimer’s Disease.” Journal of Neural Transmission 125 (5): 847–867. https://doi.org/10.1007/s00702-017-1731-x.
   PubMed Web of Science ®Google Scholar
• Lawrence, J. M., K. Schardien, B. Wigdahl, and M. R. Nonnemacher. 2023. “Roles of Neuropathology-Associated Reactive Astrocytes: A Systematic Review.” Acta neuropathologica communications 11 (1): 42. https://doi.org/10.1186/s40478-023-01526-9.
   PubMed Web of Science ®Google Scholar
• Lazarov, O., and C. Hollands. 2016. “Hippocampal Neurogenesis: Learning to Remember.” Progress in Neurobiology 138-140:1–18. https://doi.org/10.1016/j.pneurobio.2015.12.006.
   PubMed Web of Science ®Google Scholar
• Lee, F., and D. A. Lawrence. 2018. “From Infections to Anthropogenic Inflicted Pathologies: Involvement of Immune Balance.” Journal of Toxicology and Environmental Health - Part B 21 (1): 24–46. https://doi.org/10.1080/10937404.2017.1412212.
   PubMed Web of Science ®Google Scholar
• Lee, H. G., M. A. Wheeler, and F. J. Quintana. 2022. “Function and Therapeutic Value of Astrocytes in Neurological Diseases.” Nature Reviews, Drug Discovery 21 (5): 339–358. https://doi.org/10.1038/s41573-022-00390-x.
   PubMed Web of Science ®Google Scholar
• Lian, H., L. Yang, A. Cole, L. Sun, C.-A. Chiang Angie, S. W. Fowler, D. J. Shim, et al. 2015. “Nfκb-Activated Astroglial Release of Complement C3 Compromises Neuronal Morphology and Function Associated with Alzheimer’s Disease.” Neuron 85 (1): 101–115. https://doi.org/10.1016/j.neuron.2014.11.018.
   PubMed Web of Science ®Google Scholar
• Liddelow, S. A., K. A. Guttenplan, L. E. Clarke, F. C. Bennett, C. J. Bohlen, L. Schirmer, M. L. Bennett, et al. 2017. “Neurotoxic Reactive Astrocytes Are Induced by Activated Microglia.” Nature 541 (7638): 481–487. https://doi.org/10.1038/nature21029.
   PubMed Web of Science ®Google Scholar
• Li, Y., and X. Luo. 2022. “Research Progress on A1/A2 Reactive Astrocytes.” Neural Injury Funct Reconstruct 2022:017. https://doi.org/10.16780/j.cnki.sjssgncj.20210089.
   Google Scholar
• Litvinchuk, A., Y. W. Wan, D. B. Swartzlander, F. Chen, A. Cole, N. E. Propson, Q. Wang, B. Zhang, Z. Liu, and H. Zheng. 2018. “Complement C3aR Inactivation Attenuates Tau Pathology and Reverses an Immune Network Deregulated in Tauopathy Models and Alzheimer’s Disease.” Neuron 100 (6): 1337–1353. https://doi.org/10.1016/j.neuron.2018.10.031.
   PubMed Web of Science ®Google Scholar
• Lopez-Rodriguez, A. B., E. Hennessy, C. L. Murray, A. Nazmi, H. J. Delaney, D. Healy, S. G. Fagan, et al. 2021. “Acute Systemic Inflammation Exacerbates Neuroinflammation in Alzheimer’s Disease: IL-1β Drives Amplified Responses in Primed Astrocytes and Neuronal Network Dysfunction.” https://doi.org/10.1002/alz.12341.
   Google Scholar
• Maccioni, R. B., L. P. Navarrete, A. González, C. A. González, M. L. Guzmán, and N. Cortés. 2020. “Inflammation: A Major Target for Compounds to Control Alzheimer’s Disease.” Journal of Alzheimer’s Disease 76 (4): 1199–1213. https://doi.org/10.3233/JAD-191014.
   PubMed Web of Science ®Google Scholar
• Minter, M. R., J. M. Taylor, and P. J. Crack. 2016. “The Contribution of Neuroinflammation to Amyloid Toxicity in Alzheimer’s Disease.” Journal of Neurochemistry 136 (3): 457–474. https://doi.org/10.1111/jnc.13411.
   PubMed Web of Science ®Google Scholar
• Mo, C., L. Zhou, D. Huo, X. Yan, J. Jia, and Z. Yang. 2022. “The Effect of Total Flavonoids of Cymbidium on the Expression of DAT and VMAT2 Proteins in the Substantia Nigra of Parkinson’s Disease Model Mice.” Journal of Baotou Medical College 38:30–34–40. https://doi.org/10.16833/j.cnki.jbmc.2022.06.007.
   Google Scholar
• Mrak, R. E., and W. S. Griffin. 2001. “Interleukin-1, neuroinflammation, and Alzheimer’s disease.” Neurobiology of Aging 22:903–908. https://doi.org/10.1016/S0197-4580(01)00287-1. 6
   PubMed Web of Science ®Google Scholar
• Mueller, K. D., B. Hermann, J. Mecollari, and L. S. Turkstra. 2018. “Connected Speech and Language in Mild Cognitive Impairment and Alzheimer’s Disease: A Review of Picture Description Tasks.” Journal of Clinical and Experimental Neuropsychology 40 (9): 917–939. https://doi.org/10.1080/13803395.2018.1446513.
   PubMed Web of Science ®Google Scholar
• Ng, A., W. W. Tam, M. W. Zhang, C. S. Ho, S. F. Husain, R. S. McIntyre, and R. C. Ho. 2018. “IL-1β, IL-6, TNF-α and CRP in Elderly Patients with Depression or Alzheimer’s Disease: Systematic Review and Meta-Analysis.” Scientific Reports 8 (1): 12050. https://doi.org/10.1038/s41598-018-30487-6.
   PubMed Web of Science ®Google Scholar
• Plantone, D., M. Pardini, D. Righi, C. Manco, B. M. Colombo, and N. De Stefano. 2023. “The Role of TNF-α in Alzheimer’s Disease: A Narrative Review.” Cells 13 (1): 54. https://doi.org/10.3390/cells13010054.
   PubMed Web of Science ®Google Scholar
• Rodríguez-Giraldo, M., R. E. González-Reyes, S. Ramírez-Guerrero, C. E. Bonilla-Trilleras, S. Guardo-Maya, and M. O. Nava-Mesa. 2022. “Astrocytes as a Therapeutic Target in Alzheimer’s Disease–Comprehensive Review and Recent Developments.” International Journal of Molecular Sciences 23 (21): 13630. https://doi.org/10.3390/ijms232113630.
   PubMed Web of Science ®Google Scholar
• Rossner, S., D. C. Lange, U. Zeitschel, and J. R. Perez-Polo. 2005. “Alzheimer’s Disease β-Secretase BACE1 Is Not a Neuron-Specific Enzyme.” Journal of Neurochemistry 92 (2): 226–234. https://doi.org/10.1111/j.1471-4159.2004.02857.x.
   PubMed Web of Science ®Google Scholar
• Saadi, M., A. Karkhah, F. Pourabdolhossein, A. Ataie, M. Monif, and H. R. Nouri. 2020. “Involvement of NLRC4 Inflammasome Through Caspase-1 and IL-1β Augments Neuroinflammation and Contributes to Memory Impairment in an Experimental Model of Alzheimer’s Like Disease.” Brain Research Bulletin 154:81–90. https://doi.org/10.1016/j.brainresbull.2019.10.010.
   PubMed Web of Science ®Google Scholar
• Sengupta, U., A. N. Nilson, and R. Kayed. 2016. “The Role of Amyloid-β Oligomers in Toxicity, Propagation, and Immunotherapy.” eBioMedicine 6:42–49. https://doi.org/10.1016/j.ebiom.2016.03.035.
   PubMed Web of Science ®Google Scholar
• Sharma, V., A. Kaur, and T. G. Singh. 2020. “Counteracting Role of Nuclear Factor Erythroid 2-Related Factor 2 Pathway in Alzheimer’s Disease.” Biomedicine & Pharmacotherapy 129:110373. https://doi.org/10.1016/j.biopha.2020.110373.
   PubMed Web of Science ®Google Scholar
• Song, T., X. Song, C. Zhu, R. Patrick, M. Skurla, I. Santangelo, M. Green, et al. 2021. “Mitochondrial Dysfunction, Oxidative Stress, Neuroinflammation, and Metabolic Alterations in the Progression of Alzheimer’s Disease: A Meta-Analysis of In Vivo Magnetic Resonance Spectroscopy Studies.” Aging Research Reviews 72:101503. https://doi.org/10.1016/j.arr.2021.101503.
   PubMed Web of Science ®Google Scholar
• Suo, Y., C. Mo, and Z. Yang. 2023. “The Effect of Total Flavonoids of Cymbidium Fragrans on Improving Nerve Damage in Parkinson’s Disease Model Mice Through Autophagy Mediation.” Journal of Baotou Medical College 39:1–7. https://doi.org/10.16833/j.cnki.jbmc.2023.12.001.
   Google Scholar
• Swanson, A., T. Wolf, A. Sitzmann, and A. A. Willette. 2018. “Neuroinflammation in Alzheimer’s Disease: Pleiotropic Roles for Cytokines and Neuronal Pentraxins.” Behavioural Brain Research 347:49–56. https://doi.org/10.1016/j.bbr.2018.02.015.
   PubMed Web of Science ®Google Scholar
• Tarkowski, E., K. Blennow, A. Wallin, and A. Tarkowski. 1999. “Intracerebral Production of Tumor Necrosis Factor-Alpha, a Local Neuroprotective Agent, in Alzheimer Disease and Vascular Dementia.” Journal of Clinical Immunology 19 (4): 223–230. https://doi.org/10.1023/A:1020568013953.
   PubMed Web of Science ®Google Scholar
• Tiwari, S., V. Atluri, A. Kaushik, A. Yndart, and M. Nair. 2019. “Alzheimer’s Disease: Pathogenesis, Diagnostics, and Therapeutics.” International Journal of Nanomedicine 19 (14): 5541–5554. https://doi.org/10.2147/IJN.S200490.
   Google Scholar
• Vasile, F., E. Dossi, and N. Rouach. 2017. “Human Astrocytes: Structure and Functions in the Healthy Brain.” Brain Structure & Function 222 (5): 2017–2029. https://doi.org/10.1007/s00429-017-1383-5.
   PubMed Web of Science ®Google Scholar
• Verkhratsky, A., V. Parpura, N. Vardjan, and R. Zorec. 2019. “Physiology of Astroglia.” Advances in Experimental Medicine and Biology 1175:45–91. https://doi.org/10.1007/978-981-13-9913-8_3
   PubMed Web of Science ®Google Scholar
• Wegmann, S., J. Biernat, and E. Mandelkow. 2021. “A Current View on Tau Protein Phosphorylation in Alzheimer’s Disease.” Current Opinion in Neurobiology 69:131–138. https://doi.org/10.1016/j.conb.2021.03.003.
   PubMed Web of Science ®Google Scholar
• Wu, P., X. S. Yan, L. L. Zhou, X. L. Liu, D. S. Huo, W. Song, X. Fang, H. Wang, Z. J. Yang, and J. X. Jia. 2019. “Involvement of Apoptosis in the Protective Effects of Dracocephalum Moldavaica in Cerebral Ischemia Reperfusion Rat Model.” Journal of Toxicology and Environmental Health, Part A 82 (19): 1036–1044. https://doi.org/10.1080/15287394.2019.1684707.
   PubMed Web of Science ®Google Scholar
• Wu, S. J., T. Zhao, and Qin, Y. Q. 2002. China Medical Science and Technology PressChemical Composition of Modern Chinese Herbal Medicine. First ed. Beijing: China Medical Science and Technology Press.
   Google Scholar
• Xia, X., Q. L. Jiang, J. McDermott, and J. D. Han. 2018. “Aging and Alzheimer’s Disease: Comparison and Associations from Molecular to System Level.” Aging Cell 17 (5): e12802. https://doi.org/10.1111/acel.12802.
   PubMed Web of Science ®Google Scholar
• Yu, J. E., I. J. Yeo, S. B. Han, J. Yun, B. Kim, Y. J. Yong, Y. S. Lim, T. H. Kim, D. J. Son, and J. T. Hong. 2024. “Significance of Chitinase-3-Like Protein 1 in the Pathogenesis of Inflammatory Diseases and Cancer.” Experimental & Molecular Medicine 56 (1): 1–18. https://doi.org/10.1038/s12276-023-01131-9.
   PubMed Web of Science ®Google Scholar
• Zhai, W., Y. Fan, and H. Yanli. 2017. “The Effect of Total Flavonoids of Cymbidium on Learning and Memory in D-Galactose/Sodium Nitrite Induced Dementia Mice.” Chinese Journal of New Drugs 26:4. https://CNKI:SUN:ZXYZ.0.2017-22-020.
   Google Scholar
• Zhan, M., M. Ma, X. Mo, Y. Zhang, T. Li, Y. Yang, and L. Dong. 2024. “Dracocephalum Moldavica L.: An Updated Comprehensive Review of Its Botany, Traditional Uses, Phytochemistry, Pharmacology, and Application Aspects.” Fitoterapia 172:105732. https://doi.org/10.1016/j.fitote.2023.105732.
   PubMed Web of Science ®Google Scholar
• Zhao, J., T. O’Connor, and R. Vassar. 2011. “The Contribution of Activated Astrocytes to Aβ Production: Implications for Alzheimer’s Disease Pathogenesis.” Journal of Neuroinflammation 8 (1): 150. https://doi.org/10.1186/1742-2094-8-150.
   PubMedGoogle Scholar
• Zong, X., Y. Li, C. Liu, W. Qi, D. Han, L. Tucker, Y. Dong, S. Hu, X. Yan, and Q. Zhang. 2020. “Theta-Burst Transcranial Magnetic Stimulation Promotes Stroke Recovery by Vascular Protection and Neovascularization.” Theranostics 10 (26): 12090–12110. https://doi.org/10.7150/thno.51573.
   PubMed Web of Science ®Google Scholar