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Original Articles

Additional statistical evaluation and pharmacological considerations of hycanthone methanesulfonate‐induced dominant lethality

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Pages 293-299 | Received 31 May 1975, Accepted 01 Jun 1975, Published online: 20 Oct 2009

References

  • Clive , D. , Flamm , W. G. and Machesko , M. R. 1967 . Mutagenicity of hycanthone in mammalian cells . Mutat. Res. , 32 : 587
  • Cook , J. A. , Woodstock , L. and Jordan , P. in press . Two‐year follow‐up of hycanthone‐treated schistosomiasis patients in St. Lucia . Amer. J. Trop. Med. Hyg. ,
  • Dixon , R. L. and Lee , I. P. 1973 . Possible role of the blood‐testicular barrier in dominant lethal testing . Environ. Health Perspect. , 6 : 59
  • Generoso , W. M. , de Serres , F. M. , Huff , S. W. and Cain , K. T. June 30 1972 . Studies on the induction of chromosomal aberrations in mice by hycanthone , Biology Division Annual Progress Report June 30 , Oak Ridge National Laboratory .
  • Green , S. , Carr , J. V. , Sauro , F. M. and Legator , M. S. 1973a . Effects of hycanthone on spermatogonial cells, deoxyribonudeic acid synthesis in bone marrow, and dominant lethality in rats . J. Pharmacol. Exp. Ther. , 187 : 437
  • Green , S. , Sauro , F. M. and Legator , M. S. 1973b . Cytogenetic effects of hycanthone in the rat . Mutat. Res. , 17 : 239
  • Hartman , P. E. , Levine , K. , Hartman , Z. and Berger , H. 1971 . Hycanthone: A frameshift mutagen . Science , 172 : 1058
  • Rail , R. P. 1973 . Pharmacokinetic and other factors related to mutagenicity testing Environ . Health Perspect. , 6 : 67
  • Russell , W. L. and Kelly , E. M. June 30 1972 . Absence of mutagenic effect of hycanthone in mice , Biology Division Annual Progress Report June 30 , Oak Ridge National Laboratory .
  • World Health Organization . 1971 . Reports on Schistosomicidal Drugs , 83 Geneva : WHO .

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