The effects of a cocarcinogen, ferric oxide, on the metabolism of benzo[a]pyrene in the isolated perfused lung

References

• Anderson , M. W. and Eling , T. E. 1976 . Studies on the uptake, metabolism and release of endogenous and exogenous chemicals by use of the isolated perfused lung . Environ. Health Perspect. , 16 : 77 – 81 .
   PubMed Web of Science ®Google Scholar
• Autrup , H. , Harris , C. C. , Schafer , P. W. , Trump , B. F. , Stoner , G. D. and Hsu , I. C. 1979 . Uptake of benzo(a)pyrene‐ferric oxide particulates by human pulmonary macrophages and release of benzo(a)pyrene and its metabolites . Proc. Soc. Exp. Biol. Med. , 161 : 280 – 284 .
   PubMed Web of Science ®Google Scholar
• Badger , G. M. 1962 . Mode of formation of carcinogens in human environment . Natl. Cancer Inst. Monogr. , 9 : 1 – 16 .
   PubMedGoogle Scholar
• Bingham , E. , Niemeier , R. W. and Reid , J. B. 1976 . Multiple factors in carcinogenesis . Ann. N.Y. Acad. Sci. , 271 : 14 – 21 .
   PubMed Web of Science ®Google Scholar
• Butler , J. D. and Crossley , P. 1981 . Reactivity of polycyclic aromatic hydrocarbons adsorbed on soot particles . Atmos. Environ. , 15 : 91 – 94 .
   Google Scholar
• Cohen , G. M. and Moore , B. P. 1976 . Metabolism of (3H) benzo(a)pyrene by different portions of the respiratory tract . Biochem. Pharmacol. , 25 : 1623 – 1629 .
   PubMed Web of Science ®Google Scholar
• Creasia , D. A. , Poggenburg , J. K. Jr. and Nettesheim , P. 1976 . Elution of benzo(a)pyrene from carbon particles in the respiratory tract of mice . J. Toxicol. Environ. Health , 1 : 967 – 975 .
   PubMed Web of Science ®Google Scholar
• Feron , V. J. , DeJong , D. and Rijk , M. A. H. 1976 . Clearance of benzo(a)pyrene from the respiratory tract of hamster following its intratracheal instillation with or without ferric oxide . Zentralbl. Bakteriol. [Orig.] , 163 : 441 – 447 .
   PubMedGoogle Scholar
• Feron , V. J. , Huevel , V. D. , Köeter , H. B. W. M. and Beems , R. B. 1980 . Significance of particle size of benzo(a)pyrene for the induction of respiratory tract tumors in hamsters . Int. J. Cancer , 25 : 301 – 307 .
   PubMed Web of Science ®Google Scholar
• Grover , P. L. , Hewer , A. and Sims , P. 1972 . Formation of K‐region epoxides as microsomal metabolites of pyrene and benzo(a)pyrene . Biochem. Pharmacol. , 21 : 2713 – 2726 .
   PubMed Web of Science ®Google Scholar
• Grover , P. L. , Hewer , A. , Pal , K. and Sims , P. 1976 . The involvement of a diol‐epoxide in the metabolic activation of benzo(a)pyrene in human bronchial mucosa and in mouse skin . Int. J. Cancer , 18 : 1 – 6 .
   PubMed Web of Science ®Google Scholar
• Harris , C. C. , Hsu , I. C. , Stoner , G. D. , Trump , B. F. and Selkirk , J. 1978 . Human pulmonary alveolar macrophages metabolize benzo(a)pyrene to proximate and ultimate mutagens . Nature (Lond.) , 272 : 633 – 634 .
   PubMed Web of Science ®Google Scholar
• Henry , M. C. , Port , C. D. and Kaufman , D. G. 1975 . Importance of physical properties of benzo(a)‐pyrene‐ferric oxide mixtures in lung tumor induction . Cancer Res. , 35 : 207 – 217 .
   PubMed Web of Science ®Google Scholar
• Jeffrey , A. M. , Jennette , K. W. , Blobstein , S. H. , Weinstein , I. B. , Beland , F. A. , Harvey , R. G. , Kasai , H. , Miura , I. and Nakanishi , K. 1976 . Benzo(a)pyrene nucleic acid derivative found in vivo: Structure of benzo(a)pyrene tetrahydrodiol epoxide‐guanosine adduct . J. Am. Chem. Soc. , 98 (19) : 5714 – 5715 .
   PubMed Web of Science ®Google Scholar
• Kobayashi , H. and Okamoto , T. 1974 . Effect of lead oxide on the induction of lung tumors in Syrian hamsters . J. Natl. Cancer Inst. , 52 : 1605 – 1610 .
   PubMed Web of Science ®Google Scholar
• Korfmacher , W. A. , Wehry , E. L. , Mamantov , G. and Natusch , D. F. S. 1980 . Resistance to photochemical decomposition of polycyclic aromatic hydrocarbon vapor‐adsorbed on coal fly ash . Environ. Sci. Technol. , 14 : 1094 – 1099 .
   Web of Science ®Google Scholar
• Lake , B. G. , Hopkins , R. , Chakraborty , J. , Bridges , J. W. and Parke , D. V. W. 1973 . The influence of hepatic enzyme inducers and inhibitors on extrahepatic drug metabolism . Drug Metab. Dispos. , 1 : 342 – 249 .
   PubMed Web of Science ®Google Scholar
• Lubawy , W. C. and Isaac , R. S. 1980a . Acute tobacco smoke exposure alters the profile of metabolites produced from benzo(a)pyrene by the isolated perfused rabbit lung . Toxicology , 18 : 37 – 47 .
   PubMed Web of Science ®Google Scholar
• Lubawy , W. C. and Isaac , R. S. 1980b . Influence of pretreatment with tobacco smoke condensate or 3‐methylcholanthrene on (14C) benzo(a)pyrene metabolism in the isolated perfused rabbit lung . Toxicol. Lett. , 7 : 153 – 157 .
   PubMed Web of Science ®Google Scholar
• Lubawy , W. C. and Perrier , D. G. 1980 . The effect of acute tobacco smoke exposure on pulmonary benzo(a)pyrene metabolism . Environ. Res. , 21 : 438 – 445 .
   PubMed Web of Science ®Google Scholar
• Meehan , T. , Straub , K. and Calvin , M. 1976 . Elucidation of hydrocarbon structure in enzyme‐catalyzed benzo(a)pyrene poly G covalent complex . Proc. Natl. Acad. Sci. U.S.A. , 73 : 1437 – 1441 .
   PubMed Web of Science ®Google Scholar
• Mehendale , H. M. , Angevine , L. S. and Ohmiya , Y. 1981 . The isolated perfused lung: A critical evaluation . Toxicology , 21 : 1 – 16 .
   PubMed Web of Science ®Google Scholar
• Mitchell , C. E. 1982 . Distribution and retention of benzo(a)pyrene in rats after inhalation . Toxicol. Lett. , 11 : 35 – 42 .
   PubMed Web of Science ®Google Scholar
• National Academy of Sciences . 1972 . Particulate Polycyclic Organic Matter Washington, D.C.
   Google Scholar
• Niemeier , R. W. 1976 . Isolated perfused rabbit lung: A critical appraisal . Environ. Health Perspect. , 16 : 67 – 71 .
   PubMed Web of Science ®Google Scholar
• Niemeier , R. W. and Bingham , E. 1972 . An isolated perfused lung preparation for metabolic studies . Life Sci. , 11 : 807 – 820 .
   Web of Science ®Google Scholar
• Perera , F. 1981 . Carcinogenicity of airborne fine particulate benzo(a)pyrene: An appraisal of the evidence and the need for control . Environ. Health Perspect. , 42 : 163 – 181 .
   PubMed Web of Science ®Google Scholar
• Roth , J. A. 1979 . “ Use of the isolated perfused lung in biochemical toxicology ” . In Reviews in Biochemical Toxicology , Edited by: Hodgson , E. , Bend , J. R. and Philpot , R. N. 287 – 309 . Amsterdam : Elsevier/North Holland .
   Google Scholar
• Saffiotti , U. , Montesano , R. , Sellakumar , A. R. , Cefis , F. and Kaufman , D. G. 1972 . Respiratory tract carcinogenesis in hamsters induced by benzo(a)pyrene and ferric oxide . Cancer Res. , 32 : 1073 – 1981 .
   PubMed Web of Science ®Google Scholar
• Schoeny , R. and Warshawsky , D. 1983 . Mutagenicity of benzo(a)pyrene metabolites generated on the isolated perfused lung following particulate exposure . Teratogen. Carcinogen. Mutagen. , 3 : 151 – 162 .
   PubMedGoogle Scholar
• Sellakumar , A. , Stenbäck , F. and Rowlands , J. 1976 . Effects of different dusts on respiratory carcinogenesis in hamsters induced by benzo(a)pyrene and diethylnitrosamine . Eur. J. Cancer Inst. , 32 : 313 – 319 .
   Google Scholar
• Serabjit‐Singh , C. J. , Wolf , C. R. , Philpot , R. M. and Plopper , C. G. 1980 . Cytochrome P‐450: Localization in rabbit lung . Science , 207 : 1469 – 1470 .
   PubMed Web of Science ®Google Scholar
• Silverberg , E. 1981 . Cancer statistics . Ca‐Cancer Journal for Clinicians , 31 : 12 – 28 .
   Web of Science ®Google Scholar
• Smith , B. R. , Philpot , R. M. and Bend , J. R. 1978 . The metabolism of benzo(a)pyrene by the isolated perfused rabbit lung . Drug Metab. Dispos. , 6 : 425 – 431 .
   PubMed Web of Science ®Google Scholar
• Smith , B. R. , Plummer , J. L. , Ball , L. M. and Bend , J. R. 1980 . Characterization of pulmonary arene oxide biotransformation using perfused rabbit lung . Cancer Res. , 40 : 101 – 106 .
   PubMed Web of Science ®Google Scholar
• Stenback , F. and Rowland , J. 1978 . Role of particle size in the formation of respiratory tract tumors induced by benzo(a)pyrene . Eur. J. Cancer , 14 : 321 – 326 .
   PubMed Web of Science ®Google Scholar
• Stenback , F. , Sellakumar , A. and Shubik , P. 1975 . Magnesium oxide as carrier dust in benzo(a)‐pyrene‐induced carcinogenesis Syrian hamsters . J. Natl. Cancer Inst. , 54 : 861 – 867 .
   PubMedGoogle Scholar
• Stoner , G. D. , Harris , C. C. , Autrup , H. , Trump , B. F. , Kingsbury , E. W. and Myers , G. A. 1978 . Explant culture of human peripheral lung. I. Metabolism of benzo(a)pyrene . Lab. Invest. , 38 (6) : 685 – 692 .
   PubMed Web of Science ®Google Scholar
• Thorgeiorsson , S. S. and Nebert , D. W. 1977 . “ The Ah locus and the metabolism of chemical carcinogens and other foreign compounds ” . In Advances in Cancer Research , Edited by: Klein , G. and Weinhouse , S. vol. 24 , 149 – 193 . New York : Academic .
   Google Scholar
• Ueng , T. H. and Alvares , A. P. 1982 . Pulmonary cytochromes P‐450 from rabbits treated with 3‐methylcholanthrene . Mol. Pharmacol. , 22 : 221 – 228 .
   PubMed Web of Science ®Google Scholar
• Vainio , H. , Uotila , P. , Hartiala , S. and Pelkomen , O. 1976 . The fate of intratracheally installed benzo(a)pyrene in the isolated perfused rat lung of both control and 20‐methycholanthrene pretreated rats . Res. Commun. Chem. Pathol. Pharmacol. , 13 : 259 – 271 .
   PubMedGoogle Scholar
• Vesell , E. S. , Lang , C. M. , White , W. J. , Passananti , G. T. and Tripp , S. L. 1973 . Hepatic drug metabolism in rats: Impairment in dirty environment . Science , 179 : 896 – 897 .
   PubMed Web of Science ®Google Scholar
• Warshawsky , D. and Myers , B. L. 1981 . The metabolism of 7‐H‐dibenzo(c,g)carbazole, an N‐hetero‐cyclic aromatic in the isolated perfused lung . Cancer Lett. , 12 : 153 – 159 .
   PubMed Web of Science ®Google Scholar
• Warshawsky , D. , Bingham , E. and Niemeier , R. W. 1980 . The effects of N‐dodecane pretreatment on the metabolism and distribution of benzo(a)pyrene in the isolated perfused lung . Life Sci. , 27 : 1827 – 1837 .
   PubMed Web of Science ®Google Scholar
• Warshawsky , D. , Niemeier , R. W. and Bingham , E. 1981 . The influence of SO2 on the metabolism and distribution of benzo(a)pyrene in the isolated perfused rabbit lung . J. Toxicol. Environ. Health , 7 : 1001 – 1024 .
   PubMed Web of Science ®Google Scholar
• Warshawsky , D. , Niemeier , R. W. and Bingham , E. 1983 . Influence of airborne particulate on the metabolism of benzo(a)pyrene in the isolated perfused lung . J. Toxicol. Environ. Health , 11 : 503 – 517 .
   PubMed Web of Science ®Google Scholar
• Wislocki , P. G. , Wood , A. W. , Chang , R. L. , Levin , W. , Yagi , H. , Hernandez , O. , Jerina , D. M. and Conney , A. H. 1976 . High mutagenicity and toxicity of a diol epoxide derived from benzo(a)‐pyrene . Biochem. Biphys. Res. Commun. , 68 (31) : 1006 – 1012 .
   PubMed Web of Science ®Google Scholar
• Yang , S. K. , Gelboin , H. V. , Trump , B. F. , Autrup , H. and Harris , C. C. 1977 . Metabolic activation of benzo(a)pyrene ad binding to DNA cultured human bronchus . Cancer Res. , 37 : 1210 – 1215 .
   PubMed Web of Science ®Google Scholar
• Young , S. L. 1976 . An isolated perfused rat lung preparation . Environ. Health Perspect. , 16 : 61 – 66 .
   PubMed Web of Science ®Google Scholar