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Journal of Toxicology and Environmental Health Volume 2, 1976 - Issue 1
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Original Articles

Effect of water and food deprivation on hepatic microsomal metabolism of hexobarbital and aniline

Anna M. Baetjer Department of Environmental Medicine, Johns Hopkins University, School of Hygiene and Public Health, 615 North Wolfe Street, Baltimore, Maryland, 21205
&
Robert J. Rubin Department of Environmental Medicine, Johns Hopkins University, School of Hygiene and Public Health, 615 North Wolfe Street, Baltimore, Maryland
Pages 131-138 | Received 17 Nov 1975, Accepted 04 Dec 1975, Published online: 19 Oct 2009

References

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  • Baetjer , A. M. , Joardar , S. N. D. and McQuary , W. A. 1960 . Effect of environmental temperature and humidity on lead poisoning in animals . Arch. Environ. Health , 1 : 463 – 477 .
  • Campbell , T. C. and Hayes , J. R. 1974 . Role of nutrition in the drug‐metabolizing enzyme system . Pharmacol. Rev. , 26 : 171 – 197 .
  • Cooper , J. B. and Brodie , B. B. 1935 . The enzymatic metabolism of hexobarbital . J. Pharmacol. Expt Therap. , 114 : 409 – 419 .
  • Dixon , R. K. , Shultice , R. W. and Fouts , J. R. 1960 . Factors affecting drug metabolism by liver microsomes. IV. Starvation . Proc. Soc. Expt. Biol. Med. , 103 : 333 – 335 .
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  • Gram , T. E. , Guarino , A. M. , Schroeder , D. H. , Davis , D. C. , Reagan , L. R. and Gillette , J. R. 1970 . The effect of starvation on the kinetics of drug oxidation by hepatic microsomal enzymes from male and female rats . J. Pharmacol. Expt Therap. , 175 : 12 – 21 .
  • Kato , R. and Gillette , J. R. 1965 . Effect of starvation on NADPH‐dependent enzymes in liver microsomes of male and female rats . J. Pharmacol. Expt Therap. , 150 : 279 – 284 .
  • Kato , R. , Onoda , K. and Sasajima , M. 1970 . Effects of morphine treatment and starvation on the substrate interaction with P‐450 in the oxidation of drugs by liver microsomes . Japan. J. Pharmacol. , 20 : 194 – 209 .
  • LaDu , B. N. , Mandel , H. G. and Way , E. L. 1971 . Fundamentals of drug metabolism and drug disposition , 570 Baltimore : Williams & Wilkins .
  • Maines , M. D. and Westfall , B. A. 1971 . Effect of water deprivation on the metabolism of hexobarbital in the Mongolian gerbil . Comp. Gen. Pharmacol. , 2 : 311 – 316 .

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