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Original Articles

Inhibition of methyl isocyanate toxicity in mice by starvation and dexamethasone but not by sodium thiosulfate, atropine, and ethanol

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Pages 93-101 | Received 15 Apr 1987, Accepted 21 Aug 1987, Published online: 20 Oct 2009

References

  • Alarie , Y. , Ferguson , J. S. , Stock , M. F. , Weyel , D. A. and Schaper , M. 1987 . Sensory and pulmonary irritation by methyl isocyanate in mice and pulmonary irritation and possible cyanide‐like effects of methyl isocyanate in guinea pigs . Environ. Health Perspect. , 72 : 159 – 167 .
  • Alleyne , C. A. O. and Young , V. H. 1967 . Adrenocortical function in children with severe protein‐calorie malnutrition . Clin. Sci. , 33 : 189 – 200 .
  • Bellamy , D. , Leonard , R. A. , Dulieu , K. and Stevenson , A. 1968 . Starvation metabolism and plasma corticosterone with reference to the action of metoprione and propylthiouracil . Cen. Comp. Endocrinol. , 10 : 119 – 125 .
  • Bucher , J. R. , Gupta , B. N. , Schwetz , B. A. , Thompson , M. and Adkins , B. 1986 . Toxicity of inhaled methyl isocyanate (MIC) in F344/N rats and B6C3F1 mice . Toxicologist , 6 : 78
  • Dodd , D. E. , Fowler , E. H. , Snellings , W. M. , Pritts , I. M. and Baron , R. L. 1986 . Acute inhalation studies with methyl isocyanate vapor I. Methodology and LC50 determinations in guinea pigs, rats and mice . Fundam. Appl. Toxicol. , 6 : 747 – 755 .
  • Ferguson , J. S. , Schaper , M. , Stock , M. F. , Weyel , D. A. and Alarie , Y. 1986 . Sensory and pulmonary irritation with exposure to methyl isocyanate . Toxicol. Appl. Pharmacol. , 82 : 329 – 335 .
  • Flower , R. J. and Blackwell , C. J. 1979 . Anti‐inflammatory steroids induce biosynthesis of a phospholipase A2 inhibitor which prevents prostaglandin generation . Nature (Lond.) , 278 : 456 – 459 .
  • Fowler , E. H. and Dodd , D. E. 1986 . Acute inhalation studies with methyl isocyanate vapor II. Respiratory tract changes in guinea pigs, rats and mice . Fundam. Appl. Toxicol. , 6 : 756 – 771 .
  • Gupta , B. N. , Bucher , J. R. , Uriah , L. C. , Hall , L. B. and Boorman , G. A. 1986 . Pathologic changes in F344 rats following methyl isocyanate (MIC) inhalation . Toxicologist , 6 : 77
  • Haynes , R. C. and Murad , F. 1985 . “ Adrenocorticotropic hormone; Adrenocortical steroids and their synthetic analogs; Inhibitors of adrenocortical steroid biosynthesis ” . In Goodman and Cilman's The Pharmacological Basis of Therapeutics, , 7th ed. , Edited by: Gilman , A. G. , Goodman , L. S. and Gilman , A. 1459 – 1489 . New York : Macmillan .
  • Indian Council of Medical Research . 1986 . Health Effects of the Bhopal Gas Tragedy , 1 – 16 . New Delhi : ICMR .
  • James , C. W. , Schwetz , B. A. , Goehl , T. J. , Moorman , C. R. and Collins , B. J. 1986 . Lack of evidence for involvement of cyanide in methyl isocyanate (MIC) toxicity . Toxicologist , 6 : 76
  • Kamat , S. R. , Mahashur , A. A. , Tiwari , A. K. B. , Potdar , P. V. , Gaur , M. , Kolhatkar , V. P. , Vaidya , P. , Parmar , D. , Rupwate , R. , Chatterjee , T. S. , Jain , K. , Kelkar , M. D. and Kinare , G. 1985 . Early observations on the pulmonary changes and clinical morbidity due to the isocyanate gas leak at Bhopal . J. Postgrad. Med. , 31 : 63 – 72 .
  • Kimmerle , G. and Eben , A. 1964 . Zur toxicitat von methylisocyanat und dessen quantitativer be‐stimmung in der luft . Archiv. Toxikol. , 20 : 235 – 241 .
  • Marwick , C. 1985 . After coping with crisis, medicine ponders sequelae . J. Am. Med. Assoc. , 253 : 2003 – 2013 .
  • Nemery , B. , Dinsdale , D. , Sparrow , S. and Ray , D. 1985a . Effects of methyl isocyanate on the respiratory tract of rats . Br. J. Ind. Med. , 42 : 799 – 805 .
  • Nemery , B. , Sparrow , S. and Dinsdale , D. 1985b . Methyl isocyanate: Thiosulphate does not protect . Lancet , ii : 1245 – 1246 .
  • Salmon , A. G. 1986 . Bright red blood of Bhopal victims: Cyanide or MIC? . Br. J. Ind. Med. , 42 : 502
  • Salmon , A. G. , Muir , M. K. and Andersson , N. 1985 . Acute toxicity of methyl isocyanate: A preliminary study of the dose response for eye and other effects . Br. J. Ind. Med. , 42 : 795 – 798 .
  • Shasby , P. M. , Shasby , S. S. and Peach , M. J. 1985 . Polymorphonuclear leukocyte: Arachidonate edema . J. Appl. Physiol. , 59 : 47 – 55 .
  • Silver , M. J. , Hoch , W. , Kocsis , J. J. , Ingerman , C. M. and Smith , J. B. 1974 . Arachidonic acid causes sudden death in rabbits . Science , 183 : 1085 – 1086 .
  • Sutcliffe , M. 1985 . An eye witness in Bhopal . Br. Med. J. , 290 : 1883 – 1884 .
  • Varma , D. R. 1987 . “ Anatomy of the methyl isocyanate leak in Bhopal ” . In Hazard Assessment of Chemicals , Edited by: Saxena , J. vol. 5 , 233 – 289 . New York : Hemisphere .
  • Varma , D. R. and Mulay , S. 1981 . Decreased liver cytosol glucocorticoid receptors in protein‐deficient rats . Life Sci. , 28 : 2719 – 2725 .
  • Varma , D. R. , Ferguson and Alarie , Y. 1987 . Reproductive toxicity of methyl isocyanate (MIC) in mice . J. Toxicol. Environ. Health , 21 : 265 – 275 .
  • Yue , T. L. , Varma , D. R. and Powell , W. S. 1983 . Effects of protein deficiency on the metabolism of arachidonic acid by rat pleural polymorphonuclear leukocytes . Biochim. Biophys. Acta , 751 : 332 – 339 .

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