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Research Article

Assessment of skin sensitization potential of zinc oxide, aluminum oxide, manganese oxide, and copper oxide nanoparticles through the local lymph node assay: 5-bromo-deoxyuridine flow cytometry method

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References

  • Adib, Z. M., S. Ghanbarzadeh, M. Kouhsoltani, A. Y. Khosroshahi, and H. Hamishehkar. 2016. “The Effect of Particle Size on the Deposition of Solid Liquid Nanoparticles in Different Skin Layers: A Histological Study.” Advanced Pharmaceutical Bulletin 6 (1): 31–36. https://doi.org/10.15171/apb.2016.06.
  • Agarwal, H., S. Menon, S. V. Kumar, and S. Rajeshkumar. 2018. “Mechanistic Study on Antibacterial Action of Zinc Oxide Nanoparticles Synthesized Using Green Route 2018.” Chemico-Biological Interactions 286:60–70. https://doi.org/10.1016/j.cbi.2018.03.008.
  • Ahn, I., T. S. Kim, E. S. Jung, J. S. Yi, W. H. Jang, K. M. Jung, M. Park, M. S. Jung, E. Y. Jeon, Y. Heo. 2016. “Performance Standard-Based Validation Study for Local Lymph Node Assay: 5-Bromo-2-Deoxyuridine-Flow Cytometry Method.” Regulatory Toxicology and Pharmacology: RTP 80:183–194. https://doi.org/10.1016/j.yrtph.2016.06.009.
  • Alarifi, S., D. Ali, and S. Alkahtani. 2017. “Oxidative Stress-Induced DNA Damage by Manganese Dioxide Nanoparticles in Human Neuronal Cells.” BioMed Research International 2017:1–10. https://doi.org/10.1155/2017/5478790.
  • Alarifi, S., D. Ali, A. Verma, S. Alakhtani, and B. A. Ali. 2013. “Cytotoxicity and Genotoxicity of Copper Oxide Nanoparticles in Human Skin Keratinocytes Cells.” International Journal of Toxicology 32 (4): 296–307. https://doi.org/10.1177/1091581813487563.
  • Altammar, K. A. 2023. “A Review on Nanoparticles Characteristics, Synthesis, Applications, and Challenges.” Frontiers in Microbiology 14:1155622. https://doi.org/10.3389/fmicb.2023.1155622.
  • Anjum, S., M. Hashim, S. A. Malik, M. Khan, J. M. Lorenzo, B. H. Abbasi, and C. Hano. 2021. “Recent Advances in Zinc Oxide Nanoparticles (Zno NPs) for Cancer Diagnosis, Target Drug Delivery, and Treatment.” Cancers 13 (18): 4570. https://doi.org/10.3390/cancers13184570.
  • Baghdadi, A. M., A. A. Saddiq, A. Aissa, Y. Algamal, and N. M. Khalil. 2022. “Structural Refinement and Antimicrobial Activity of Aluminum Oxide Nanoparticles.” Journal of the Ceramic Society of Japan 130 (3): 257–263. https://doi.org/10.2109/jcersj2.21140.
  • Balcucho, J., D. M. Narváez, and J. L. Castro-Mayorga. 2020. “Antimicrobial and Biocompatible Polycaprolactone and Copper Oxide Nanoparticle Wound Dressings Against Methicillin-Resistant Staphylococcus Aureus.” Nanomaterials: Overview and Historical Perspectives 10 (9): 1–21. https://doi.org/10.3390/nano10091692.
  • Bi, J., C. Mo, S. Li, M. Huang, Y. Lin, P. Yuan, A. Z. Liu, B. Jia, and S. Xu. 2023. “Immunotoxicity of Metal and Metal Oxide Nanoparticles: From Toxic Mechanisms to Metabolism and Outcomes.” Biomaterials Science 11 (12): 4151–4183. https://doi.org/10.1039/D3BM00271C.
  • Borkow, G., and J. Gabbay. 2005. “Copper As a Biocidal Tool.” Current Medicinal Chemistry 12 (18): 2163–2175. https://doi.org/10.2174/0929867054637617.
  • Bushell, M., S. Beauchemin, F. Kunc, D. Gardner, J. Ovens, F. Toll, D. Kennedy. 2020. “Characterization of Commercial Metal Oxide Nanomaterials; Crystalline Phase, Particle Size and Specific Surface Area.” Nanomaterials (Basel) 10 (9): 1812. https://doi.org/10.3390/nano10091812.
  • Carneiro, M. F. H., and F. Bsarbosa. 2016. “Gold Nanoparticles: A Critical Review of Therapeutic Applications and Toxicological Aspects.” Journal of Toxicology and Environmental Health, Part B 19 (3–4): 129–148. https://doi.org/10.1080/10937404.2016.1168762.
  • Cho, W. S., R. Duffin, S. E. M. Howie, C. J. Scotton, W. A. H. Wallace, W. MacNee, M. Bradley, I. L. Megson, and K. Donaldson. 2011. “Progressive Severe Lung Injury by Zinc Oxide Nanoparticles; the Role of Zn2+ Dissolution Inside Lysosomes.” Particle and Fibre Toxicology 8 (1): 1–16. https://doi.org/10.1186/1743-8977-8-27.
  • Cho, W. S., R. Duffin, C. A. Poland, A. Duschl, G. J. Oostingh, W. MacNee, M. Bradley, I. L. Megson, and K. Donaldson. 2012. “Differential Pro-Inflammatory Effects of Metal Oxide Nanoparticles and Their Soluble Ions in vitro and in vivo Zinc and Copper Nanoparticles, but Not Their Ions, Recruit Eosinophils to the Lungs.” Nanotoxicology 6 (1): 22–35. https://doi.org/10.3109/17435390.2011.552810.
  • da Silva, R. M. G., I. D. N. Pereira, L. C. Zibordi, P. S. P. Rosatto, F. O. Granero, C. C. M. Figueiredo, C. J. L. Constanmtino. 2024. “Cytotoxic, Antioxidant, and Antiglycation Activities, and Tyrosinase Inhibition Using Silver Nanoparticles Synthesized by Leaf Extract of Solanum Aculeatissimum Jacq.” Journal of Toxicology and Environmental Health Part A 87 (2): 57–76. https://doi.org/10.1080/15287394.2023.2275691.
  • De, A., S. Ghosh, M. Chakrabarti, I. Ghosh, R. Banerjee, and A. Mukherjee. 2020. “Effect of Low-Dose Exposure of Aluminium Oxide Nanoparticles in Swiss Albino Mice: Histopathological Changes and Oxidative Damage.” Toxicology and Industrial Health 36 (8): 567–579. https://doi.org/10.1177/0748233720936828.
  • Demir, E., A. Creus, and R. Marcos. 2014. “Genotoxicity and DNA Repair Processes of Zinc Oxide Nanoparticles.” Journal of Toxicology and Environmental Health Part A 77 (21): 1292–1303. https://doi.org/10.1080/15287394.2014.935540.
  • EU SCCS. 2023. “Opinion on the Safety of Aluminium in Cosmetic Products. SCCS/1644/22.” Luxembourg: European Commission Health and Food safety.
  • Farjami, A., S. Salatin, S. Jafari, M. Mahmoudian, and M. Jelvehgari. 2021. “The Factors Determining the Skin Penetration and Cellular Uptake of Nanocarriers: New Hope for Clinical Development.” Current Pharmaceutical Design 27 (42): 4315–4329. https://doi.org/10.2174/1381612827666210810091745.
  • Fernández-Pampín, N., J. J. González Plaza, A. García-Gómez, E. Peña, C. Rumbo, R. Barros, S. Martel-Martín, S. Aparicio, and J. A. Tamayo-Ramos. 2022. “Toxicology Assessment of Manganese Oxide Nanomaterials with Enhanced Electrochemical Properties Using Human In Vitro Models Representing Different Exposure Routes.” Scientific Reports 12 (1): 1–11. https://doi.org/10.1038/s41598-022-25483-w.
  • Fytianos, G., A. Rahdar, and G. Z. Kyzas. 2020. “Nanomaterials in Cosmetics: Recent Updates.” Nanomaterials: Overview and Historical Perspectives 10 (5): 1–16. https://doi.org/10.3390/nano10050979.
  • Gautam, R., S. J. Yang, A. Maharjan, J. H. Jo, M. Acharya, Y. Heo, and C. Y. Kim. 2021. “Prediction of Skin Sensitization Potential of Silver and Zinc Oxide Nanoparticles Through the Human Cell Line Activation Test.” Frontiers in Toxicology 3:649666. https://doi.org/10.3389/ftox.2021.649666.
  • Gharpure, S., and B. Ankamwar. 2020. “Synthesis and Antimicrobial Properties of Zinc Oxide Nanoparticles.” Journal of Nanoscience and Nanotechnology 20 (10): 5977–5996. https://doi.org/10.1166/jnn.2020.18707.
  • Girigoswami, K. 2018. “Toxicity of Metal Oxide Nanoparticles.” Advances in Experimental Medicine and Biology 1048:99–122. https://doi.org/10.1007/978-3-319-72041-8_7.
  • Gojova, A., B. Guo, R. S. Kota, J. C. Rutledge, I. M. Kennedy, and A. I. Barakat. 2007. “Induction of Inflammation in Vascular Endothelial Cells by Metal Oxide Nanoparticles: Effect of Particle Composition.” Environmental Health Perspectives 115:403–409. https://doi.org/10.1289/ehp.8497.
  • Greish, K., G. Thiagarajan, H. Herd, R. Price, H. Bauer, D. Hubbard, A. Burckle. 2012. “Size and Surface Charge Significantly Influence the Toxicity of Silica and Dendritic Nanoparticles.” Nanotoxicology 6 (7): 713–723. https://doi.org/10.3109/17435390.2011.604442.
  • Gulson, B., H. Wong, M. Korsch, L. Gomez, P. Casey, M. McCall, M. McCulloch, J. Trotter, J. Stauber, and G. Greenoak. 2012. “Comparison of Dermal Absorption of Zinc from Different Sunscreen Formulations and Differing UV Exposure Based on Stable Isotope Tracing.” Science of the Total Environment 420:313–318. https://doi.org/10.1016/j.scitotenv.2011.12.046.
  • Hassanpour, P., Y. Panahi, A. Ebrahimi-Kalan, A. Akbarzadeh, S. Davaran, A. N. Nasibova, R. Khalilov, and T. Kavetskyy. 2018. “Biomedical Applications of Aluminium Oxide Nanoparticles.” Micro & Nano Letters 13 (9): 1227–1231. https://doi.org/10.1049/mnl.2018.5070.
  • Holmes, A. M., I. Kempson, T. Turnbull, D. Paterson, and M. S. Roberts. 2020. “Penetration of Zinc into Human Skin After Topical Application of Nano Zinc Oxide Used in Commercial Sunscreen Formulations.” ACS Applied Bio Materials 3 (6): 3640–3647. https://doi.org/10.1021/acsabm.0c00280.
  • Jang, Y. S., E. Y. Lee, Y. H. Park, S. H. Jeong, S. G. Lee, Y. R. Kim, M. K. Kim, and S. W. Son. 2012. “The Potential for Skin Irritation, Phototoxicity, and Sensitization of ZnO Nanoparticles.” Molecular & Cellular Toxicology 8 (2): 171–177. https://doi.org/10.1007/s13273-012-0021-9.
  • Jeong, J., S. H. Kim, S. Lee, D. K. Lee, Y. Han, S. Jeon, and W. S. Cho. 2018. “Differential Contribution of Constituent Metal Ions to the Cytotoxic Effects of Fast-Dissolving Metal-Oxide Nanoparticles.” Frontiers in Pharmacology 9:15. https://doi.org/10.3389/fphar.2018.00015.
  • Johnston, L. J., X. Du, A. Zborowski, and D. C. Kennedy. 2024. “Characterization and Cellular Toxicity Studies of Commercial Manganese Oxide Nanoparticles.” Nanomaterials: Overview and Historical Perspectives 14 (2): 198. https://doi.org/10.3390/nano14020198.
  • Joo, S. J., R. Gautam, J. H. Lee, H. J. Kim, S. J. Yang, J. H. Jo, M. Acharya, A. Maharjan, Y. G. Kim, Y. M. Lim. 2019. “Prediction of the Skin Sensitization Potential of Polyhexamethylene Guanidine Phosphate, Oligo(2-(2-Ethoxy)ethoxyethyl) Guanidinium Chloride, Triclosan, and Mixtures of These Compounds with the Excipient Propylene Glycol Through the Local Lymph Node Assay: BrdU-FCM.” Toxicology and Industrial Health 35 (10): 638–646. https://doi.org/10.1177/0748233719884853.
  • Karuppannan, S. K., R. Ramalingam, S. B. M. Khalith, S. A. Musthafa, M. J. H. Dowlath, G. Munuswamy-Ramanujam, and K. D. Arunachalam. 2021. “Copper Oxide Nanoparticles Infused Electrospun Polycaprolactone/Gelatin Scaffold As an Antibacterial Wound Dressing.” Materials Letters 294:129787. https://doi.org/10.1016/j.matlet.2021.129787.
  • Katz, L. M., K. Dewan, and R. L. Bronough. 2015. “Nanotechnology in Cosmetics.” Food & Chemical Toxicology 85:127–137. https://doi.org/10.1016/j.fct.2015.06.020.
  • Kim, S. H., Y. Heo, S. J. Choi, Y. J. Kim, M. S. Kim, H. Kim, E. Jo, C. W. Song, and K. Lee. 2016. “Safety Evaluation of Zinc Oxide Nanoparticles in Terms of Acute Dermal Toxicity, Dermal Irritation and Corrosion, and Skin Sensitization.” Molecular & Cellular Toxicology 12 (1): 93–99. https://doi.org/10.1007/s13273-016-0012-3.
  • Kim, K. B., Y. W. Kim, S. K. Lim, T. H. Roh, D. Y. Bang, S. M. Choi, D. S. Lim, Y. J. Kim, S. H. Baek, M. K. Kim. 2017. “Risk Assessment of Zinc Oxide, a Cosmetic Ingredient Used As a UV Filter of Sunscreens.” Journal of Toxicology and Environmental Health, Part B 20 (3): 155–182. https://doi.org/10.1080/10937404.2017.1290516.
  • Kim, S. H., D. H. Lee, S. Choi, J. Y. Yang, K. Jung, J. Jeong, J. H. Oh, and J. H. Lee. 2021. “Skin Sensitization Potential and Cellular Ros-Induced Cytotoxicity of Silica Nanoparticles.” Nanomaterials: Overview and Historical Perspectives 11 (8): 2140. https://doi.org/10.3390/nano11082140.
  • Kim, S. H., J. H. Lee, K. Jung, J. Y. Yang, H. S. Shin, J. P. Lee, J. Jeong, J. H. Oh, and J. K. Lee. 2021. “Copper and Cobalt Ions Released from Metal Oxide Nanoparticles Trigger Skin Sensitization.” Frontiers in Pharmacology 12:627781. https://doi.org/10.3389/fphar.2021.627781.
  • Kim, S. H., D. H. Lee, J. H. Lee, J. Y. Yang, J. H. Seok, K. K. Jung, and J. H. Lee. 2021. “Evaluation of the Skin Sensitization Potentials of Metal Oxide Nanoparticles Using the ARE-Nrf2 Luciferase KeratinoSens Assay.” Toxicological Research 37 (2): 277–284. https://doi.org/10.1007/s43188-020-00071-0.
  • Koerich, J. S., D. J. Nogueira, V. P. Vaz, C. Simioni, M. L. N. da Silva, L. C. Ouriques, D. S. Vicentini, and W. G. Matias. 2020. “Toxicity of Binary Mixtures of Al2O3 and ZnO Nanoparticles Toward Fibroblast and Bronchial Epithelium Cells.” Journal of Toxicology and Environmental Health Part A 83 (9): 363–377. https://doi.org/10.1080/15287394.2020.1761496.
  • Liu, J., X. Feng, L. Wei, L. Chen, B. Song, and L. Shao. 2016. “The Toxicology of Ion-Shedding Zinc Oxide Nanoparticles.” Critical Reviews in Toxicology 46 (4): 348–384. https://doi.org/10.3109/10408444.2015.1137864.
  • Liu, J., Y. Kang, S. Yin, B. Song, L. Wei, L. Chen, and L. Shao. 2017. “Zinc Oxide Nanoparticles Induce Toxic Responses in Human Neuroblastoma SHSY5Y Cells in a Size-Dependent Manner.” International Journal of Nanomedicine 12:8085–8099. https://doi.org/10.2147/IJN.S149070.
  • Mihranyan, A., N. Ferraz, and M. Strømme. 2012. “Current Status and Future Prospects of Nanotechnology in Cosmetics.” Progress in Materials Science 57 (5): 875–910. https://doi.org/10.1016/j.pmatsci.2011.10.001.
  • Mitchell, M. J., M. M. Billingsley, R. M. Haley, M. E. Wechsler, N. A. Peppas, and R. Langer. 2021. “Engineering Precision Nanoparticles for Drug Delivery.” Nature Reviews Drug Discovery 20 (2): 101–124. https://doi.org/10.1038/s41573-020-0090-8.
  • Mohammed, Y. H., A. Holmes, I. N. Haridass, W. Y. Sanchez, H. Studier, J. E. Grice, H. A. E. Benson, and M. S. Roberts. 2019. “Support for the Safe Use of Zinc Oxide Nanoparticle Sunscreens: Lack of Skin Penetration or Cellular Toxicity After Repeated Application in Volunteers.” The Journal of Investigative Dermatology 139 (2): 308–315. https://doi.org/10.1016/j.jid.2018.08.024.
  • Monteiro-Riviere, N. A., K. Wiench, R. Landsiedel, S. Schulte, A. O. Inman, and J. E. Riviere. 2011. “Safety evaluation of sunscreen formulations containing titanium dioxide and zinc oxide nanoparticles in UVB sunburned skin: An in vitro and in vivo study.” Toxicological Sciences: An Official Journal of the Society of Toxicology 123 (1): 264–280. https://doi.org/10.1093/toxsci/kfr148.
  • OECD. 2014. “The Adverse Outcome Pathway for Skin Sensitisation Initiated by Covalent Binding to Proteins.” OECD Series on Testing and Assessment, No. 168. Paris: OECD Publishing. https://doi.org/10.1787/9789264221444-en.
  • OECD. 2016. “Guidance on the Reporting of Defined Approaches and Individual Information Sources to Be Used within Integrated Approaches to Testing and Assessment (IATA) for Skin Sensitization.” OECD Series on Testing and Assessment, No.256. Paris: OECD Publishing. https://doi.org/10.1878/9789264279285-en.
  • OECD. 2018. “Test No. 442B: Skin Sensitisation: Local Lymph Node Assay: BrdU-ELISA or -FCM. OECD Guidelines for the Testing of Chemicals, Section 4.” Paris: OECD Publishing. https://doi.org/10.1787/9789264090996-en.
  • OECD. 2023. “Test No. 442E: In vitro Skin Sensitisation: In vitro Skin Sensitisation Assays Addressing the Key Event on Activation of Dendritic Cells on the Adverse Outcome Pathway for Skin Sensitisation.” Paris: OECD Publishing. https://doi.org/10.1787/9789264264359-en.
  • Porrawatkul, P., P. Nuengmatcha, A. Kuyyogsuy, R. Pimsen, and P. Rattanaburi. 2023. “Effect of Na and Al Doping on ZnO Nanoparticles for Potential Application in Sunscreens.” Journal of Photochemistry and Photobiology B, Biology 240:112668. https://doi.org/10.1016/j.jphotobiol.2023.112668.
  • Prach, M., V. Stone, and L. Proudfoot. 2013. “Zinc Oxide Nanoparticles and Monocytes: Impact of Size, Charge and Solubility on Activation Status.” Toxicology and Applied Pharmacology 266 (1): 19–26. https://doi.org/10.1016/j.taap.2012.10.020.
  • Rancan, F., Q. Gao, C. Graf, S. Troppens, S. Hadam, S. Hackbarth, C. Kembuan, U. Blume-Peytavi, E. Ruhl, J. Lademan. 2012. “Skin Penetration and Cellular Uptake of Amorphous Silica Nanoparticles with Variable Size, Surface Functionalization, and Colloidal Stability.” Agricultural Science & Technology Nano 6 (8): 6829–6842. https://doi.org/10.1021/nn301622h.
  • Raszewska-Famielec, M., and J. Flieger. 2022. “Nanoparticles for Topical Application in the Treatment of Skin Dysfunctions—An Overview of Dermo-Cosmetic and Dermatological Products.” International Journal of Molecular Sciences 23 (24): 15980. https://doi.org/10.3390/ijms232415980.
  • REACH. 2006. “Regulation (EC) No 1907/2006 of the European Parliament and of the Council of 18 December 2006 Concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH), Establishing a European Chemical Agency.” http://data.europa.eu/eli/reg/2006/1907/2023-12-01.
  • Rizvi, S. A. A., and A. M. Saleh. 2018. “Applications of Nanoparticle Systems in Drug Delivery Technology.” Saudi Pharmaceutical Journal 26 (1): 64–70. https://doi.org/10.1016/j.jsps.2017.10.012.
  • Sahu, D., G. M. Kannan, M. Tailang, and R. Vijayaraghavan. 2016. “In Vitro Cytotoxicity of Nanoparticles: A Comparison Between Particle Size and Cell Type.” Journal of Nanoscience 2016:1–9. https://doi.org/10.1155/2016/4023852.
  • Sahu, D., G. M. Kannan, and R. Vijayaraghavan. 2014. “Size-Dependent Effect of Zinc Oxide on Toxicity and Inflammatory Potential of Human Monocytes.” Journal of Toxicology and Environmental Health Part A 77 (4): 177–191. https://doi.org/10.1080/15287394.2013.853224.
  • Sccs, E. U. 2021. Opinion on the Safety of Copper (Nano) and Colloidal Copper (Nano). SCCS/162/2020. Luxembourg: European Commission Health and Food safety.
  • Seth, D., K. Cheldize, D. Brown, and E. E. Freeman. 2017. “Global Burden of Skin Disease: Inequities and Innovations.” Current Dermatology Reports 6 (3): 204–210. https://doi.org/10.1007/s13671-017-0192-7.
  • Settivari, R. S., J. C. Rowlands, D. M. Wilson, S. M. Arnold, and P. J. Spencer. 2016. “Application of Evolving Computational and Biological Platforms for Chemical Safety Assessment”. In A Comprehensive Guide to Toxicology in Nonclinical Drug Development, 2nd, 843–873. Elsevier Inc. https://doi.org/10.1016/B978-0-12-803620-4.00032-3.
  • Singh, R. P., R. Handa, and G. Manchanda. 2021. “Nanoparticles in Sustainable Agriculture: An Emerging Opportunity.” Journal of Controlled Release 329:1234–1248. https://doi.org/10.1016/j.jconrel.2020.10.051.
  • Stankic, S., S. Suman, F. Haque, and J. Vidic. 2016. “Pure and Multi Metal Oxide Nanopatricles: Synthesis, Antibacterial and Cytotoxic Properties.” Journal of Nanobiotechnology 14 (1): 73. https://doi.org/10.1186/s12951-016-0225-6.
  • Syalsabilla, M., F. Sofaturahman, M. Syuriyani, L. R. Septiana, N. Raisa, R. Jonuarti, and R. Hidayat. 2023. “The Effect of Compositional Optical Analysis of ZnO/TiO2 Composites in a Sunscreen Product.” Pillars Physics 16 (2): 169–179. https://doi.org/10.24036/14929171074.
  • Try, C., B. Moulari, A. Béduneau, O. Fantini, D. Pin, Y. Pellequer, and A. Lamprecht. 2016. “Size Dependent Skin Penetration of Nanoparticles in Murine and Porcine Dermatitis Model.” European Journal of Pharmaceutics & Biopharmaceutics 100:101–108. https://doi.org/10.1016/j.ejpb.2016.01.002.
  • Verbič, A., M. Gorjanc, and B. Simončič. 2019. “Zinc Oxide for Functional Textile Coatings: Recent Advances.” Coatings 9 (9): 17–23. https://doi.org/10.3390/coatings9090550.
  • Wang, Z., N. Li, J. Zhao, J. C. White, P. Qu, and B. Xing. 2012. “CuO Nanoparticle Interaction with Human Epithelial Cells: Cellular Uptake, Location, Export, and Genotoxicity.” Chemical Research in Toxicology 25 (7): 1512–1521. https://doi.org/10.1021/tx3002093.
  • Xiong, L., M. Zhao, Y. Fan, S. Wang, Y. G. Yang, X. Li, D. Zhao, and F. Zhang. 2019. “Manganese Oxide Nanoclusters for Skin Photoprotection.” ACS Applied Bio Materials 2 (9): 3974–3982. https://doi.org/10.1021/acsabm.9b00528.
  • Yoshioka, Y., E. Kuroda, T. Hirai, Y. Tsutsumi, and K. J. Ishii. 2017. “Allergic Responses Induced by the Immunomodulatory Effects of Nanomaterials Upon Skin Exposure.” Frontiers in Immunology 8:169. https://doi.org/10.3389/fimmu.2017.00169.
  • Yousefalizadegan, N., Z. Mousavi, T. Rastegar, Y. Razavi, and P. Najafizadeh. 2019. “Reproductive Toxicity of Manganese Dioxide in Forms of Micro- and Nanoparticles in Male Rats.” International Journal of Reproductive Biomedicine 17:361–370. https://doi.org/10.18502/ijrm.v17i5.4603.
  • Zanoni, I., M. Crosera, S. Ortelli, M. Blosi, G. Adami, F. L. Filon, and A. L. Costa. 2019. “CuO Nanoparticle Penetration Through Intact and Damaged Human Skin.” New Journal of Chemistry 43 (43): 17033–17039. https://doi.org/10.1039/C9NJ03373D.

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