Orbea variegata (L.) Haw in skin carcinogenesis: insights from an in vivo male Swiss mouse model study

References

• Adamus-Grabicka, A. A., P. Hikisz, and J. Sikora. 2024. “Nanotechnology As a Promising Method in the Treatment of Skin Cancer.” International Journal of Molecular Sciences 25 (4): 2165. https://doi.org/10.3390/ijms25042165.
   PubMed Web of Science ®Google Scholar
• Adnan, M., V. R. Pasupuleti, and M. Patel. 2023. “Editorial: Evolution of Phytochemicals and Phytotherapies in the Treatment and Management of Cancer: Targeted Strategies in Cancer Precision Medicine.” Frontiers in Pharmacology 14:1326474. https://doi.org/10.3389/fphar.2023.1326474.
   PubMed Web of Science ®Google Scholar
• Aebi, H. 1984. “Catalase In Vitro.” In Methods in Enzymology, edited by Packer L, 121–126. Vol. 105. Cambridge, Massachusetts: Academic press.
   Google Scholar
• Ahmed, B., M. I. Qadir, and S. Ghafoor. 2020. “Malignant Melanoma: Skin Cancer− Diagnosis, Prevention, and Treatment.” Critical Review Eukaryotic Gene Expression 30 (4): 291–297. https://doi.org/10.1615/CritRevEukaryotGeneExpr.2020028454.
   PubMed Web of Science ®Google Scholar
• Al-Fatimi, M. 2019. “Ethnobotanical Survey of Medicinal Plants in Central Abyan Governorate, Yemen.” Journal of Ethnopharmacology 241:111973. https://doi.org/10.1016/j.jep.2019.111973.
   PubMed Web of Science ®Google Scholar
• Alfonzetti, T., S. Yasmin-Karim, W. Ngwa, and S. Avery. 2021. “Phytoradiotherapy: An Integrative Approach to Cancer Treatment by Combining Radiotherapy with Phytomedicines.” Frontiers in Oncology 10:624663. https://doi.org/10.3389/fonc.2020.624663.
   PubMed Web of Science ®Google Scholar
• Ali, H., S. Dixit, D. Ali, S. M. Alqahtani, S. Alkahtani, and S. Alarifi. 2015. “Isolation and Evaluation of Anticancer Efficacy of Stigmasterol in a Mouse Model of DMBA-Induced Skin Carcinoma.” Drug Design, Development and Therapy 9:2793–2800. https://doi.org/10.2147/DDDT.S83514.
   PubMed Web of Science ®Google Scholar
• Ali, S., M. R. Khan, S. M. Irfanullah, and Z. Zahra. 2018. “Phytochemical Investigation and Antimicrobial Appraisal of Parrotiopsis Jacquemontiana (Decne) Rehder.” BMC Complementary and Alternative Medicine 18 (1): 1–15. https://doi.org/10.1186/s12906-018-2114-z.
   PubMedGoogle Scholar
• Altun, İ., and A. Sonkaya. 2018. “The Most Common Side Effects Experienced by Patients Were Receiving First Cycle of Chemotherapy.” Iran Journal of Public Health 47 (8): 1218–1219. PMID: 30186799; PMCID: PMC6123577.
   PubMed Web of Science ®Google Scholar
• Alzahrani, S. M., H. A. Al Doghaither, and A. B. Al‑Ghafari. 2021. “General Insight into Cancer: An Overview of Colorectal Cancer.” Molecular and Clinical Oncology 15 (6): 1–8. https://doi.org/10.3892/mco.2021.2433.
   Web of Science ®Google Scholar
• Arnold, M., D. Singh, M. Laversanne, J. Vignat, S. Vaccarella, F. Meheus, A. E. Cust, et al. 2022. “Global Burden of Cutaneous Melanoma in 2020 and Projections to 2040.” JAMA Dermatology 158 (5): 495–503. https://doi.org/10.1001/jamadermatol.2022.0160.
   PubMed Web of Science ®Google Scholar
• Auwal, M. S., S. Saka, I. A. Mairiga, K. A. Sanda, A. Shuaibu, and A. Ibrahim. 2014. “Preliminary Phytochemical and Elemental Analysis of Aqueous and Fractionated Pod Extracts of Acacia Nilotica (Thorn mimosa).” Veterinary Research Forum 5 (2): 95–100.
   PubMedGoogle Scholar
• Babino, G., A. Lallas, C. Longo, E. Moscarella, R. Alfano, and G. Argenziano. 2015. “Dermoscopy of Melanoma and Non-Melanoma Skin Cancer.” Italian Journal of Dermatology and Venereology 150 (5): 507–519.
   Google Scholar
• Benayad, S., H. Wahnou, R. El Kebbaj, B. Liagre, V. Sol, M. Oudghiri, E. M. Saad, R. E. Duval, and Y. Limami. 2023. “The Promise of Piperine in Cancer Chemoprevention.” Cancers 15 (22): 5488. https://doi.org/10.3390/cancers15225488.
   PubMed Web of Science ®Google Scholar
• Bensusan, K. 2009. “Taxonomy and Conservation Status of Moroccan Stapeliads (Apocynaceae-Asclepiadoideae-Ceropegieae-Stapeliinae).” Bulletin de l’Institut Scientifique, Rabat, Section Sciences de la Vie 31 (2): 67–77.
   Google Scholar
• Benzie, I. F., and J. J. Strain. 1996. “The Ferric Reducing Ability of Plasma (FRAP) As a Measure of “Antioxidant power”: The FRAP Assay.” Analytical Biochemistry 239 (1): 70–76. https://doi.org/10.1006/abio.1996.0292.
   PubMed Web of Science ®Google Scholar
• Boadi, W. Y., C. Stevenson, D. Johnson, and M. A. Mohamed. 2021. “Flavonoids Reduce Lipid Peroxides and Increase Glutathione Levels in Pooled Human Liver Microsomes (HLMs).” Advances in Biological Chemistry 11 (6): 283–295. https://doi.org/10.4236/abc.2021.116019.
   PubMedGoogle Scholar
• Bray, F., M. Laversanne, H. Sung, J. Ferlay, R. L. Siegel, I. Soerjomataram, and A. Jemal. 2024. “Global Cancer Statistics 2022; GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries.” CA Cancer Journal Clinics 74 (3): 229–263. https://doi.org/10.3322/caac.21834.
   PubMed Web of Science ®Google Scholar
• Chandra, J., N. Hasan, N. Nasir, S. Wahab, P. V. Thanikachalam, A. Sahebkar, F. J. Ahmad, and P. Kesharwani. 2023. “Nanotechnology-Empowered Strategies in Treatment of Skin Cancer.” Environmental Research 235:116649. https://doi.org/10.1016/j.envres.2023.116649.
   PubMed Web of Science ®Google Scholar
• Cherrada, N., A. E. Chemsa, E. Erol, A. G. Akyildiz, H. O. Dinc, N. Gheraissa, D. G. Amara, A. Rebiai, M. S. Abdel-Kader, and M. Messaoudi. 2023. “Phytochemical Profiling of Salsola Tetragona Delile by LC-HR/MS and Investigation of the Antioxidant, Anti-Inflammatory, Cytotoxic, Antibacterial and Anti-SARS-CoV-2 Activities.” Saudi Pharmaceutical Journal 31 (9): 101731. https://doi.org/10.1016/j.jsps.2023.101731.
   PubMed Web of Science ®Google Scholar
• Dias, M. C., D. C. Pinto, and A. M. Silva. 2021. “Plant Flavonoids: Chemical Characteristics and Biological Activity.” Molecules 26 (17): 5377. https://doi.org/10.3390/molecules26175377.
   PubMed Web of Science ®Google Scholar
• D’Orazio, J., S. Jarrett, A. Amaro-Ortiz, and T. Scott. 2013. “UV Radiation and the Skin.” International Journal of Molecular Sciences 14 (6): 12222–12248. https://doi.org/10.3390/ijms140612222.
   PubMed Web of Science ®Google Scholar
• Douki, T. 2020. “Oxidative Stress and Genotoxicity in Melanoma Induction: Impact on Repair Rather Than Formation of DNA Damage?” Photochemistry and Photobiology 96 (5): 962–972. https://doi.org/10.1111/php.13278.
   PubMed Web of Science ®Google Scholar
• Durante, G., E. Broseghini, F. Comito, M. Naddeo, M. Milani, I. Salamon, E. Campione, E. Dika, and M. Ferracin. 2022. “Circulating MicroRNA Biomarkers in Melanoma and Non-Melanoma Skin Cancer.” Expert review of molecular diagnostics 22 (3): 305–318. https://doi.org/10.1080/14737159.2022.2049243.
   PubMed Web of Science ®Google Scholar
• El Faqer, O., S. Rais, I. Elkoraichi, A. El Amrani, M. Dakir, Y. Zaid, and E. M. Mtairag. 2022. “Phytochemical Characterization and Immunomodulatory Effects of Aqueous and Ethanolic Extracts and Essential Oil of Moroccan Laurus Nobilis L. (Lauraceae) on Human Neutrophils.” Journal of Herbmed Pharmacology 12 (1): 92–99. https://doi.org/10.34172/jhp.2023.08.
   Google Scholar
• El-Harakeh, M., S. Al-Ghadban, and R. Safi. 2021. “Medicinal Plants Towards Modeling Skin Cancer.” Current Drug Targets 22 (2): 148–161. https://doi.org/10.2174/1389450121666201005103521.
   PubMed Web of Science ®Google Scholar
• El Sayed, K. A., A. F. Halim, A. M. Zaghloul, J. D. McChesney, M. P. Stone, M. Voehler, and K. Hayashi. 1995. “Pregnane Glycosides from Stapelia Variegata.” Phytochemistry 39 (2): 395–403. https://doi.org/10.1016/0031-9422(94)00858-Q.
   PubMed Web of Science ®Google Scholar
• Fahradyan, A., A. C. Howell, E. M. Wolfswinkel, M. Tsuha, P. Sheth, and A. K. Wong. 2017. “Updates on the Management of Non-Melanoma Skin Cancer (NMSC).” Healthcare (Basel) 5 (4): 82. https://doi.org/10.3390/healthcare5040082.
   PubMedGoogle Scholar
• Farhan, M., M. F. Ullah, M. Faisal, A. A. Farooqi, U. Y. Sabitaliyevich, B. Biersack, and A. Ahmad. 2019. “Differential Methylation and Acetylation As the Epigenetic Basis of resveratrol’s Anticancer Activity.” Medicines (Basel) 6 (1): 24. https://doi.org/10.3390/medicines6010024. PMID: 30781847; PMCID: PMC6473688.
   PubMedGoogle Scholar
• Farooqi, A. A., and R. Attar. 2023. “Role of Platelet-Derived Growth Factor-Mediated Signaling in Carcinogenesis and Metastasis.” Cellular and Molecular Biology 69:300–302. https://doi.org/10.14715/cmb/2023.69.14.49. PMID: 38279414.
   PubMed Web of Science ®Google Scholar
• Farooqi, A. A., P. Marina, G. Andreia, F. Fulvia, R. Salette, A. Rukset, Y. S. Uteuliyev, X. Baojun, and A. Aamir. 2020. “EGCG Mediated Targeting of Deregulated Signaling Pathways and Non-Coding RNAs in Different Cancers: Focus on JAK/STAT, Wnt/β-Catenin, TGF/SMAD, NOTCH, SHH/GLI, and TRAIL Mediated Signaling Pathways.” Cancers 12 (4): 951. https://doi.org/10.3390/cancers12040951.
   PubMed Web of Science ®Google Scholar
• Ferreira, P. M. P., D. D. R. Arcanjo, and A. P. Peron. 2023. “Drug Development, Brazilian Biodiversity and Political Choices: Where Are We Heading?” Journal of Toxicology and Environmental Health, Part B 26 (5): 257–274. https://doi.org/10.1080/10937404.2023.2193762.
   PubMed Web of Science ®Google Scholar
• Flammiger, A., and H. Maibach. 2006. “Sulfuric Acid Burns (Corrosion and Acute Irritation): Evidence-Based Overview to Management.” Cutaneous and Ocular Toxicology 25 (1): 55–61. https://doi.org/10.1080/15569520500536634.
   PubMed Web of Science ®Google Scholar
• Gado, F., M. Digiacomo, J. E. Salsano, M. Macchia, and C. Manera. 2021. “Phenolic Compounds in Prevention and Treatment of Skin Cancers: A Review.” Current Medicinal Chemistry 28 (33): 6730–6752. https://doi.org/10.2174/0929867328666210324160324.
   PubMed Web of Science ®Google Scholar
• Glaviano, A., A. S. C. Foo, H. Y. Lam, K. C. H. Yap, W. Jacot, R. H. Jones, H. Eng, et al. 2023. “P13/AKT/mTOR Signaling Transduction Pathway and Targeted Therapies in Cancer.” Molecular Cancer 22 (1): 138. https://doi.org/10.1186/s12943-023-01827-6.
   PubMed Web of Science ®Google Scholar
• Gülçin, İ., Z. Huyut, M. Elmastaş, and H. Y. Aboul-Enein. 2010. “Radical Scavenging and Antioxidant Activity of Tannic Acid.” Arabian Journal of Chemistry 3 (1): 43–53. https://doi.org/10.1016/j.arabjc.2009.12.008.
   Web of Science ®Google Scholar
• Hasan, N., A. Nadaf, M. Imran, U. Jiba, A. Sheikh, W. H. Almalki, S. S. Almujri, Y. H. Mohammed, P. Kesharwani, and F. J. Ahmad. 2023. “Skin Cancer: Understanding the Journey of Transformation from Conventional to Advanced Treatment Approaches.” Molecular Cancer 22 (1): 168. https://doi.org/10.1186/s12943-023-01854-3.
   PubMed Web of Science ®Google Scholar
• Hba, S., S. Ghaddar, H. Wahnou, A. Pinon, R. El Kebbaj, C. Pouget, V. Sol, B. Liagre, M. Oudghiri, and Y. Limami. 2023. “Natural Chalcones and Derivatives in Colon Cancer: Pre-Clinical Challenges and the Promise of Chalcone-Based Nanoparticles.” Pharmaceutics 15 (12): 2718. https://doi.org/10.3390/pharmaceutics15122718.
   PubMed Web of Science ®Google Scholar
• Heath, M. S., and A. Bar. 2023. “Basal Cell Carcinoma.” Dermatologic Clinics 41 (1): 13–21. https://doi.org/10.1016/j.det.2022.07.005.
   PubMed Web of Science ®Google Scholar
• Kerche, L. E., I. M. Carrara, P. C. Marinello, D. G. Cavalcante, C. S. Danna, R. Cecchini, A. L. Cecchini, and A. E. Job. 2023. “Antioxidant and Photoprotective Role of Latex C-Serum from Hevea Brasiliensis During 15-Week UVB Irradiation in Male Hairless SKH-1 Mice.” Journal of Toxicology and Environmental Health Part A 86 (22): 846–858. https://doi.org/10.1080/15287394.2023.2255885.
   PubMedGoogle Scholar
• Khan, N. H., M. Mir, L. Qian, M. Balouch, M. F. Ali Khan, A. U. Rehman, E. E. Ngowi, D. D. Wu, and X. Y. Ji. 2022. “Skin Cancer Biology and Barriers to Treatment: Recent Applications of Polymeric Micro/Nanostructures.” Journal of Advanced Research 36:223–247. https://doi.org/10.1016/j.jare.2021.06.014.
   PubMed Web of Science ®Google Scholar
• Klaunig, J. E. 2018. “Oxidative Stress and Cancer.” Current Pharmaceutical Design 24 (40): 4771–4778. https://doi.org/10.2174/1381612825666190215121712.
   PubMed Web of Science ®Google Scholar
• Kontomanolis, E. N., A. Koutras, A. Syllaios, D. Schizas, A. Mastoraki, N. Garmpis, Diakosavvas, M., Angelou, K., Tsatsaris, G., Pagkalos, A., Ntounis, T., Fasoulakis, Z. 2020. “Role of Oncogenes and Tumor-Suppressor Genes in Carcinogenesis: A Review.” Anticancer Research 40 (11): 6009–6015. https://doi.org/10.21873/anticanres.14622.
   PubMed Web of Science ®Google Scholar
• Kumar, R., G. Deep, and R. Agarwal. 2015. “An Overview of Ultraviolet B Radiation-Induced Skin Cancer Chemoprevention by Silibinin.” Current Pharmacology Reports 1 (3): 206–215. https://doi.org/10.1007/s40495-015-0027-9.
   PubMedGoogle Scholar
• Laikova, K. V., V. V. Oberemok, A. M. Krasnodubets, N. V. Gal’chinsky, R. Z. Useinov, I. A. Novikov, Z. Z. Temirova, et al. 2019. “Advances in the Understanding of Skin Cancer: Ultraviolet Radiation, Mutations, and Antisense Oligonucleotides As Anticancer Drugs.” Molecules 24 (8): 1516. https://doi.org/10.3390/molecules24081516.
   PubMed Web of Science ®Google Scholar
• Lenz, T. I., and J. M. Facelli. 2003. “Shade Facilitates an Invasive Stem Succulent in a Chenopod Shrubland in South Australia.” Austral Ecology 28 (5): 480–490. https://doi.org/10.1046/j.1442-9993.2003.01304.x.
   Web of Science ®Google Scholar
• Liang, S., M. A. Shamim, A. Shahid, M. Chen, K. H. Cleveland, C. Parsa, R. Orlando, B. T. Andresen, and Y. Huang. 2021. “Prevention of Skin Carcinogenesis by the Non-β-Blocking R-Carvedilol Enantiomer.” Cancer Prevention Research 14 (5): 527–540. https://doi.org/10.1158/1940-6207.CAPR-20-0609.
   PubMed Web of Science ®Google Scholar
• Limami, Y., A. Pinon, H. Wahnou, M. Oudghiri, B. Liagre, A. Simon, and R. E. Duval. 2023. “Ursolic acid’s Alluring Journey: One Triterpenoid Vs. Cancer Hallmarks.” Molecules 28 (23): 7897. https://doi.org/10.3390/molecules28237897.
   PubMed Web of Science ®Google Scholar
• Liu, H.-M., M. Y. Cheng, M. H. Xun, Z. W. Zhao, Y. Zhang, W. Tang, J. Cheng, J. Ni, and W. Wang. 2023. “Possible Mechanisms of Oxidative Stress-Induced Skin Cellular Senescence, Inflammation, and Cancer and the Therapeutic Potential of Plant Polyphenols.” International Journal of Molecular Sciences 24 (4): 3755. https://doi.org/10.3390/ijms24043755.
   PubMed Web of Science ®Google Scholar
• Liu, Z., J. S. Gonzalez, H. Wang, S. Gunasekaran, and T. Runge. 2015. “Dairy Manure Protein Analysis Using UV-Vis Based on the Bradford Method.” Analytical Methods 7 (6): 2645–2652. https://doi.org/10.1039/C4AY03006K.
   Web of Science ®Google Scholar
• Massaugue, J., and K. Ganesh. 2021. “Metastasis-Initiating Cells and Ecosystems.” Cancer Discovery 11 (4): 971–994. https://doi.org/10.1158/2159-8290.CD-21-0010.
   PubMed Web of Science ®Google Scholar
• Mbaebie, B. O., H. O. Edeoga, and A. J. Afolayan. 2012. “Phytochemical Analysis and Antioxidants Activities of Aqueous Stem Bark Extract of Schotia Latifolia Jacq.” Asian Pacific Journal of Tropical Biomedicine 2 (2): 118–124. https://doi.org/10.1016/S2221-1691(11)60204-9.
   PubMedGoogle Scholar
• Md Roduan, M. R., R. A. H. Roslida Abd Hamid, and N. M. Norhafizah Mohtarrudin. 2019. “Modulation of Cancer Signalling Pathway (S) in Two-Stage Mouse Skin Tumorigenesis by Annonacin.” BMC Complementary and Alternative Medicine 19 (1): 238. https://doi.org/10.1186/s12906-019-2650-1.
   PubMed Web of Science ®Google Scholar
• Mubarak, A. Y., B. M. Al-Attab, and M. A. Almaqtar. 2023. “Evaluation of the Total Content of Phenols and Flavonoids in Two Different Extracts of Orbea Wissmannii O. Schwart and Their Toxic Effect on WI38 and HepG2 Cell Lines.” Journal of Amran University 3 (5): 8–108. https://doi.org/10.59145/jaust.v3i5.55.
   Google Scholar
• Nasim, N., I. S. Sandeep, and S. Mohanty. 2022. “Plant-Derived Natural Products for Drug Discovery: Current Approaches and Prospects.” The Nucleus 65 (3): 399–411. https://doi.org/10.1007/s13237-022-00405-3.
   PubMed Web of Science ®Google Scholar
• National Research Council. 2011. Guide for the Care and Use of Laboratory Animals. 8th ed. Washington (DC): National Academies Press (US). http://www.ncbi.nlm.nih.gov/books/NBK54050/.
   Google Scholar
• Ndayambaje, M., H. Wahnou, M. Sow, O. Chgari, T. Habyarimana, M. Karkouri, Y. Limami, A. Naya, and M. Oudghiri. 2024. “Exploring the Multifaceted Effects of Ammi visnaga: Subchronic Toxicity, Antioxidant Capacity, Immunomodulatory, and Anti-Inflammatory Activities.” Journal of Toxicology and Environmental Health Part A 87 (4): 150–165. https://doi.org/10.1080/15287394.2023.2289430.
   PubMed Web of Science ®Google Scholar
• Neagu, M., C. Caruntu, C. Constantin, D. Boda, S. Zurac, D. A. Spandidos, and A. M. Tsatsakis. 2016. “Chemically Induced Skin Carcinogenesis: Updates in Experimental Models (Review).” Oncology Reports 35 (5): 2516–2528. https://doi.org/10.3892/or.2016.4683. Epub 2016 Mar 17. PMID: 26986013; PMCID: PMC4811393.
   PubMed Web of Science ®Google Scholar
• Ng, C. Y., H. Yen, H. Y. Hsiao, and S. C. Su. 2018. “Phytochemicals in Skin Cancer Prevention and Treatment: An Updated Review.” International Journal of Molecular Sciences 19 (4): 941. https://doi.org/10.3390/ijms19040941.
   PubMed Web of Science ®Google Scholar
• Nichols, J. A., and S. K. Katiyar. 2010. “Skin Photoprotection by Natural Polyphenols: Anti-Inflammatory, Antioxidant and DNA Repair Mechanisms.” Archives of Dermatological Research 302 (2): 71–83. https://doi.org/10.1007/s00403-009-1001-3.
   PubMed Web of Science ®Google Scholar
• Nortjie, E., M. Basitere, D. Moyo, and P. Nyamukamba. 2022. “Extraction Methods, Quantitative and Qualitative Phytochemical Screening of Medicinal Plants for Antimicrobial Textiles: A Review.” Plants 11 (15): 2011. https://doi.org/10.3390/plants11152011.
   Google Scholar
• Plowes, D. C. 2013. “Orbea-An Overview of Its Taxonomy and a List of Included Species.” Bradleya 31 (31): 159–164. https://doi.org/10.25223/brad.n31.2013.a21.
   Google Scholar
• Prieto, P., M. Pineda, and M. Aguilar. 1999. “Spectrophotometric Quantitation of Antioxidant Capacity Through the Formation of a Phosphomolybdenum Complex: Specific Application to the Determination of Vitamin E.” Analytical Biochemistry 269 (2): 337–341. https://doi.org/10.1006/abio.1999.4019.
   PubMed Web of Science ®Google Scholar
• Pucci, C., C. Martinelli, D. De Pasquale, M. Battaglini, N. di Leo, A. Degl’innocenti, M. B. Gümüş, F. Drago, and G. Ciofani. 2022. “Tannic Acid–Iron Complex-Based Nanoparticles As a Novel Tool Against Oxidative Stress.” ACS Applied Materials and Interfaces 14 (14): 15927–15941. https://doi.org/10.1021/acsami.1c24576.
   PubMed Web of Science ®Google Scholar
• Rana, A., M. Samtiya, T. Dhewa, V. Mishra, and R. E. Aluko. 2022. “Health Benefits of Polyphenols: A Concise Review.” Journal of Food Biochemistry 46 (10): e14264. https://doi.org/10.1111/jfbc.14264.
   PubMed Web of Science ®Google Scholar
• Roghini, R., and K. Vijayalakshmi. 2018. “Phytochemical Screening, Quantitative Analysis of Flavonoids and Minerals in Ethanolic Extract of Citrus Paradisi.” International Journal of Pharmaceutical Sciences and Research 9 (11): 4859–4864. http://dx.doi.org/10.13040/IJPSR.0975-8232.9(11).4859-64.
   Google Scholar
• Sales, P., M. de Oliveira, J. M. Figueiredo Watanabe, A. P. da Silva Barbosa, B. C. A. da Mata, M. de Jesus e Silva Viana, P. C. Dalia Rego Medeiros, et al. 2023. “Phytochemical Characterization, Isolation, Antioxidant and Cytogenotoxic Activity of Leaves of Heliotropium Elongatum (Lehm) I.M. Johnst.” Journal of Toxicology and Environmental Health Part A 86 (23): 871–897. https://doi.org/10.1080/15287394.2023.2254815.
   PubMedGoogle Scholar
• Samiry, I., A. Pinon, Y. Limami, S. Rais, Y. Zaid, M. Oudghiri, B. Liagre, and E. M. Mtairag. 2023. “Antitumoral Activity of Caralluma Europaea on Colorectal and Prostate Cancer Cell Lines.” Journal of Toxicology and Environmental Health Part A 86 (7): 230–240. https://doi.org/10.1080/15287394.2023.2181898.
   PubMed Web of Science ®Google Scholar
• Samokyszyn, V. M., and L. J. Marnett. 1990. “Inhibition of Liver Microsomal Lipid Peroxidation by 13-Cis-Retinoic Acid.” Free Radical Biology and Medicine 8 (5): 491–496. https://doi.org/10.1016/0891-5849(90)90063-O.
   PubMed Web of Science ®Google Scholar
• Sample, A., and Y.-Y. He. 2018. “Mechanisms and Prevention of UV-Induced Melanoma.” Photodermatology, Photoimmunology & Photomedicine 34 (1): 13–24. https://doi.org/10.1111/phpp.12329.
   PubMed Web of Science ®Google Scholar
• Sarkar, S., G. Horn, K. Moulton, A. Oza, S. Byler, S. Kokolus, and M. Longacre. 2013. “Cancer Development, Progression, and Therapy: An Epigenetic Overview.” International Journal of Molecular Sciences 14 (10): 21087–21113. https://doi.org/10.3390/ijms141021087. PMID: 24152442; PMCID: PMC3821660.
   PubMed Web of Science ®Google Scholar
• Schulz, I., H.-C. Mahler, S. Boiteux, and B. Epe. 2000. “Oxidative DNA Base Damage Induced by Singlet Oxygen and Photosensitization: Recognition by Repair Endonucleases and Mutagenicity.” Mutation Research/DNA Repair 461 (2): 145–156. https://doi.org/10.1016/S0921-8777(00)00049-5.
   Google Scholar
• Sharma, J., and P. K. Goyal. 2015. “Chemoprevention of Chemical-Induced Skin Cancer by Panax Ginseng Root Extract.” Journal of Ginseng Research 39 (3): 265–273. https://doi.org/10.1016/j.jgr.2015.01.005.
   PubMed Web of Science ®Google Scholar
• Si, Y., X. S. Sha, L. L. Shi, H. Y. Wei, Y. X. Jin, G. X. Ma, and J. Zhang. 2022. “Review on Pregnane Glycosides and Their Biological Activities.” Phytochemistry Letters 47:1–17. https://doi.org/10.1016/j.phytol.2021.10.007.
   Web of Science ®Google Scholar
• Sung, H., J. Ferlay, R. L. Siegel, M. Laversanne, I. Soerjomataram, A. Jemal, and F. Bray. 2021. “Global Cancer Statistics 2020: GLOBACAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries.” CA: A Cancer Journal for Clinicians 71 (3): 209–249. https://doi.org/10.3322/caac.21660.
   PubMed Web of Science ®Google Scholar
• Wahnou, H., B. Liagre, V. Sol, H. El Attar, R. Attar, M. Oudghiri, R. E. Duval, and Y. Limami. 2023. “Polyphenol-Based Nanoparticles: A Promising Frontier for Enhanced Colorectal Cancer Treatment.” Cancers 15 (15): 3826. https://doi.org/10.3390/cancers15153826.
   PubMed Web of Science ®Google Scholar
• Wahnou, H., Y. Limami, and M. Oudghiri. 2024. “Flavonoids and Flavonoid-Based Nanoparticles for Osteoarthritis and Rheumatoid Arthritis Management.” Biochemistry (Moscow) 4 (1): 38–61. https://doi.org/10.3390/biochem4010003.
   Google Scholar
• Wahnou, H., M. Ndayambaje, Z. Ouadghiri, S. Benayad, H. Elattar, O. Chgari, A. Naya, Y. Zaid, and M. Oudghiri. 2024. “Artemisia Herba-alba: Antioxidant Capacity and Efficacy in Preventing Chronic Arthritis In Vivo.” Inflammopharmacology. https://doi.org/10.1007/s10787-024-01463-6. Epub ahead of print. PMID: 38607503.
   Web of Science ®Google Scholar
• Wahnou, H., I. Youlyouz-Marfak, B. Liagre, V. Sol, M. Oudghiri, R. E. Duval, and Y. Limami. 2023. “Shining a Light on Prostate Cancer: Photodynamic Therapy and Combination Approaches.” Pharmaceutics 15 (6): 1767. https://doi.org/10.3390/pharmaceutics15061767.
   PubMed Web of Science ®Google Scholar
• Waldman, A., and C. Schmults. 2019. “Cutaneous Squamous Cell Carcinoma.” Hematology/Oncology Clinics of North America 33 (1): 1–12. https://doi.org/10.1016/j.hoc.2018.08.001.
   PubMed Web of Science ®Google Scholar
• Wang, Z., S. Xiao, J. Huang, S. Liu, M. Xue, and F. Lu. 2021. “Chemoprotective Effect of Boeravinone B Against DMBA/Croton Oil Induced Skin Cancer via Reduction of Inflammation.” Journal of Oleo Science 70 (7): 955–964. https://doi.org/10.5650/jos.ess21055.
   PubMed Web of Science ®Google Scholar
• Wang, X., H. Zhang, and X. Chen. 2019. “Drug Resistance and Combating Drug Resistance in Cancer.” Cancer Drug Resistance 2:141–160. https://doi.org/10.20517/cdr.2019.10.
   PubMedGoogle Scholar
• Warr, D. G. 2008. “Chemotherapy-And Cancer-Related Nausea and Vomiting.” Current Oncology 15 (11): S4–S9. https://doi.org/10.3747/co.2008.171.
   PubMedGoogle Scholar
• Yam, M. F., L. F. Ang, O. Z. Ameer, I. M. Salman, H. A. Aziz, and M. Z. Asmawi. 2009. “Anti-Inflammatory and Analgesic Effects of Elephantopus Tomentosus Ethanolic Extract.” Journal of Acupuncture and Meridian Studies 2 (4): 280–287. https://doi.org/10.1016/S2005-2901(09)60069-8.
   PubMedGoogle Scholar
• Zeng, L., B. J. Gowda, M. G. Ahmed, M. A. Abourehab, Z. S. Chen, C. Zhang, J. Li, and P. Kesharwani. 2023. “Advancements in Nanoparticle-Based Treatment Approaches for Skin Cancer Therapy.” Molecular Cancer 22 (1): 10. https://doi.org/10.1186/s12943-022-01708-4.
   PubMed Web of Science ®Google Scholar
• Zeng, X., W. Jiang, Z. Du, and J. L. Kokini. 2023. “Encapsulation of Tannins and Tannin-Rich Plant Extracts by Complex Coacervation to Improve Their Physicochemical Properties and Biological Activities: A Review.” Critical Reviews in Food Science and Nutrition 63 (18): 3005–3018. https://doi.org/10.1080/10408398.2022.2075313.
   PubMed Web of Science ®Google Scholar