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Part five: Risk branches in industry

Potential carcinogenic and mutagenic industrial chemicals. I. Alkylating agents

Pages 1133-1177 | Published online: 20 Oct 2009

References

  • ACGIH . 1976 . Threshold Limit Values for Chemical Substances in Workroom Air Adopted by ACGIH for 1976 , Cincinnati : American Conference of Governmental Industrial Hygienists .
  • Ahmed , M. G. , Alder , R. W. , James , G. H. , Sinnoutt , M. L. and Whiting , M. C. 1968 . Alkylations with methyl and ethyl fluorosulphonates . J. Chem. Soc. Chem Commun. , : 1533 – 1534 .
  • Alarcon , R. A. , Meienhofer , J. and Antherton , E. 1972 . Isophosphamide as a new acrolein‐producing and antineoplastic isomer of cyclophosphamide . Cancer Res. , 32 : 2519 – 2523 .
  • Albert , R. E. , Pasternack , B. S. , Shore , R. E. , Lippman , M. , Nelson , N. and Ferris , B. 1975 . Mortality patterns among workers exposed to chioromethyl ethers . Environ. Health Perspect. , 11 : 209 – 214 .
  • Alderson , T. 1964 . Ethylation versus methylation in mutation of E. coli and Drosophila . Nature (Lond.) , 203 : 1404 – 1406 .
  • Alexander , M. L. and Glanger , E. 1965 . Genetic damage induced by ethylenimine . Proc. Natl. Acad. Sci. U.S.A. , 53 : 282 – 285 .
  • Ames , B. N. 1979a . Identifying environmental chemicals causing mutations and cancer . Science , 204 : 587 – 593 .
  • Ames , B. N. 1979b . The detection and hazards of environmental carcinogens/mutagens . Am. Chem. Soc. Symp. 5 , 94 : 1 – 11 .
  • Andersen , M. , Kiel , P. , Larsen , H. and Maxild , J. 1978 . Mutagenic action of aromatic epoxy resins . Nature (Load.) , 276 : 391 – 392 .
  • Andrews , A. W. , Zawistowski , E. S. and Valentine , C. R. 1976 . A comparison of the mutagenic properties of vinyl chloride and methyl chloride . Mutat. Res. , 40 : 273 – 276 .
  • Anon. 1976 . Shell Oil reports 14 cases of cancer at Texas facilities . Occup. Health Safety Lett. , 8 July : 27
  • Anon. 1977a . Chem. Eng. News , 55 (18) : 10
  • Anon. 1977b . Epichlorohydrin causes nose cancers in rats, NYU's Nelson reports . Pestic. Toxic Chem. News , 5 : 27 – 28 .
  • Anon. 1977c . Ethylene dibromide: Institute recommends ceiling limit one milligram, engineering controls . Chem. Regulation Rep. , 1 (36) : 13
  • Anon. 1977d . Kennedy adds chemical amendments to Clean Air Act, hears EPA's current efforts . Toxic Mater. News , 4 (20) : 127
  • Anon. 1977e . NIOSH says workers must know hazards . Chem. Ecol. , June : 5
  • Anon. 1978a . FDA proposes ethylene oxide limits for mastitis preparations . Food Chem. News , 26 June : 73 – 74 .
  • Anon. 1978b . FDA proposes exposure levels, residue limits on medical devices . Chem. Regulation Rep. , 2 : 480 – 481 .
  • Anon. 1978c . HEW‐study links 20% of cancer to jobs . Chem. Eng. News , 56 (38) : 7
  • Anon. 1978d . Summary and conclusions of HEW report on estimates of cancer related to occupational factors . Occup. Health Safety Lett. , 8 : 2
  • Anon. 1979a . Formaldehyde . Chem. Eng. News , 57 (4) : 14
  • Anon. 1979b . NIOSH says epichlorohydrin should be treated as human carcinogen . Food Chem. News , 20 : 53
  • Anon. 1979c . Dupont report on nasal tumors from PGE in resins . Pestic. Toxic Chem. News , 7 : 8 – 9 .
  • Anon. 1979d . Key polymers: Epoxides . Chem. Eng. News , 58 (12) : 14
  • Applegren , L. F. , Eneroth , G. , Grant , C. , Landstrom , L. E. and Tenghagen , K. 1978 . Testing of ethylene oxide for mutagenicity using the micronucleus test in mice and rats . Ada Pharmacol. Toxicol. , 43 : 69 – 71 .
  • Arcos , J. C. 1978 . Criteria for selecting chemical compounds for carcinogenicity testing: An essay . J. Environ. Pathol. Toxicol. , 1 : 433 – 458 .
  • Ashby , J. , Anderson , D. and Styles , J. A. 1978 . The potential carcinogenicity of methylfluorosulphonate (CH3OSO2F, Magic Methyl) . Mutat. Res. , 51 : 285 – 287 .
  • Auerbach , C. , Moutschendahmen , M. and Moutschen , J. 1977 . Genetic and cytogenetical effects of formaldehyde and related compounds . Mutat. Res. , 39 : 317 – 362 .
  • Baier , E. J. Jan. 23 1978 . “ Statement on ethylene dichloride before the Subcommittee on Oversight and Investigations ” . Jan. 23 , Washington, D.C. : House Committee on Interstate and Foreign Commerce .
  • Bardodej , Z. and Bardodejova , E. 1970 . Biotransformation of ethyl benzene, styrene and alpha‐methyl‐styrene in man . Am. Ind. Hyg. Assoc. J. , 31 : 206 – 212 .
  • Bartsch , H. 1976 . Predictive value for mutagenicity tests for chemical carcinogenesis . Mutat. Res. , 38 : 177 – 190 .
  • Bartsch , H. , Malaveille , C. , Barbin , A. , Tomatis , L. and Montesano , R. 1976 . Mutagenicity and metabolism of vinyl chloride and related compounds . Environ. Health Perspect. , 17 : 193 – 297 .
  • Beitchman , B. D. 1966 . Cross‐linked isocyanurate‐polyurethan elastomers and plastics prepared with triethylenediamine‐cocatalyst combinations . Rubber Age , 98 (2) : 65 – 72 .
  • Bignami , M. , Cardamone , G. , Comba , P. , Ortali , V. A. , Morpurgo , G. and Carere , A. 1974 . Relationship between chemical structure and mutagenic activity in some pesticides: The use of Salmonella typhimurium and Aspergillus nidulans . Mutat. Res. , 46 : 243 – 244 .
  • Bird , M. J. 1952 . Chemical production in mutations in Drosophila: Comparison of techniques . J. Genet. , 50 : 480 – 485 .
  • Blum , A. and Ames , B. N. 1977 . Flame‐retardant additives as possible cancer hazards . Science , 195 : 17 – 23 .
  • Blum , A. , Gold , M. B. , Ames , B. N. Kenyon , C. 1978 . Children absorb Tris‐BP flame retard ant from sleepwear: Urine contains the mutagenic metabolite, 2,3‐dibromopropanol . Science , 201 : 1020 – 1022 .
  • Bootman , J. , Lodge , D. C. and Whatley , H. E. 1979 . Mutagenic activity of propylene oxide in bacterial and mammalian systems . Mutat. Res. , 67 : 101 – 112 .
  • Bourne , L. G. , Milner , F. J. M. and Alberman , K. B. 1959 . Health problems of epoxy resins and anine‐curing agents . Br. J. Ind. Med. , 16 : 81 – 97 .
  • Boyland , E. 1969 . The correlation of experimental carcinogenesis and cancer in man . Prog. Exp. Tumor Res. , 11 : 222 – 234 .
  • Braun , R. , Fischer , G. W. and Schöneich , J. 1977 . The mutagenicity and DNA‐damaging activity of cyclic aliphatic sulfuric acid esters . Chem.‐Biol. Interact. , 19 : 241 – 252 .
  • Brem , H. , Stein , A. B. and Rosenkranz , H. S. 1974 . The mutagenicity and DNA modifying effects of haloalkanes . Cancer Res. , 34 : 2576 – 2579 .
  • Brookes , P. and Lawley , P. D. 1961 . The alkylation of guanosine and guanylic acid . J. Chem. Soc. , : 3923 – 3928 .
  • Brunken , J. , Glöcilner , G. and Poppe , E. J. 1961 . Uber cyclische sulfate und ihre Verwendung zur herstellung von sulfate betainen . Veroeff. Wiss. Photo‐Lab. AGFA , 9 : 61
  • Brusick , D. J. 1977a . In vitro mutagenesis assays as predictors of chemical carcinogenesis in mammals . Clin. Toxicol. , 10 : 79 – 109 .
  • Brusick , D. J. 1977b . The genetic properties of beta‐propiolactone . Mutat. Res. , 39 : 241 – 256 .
  • Busk , L. 1979 . Mutagenic effects of styrene and styrene oxide . Mutat. Res. , 67 : 201 – 208 .
  • Carter , L. J. 1979 . Toxic substances legislation: How well are laws being implemented? . Science , 201 : 1198 – 1199 .
  • CEQ . 1971 . Toxic Substances , Washington, D.C : Council on Environmental Quality .
  • Chang , T. H. and Elequin , F. T. 1967 . Induction of chromosome aberrations in cultured human cells by ethyleneimine and its relation to the cell cycle . Mutat. Res. , 4 : 83 – 87 .
  • Clayson , D. Human epidemiology and laboratory correlations . Paper presented at the Chemical Carcinogenesis Meeting . June 1–4 , Mescalero, New Mexico. Toxicol. Forum .
  • Clement Associates . 1977 . “ Information dossiers on substances designated by TSCA interagency testing committee ” . Report on Contract NSF‐C‐ENV‐77–15417
  • Cline , J. C. , Thompson , C. Z. and McMahon , R. E. A convenient technique for the detection of volatile liquid mutagens in ten tester strains . Proc. 9th Annu. Meet. Environ. Mutagen Soc. March 9–13 , San Francisco. pp. 68 – 69 .
  • Connor , T. H. 1979 . The mutagenicity of trimethylphosphate . Mutat. Res. , 65 : 121 – 131 .
  • Corbett , T. H. , Heidelberger , G. and Dove , W. F. 1970b . Determination of the mutagenic activity to bacteriophage T4 of carcinogenic and non‐carcinogenic compounds . Mol. Pharmacol. , 6 : 667 – 679 .
  • Corbett , T. H. , Dove , W. F. and Heidelberger , C. Attempts to correlate carcinogenic with mutagenic activity using bacteriophage . Abstr. 19th Int. Cancer Congr. May 22–29 , Houston. Vol. 10 , pp. 66 – 62 .
  • Couch , D. B. , Forbes , N. L. and Hsie , A. W. 1978 . Comparative mutagenicity of alkylsulfate and alkanesulfonate derivatives in Chinese hamster ovary cells . Mutat. Res. , 57 : 217 – 224 .
  • Daly , J. W. , Jerina , D. M. and Witkop , B. 1972 . Arene oxides and the NIH shift: The metabolism, toxicity and carcinogenicity of aromatic compounds . Experientia , 28 : 1129 – 1149 .
  • Dean , B. J. and Thorpe , E. 1972 . Studies with dichlorvos vapour in dominant lethal mutation tests in mice . Arch. Toxikol. , 30 : 51 – 59 .
  • deMeester , C. , Poncelet , F. , Roberfroid , M. , Rondelet , J. and Mercier , M. 1977 . Mutagenicity of styrene and styrene oxide . Mutat. Res. , 56 : 147 – 152 .
  • de Raat , W. K. 1978 . Induction of sister chromatid exchanges by styrene and its presumed metabolite styrene oxide in the presence of rat liver homogenate . Chem.‐Blol. Interact. , 20 : 163 – 170 .
  • Donner , M. , Sorsa , M. and Vainio , H. 1979 . Recessive lethals induced by styrene and styrene oxide in Drosophila melanogaster . Mutat. Res. , 67 : 373 – 376 .
  • Druckrey , H. 1963 . Carcinogenicity and chemical structure of nitrosamines . Acta Unio Int. Contra Cancrum , 19 : 510 – 524 .
  • Druckrey , H. , Preussmann , R. , Nashed , N. and Ivankovic , S. 1966 . Carcinogenic alkylierende subsatanzen. I. Dimethylsuflate, carcinogene Wirkung an ratten und wahrscheinliche Ursache von berufskrebs . Z. Krebsforsch. , 68 : 103 – 115 .
  • Druckrey , H. , Krause , H. and Preussmann , R. 1970a . Carcinogenic alkylating agents. III. Alkyl halides, alkyl sulfates, alkyl sulfonates and ring‐stressed heterocycles . Z. Krebsforsch. , 74 : 241 – 249 .
  • Druckrey , H. , Krause , H. , Preussmann , R. , Ivankovic , S. and Landschutz , C. 1970b . Carcinogenic alkylating substances. IV. 1,3‐Propane sultone and 1,4‐butane sultone . Z. Krebsforsch. , 75 : 69 – 84 .
  • Druckrey , H. , Gimmy , J and Landschutz , C. 1973 . Carcinogenicity of diisopropylsulfate and non‐carcinogenicity of monomethylsulfate in BD‐rats . Z. Krebsforsch. , 79 : 135 – 139 .
  • Duncan , W. A. M. and Snow , G. A. 1962 . Some observations on triethylene glycol diglycidyl ether–a new tumor inhibitory alkylating agent . Biochem. J. , 82 : 8P – 9P .
  • Dunkel , V. G. , Wolff , J. S. and Pienta , R. J. 1977 . In vitro transformation as a presumptive test for detecting chemical carcinogens . Cancer Bull. , 29 : 167 – 174 .
  • du Pont de Nemours . 1978 . “ Haskell Laboratory Reports on Glycidyl Ethers ” . 225 – 74 . 133 – 76 . 163 – 75 . Nos. 164–75
  • Dyer , K. F. and Hanna , P. J. 1972 . Mutagenic and antifertility activity of trimethyl phosphate in D. melanogaster . Mutat. Res. , 16 : 327 – 330 .
  • Eckardt , R. E. 1974 . Annals of industry‐noncasualties of the workplace . J. Occup. Med. , 15 : 472 – 477 .
  • Edwards , K. , Jackson , H. and Jones , A. R. 1970 . Studies with alkylating esters. II. A chemical interpretation through metabolic studies of the infertility effects of ethylene dimethanesulfonate and ethylene dibromide . Biochem. Pharmacol. , 19 : 1783 – 1789 .
  • Ehrenberg , L. , Hiesche , K. D. , Osterman‐Golkar , S. and Wennberg , I. 1974a . Effects of genetic risks of alkylating agents: Tissue doses in the mouse from air contaminated with ethylene oxide . Mutat. Res. , 24 : 83 – 103 .
  • Ehrenberg , L. , Osterman‐Golkar , S. , Singh , D. and Lundquist , U. 1974b . On the reaction kinetics and mutagenic activity of methylating and beta‐halogeno ethylating gasoline additives . Radiat. Bot. , 15 : 185 – 187 .
  • El Masri , A. M. , Smith , N. J. and Williams , R. T. 1958 . Studies on detoxification. No. 73. The metabolism of alkylbenzenes, phenylacetylene and phenylethylene (styrene) . Biochem. J. , 68 : 199 – 204 .
  • Elmenhorst , H. and Schultz , C. 1968 . Fluctige inhalstoffe des tabakrauches, die chemischen bestandteile der gas‐damptf‐phase . Beitr. Tabakforsch. , 4 : 90 – 123 .
  • Embree , J. W. and Hine , C. H. 1975 . Mutagenicity of ethylene oxide . Toxicol. Appl. Pharmacol. , 33 : 172 – 173 .
  • Embree , J. W. , Lyon , J. P. and Hine , C. H. 1977 . The mutagenic potential of ethylene oxide using the dominant lethal assay in rats . Toxicol. Appl. Pharmacol. , 40 : 261 – 267 .
  • Engström , K. , Härkönen , H. , Kalliokoski , P. and Rantanen , J. 1976 . Urinary mandelic acid concentration after occupational exposure to styrene and its use as a biological exposure test . Scand. J. Work Environ. Health , 3 : 21 – 30 .
  • EPA . Oct 17 1975 . “ Draft report for Congress: Preliminary assessment of suspected carcinogens in drinking water ” . Oct 17 , Washington, D.C. : Office of Toxic Substances .
  • EPA . 1977a . A study of industrial data on candidate chemicals for testing . Report on contract , : 68 – 01 . 4109
  • EPA . 1977b . Status Assessment of Toxic Chemicals No. 14: Tris(23‐dibromopropyl) Phosphate , Cincinatti, Ohio : Industrial Environmental Research Laboratory .
  • EPA . 1978 . Environmental Protection Agency position document for the rebuttable presumption against registration of pesticide products containing ethylene oxide . Chem. Regulation Rep. , 1 : 1650 – 1657 .
  • Epstein , S. S. , Bass , W. , Arnold , E. and Bishop , Y. 1970 . Mutagenicity of trimethyl phosphate in mice . Science , 168 : 584 – 586 .
  • Epstein , S. S. , Arnold , E. , Andrea , J. , Bass , W. and Bishop , Y. 1972 . Detection of chemical mutagens by the dominant lethal assay in the mouse . Toxicol. Appl. Pharmacol. , 23 : 288 – 325 .
  • Fabry , L. , Leonard , A. and Roberfroid , M. 1979 . Mutagenicity tests with styrene oxide in mammals . Mutat. Res. , 51 : 377 – 381 .
  • Fahmy , O. G. and Fahmy , M. J. 1970 . Gene elimination in carcinogenesis: Reinterpretation of the somatic mutation theory . Cancer Res. , 30 : 195 – 205 .
  • Fahrig , R. 1971 . Metabolic activation of aryldialkyltriazenes in the mouse: Induction of mitotic gene conversion in S. cerevisiae in the host‐mediated assay . Mutat. Res. , 13 : 436 – 439 .
  • Fahrig , R. 1974 . Development of host‐mediate mutagenicity tests. I. Differential response of yeast cells injected into testes of rats and peritoneum of mice and rats to mutagens . Mutat. Res. , 26 : 29 – 36 .
  • Farrow , M. G. 1975 . The use of trimethylphosphate (TMP) as a positive control agent in the dominant lethal, cytogenetic and host‐mediated assays . Mutat. Res. , 31 : 314 – 315 .
  • FDA . 1978 . Ethylene oxide, ethylene chlorohydrin and ethylene glycol, proposed maximum residue limits and maximum levels of exposure . Fed. Regist. , 43 : 27474 – 27 . 483
  • Feldman , N. Y. 1975 . Reaction of nucleic acids and nucleoproteins with formaldehyde . Prog. Nucleic Acids Res. Mol. Biol. , 13 : 1 – 49 .
  • Feron , V. J. 1972 . Respiratory tract tumors in hamsters after intratracheal instillations of benzo(a)pyrene alone and with furfural . Cancer Res. , 32 : 28 – 36 .
  • Filippova , L. M. , Pan'shin , O. A. and Kostyankovskii , R. G. 1967 . Chemical mutagens. IV. Mutagenic activity of germinal systems . Genetika , 3 : 134 – 136 .
  • Fischer , F. F. 1964 . Propane sultone . Inc. Eng. Chem. , 56 : 41 – 42 .
  • Fishbein , L. 1969 . Degradation and residues of alkylating agents . Ann. N.Y. Acad. Sci. , 163 : 869 – 894 .
  • Fishbein , L. 1976a . Industrial mutagens and potential mutagens. I. Halogenated derivatives . Mutat. Res. , 32 : 267 – 308 .
  • Fishbein , L. 1976b . Potential hazards of fumigant residues . Environ. Health Perspect. , 14 : 39 – 45 .
  • Fishbein , L. 1979 . Potential Industrial Carcinogens and Mutagens , 93 – 117 . 118 – 120 . 532 Amsterdam : Elsevier .
  • Fishbein , L. , Flamm , W. G. and Falk , H. L. 1970 . Chemical Mutagens , 143 – 145 . 216 – 217 . 253 – 258 . New York : Academic .
  • Friedman , M. A. , Greene , E. J. , Sherrod , J. A. and Salerno , A. J. 1978 . Activity of phenylglycidyl ether (PGE) in genetic in vitro screening tests . Pharmacologist , 20 : 154 – 159 .
  • Glaser , Z. R. 1979 . Ethylene oxide: Toxicology review and field study results of hospital use . J. Environ. Pathol. Toxicol. , 2 : 173 – 208 .
  • Glatt , H. R. , Metzler , M. , Neumann , H. G. and Oesch , F. 1976 . Metabolie epoxidation of trons‐4‐acetyl‐aminostilbene: A protective mechanism against its activation to a mutagen . Biochem. Biophys. Res. Commun. , 73 : 1025 – 1029 .
  • Glatt , H. R. , Oesch , F. , Frigerio , A. and Garattini , S. 1975 . Epoxides metabolically produced from some carcinogens and from some chronically used drugs . Int. J. Cancer , 16 : 787 – 796 .
  • Gold , M. D. , Blum , A. and Ames , B. N. 1978 . Another flame retardant, tris(1,3‐dichloro‐2‐propyl) phosphate, and its expected metabolites are mutagens . Science , 200 : 785 – 788 .
  • Goldschmidt , B. M. , Frenkel , K. and Van Duuren , B. L. 1974 . The reaction of propane sultone with guanosine, adenosine and related compounds . J. Heterocycl. Chem. , 11 : 719 – 726 .
  • Granville , G. C. 1979 . Mutagenic effect of aromatic epoxy resins . Nature (Lond.) , 279 : 352 – 353 .
  • Greene , E. J. , Friedman , M. A. , Sherrod , J. A. and Salerno , A. J. 1979 . In vitro mutagenicity and cell transformation screening of phenylglycidyl ether . Mutat. Res. , 67 : 9 – 19 .
  • Grover , P. L. and Sims , P. 1970 . Interactions of the K‐region epoxides of phenanthrene and dibenz(a,h)‐anthracene with nucleic acids and histone . Biochem. Pharmacol. , 19 : 2251 – 2259 .
  • Gutsche , C. D. and Pasto , D. J. 1975 . Fundamentals of Organic Chemistry , 693 Englewood Cliffs, N.J. : Prentice‐Hall .
  • Haddow , A. 1967 . Proceedings of the 9th International Cancer Congress Tokyo Japan . 1967 . Edited by: Harris , R. J. C. pp. 111 – 115 . New York : Springer‐Verlag .
  • Hanna , P. J. and Dyer , K. F. 1975 . Mutagenicity of organo phosphorus compounds in bacteria and Drosophila . Mutat. Res. , 28 : 405 – 420 .
  • Härkönen , H. , Kalliokoski , P. , Hietala , S. and Hernberg , S. 1974 . Concentrations of mandelic acid and phenylglyoxylic acid in urine as indicators of styrene exposure . Work Environ. Health , 11 : 162 – 170 .
  • Hawley , G. F. 1971 . The Condensed Chemical Dictionary , 8th Ed. , 367 New York : Van Nostrand .
  • Hayes , E. R. 1963 . “ Acetyladehyde ” . In Kirk‐Othmer Encyclopedia of Chemical Technology , 2d ed. , vol. 1 , 75 – 95 . New York : Interscience .
  • Heslot , H. 1962 . Etude quantitative de reversions biochimiques induites chez la levure S. pombe par des radiations et des substances radiomimetiques . Abh. Dtsch. Akad. Wiss. Berlin Kl. Med. , : 193 – 196 .
  • Higginson , J. 1968 . Present trends in cancer epidemiology . Proc. Can. Cancer Res. Conf. , 8 : 40 – 75 .
  • Hine , C. H. , Guzman , R.J. , Coursey , M. M. , Wellington , J. S. and Anderson , H. H. 1958 . An investigation of the oncogenic activity of two representative epoxy resins . Cancer Res. , 18 : 20 – 26 .
  • Hite , M. , Rinehart , W. , Braun , W. and Peck , H. 1979 . Acute toxicity of methyl fluorosulfonate (Magic Methyl) . Am. Ind. Hyg. Assoc. J. , 40 : 600 – 603 .
  • Holland , J. M. , Gosslee , D. G. and Williams , N. J. 1979 . Epidermal carcinogenicity of bis(2,3‐epoxy‐cyclopentyl) ether, 2,2‐bis(p‐glycidyloxyphenyl)propane, and m‐phenylenediamine in male and female C3H and C57B1/6 mice . Cancer Res. , 39 : 1718 – 1725 .
  • Huberman , E. , Kuroki , T. , Marquardt , H. , Selkirk , J. K. , Heidelberger , C. , Grover , P. L. and Sims , P. 1972 . Transformation of hamster embryo cells by epoxides and other derivatives of polycyclic hydrocarbons . Cancer Res. , 32 : 1391 – 1396 .
  • Huberman , E. , Bartsch , H. and Sachs , L. 1975 . Mutation induction in Chinese hamster D‐79 cells by two vinyl chloride metabolites, chloroethylene oxide and 2‐chloroacetaldehyde . Int. J. Cancer , 16 : 639 – 644 .
  • Hueper , W. C. 1963 . Environmental carcinogenesis in man and animals . Ann. N.Y. Acad. Sci. , 108 : 963 – 1038 .
  • Hueper , W. C. 1969 . Occupational and Environmental Cancer of the Urinary System , New Haven, Conn. : Yale Univ. Press .
  • IARC . 1974a . Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man , vol. 4 , 259 – 269 . 276 – 281 . Lyon : International Agency for Research on Cancer .
  • IARC . 1974b . Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man , vol. 7 , 223 – 230 . Lyon : International Agency for Research on Cancer .
  • IARC . 1975 . Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man , vol. 9 , 37 – 46 . 47 – 49 . 61 – 65 . Lyon : International Agency for Research on Cancer .
  • IARC . 1976 . Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man , vol. 11 , 157 – 167 . 176 – 181 . 191 – 199 . 201 – 208 . Lyon : International Agency for Research on Cancer .
  • IARC . 1978 . Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man , vol. 17 , Lyon : International Agency for Research on Cancer .
  • Ikeda , M. and Imamura , L. 1974 . Evaluation of hippuric, phenyl glyoxylic and mandelic acids in urine as indicators of styrene exposure . Int. Arch. Arbeitsmed. , 32 : 93 – 101 .
  • Isakova , G. L. 1971 . A study of the mutagenic effect of chemical substances for hygienic standardization . Gig. Sanit. , 10 : 9 – 13 .
  • Izard , C. 1973 . Recherches sur les effets mutagenes de l'acrolein et de des duex epoxydes: Le glycidol et le glycidal, sur S. cerevisiae . C.R. Acad. Sci. Ser. D. , 276 : 3037 – 3040 .
  • Jensen , K. A. , Kirk , I. , Kolmark , G. and Westergaard , M. 1951 . Chemically induced mutations in Neurospora . Cold Spring Harbor Symp. Quant. Biol. , 16 : 245 – 261 .
  • Jerina , D. M. and Daly , J. W. 1974 . Arene oxides: A new aspects of drug metabolism . Science , 185 : 573 – 582 .
  • Jongen , W. M. F. , Alink , G. M. and Koeman , J. H. 1978 . Mutagenic effect of dichloromethane on Salmonella typhimurium . Mutat. Res. , 56 : 245 – 248 .
  • Kailos , G. J. and Solomon , R. A. 1973 . Investigation of the formation of bis(chloromethyl) ether in simulated hydrogen chloride‐formaldehyde atmospheric environments . Am. Ind. Hyg. Assoc. J. , 34 : 469 – 473 .
  • Kerst , A. F. 1974 . Toxicology of tris(2,3‐dibromopropyl) phosphate . J. Fire Flammability Fire Retardant Chem. (Suppl.) , 1 : 205 – 215 .
  • Kilbey , B. J. and Kolmark , H. G. 1968 . A mutagenic aftereffect associated with ethylene oxide in Neurospora crassa . Mol. Gen. Genet. , 101 : 185 – 188 .
  • Kleupfer , R. D. and Fairless , B. J. 1972 . Characterization of organic compounds in municipal water supply . Environ. Sci. Technol. , 6 : 1062 – 1063 .
  • Kolar , G. F. , Fahrig , R. and Vogel , E. 1974 . Structure activity dependence in some novel ring‐substituted 3,3'‐dimethyl‐1‐phenyltriazenes. Genetic effect in Drosophila and S. cerevisiae . Chem.‐Biol. Interact. , 9 : 365 – 371 .
  • Kolmark , G. 1956 . Mutagenic properties of esters of inorganic acids investigated by the Neurospora back mutation test . Ser. Physiol. , 26 : 205 – 220 .
  • Kolmark , G. and Giles , N. H. 1955 . Comparative studies of monoepoxides as inducers of reverse mutations in Neurospora . Genetics , 40 : 890 – 902 .
  • Kolmark , G. and Kilbey , B. J. 1968 . Kinetic studies of mutation induction by epoxides in. Neurospora crassa . Mol. Gen. Genet. , 401 : 89 – 98 .
  • Kortselius , M. J. H. 1979 . Induction of sex‐linked recessive lethals and autosomal translocations by beta‐propiolactone in Drosophila: Influence of the route of administration on mutagenic activity . Mutot. Res. , 66 : 55 – 63 .
  • Kriek , E. and Emmelot , P. 1964 . Methylation of deoxyribonucelic acid by diazomethane . Biochim. Biophys. Acta , 91 : 59 – 66 .
  • Krüger , F. W. , Preussmann , R. and Niepelt , N. 1973 . Mechanism of carcinogenesis by 1‐aryl‐3,3‐dialkyl‐triazenes. III. In vivo methylation of RNA and DNA with 1‐phenyl‐3,3‐14C‐dimethyl triazene . Biochem. Pharmacol. , 20 : 529 – 533 .
  • Kubinski , Z. O. and Kubinski , H. 1978 . Alterations in Bacillus subtilis transforming DNA induced by beta‐propiolactone and 1,3‐propane sultone, two mutagenic and carcinogenic alkylating agents . J. Bacteriol. , 136 : 854 – 866 .
  • Kucerova , M. , Zhurokov , V. S. , Polivkova , Z. and Ivanova , J. E. 1977 . Mutagenic effect of epichlorohydrin. II. Analysis of chromosomal aberrations in lymphocytes of persons exposed to epichlorohydrin . Mutat. Res. , 48 : 355 – 360 .
  • Lawley , P. D. 1976 . “ Carcinogenesis by alkylating agents ” . In Chemical Carcinogenesis , ACS Monogr. 173 Edited by: Searle , C. E. 83 – 244 . Washington, D.C. : American Chemical Society .
  • Lawley , P. D. and Jarman , N. 1972 . Alkylation by propylene oxide of deoxyribonucleic acid, adenine, guanosine and deoxyguanylic acid . Biochem. J. , 126 : 893 – 900 .
  • Leibman , K. C. 1975 . Metabolism and toxicity of styrene . Environ. Health Perspect. , 11 : 115 – 119 .
  • Leibman , H. C. and Ortiz , E. 1969 . Oxidation of styrene in liver microsomes . Biochem. Pharmacol. , 18 : 552 – 558 .
  • Lichtenberger , J. and Lichtenberger , R. 1948 . Sur les sulfates de diols . Bull. Soc. Chim. Fr. , 12 : 1002 – 1005 .
  • Linnainmaa , K. , Meretoja , T. , Sursa , M. and Vainio , H. 1978 . Cytogenetic effects of styrene and styrene oxide . Mutat. Res. , 58 : 277 – 286 .
  • Loprieno , N. , Abbondandolo , A. , Barale , R. Baroncelli , S. 1976 . Mutagenicity of industrial compounds: Styrene and its possible metabolite styrene oxide . Mutat. Res. , 40 : 317 – 324 .
  • Loveless , A. 1966 . Genetic and Allied Effects of Alkylating Agents , London : Butterworth .
  • Lowenheim , F. A. and Moran , M. K. 1975 . “ Epichlorohydrin ” . In Faith Keyes and Clark's Industrial Chemicals , 4th ed. , 335 – 338 . New York : Wiley .
  • Lynch , J. , Hanis , N. M. , Bird , M. G. , Murray , K. J. and Walsh , J. P. 1979 . An association of upper respiratory cancer with exposure to diethylsulfate . J. Occup. Med. , 21 : 333 – 341 .
  • Lyon , J. P. , Jenkins , L. J. , Jones , R. A. , Coon , R. A. and Siegel , J. 1970 . Repeated and continuous exposure of laboratory animals to acrolein . Toxicol. Appl. Pharmacol. , 17 : 726 – 732 .
  • Malaveille , C. , Bartsch , H. , Barbin , A. , Camus , A. M. and Montesano , R. 1975 . Mutagenicity of vinyl chloride, chloroethylene oxide, chloroacetaldehyde and chloroethanol . Biochem. Biophys. Res. Commun. , 63 : 363 – 370 .
  • Malaveille , C. , Kolar , G. F. and Bartsch , H. 1976 . Rat and mouse tissue‐mediated mutagenicity of ring‐substituted 3,3‐dimethyl‐1‐phenyltriazenes in Salmonella typhimurium . Mutat. Res. , 36 : 1 – 10 .
  • Marniemi , J. and Parkki , M. G. 1975 . Radiochemical assay of glutathione S‐epoxidetransferase and its enhancement by phenobarbital in vivo . Biochem. Pharmacol. , 24 : 1569 – 1572 .
  • Marquardt , H. , Schwaier , R. and Zimmermann , F. 1963 . Nicht‐mutagenitat von nitrosaminen bei Neurospora crassa . Naturwissenschaften , 50 : 135 – 140 .
  • Marquardt , H. , Zimmermann , F. K. and Schwaier , R. 1964 . The action of carcinogenic nitrosamines and nitrosamides on the adenine‐G‐45 reverse mutation system of S. cerevisiae . Z. Vererbungsl. , 95 : 82 – 96 .
  • Maugh , T. H. II . 1977 . Carcinogens in the workplace: Where to start cleaning up . Science , 197 : 1268 – 1269 .
  • Maugh , T. H. II . 1978a . Chemical carcinogens: The scientific basis for regulation . Science , 201 : 1200 – 1205 .
  • Maugh , T. H. II . 1978b . Chemicals: How many are there? . Science , 199 : 162
  • McCann , J. , Choi , E. , Yamasaki , J. and Ames , B. N. 1975a . Detection of carcinogens as mutagens in the Salmonella/microsome test: Assay of 300 chemicals . Proc. Natl. Acad. Sci. U.S.A. , 72 : 5135 – 5139 .
  • McCann , J. , Simmon , V. , Streitweiser , D. and Ames , B. N. 1975b . Mutagenicity of chloroacetaldehyde, a possible metabolic product of 1,2‐dichloroethane (ethylene dichloride), chloroethanol (ethylene chlorohydrin), vinyl chloride and cyclophosphamide . Proc. Natl. Acad. Sci. U.S.A. , 72 : 3190 – 3193 .
  • McCann , J. , Spingarn , N. E. , Kobori , J. and Ames , B. N. 1975c . Detection of carcinogens as mutagens: Bacterial tester strains with R‐factor plasmids . Proc. Natl. Acad. Sci. U.S.A. , 72 : 979 – 983 .
  • Meretoja , T. , Vainio , H. , Sorsa , M. and Härkönen , H. 1977 . Occupational styrene exposure and chromosomal aberrations . Mutat. Res. , 56 : 193 – 197 .
  • Meretoja , T. , Vainio , H. and Jarventaus , H. 1978 . Clastogenic effects of styrene exposure on bone marrow cells of rat . Toxicol. Lett. , 1 : 315 – 318 .
  • Miller , J. A. 1970 . Carcinogenesis by chemicals: An overview . Cancer Res. , 30 : 559 – 576 .
  • Miller , J. A. and Miller , E. C. 1975 . Metabolism and reactivity of chemical carcinogens . Mutat. Res. , 33 : 25 – 26 .
  • Milvy , P. and Grasso , A. J. 1976 . Mutagenic activity of styrene oxide (1,2‐epoxyethylbenzene) as presumed styrene metabolite . Mutat. Res. , 40 : 15 – 18 .
  • Mizrahi , I. J. and Emmelot , P. 1962 . The effect of cysteine on the metabolic changes produced by two carcinogenic N‐nitroso dialkylamines in rat liver . Cancer Res. , 22 : 339 – 343 .
  • Muir , W. R. 1976 . Prevention of occupational cancer–toward an integrated program of government action (discussion of part IV) . Ann. N.Y. Acad. Sci. , 271 : 491 – 495 .
  • Nakao , Y. and Auerbach , R. 1967 . Test of possible correlation between cross‐linking and chromosome breaking abilities of chemical mutagens . Z. Vererbungsl. , 92 : 457 – 461 .
  • Naumann , C. H. , Sparrow , A. H. and Schairer , L. A. 1976 . Comparative effects of ionizing radiation and two gaseous chemical mutagens on somatic mutation induction in one mutable and two non‐mutable clones of Tradescantia . Mutat. Res. , 38 : 53 – 70 .
  • NCI . Feb. 22–26 1976 . “ 4th Annual Collaborative Conference, Carcinogenesis Program ” . Feb. 22–26 , Orlando, Fla. : National Cancer Institute .
  • NCI . 1977 . Results of Bioassay with Tris , Bethesda, Md. : National Cancer Institute .
  • NCI . 1978a . Bioassay of 72‐Dichloroethane for Possible Carcinogenicity. DHEW Publ. (NIH)78–7305 , Bethesda, Md. : National Cancer Institute .
  • NCI . 1978b . Bioassay of Trimethylphosphate for Possible Carcinogenicity. DHEW Publ (NIH)78–1331 , Bethesda, Md. : National Cancer Institute .
  • Nelson , N. 1976 . The chloroethers–occupational carcinogenesis: A summary of laboratory and epidemiology studies . Ann. N.Y. Acad. Sci. , 271 : 81 – 90 .
  • Newsome , J. R. , Norman , V. and Keith , C. H. 1965 . Vapor phase analysis of tobacco smoke . Tob. Sci. , 9 : 102 – 110 .
  • NIOSH . 1976 . Criteria for a Recommended Standard: Occupational Exposure to Epichlorohydrin , Washington, D.C. : National Institute for Occupational Safety and Health .
  • NIOSH . 1978a . Criteria for a Recommended Standard: Occupational Exposure to Glycldyl Ethers. DHEW (NIOSH) Publ. 78–166
  • NIOSH . 1978b . Criteria for a Recommended Standard: Occupational Exposure to Glycidyl Ethers , Washington, D.C. : National Institute for Occupational Safety and Health .
  • NIOSH . 1978c . Current Intelligence Bulletin No. 29 Glycidyl Ethers , Washington, D.C. : National Institute for Occupational Safety and Health .
  • Nishioka , H. 1973 . Lethal and mutagenic action of formaldehyde, Hcr+ and Her– strains, E. coli . Mutat. Res. , 17 : 261 – 265 .
  • Nishioka , H. and Ohtani , H. 1978 . Mutagenicity of epoxide resins, constituents and commercial adhesives in bacterial test systems . Mutat. Res. , 54 : 247 – 248 .
  • NTP . 1979 . Agency Nominees for Compounds to be Tested under National Toxicology Program , Washington, D.C. : National Toxicology Program Executive Meeting .
  • Obe , G. and Beek , B. 1979 . Mutagenic activity of aldehydes . Drug Alcohol Dependence , 4 : 91 – 94 .
  • Obe , G. and Ristow , H. 1977 . Acetaldehyde, but not ethanol, induces sister chromatid exchanges in Chinese hamster cells in vitro . Mutat. Res. , 56 : 211 – 213 .
  • Obe , G. , Ristow , H. and Herha , J. 1977 . Alcohol Intoxication and Withdrawal , Edited by: Gross , M. M. vol. 3A , 47 – 70 . New York : Plenum .
  • Oesch , F. 1972 . Mammalian epoxyde hydrases–inducible enzymes catalyzing the inactivation of carcinogenic and cytotoxic metabolites derived from aromatic and olefinic compounds . Xenobiotica , 3 : 305 – 340 .
  • Oesch , F. 1976 . Metabolic transformation of clinically used drugs to epoxides: New perspectives in drug‐drug interactions . Biochem. Pharmacol. , 25 : 1935 – 1937 .
  • Ohtsuji , H. and Ikeda , M. 1970 . A rapid colorimetric method for the determination of phenylglyoxylic and mandelic acids. Its application to the urinalysis of workers exposed to styrene vapour . Br. J. Ind. Med. , 27 : 150 – 154 .
  • Ohtsuji , H. and Ikeda , M. 1971 . The metabolism of styrene in the rat and the stimulatory effect of phenobarbital . Toxkol. Appl. Pharmacol. , 18 : 321 – 326 .
  • Ong , T. M. and DeSerres , F. J. 1971 . The mutagenicity of 1‐phenyl‐3,3‐dimethyltriazene and 1‐phenyl‐3‐monomethyltriazene in . Neurospora crassa. Mutat. Res. , 13 : 276
  • Ong , T. M. and De Serres , F. J. 1973a . Genetic characterization of ad‐3 mutants induced by chemical mutagens, 1‐phenyl‐3‐monomethyltriazene and 1‐phenyl‐3,3‐dimethyltriazene, in Neurospora crassa . Mutat. Res. , 20 : 17 – 23 .
  • Ong , T. M. and De Serres , F. J. 1973b . The mutagenicity of 1‐phenyl‐3,3‐dimethyl triazene and 1‐phenyl‐3‐monomethyltriazene in Neurospora crassa . Mutat. Res. , 18 : 251 – 255 .
  • OSHA . 1973 . Code of Federal Regulations , 21 Washington, D.C. : Government Printing Office . title 29, pt. 1910.23
  • Osterberg , R. E. , Bierbower , G. W. and Hehir , R. M. 1977 . Renal and testicular damage following dermal application of the flame retardant tris(2,3‐dibromopropyl) phosphate . J. Toxicol. Environ. Health , 3 : 979 – 987 .
  • Osterman‐Golkar , S. and Wachtmeister , C. A. 1976 . On the reaction kinetics in water of 1,3‐propane sultone and 1,4‐butane sultone: A comparison of reaction rates and mutagenic activity of some alkylating agents . Chem.‐Blol. Interact. , 14 : 195 – 198 .
  • Parkki , M. G. , Marniemi , J. and Vainio , H. 1976 . Action of styrene and its metabolites styrene oxide and styrene glycol on activities of xenobiotic biotransformation enzymes in rat liver in vivo . Toxicol. Appl. Pharmacol. , 38 : 59 – 70 .
  • Pelacanos , M. and Alderson , T. 1964 . The mutagenic action of diethyl sulfate in Drosophila melanogaster. I. The dose‐mutagenic response to larval and adult feeding . Mutat. Res. , 1 : 173 – 177 .
  • Pelofsky , A. H. 1972 . Propylene‐sulfuric acid reaction . Ind. Eng. Chem. Prod. Res. Dew. , 11 (2) : 21 – 24 .
  • Picciano , D. 1979 . Cytogenetic investigation of occupational exposure to epichlorohydrin . Mutat. Res. , 66 : 169 – 173 .
  • Plant , S. G. P. and Sidgwick , N. V. 1921 . The absorption of ethylene and propylene by sulfuric acid . J. Soc. Chem. Ind. London , 40 : 14T
  • Poirier , L. A. , Stoner , G. D. and Shimkin , M. B. 1975 . Bioassays of alkyl halides and nucleotide base analogs by pulmonary tumor response in strain A mice . Cancer Res. , 35 : 1411 – 1415 .
  • Poppe , E. J. 1969 . Sensibilizierungsfarbstoffe mit sauren substituenten . Z. Wiss. Photogr. Photophys. Photochem. , 63 : 149 – 152 .
  • Powers , M B. , Voelker , W. , Page , N. P. , Weisburger , E. K. and Kraybill , H. F. 1975 . Carcinogenicity of ethylene dibromide (EDB) and 1,2‐dibromo‐3‐chloropropane (DBCP) . Toxicol. Appl. Pharmacol. , 33 : 171 – 172 .
  • Preussmann , R. and von Hodenberg , A. 1970 . Mechanism of carcinogenesis with 1‐aryl‐3,3‐dialkyl‐triazenes. II. In vitro alkylation of guanosine, RNA and DNA with aryl‐monoalkyltriazenes to form 7‐alkylguanine . Biochem. Pharmacol. , 19 : 1505 – 1508 .
  • Preussman , R. , Druckrey , H. , Ivankovic , S. and von Hodenberg , A. 1969a . Chemical structure and carcinogenicity of aliphatic hydrazo, azo, and azoxy compounds and of triazenes, potential in vivo alkylating agents . Ann. N.Y. Acad. Sci. , 163 : 697 – 716 .
  • Preussmann , R. , von Hodenberg , A. and Hengy , H. 1969b . Mechanism of carcinogenesis with 1‐aryl‐3,3‐dialkyltriazenes, enzymatic dealkylation by rat liver microsomal fraction in vitro . Biochem. Pharmacol. , 18 : 1 – 13 .
  • Preussmann , R. , Ivankovic , S. , Landschutz , C. , Gimmy , J. , Flohr , E. and Griesbach , U. 1974 . Carcinogene Wirkung von 13 aryldialkyl triazenen an BD‐ratten . Z. Krebsforsch. , 81 : 285 – 310 .
  • Privai , M. J. , McCoy , E. C. , Gutter , B. and Rosenkranz , H. S. 1977 . Tris(2,3‐dibromopropyl) phosphate: Mutagenicity of a widely used flame retardant . Science , 195 : 76 – 78 .
  • Pullin , T. and Legator , M. S. 1977 . “ Integrated mutagenicity testing program ” . In Report submitted to NIOSH by Dow Chemical Co , Midland, Mich. : Health and Environmental Research .
  • Purchase , I. F. H. , Longstaff , E. , Ashby , J. , Styles , J. A. , Anderson , D. , Leferre , P. A. and Westwood , F. R. 1978 . An evaluation of 6 short‐term tests for detecting organic chemical carcinogens . Br. J. Cancer , 37 : 873 – 948 .
  • Rannug , U. , Gothe , R. and Wachtmeister , C. A. 1976 . The mutagenicity of chloroethylene oxide, chloroacetaldehyde, 2‐chloroethanol and chloroacetic acid, conceivable metabolites of vinyl chloride . Chem.‐Biol. Interact. , 12 : 251 – 263 .
  • Rapoport , I. A. 1948a . Action of ethylene oxide, glycides and glycols on genetic mutations . Dokl. Akad. Nauk SSSR , 60 : 469 – 472 .
  • Rapoport , I. A. 1948b . Alkylation of the gene molecule . Dokl. Akad. Nauk SSSR , 59 : 1183 – 1186 .
  • Rapoport , I. A. 1948c . Mutations under the influence of unsaturated aldehydes . Dokl. Akad. Nauk. SSSR , 61 : 713 – 715 .
  • Ristow , H. and Obe , G. 1978 . Acetaldehyde induces cross‐links in DNA and causes sister‐chromatid exchanges in human cells . Mutat. Res. , 58 : 115 – 119 .
  • Rohm & Haas Co . 1972 . Reactions of formaldehyde and HCI form Bis‐CME . News release , Dec. 27
  • Rosen , A. A. , Sheel , R. T. and Ettinger , M. B. 1963 . Relationship of river water to specific organic contaminants . J. Water Pollut. Control. Fed. , 35 : 777 – 782 .
  • Rosenkranz , H. S. 1972 . Formaldehyde as a possible carcinogen . Bull. Environ. Contam. Toxicol. , 8 : 242 – 248 .
  • Rosenkranz , H. S. 1977 . Mutagenicity of halogenated olefins and their derivatives . Environ. Health Perspect. , 21 : 79 – 84 .
  • Rosenkranz , H. S. and Wlodkowski , T. J. 1974 . Mutagenicity of ethylene chlorohydrin, a degradation product present in foodstuffs exposed to ethylene oxide . J. Agric. Food Chem. , 22 : 407 – 409 .
  • Rosenkranz , S. , Carr , H. S. and Rosenkranz , H. S. 1974 . 2‐Haloethanols: Mutagenicity and reactivity with DNA . Mutat. Res. , 26 : 367 – 370 .
  • Rudali , G. , Apiou , F. , Boyland , E. and Castegnaro , M. 1976 . A propos de l'action canceriegene de la gamma‐butyrolactone chez les souris . C.R. Acad. Sci. , 282 : 799 – 802 .
  • Schalet , A. 1954 . “ The mutagenic action of 1,2‐propylene oxide and ethyl sulfate on mature sperm ” . In Drosophila Information Service 28 Part 2: Notes Bibliography Directory , 155 Eugene, Ore. : Univ. of Oregon .
  • Schmid , W. 1975 . The micronucleus test . Mutat. Res. , 31 : 9 – 15 .
  • Schoental , R. and Magee , P. N. 1960 . Induction of squamous carcinoma of the lung and of the stomach and esophagus by diazomethane and N‐methyl‐N‐nitroso urethan, respectively . Br. J. Cancer , 186 : 420 – 422 .
  • Schöneich , J. 1976 . Safety evaluation based on microbial assay procedures . Mutat. Res. , 41 : 89 – 93 .
  • Schwaier , R. , Zimmermann , F. K. and von Laer , U. 1965 . The effect of temperature on the mutation induction in yeast by N‐alkyl nitrosamides and nitrous acid . Z. Vererbungsl. , 97 : 72 – 74 .
  • Selikoff , I. J. and Hammond , E. C. Environmental cancer in the year 2000 . Presented at the 7th National Cancer Conference . Sept. 29 , Los Angeles.
  • Semenova , V. N. 1971 . The toxicological characteristics of ethylene chlorohydrin in air of working areas . Gig. Sanit. , 36 : 37 – 40 .
  • Shackelford , W. M. and Keith , L. H. 1976 . Frequency of Organic Compounds Identified in Water , EPA. 600/4–76–062 214 Athens, Ga. : Environmental Protection Agency .
  • Shamberger , R. J. , Corlett , C. L. , Beaman , K. D. and Kasten , B. L. 1979 . Antioxidants reduce the mutagenic effect of malonaldehyde and beta‐propiolactone. IX. Antioxidants and Cancer . Mutat. Res. , 66 : 349 – 355 .
  • Simmon , V. 1979 . In vitro assays for recombinogenic activity of chemical carcinogens and related compounds with Saccharomyces cerevlsiae . J. Natl. Cancer Inst. , 62 : 901 – 909 .
  • Simmon , V. F. , Kauhanen , K. and Tardiff , R.G. 1977 . “ Mutagenic activity of chemicals identified in drinking water ” . In Progress in Genetic Toxicology , Edited by: Scott , D. , Bridges , B. A. and Sobels , F. H. 249 – 256 . Amsterdam : Elsevier/North‐Holland and Biomedical .
  • Smith , H. H. and Srb , A. M. 1957 . Induction of mutations with beta‐propiolactone . Science , 114 : 490 – 492 .
  • Sorin , B. 1974 . Health Hazards from Epoxy , Edited by: Ehrner , S. and Sjoholm , O. 6 – 10 . Stockholm : Arbetarskyddsstyrelen .
  • Sram , R. , Cerna , M. and Kucerova , M. 1976 . The genetic risk of epichlorohydrin as related to the occupational exposure . Biol. Zbl. , 95 : 451 – 462 .
  • SRI . 1977 . A Study of Industrial Data on Candidate Chemicals for Testing , EPA‐560/5–77–066 4 – 29 . 4 – 31 . Menlo Park, Calif. : Stanford Research Inst .
  • Stoltz , D. R. and Withey , R. J. 1977 . Mutagenicity testing of styrene and peroxide in Salmonella typhimurium . Bull. Environ. Contam. Toxicol. , 17 : 739 – 742 .
  • Strauss , B. and Okubo , S. 1960 . Protein synthesis and the induction of mutations in E. coli by alkylating agents . J. Bacteriol. , 79 : 464 – 470 .
  • Streklova , E. E. 1975 . Mutagenic effect of ethylene oxide on reproductive and somatic cells in male white rats . Toksikol. Nov. Prom. Khim. Veshchestv , 14 : 11 – 16 .
  • Swern , D. , Wieder , R. , McDonough , M. , Meranze , D. R. and Shimkin , M. B. 1970 . Investigations of fatty acids and derivatives for carcinogenic activity . Cancer Res. , 30 : 1037 – 1046 .
  • Testa , B. and Jenner , P. 1976 . Drug Metabolism: Chemical and Biochemical Aspects , 56 – 61 . New York : Dekker .
  • Thomas , H. F. , Brown , D. L. , Hartman , P. E. , White , E. H. and Hartman , Z. 1979 . Aryl‐monoalkyl and cyclic triazenes: Direct acting mutagens . Mutat. Res. , 60 : 25 – 32 .
  • Tomatis , L. 1976 . The IARC program on the evaluation of the carcinogenic risk of chemicals to man . Ann. N.Y. Acad. Sci. , 271 : 296
  • Torkelson , T. R. , Sadek , S. E. , Rowe , V. K. , Kodama , J. K. , Anderson , H. H. , Loquvam , G. S. and Hine , C. H. 1961 . Toxicological investigations of l,2‐dibromo‐3‐chloropropane . Toxicol. Appl. Pharmacol. , 3 : 545 – 559 .
  • Train , R. E. 1977 . Environmental cancer . Science , 195 : 443
  • Ulland , U. B. , Finkelstein , B. M. , Weisburger , E. K. , Rice , J. M. and Weisburger , J. H. 1971 . Carcinogenicity of industrial chemical propyleneimine and propane sultone . Nature (Lond.) , 230 : 460 – 461 .
  • U.S. Tariff Commission . 1964 . Synthetic Organic Chemicals U.S. Production and Sales (annual) , Washington, D.C. : Government Printing Office . 1974
  • Vainio , H. 1978 . Vinyl chloride and vinyl benzene (styrene)–metabolism, mutagenicity and carcinogenicity . Chem.‐Biol. Interact. , 22 : 117 – 124 .
  • Vainio , H. , Paakkonen , R. , Ronnholm , K. , Raunio , V. and Pelkonen , O. 1976 . A study on the mutagenic activity of styrene and styrene oxide . Scand. J. Work. Environ. Health , 3 : 147 – 151 .
  • Van Duuren , B. L. 1969 . Carcinogenic epoxides, lactones and halo‐ethers and their mode of action . Ann. N.Y. Acad. Sci. , 163 : 633 – 651 .
  • Van Duuren , B. L. and Goldsmith , B. M. 1966 . Carcinogenicity of epoxides, lactones and peroxy compounds. III. Biological activity and chemical reactivity . J. Med. Chem. , 9 : 77 – 83 .
  • Van Duuren , B. L. , Orris , L. and Nelson , N. 1965 . Carcinogenicity of epoxides, lactones and peroxy compounds. II . J. Natl. Cancer Inst. , 35 : 707 – 717 .
  • Van Duuren , B. L. , Langseth , L. , Orris , L. , Teebor , G. , Nelson , N. and Kushner , M. 1966 . Carcinogenicity of epoxides, lactones and peroxy compounds. IV. Tumor response in epithelial and connective tissues in mice and rats . J. Natl. Cancer Inst. , 37 : 825 – 834 .
  • Van Duuren , B. L. , Langseth , L. , Goldschmidt , B. M. and Orris , L. 1967a . Carcinogenicity of epoxides, lactones, and peroxy compounds. VI. Structure and carcinogenic activity . J. Natl. Cancer Inst. , 39 : 1217 – 1225 .
  • Van Duuren , B. L. , Langseth , L. , Orris , L. , Baden , M. and Kushner , M. 1967b . Carcinogenicity of epoxides, lactones and peroxy compounds. V. Subcutaneous injection in rats . J. Natl. Cancer Inst. , 39 : 113 – 1216 .
  • Van Duuren , B. L. , Goldschmidt , B. M. , Katz , C. , Langseth , L. , Mercado , C. and Sivak , A. 1968 . Alpha‐haloethers: A new type of alkylating carcinogen . Arch. Environ. Health , 16 : 472 – 476 .
  • Van Duuren , B. L. , Melchionne , S. , Blair , R. , Goldschmidt , B. M. and Katz , C. 1971 . Carcinogenicity of isoesters and epoxides and lactones: Aziridine ethanol, propane sultone and related compounds . J. Natl. Cancer Inst. , 46 : 143 – 150 .
  • Van Duuren , B. L. , Katz , C. , Goldschmidt , B. M. , Frenkel , K. and Sivak , A. 1972 . Carcinogenicity of haloethers. II. Structure‐activity relationships of analogs of bis(chloromethyl) ether . J. Natl. Cancer Inst. , 48 : 1431 – 1439 .
  • Van Duuren , B. L. , Goldschmidt , B. M. , Katz , C. , Seidman , I. and Paul , J. C. 1974 . Carcinogenic activity of alkylating agents . J. Natl. Cancer Inst. , 53 : 695 – 700 .
  • Vogel , E. 1971 . Chemische konstitution and mutagene Wirkung. VI. Induktion dominanter und rezessiv‐geschlechts‐gebundener letalmutationen durch aryldialkyltriazene bei Drosophila melanogaster . Mutat. Res. , 11 : 397 – 410 .
  • Vogel , E. and Chandler , J. L. R. 1974 . Mutagenicity testing of cyclamate and some pesticides in Drosophila malanogaster . Experientia , 30 : 621 – 623 .
  • Vogel , E. , Fahrig , R. and Obe , G. 1973 . Triazenes, a new group of indirect mutagens, comparative investigations of the genetic effects of different aryl dialkyl triazenes using S. cerevisiae, the host‐mediated assay, Drosophila melanogaster and human chromosomes in vitro . Mutat. Res. , 21 : 123 – 136 .
  • Voogd , C. E. 1973 . Mutagenic action of epoxy compounds and several alcohols . Mutat. Res. , 21 : 52 – 53 .
  • Vouk , V. B. 1976 . Introductory statement. WHO‐NIEHS Symposium on Potential Health Hazards from Technological Developments in Plastic and Synthetic Rubber Industries, Research Triangle Park, N.C. . Environ. Health Perspect. , 17 : 1 – 2 .
  • Wade , D. R. , Airy , S. C. and Sinsheimer , J. E. 1978 . Mutagenicity of aliphatic epoxides . Mutat. Res. , 58 : 217 – 223 .
  • Wade , M. J. and Moyer , J. 1976 . The mutagenicity of epoxides . Fed. Proc. , 35 : 404
  • Wade , M. J. , Moyer , J. W. and Hine , C. H. 1978 . Mutagenic action of a series of epoxides , Publ. 78–2 San Francisco : Univ. of California School of Medicine .
  • Wade , M. J. , Moyer , J. W. and Hine , C. H. 1979 . Mutagenic action of a series of epoxides . Mutat. Res. , 66 : 367 – 371 .
  • Wang , I. Y. , Rasmussen , R. E. and Crooker , T. T. 1972 . Isolation and characterization of an active DNA‐binding metabolite of benzo(a)pyrene from hamster liver microsomal incubation systems . Biochem. Biophys. Res. Commun. , 49 : 1142 – 1149 .
  • Weil , C. S. , Smyth , H. F. Jr. and Nale , T. W. 1952 . Quest for a suspected industrial carcinogen . Arch. Ind. Hyg. Occup. Med. , 5 : 535 – 547 .
  • Weil , C. S. , Condra , N. , Haun , C. and Striegel , J. A. 1963 . Experimental carcinogenicity and acute toxicity of representative epoxides . Am. Ind. Hyg. Assoc. J. , 24 : 305 – 325 .
  • Weinhouse , S. 1977 . “ Problems in the assessment of human risk of carcinogenesis by chemicals ” . In Origins of Human Cancer , Edited by: Hiatt , H. H. , Watson , J. D. , Winsten , J. A. and Book , C. 1307 – 1310 . Cold Spring Harbor, New York : Cold Spring Harbor Laboratory .
  • Weisburger , J. H. 1976 . “ Bioassays and tests for chemical carcinogens ” . In Chemical Carcinogenesis , Edited by: Searle , C. E. 1 – 23 . Washington, D.C. : American Chemical Society .
  • Weisburger , J. H. and Williams , G. M. 1975 . “ Metabolism of chemical carcinogens ” . In Cancer , Edited by: Becker , F. F. 185 – 234 . New York : Decker .
  • Wesley , F. , Rourke , B. and Darbishire , O. 1965 . The formation of persistent toxic chlorohydrins in foodstuffs by fumigation with ethylene oxide and with propylene oxide . J. Food Sci. , 30 : 1037 – 1042 .
  • White , E. H. and Scherrer , H. 1961 . The triazene method for the deamination of aliphatic amines . Tetrahedron Lett. , : 758 – 762 .
  • White , E. H. , Maskill , H. , Woodcock , D. J. and Schroeder , M. A. 1969 . Carbonium ions formed in the triazene method of deamination . Tetrahedron Lett. , : 1713 – 1716 .
  • WHO . 1964 . Prevention of cancer . WHO Tech. Rep. Ser. , : 276
  • WHO . 1972 . Health Hazard of the Human Environment , 213 – 323 . Geneva : World Health Organization .
  • Willson , J. E. 1970 . Ethylene oxide sterilant residues . Bull. Parenter. Drug. Assoc. , 24 : 226 – 234 .
  • Winell , M. A. 1975 . An international comparison of hygienic standards for chemicals in the work environment . Ambio , 4 : 34 – 36 .
  • Withey , J. R. 1977 . “ Mutagenic, carcinogenic and teratogenic hazards arising from human exposure to plastics additives ” . In Origins of Human Cancer , Edited by: Hiatt , H. H. , Watson , J. D. and Winsten , J. A. 219 – 242 . Cold Spring Harbor, New York : Cold Spring Harbor Laboratory . book A
  • Wood , A. S. , Goode , R. L. , Chang , R. L. , Levin , W. Conney , A. H. 1975 . Mutagenic and cytotoxic activity of benzo(a)pyrene 4,5‐, 7,8‐, and 9, 10‐oxides and the six corresponding phenols . Proc. Natl. Acad. Sci. U.S.A. , 72 : 3176 – 3180 .
  • Zdzienicka , M. , Tudek , B. , Zielenska , M. and Szymczyk , T. 1978 . Mutagenic activity of furfural in Salmonella typhimurium TA100 . Mutat. Res. , 58 : 205 – 209 .
  • Zeldin , P. E. , Bhattacharaya , P. D. , Kubinski , H. and Nietert , W. C. 1975 . Macromolecular complexes produced by 1,3‐propane sultone . Cancer Res. , 35 : 1445 – 1457 .

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