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Original Articles

Toxicological evaluation of 4‐vinylcyclohexene. II. Induction of ovarian tumors in female B6C3F1 mice by chronic oral administration of 4‐vinylcyclohexene

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Pages 507-524 | Received 18 Jul 1986, Accepted 04 Nov 1986, Published online: 20 Oct 2009

References

  • American Conference of Governmental Industrial Hygienists . 1983 . TLVs: Threshold limit values for chemical substances and physical agents in the work environment with intended changes for 1983–84 , Cincinnati, Ohio : ACGIH .
  • Armitage , P. 1971 . Statistical Methods in Medical Research 362 – 365 .
  • Boorman , G. A. and Eustis , S. L. 1986 . “ The Pathology Working Group as a means for assuring pathology quality in toxicological studies ” . In Managing Conduct and Data Quality of Toxicology Studies , Edited by: Hoover , B. K. , Baldwin , J. K. , Uelner , A. F. , Whitmire , C. E. , Davies , C. L. and Bristol , D. W. 271 – 275 . Princeton, N.J. : Princeton Scientific .
  • Boorman , G. , Montogmery , C. Jr. , Hardisty , J. , Eustis , S. , Wolfe , M. and McConnell , E. 1985 . “ Quality assurance in pathology for rodent toxicology and carcinogenicity tests ” . In Handbook of Carcinogen Testing , Edited by: Milman , H. and Weisburger , E. 345 – 357 . Park Ridge, N.J. : Noyes .
  • Boyland , E. and Williams , K. 1965 . An enzyme catalysing the conjugation of epoxides with glutathione . Biochem. J. , 94 : 190 – 197 .
  • Bristol , D. W. 1986 . “ National Toxicology Program approach to monitoring study performance ” . In Managing Conduct and Data Quality of Toxicology Studies , Edited by: Hoover , B. K. , Baldwin , J. K. , Deiner , A. F. , Whitmire , C. E. , Davies , C. L. and Bristol , D. W. 79 – 97 . Princeton, N.J. : Princeton Scientific .
  • Collins , J. J. and Manus , A. G. 1987 . Toxicological evaluation of 4‐vinylcyclohexene. I. Prechronic (14‐day) and subchronic (13‐week) gavage studies in Fischer 344 rats and B6C3F1 mice . J. Toxicol. Environ. Health , 21 : 493 – 505 .
  • Cox , D. 1972 . Regression models and life tables . J. R. Sfat. Soc. , B34 : 187 – 220 .
  • Dunn , T. 1979 . “ Tumours of the adrenal gland ” . In Pathology of Tumours in Laboratory Animals, vol. II, Tumours of the Mouse , IARC Scientific Publication no. 23 vol. II , 475 – 486 . Lyon, , France : IARC .
  • El‐Tantawy , M. and Hammock , B. 1980 . The effect of hepatic microsomal and cytosolic subcellular fractions on the mutagenic activity of epoxide‐containing compounds in the Salmonella assay . Mutat. Res. , 79 : 59 – 71 .
  • Frantz , S. and Sinsheimer , J. 1981 . Bacterial mutagenicity and toxicity of cycloaliphatic epoxides . Mutat. Res. , 90 : 67 – 78 .
  • Fraser , D. and Rappaport , S. 1976 . Health aspects of the curing of synthetic rubbers . Environ. Health Perspect. , 17 : 45 – 53 .
  • Gart , J. , Chu , K. and Tarone , R. 1979 . Statistical issues in interpretation of chronic bioassay tests for carcinogenicity . J. Natl. Cancer Inst. , 62 : 957 – 974 .
  • Gervasi , P. , Abbondandolo , A. , Citti , L. and Turchi , G. Microsomal 4‐vinylcyclohexene monooxygenase and mutagenic activity of metabolic intermediates . Proc. Int. Conf. Industrial and Environmental Xenobiotics: Biotransformation and Pharmacokinetics . Edited by: Gut , I. pp. 205 – 210 . Berlin : Springer‐Verlag .
  • Giannarini , C. , Citti , L. , Gervasi , P. and Turchi , G. 1981 . Effects of 4‐vinylcyclohexene and its main oxirane metabolite on mouse enzymes and glutathione levels . Toxicol. Lett. , 8 : 115 – 121 .
  • Hardisty , J. F. and Boorman , G. A. 1986 . “ National Toxicology Program pathology quality assurance procedures ” . In Managing Conduct and Data Quality of Toxicology Studies , Edited by: Hoover , B. K. , Baldwin , J. K. , Uelner , A. F. , Whitmire , C. E. , Davies , C. L. and Bristol , D. W. 263 – 269 . Princeton, N.J. : Princeton Scientific .
  • Haseman , J. 1984 . Statistical issues in the design, analysis and interpretation of animal carcinogenicity studies . Environ. Health Perspect. , 58 : 385 – 392 .
  • Haseman , J. , Huff , J. and Boorman , G. 1984 . Use of historical control data in carcinogenicity studies in rodents . Toxicol. Pathol. , 12 : 126 – 135 .
  • Hayakawa , T. , Udenfriend , S. , Yagi , H. and Jerina , D. 1975 . Substrates and inhibitors of hepatic glutathione S‐epoxide transferase . Arch. Biochem. Biophys. , 170 : 438 – 451 .
  • Huff , J. , Melnick , R. , Solleveld , H. , Haseman , J. and Powers , M. 1985 . Multiple organ carcinogenicity of 1,3‐butadiene in B6C3F1 mice after 60 weeks of inhalation exposure . Science , 227 : 548 – 549 .
  • Kaplan , E. and Meier , P. 1958 . Nonparametric estimation of incomplete observations . J. Am. Stat. Assoc. , 53 : 457 – 481 .
  • Mantel , N. and Haenszel , W. 1959 . Statistical aspects of the analysis of data from retrospective studies of disease . J. Natl. Cancer Inst. , 22 : 719 – 748 .
  • Maronpot , R. and Boorman , G. 1982 . Interpretation of rodent hepatocellular tumors in chemical safety assessment . Toxicol. Pathol. , 10 : 71 – 80 .
  • Mortelmans , K. , Haworth , S. , Lawlor , T. , Speck , W. , Tainer , B. and Zeiger , E. 1986 . Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals . Environ. Mutagen. , 8 (suppl. 7) : 1 – 119 .
  • Murray , M. and Cummins , J. 1979 . Mutagenic activity of epoxy embedding reagents employed in electron microscopy . Environ. Mutagen. , 1 : 307 – 313 .
  • National Toxicology Program . 1984 . Toxicology and carcinogenesis studies of 1,3‐butadiene in B6C3F1 mice , NTP technical report no. 288 Research Triangle Park, N.C. : U.S. Department of Health and Human Services, Public Health Services, National Institutes of Health .
  • National Toxicology Program . 1986 . Toxicology and carcinogenesis studies of 4‐vinylcyclohexene in F344/N rats and B6C3F1 mice , NTP technical report no. 303 Research Triangle Park, N.C. : U.S. Department of Health and Human Services, Public Health Services, National Institutes of Health. Public Information, National Toxicology Program . P.O. Box 12233
  • Simmon , V. and Baden , J. 1980 . Mutagenic activity of vinyl compounds and derived epoxides . Mutat. Res. , 78 : 227 – 231 .
  • Tarone , R. 1975 . Tests for trend in life table analysis . Biometrika , 62 : 679 – 682 .
  • Turchi , C. , Bonatti , S. , Citti , L. , Gervasi , P. , Abbondandolo , A. and Presciuttini , S. 1981 . Alkylating properties and genetic activity of 4‐vinylcyclohexene metabolites and structurally related epoxides . Mutat. Res. , 83 : 419 – 430 .
  • Van Duuren , B. , Nelson , N. , Orris , L. , Palmes , E. and Schmitt , F. 1963 . Carcinogenicity of epoxides, lactones, and peroxy compounds . J. Natl. Cancer Inst. , 31 : 41 – 55 .
  • Van Duuren , B. , Langseth , L. , Goldschmidt , B. and Orris , L. 1967 . Carcinogenicity of epoxides, lactones, and peroxy compounds. VI. Structure and carcinogenic activity . J. Natl. Cancer Inst. , 39 : 1217 – 1228 .
  • Voogd , C. , Van der Stel , J. and Jacobs , J. 1981 . The mutagenic action of alipathic epoxides . Mutat. Res. , 89 : 269 – 282 .
  • Watabe , T. , Hiratsuka , A. , Isobe , M. and Ozawa , N. 1980 . Metabolism of d‐limonene by hepatic microsomes to non‐mutagenic epoxides toward . Salmonella typhimurium. Biochem. Pharmacol. , 29 : 1068 – 1071 .
  • Watabe , T. , Hiratsuka , A. , Ozawa , N. and Isobe , M. 1981 . A comparative study on the metabolism of d‐limonene and 4‐vinylcyclohex‐1‐ene by hepatic microsomes . Xenobiotica , 11 : 333 – 344 .

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