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Original Articles

Transplacental and mammary passage of radioactivity in rats treated vaginally and orally with [14C]propranolol

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Pages 1-18 | Received 05 Jan 1987, Accepted 14 Aug 1987, Published online: 20 Oct 2009

References

  • Ananth , J. 1978 . Side effects in the neonate from psychotropic agents excreted through breastfeeding . Am. J. Psychiatr. , 135 : 801 – 805 .
  • Anderson , P. O. and Salter , F. J. 1976 . Propranolol therapy during pregnancy and lactation . Am. J. Cardiol. , 37 : 325
  • Bauer , J. H. , Pape , B. , Zajicek , J. and Groshong , T. 1979 . Propranolol in human plasma and breast milk . Am. J. Cardiol. , 43 : 860 – 862 .
  • Bott‐Kanner , G. , Schweitzer , A. , Schoenfeld , A. , Joel‐Cohen , J. and Rosenfeld , J. B. 1978 . Treatment with propranolol and hydrallazine throughout pregnancy in a hypertensive patient: A case report . Isr. J. Med. Sri. , 14 : 466 – 468 .
  • Bott‐Kanner , G. , Schweitzer , A. , Reisner , S. H. , Joel‐Cohen , S. J. and Rosenfeld , J. B. 1980 . Propranolol and hydrallazine in the management of essential hypertension in pregnancy . Br. J. Obstet Gynecol. , 87 : 110 – 114 .
  • Campbell , J. W. 1985 . A possible teratogenic effect of propranolol . N. Engl. J. Med. , 313 : 518
  • Chen , T. W. , Huang , T. P. , Yand , W. C. and Hong , C. Y. 1985 . Propranolol intoxication: Three cases’ experiences . Vet. Hum. Toxicol. , 27 : 528 – 530 .
  • Cottrill , C. N. , McAllister , R. G. Jr. , Gettes , L. and Noonan , J. A. 1977 . Propranolol therapy during pregnancy, labor, and delivery: Evidence for transplacental drug transfer and impaired neonatal drug disposition . J. Pediatr. , 91 : 812 – 814 .
  • Ehrnebo , M. , Agurell , S. , Jailing , B. and Boréus , L. O. 1971 . Age differences in drug binding by plasma proteins: Studies on human foetuses, neonates and adults . Eur. J. Clin. Pharmacol. , 3 : 189 – 193 .
  • Eliahou , H. E. , Silverberg , D. S. , Reisin , E. , Romem , I. , Mashiach , S. and Seer , D. M. 1978 . Propranolol for the treatment of hypertension in pregnancy . Br. J. Obstet. Gynecol. , 85 : 431 – 436 .
  • Erkkola , R. , Lammintausta , R. , Liukko , P. and Antilla , M. 1982 . Transfer of propranolol and satolol across the human placenta . Acta Obstet. Gynecol. Scand. , 61 : 31 – 34 .
  • Fiddler , G. I. 1974 . Propranolol and pregnancy . Lancet , 2 : 722 – 723 .
  • Gladstone , G. R. , Hordof , A. and Gersony , W. M. 1975 . Propranolol administration during pregnancy: Effects on the fetus . J. Pediatr. , 86 : 962 – 964 .
  • Habib , A. and McCarthy , J. S. 1977 . Effects on the neonate of propranolol administered during pregnancy . J. Pediatr. , 91 : 808 – 811 .
  • Hayes , A. and Cooper , R. G. 1971 . Studies on the absorption, distribution and excretion of propranolol in rat, dog and monkey . J. Pharmacol. Exp. Ther. , 176 : 302 – 311 .
  • Hong , C. Y. , Chaput De Saintonge , D. M. and Turner , P. 1981 . The inhibitory action of procaine, (+)‐propranolol and (±)‐propranolol on human sperm motility: Antagonism by caffeine . Br. J. Clin. Pharmacol. , 12 : 751 – 753 .
  • Hong , C. Y. , Yang , W. C. and Chiang , B. N. 1983 . Importance of membrane stabilizing effect in massive overdose of propranolol: Plasma level study in a fatal case . Hum. Toxicol. , 2 : 511 – 517 .
  • Imoto , R. M. 1980 . Digoxin, propranolol, quinidine, and pregnancy . Drug Intell. Clin. Pharm. , 14 : 100 – 101 .
  • Jensen , O. H. 1984 . Fetal heart rate response to a controlled sound stimulus after propranolol administration to the mother . Acta Obstet. Gynecol. Scand. , 63 : 199 – 202 .
  • Joelsson , I. , Barton , M. D. , Daniel , S. , James , S. and Adamsons , K. 1972 . The response to the unanesthetized sheep fetus to sympathomimetic amines and adrenergic blocking agents . Am. J. Obstet. Gynecol. , 114 : 43 – 50 .
  • Kirkpatrick , F. H. , Gordesky , S. E. and Marinetti , G. F. 1974 . Differential solubilization of proteins, phospholipids, and cholesterol of erythrocyte membranes by detergents . Biochim. Biophys. Acta , 345 : 154 – 161 .
  • Kristinsson , J. and Johannesson , T. 1977 . A case of fatal propranolol intoxication . Acta Pharmacol. Toxicol. , 41 : 190 – 192 .
  • Langer , A. , Hung , C. T. , McA'nulty , J. A. , Harrigan , J. T. and Washington , E. 1974 . Adrenergic blockade: A new approach to hyperthyroidism during pregnancy . Obstet. Gynecol. , 44 : 181 – 186 .
  • Levitan , A. A. and Manion , J. C. 1973 . Propranolol therapy during pregnancy and lactation . Am. J. Cardiol. , 32 : 247
  • Lieberman , B. A. , Stirrat , G. M. , Cohen , S. L. , Beard , R. W. , Pinker , G. D. and Belsey , E. 1978 . The possible adverse effect of propranolol on the fetus in pregnancies complicated by severe hypertension . Br. J. Obstet. Gynecol. , 85 : 678 – 683 .
  • Marshall , A. W. , Mihaly , G. W. , Smallwood , R. A. , Morgan , D. J. and Hardy , K. J. 1981 . Fetal hepatic function: The disposition of propranolol in the pregnant sheep . Res. Commun. Chem. Pathol. Pharmacol. , 32 : 3 – 25 .
  • Masuoka , D. and Hansson , E. 1967 . Autoradiographic distribution studies of adrenergic blocking agents. II. 14C‐propranolol, a β‐receptor‐type blocker . Acta Pharmacol. Toxicol. , 25 : 447 – 455 .
  • McNay , J. L. , Fuller , E. , Kishimoto , T. , Malveax , E. and Dayton , P. G. 1969 . Lack of active transfer of 14C‐tetraethylammonium and para‐aminohippuric acid by the term sheep placenta . Proc. Soc. Exp. Biol. Med. , 131 : 51 – 56 .
  • O'Connor , P. C. , Jick , H. , Hunger , J. R. , Stergachis , A. and Madsen , S. 1981 . Propranolol and pregnancy outcome . Lancet , 2 : 1168
  • Patel , L. G. , Warrington , S. J. and Pearson , R. M. 1983 . Propranolol concentrations in plasma after insertion into the vagina . Br. Med. J. , 287 : 1247 – 1248 .
  • Pearson , R. M. , Hong , C. Y. , Patel , L. G. , Turner , P. , Potts , D. M. , Wheeler , R. and Zipper , J. 1984 . Studies on membrane‐active vaginal spermicides . Contracept. Deliv. Syst. , 5 : 303 – 309 .
  • Pruyn , S. C. , Phelan , J. P. and Buckanan , G. C. 1979 . Long‐term propranolol therapy in pregnancy: Maternal and fetal outcome . Am. J. Obstet. Gynecol. , 135 : 485 – 489 .
  • Reed , R. L. , Cheney , C. B. , Fearon , R. E. , Hook , R. and Hehre , F. W. 1974 . Case report . Anesthes. Analges. Current Res. , 53 : 214 – 218 .
  • Sabom , M. B. , Curry , R. C. and Wise , D. E. 1978 . Propranolol therapy during pregnancy in a patient with idiopathic hypertrophic subaortic stenosis: Is it safe? . South. Med. J. , 71 : 328 – 329 .
  • Sager , G. , Nilsen , O. B. and Jacobsen , S. 1979 . Variable binding of propranolol in human serum . Biochem. Pharmacol. , 28 : 905 – 911 .
  • Savage , R. L. 1977 . Drugs and breast milk . J. Human Nutr. , 31 : 459 – 464 .
  • Schoenfeld , N. , Epstein , O. , Nemesh , L. , Rosen , M. and Atsmon , A. 1978 . Effects of propranolol during pregnancy and development of rats. I. Adverse effects during pregnancy . Pediatr. Res. , 12 : 747 – 750 .
  • Schoenfeld , N. , Epstein , O. , Rosen , M. and Atsmon , A. 1985 . Effects of propranolol during pregnancy and development of rats. II. Adverse effects on development . Eur. J. Pediatr. , 143 : 194 – 195 .
  • Shand , D. G. , Evans , G. H. and Nies , A. S. 1971 . The almost‐complete hepatic extraction of propranolol during intravenous administration in the dog . Life Sci. , 10 : 1417 – 1421 .
  • Shand , D. G. , Rangno , R. E. and Evans , G. H. 1972 . The disposition of propranolol. II. Hepatic elimination in the rat . Pharmacology , 8 : 344 – 352 .
  • Sheppard , G. P. 1979 . High‐dose propranolol in schizophrenia . Br. J. Psychiat. , 134 : 470 – 476 .
  • Smith , R. C. and Berge , M. 1985 . Systemic absorption after intravaginal propranolol . Lancet , 1 : 112
  • Smith , M. T. , Livingstone , I. , Eadie , M. J. , Hooper , W. D. and Triggs , E. J. 1983a . Chronic propranolol administration during pregnancy: Maternal pharmacokinetics . Eur. J. Clin. Pharmacol. , 25 : 481 – 490 .
  • Smith , M. T. , Livingstone , I. , Eadie , E. J. , Hooper , W. D. and Triggs , E. J. 1983b . Metabolism of propranolol in the human maternal‐placental‐foetal unit . Eur. J. Clin. Pharmacol. , 24 : 727 – 732 .
  • Smith , M. T. , Livingstone , I. , Hooper , W. D. , Eadies , M. J. and Triggs , E. J. 1983c . Propranolol, propranolol glucuronide, and naphthoxylactic acid in breast milk and plasma . Ther. Drug Monit. , 5 : 87 – 93 .
  • Taylor , E. A. and Turner , P. 1981 . Anti‐hypertensive therapy with propranolol during pregnancy and lactation . Postgrad. Med. J. , 57 : 427 – 430 .
  • Tcherdakoff , P. H. and Kreft , C. 1977 . Utilisation du propranolol au cours de la grossesse . Med. Hyg. , 35 : 42 – 46 .
  • Turner , J. E. and Cravey , R. H. 1975 . A fatal case involving propranolol and codeine . Clin. Toxicol. , 8 : 271 – 275 .
  • Tynan , R. F. , Fisher , M. M. D. and Ibels , L. S. 1981 . Self‐poisoning with propranolol . Med. J. Aust. , 1 : 82 – 83 .
  • Walle , T. and Gaffney , T. E. 1972 . Propranolol metabolism in man and dog: Mass spectrometric identification of six new metabolites . Clin. Pharmacol. Ther. , 182 : 83 – 92 .
  • Walle , T. , Fagan , T. C. , Conradi , E. C. , Walle , U. K. and Gaffney , T. E. 1979 . Presystemic and systemic glucuronidation of propranolol . Clin. Pharmacol. Ther. , 26 : 167 – 172 .
  • Wilson , J. T. 1981 . “ Prevalence and advantages of breast feeding ” . In Drugs in Breast Milk , Edited by: Wilson , J. T. 2 – 3 . New York : Adis Press .
  • Yaffe , S. J. and Stern , L. 1976 . “ Clinical implications of perinatal pharmacology ” . In Perinatal Pharmacology and Therapeutics , Edited by: Mirkin , B. L. 355 – 428 . New York : Academic Press .
  • Zipper , J. , Bruzzone , M. E. , Angelo , S. , Munoz , V. and Wheeler , R. G. 1982 . Effect of topically applied adrenergic blockers on fertility . Int. J. Fertil. , 27 : 342 – 345 .
  • Zipper , J. , Wheeler , R. G. , Potts , D. M. and Rivera , M. 1983 . Propranolol as a novel, effective spermacide: Preliminary findings . Br. Med. J. , 287 : 1245 – 1246 .

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