Pathology reevaluation of the kociba et al. (1978) bioassay of 2,3,7,8‐TCDD: Implications for risk assessment

References

• Bayard , S. P. 1988 . “ Quantitative implications of the use of different extrapolation procedures for low‐dose cancer risk estimates from exposure to 2,3,7,8‐TCDD ” . In A Cancer Risk‐Specific Dose Estimate for 2,3,7,8‐TCDD. Review Draft. Appendix A , EPA/600/6–88/007Aa and Ab Washington, D.C. : U.S. Environmental Protection Agency, Office of Health and Environmental Assessment .
   Google Scholar
• Birnbaum , L. S. , McDonald , M. M. , Blair , P. C. , Clark , A. M. and Harris , M. W. 1990 . Differential toxicity of 2,3,7,7‐tetrachlorodibenzo‐p‐dioxin (TCDD) in C57BL/6J mice cogenic at the Ah locus . Fundam. Appl. Toxicol. , 15 : 186 – 200 .
   PubMedGoogle Scholar
• Bond , G. G. , Bodner , K. M. and Cook , R. R. 1989 . Phenoxy herbicides and cancer: Insufficient epidemiologic evidence for a causal relationship . Fundam. Appl. Toxicol. , 12 : 172 – 188 .
   PubMedGoogle Scholar
• Bonvalot , Y. , Abenhaim , L. and Bard , D. 1989 . Uncertainty in quantitative carcinogenic risk assessment procedures for 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin . Chemosphere , 19 : 623 – 628 .
   Web of Science ®Google Scholar
• Bookstaff , R. C. , Kamel , F. , Moore , R. W. , Bjerke , D. L. and Peterson , R. E. 1990 . Altered regulation of pituitary gonadotropin‐releasing hormone (GnRH) receptor number and pituitary responsiveness to GnRH in 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin‐treated male rats . Toxicol. Appl. Pharmacol. , 105 : 78 – 92 .
   PubMed Web of Science ®Google Scholar
• Brown , S. L. , Brett , S. M. , Gough , M. , Rodericks , J. V. , Tardiff , R. G. and Turnball , D. 1988 . Review of interspecies risk comparisons . Regul. Toxicol. Pharmacol. , 8 : 191 – 206 .
   PubMed Web of Science ®Google Scholar
• Cook , J. C. , Gaido , K. W. and Greenlee , W. F. 1987 . Ah receptor: Relevance of mechanistic studies to human risk assessment . Environ. Health Perspect. , 76 : 71 – 77 .
   PubMed Web of Science ®Google Scholar
• Crouch , E. and Wilson , R. 1979 . Interspecies comparison of carcinogenic potency . J. Toxicol. Environ. Health. , 5 : 1095 – 1118 .
   PubMed Web of Science ®Google Scholar
• Crump , K. , Allen , B. and Shipp , A. 1989 . Choice of dose measure for extrapolating carcinogenic risk from animals to humans: An empirical investigation of 23 chemicals . Health Phys. , 57 : 387 – 393 .
   PubMed Web of Science ®Google Scholar
• Denison , M. S. , Fisher , J. M. and Whitlock , J. P. 1988 . The DNA recognition site for the dioxin‐Ah receptor complex: Nucleotide sequence and functional analysis . J. Biol Chem. , 263 : 17,221 – 17,224 .
   Google Scholar
• Di Domenico , A. 1990 . Guidelines for the definition of environmental action alert thresholds for polychlorodibenzodioxins and polychlorodibenzofurans . Regul. Toxicol. Pharmacol. , 11 : 8 – 23 .
   PubMed Web of Science ®Google Scholar
• Farber , E. 1987 . Pathogenesis of experimental liver cancer: Comparison with humans . Mouse Liver Tumors Arch. Toxicol. Suppl. , 10 : 281 – 288 .
   PubMedGoogle Scholar
• Fingerhut , M. A. , Halperin , W. E. , Marlow , D. A. , Piacitelli , L. A. , Honchar , P. A. , Sweeney , M. H. , Griefe , A. L. , Dill , P. A. , Steenland , K. and Suruda , A. J. January 1991a . “ Mortality Among U.S. Workers Employed in the Production of Chemicals Contaminated with 2,3,7,8‐Tetrachlorodibenzo‐p‐dioxin (TCDD) ” . NTIS PB91–125971 January , Final Report, U.S. Department of Health and Human Services, National Institute for Occupational Safety and Health .
   Google Scholar
• Fingerhut , M. A. , Halperin , W. E. , Marlow , D. A. , Piacitelli , L. A. , Honchar , P. A. , Sweeney , M. H. , Griefe , A. L. , Dill , P. A. , Steenland , K. and Suruda , A. J. 1991b . Cancer mortality in workers exposed to 2,3,7,8‐tetrachloro‐dibenzo‐p‐dioxin . N. Engl. J. Med. , 324 : 212 – 218 .
   PubMed Web of Science ®Google Scholar
• Flodstrom , S. and Ahlborg , U.G. 1989 . Tumor promoting effects of 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin (TCDD)—Effects of exposure duration, administration schedule, and type of diet . Che‐mospherer , 19 : 779 – 783 .
   Web of Science ®Google Scholar
• Fries , G. F. and Paustenbach , D. J. 1990 . Evaluation of potential transmission of 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin‐contaminated incinerator emissions to humans via food . J. Toxicol. Environ. Health , 29 : 1 – 43 .
   PubMed Web of Science ®Google Scholar
• Gart , J. J. , Krewski , D. , Lee , P. N. , Tarone , R. E. and Wahrendorf , J. 1986 . Statistical Methods in Cancer Research. III. The Design and Analysis of Long‐Term Animal Experiments , Lyon , , France : International Agency for Research on Cancer .
   Google Scholar
• Gallo , M. 1988 . “ Rationale for a hormone‐like mechanism of 2,3,7,8‐TCDD for use in risk assessment ” . In A Cancer Risk‐Specific Dose Estimate for 2,3,7,8‐TCDD. Review Draft. Appendix F , EPA/600/6–88/007Aa and Ab. Washington, D.C. : U.S. Environmental Protection Agency, Office of Health and Environmental Assessment .
   Google Scholar
• Geiger , L. E. and Neal , R. A. 1981 . Mutagenicity testing of 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin in histidine auxotrophs of Salmonella typhimurium . Toxicol. Appl. Pharmacol. , 59 : 125 – 129 .
   PubMed Web of Science ®Google Scholar
• Goldstein , J. A. , Lin , F. H. , Stohs , S. J. , Graham , M. , Clarke , G. , Birnbaum , L. S. and Lucier , G. W. 1990 . “ The effects of TCDD on receptors for epidermal growth factor, glucocorticoid, and estrogen in Ah‐responsive and ‐nonresponsive congenic mice and the effects of TCDD on estradiol metabolism in a liver tumor promotion model in female rats ” . In Mouse Liver Carcinogenesis: Mechanisms and Species Comparisons , Edited by: Stevenson , D. E. , Popp , J. A. , Ward , J. M. , McClain , R. M. , Slaga , T. J. and Pitot , H. C. 187 – 202 . New York : Wiley‐Liss .
   Google Scholar
• Greenlee , W. F. 1988 . Dioxin carcinogenesis—A perspective . CIIT Activities , 8 : 1 – 6 .
   Google Scholar
• Greenlee , W. F. , Skopek , T. R. , Gaido , K. and Walker , C. 1990 . “ Comparative genetic mechanisms of 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin (TCDD)‐induced tumors ” . In Mouse Liver Carcinogenesis: Mechanisms and Species Comparisons , Edited by: Stevenson , D. E. , Popps , J. A. , Ward , J. M. , McClain , R. M. , Slaga , T. J. and Pitot , H. C. 177 – 186 . New York : Wiley‐Liss .
   Google Scholar
• Harris , M. , Zacharewski , T. , Piskorska‐Pliszczynska , J. , Rosengren , R. and Safe , S. 1990 . Structure‐dependent induction of aryl hydrocarbon hydroxylase activity in C57BL/6 mice by 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin and related congeners: Mechanistic studies . Toxicol. Appl. Pharmacol. , 105 : 243 – 253 .
   PubMed Web of Science ®Google Scholar
• Haseman , J. K. 1990 . Use of statistical decision rules for evaluating laboratory animal carcinogenic‐ity studies . Fundam. Appl. Toxicol. , 14 : 637 – 648 .
   PubMedGoogle Scholar
• Holder , J. W. and Menzel , H. M. 1989 . Analysis of 2,3,7,8‐TCDD tumor promotion activity and its relationship to cancer . Chemosphere , 19 : 861 – 868 .
   Web of Science ®Google Scholar
• Howe , R. B. , Crump , K. S. and Landingham , C. V. 1986 . Global'86. A Computer Program to Extrapolate Quantal Animal Toxicity Data to Low Doses , Ruston , La. : K. S. Crump and Company, Inc. .
   Google Scholar
• Keenan , R. E. , Wenning , R. J. and Parsons , A. H. November 28 1989 . “ Sensitivity Analysis for Dioxin Risk Assessment and Implications for Determining Acceptable Levels of Daily Exposure ” . November 28 , Augusta , Me. : State of Maine Department of Health Services, Scientific Advisory Panel . Submitted to
   Google Scholar
• Kimbrough , R. D. , Falk , H. , Stehr , P. and Fries , G. F. 1984 . Health implications of 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin (TCDD) contamination of residential soil . J. Toxicol. Environ. Health , 14 : 47 – 93 .
   PubMed Web of Science ®Google Scholar
• Kimbrough , R. D. 1990 . How toxic is 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin to humans? . J. Toxicol. Environ. Health , 30 : 261 – 271 .
   PubMed Web of Science ®Google Scholar
• Kociba , R. J. , Keyes , D. G. , Beyer , J. E. , Carreon , R. M. , Wade , C. E. , Dittenber , D. A. , Kalnins , R. P. , Frauson , L. E. , Park , C. N. , Barnard , S. D. , Hummel , R. A. and Humistan , C. G. 1978 . Results of a two‐year chronic toxicity and oncogenicity study of 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin in rats . Toxicol. Appl. Pharmacol. , 46 : 279 – 303 .
   PubMed Web of Science ®Google Scholar
• Leung , H‐W. , Ku , R. H. , Paustenbach , D. J. and Anderson , M. E. 1988 . A physiologically based pharmacokinetic model for 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin in C57BL/6J and DBA/2J mice . Toxicol. Lett. , 42 : 15 – 28 .
   PubMed Web of Science ®Google Scholar
• Leung , H‐W. , Paustenbach , D. J. , Murray , F. J. and Anderson , M. E. 1990a . A physiological pharmacokinetic description of the tissue distribution and enzyme‐inducing properties of 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin in the rat . Toxicol. Appl. Pharmacol. , 103 : 399 – 410 .
   PubMed Web of Science ®Google Scholar
• Leung , H.‐W. , Poland , A. , Paustenbach , D. J. , Murray , F. J. and Anderson , M. E. 1990b . Pharmacoki‐netics of [125l]‐2‐iodo‐3,7,8‐trichlorodibenzo‐p‐dioxin in mice: Analysis with a physiological modeling approach . Toxicol. Appl. Pharmacol. , 103 : 411 – 419 .
   PubMed Web of Science ®Google Scholar
• Lin , F. H. , Stohs , S. J. , Birnbaum , L. S. , Clark , G. , Lucier , G. W. and Goldstein , J. A. 1991 . The effects of 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin (TCDD) on the hepatic estrogen and glucocorticoid re‐ceptors in congenic strains of Ah responsive and Ah nonresponsive C57BL/B6 mice . Toxicol. Appl. Pharmacol. , 108 : 129 – 139 .
   PubMed Web of Science ®Google Scholar
• Loehr , R. C. November 28 1989 . “ Letter from Mr. R. C. Loehr, Chair, Executive Committee ” . November 28 , U.S. EPA Science Advisory Board, to Mr. William Reilly, Administrator, U.S. EPA .
   Google Scholar
• Maronpot , R. R. , Montgomery , C. A. , Boorman , G. A. and McConnell , E. E. 1986 . National Toxicology Program nomenclature for hepatoproliferative lesions of rats . Toxicol. Pathol. , 14 : 263 – 273 .
   PubMedGoogle Scholar
• McConnell , E. E. , Solleveld , H. A. , Swenberg , J. A. and Boorman , G. A. 1988 . “ Guidelines for combining neoplasms for evaluation of rodent carcinogenesis studies ” . In Carcinogenicity, The Design, Analysis, and Interpretation of Long‐Term Animal Studies , Edited by: Grice , H. C. and Cimineri , J. L. 183 – 196 . New York : Springer‐Verlag .
   Google Scholar
• Meistrich , M. L. 1988 . Estimation of human reproductive risk from animal studies: Determination of interspecies extrapolation factors for steroid hormone effects on the male . Risk Anal. , 8 : 27 – 33 .
   PubMed Web of Science ®Google Scholar
• Mordenti , J. 1986 . Man versus beast: Pharmacokinetic scaling in mammals . J. Pharmacol. Sci. , 75 : 1028 – 1040 .
   PubMed Web of Science ®Google Scholar
• Pathology Working Group . March 13 1990a . “ Pathology Working Group Report on 2,3,7,8‐Tetrachlorodibenzo‐p‐dioxin Chronic Toxicity/Carcinogenicity Study in Sprague‐Dawley Rats ” . Edited by: Sauer , R. M. March 13 , PWG Chairperson, PATHCO, INC. . and submitted to R. A. Michaels, Chairperson, Maine Scientific Advisory Panel
   Google Scholar
• Pathology Working Group . April 27 1990b . “ Hepatotoxicity in Female Sprague‐Dawley Rats Treated with 2,3,7,8‐Tetrachlorodibenzo‐p‐dioxin (TCDD) ” . Edited by: Sauer , R. M. April 27 , PWG Chairperson, and D. G. Goodman, PATHCO, INC. . and submitted to R. A. Michaels, Chairperson, Maine Scientific Advisory Panel
   Google Scholar
• Paustenbach , D. J. , Layard , M. W. , Wenning , R. J. and Keenan , R. E. 1991 . Risk assessment of 2,3,7,8‐TCDD using a biologically‐based cancer model: A re‐evaluation of the Kociba et al. (1978) bioassay using 1978 and 1990 histopathology criteria . J. Toxicol. Environ. Health , 34 : 11 – 26 .
   PubMed Web of Science ®Google Scholar
• Paustenbach , D. J. , Shu , H. P. and Murray , F. J. 1986 . A critical examination of assumptions used in risk assessments of dioxin contaminated soil . Regul. Toxicol. Pharmacol. , 6 : 284 – 307 .
   PubMed Web of Science ®Google Scholar
• Pitot , H. C. , Goldsworthy , T. , Campbell , H. A. and Poland , A. 1980 . Quantitative evaluation of the promotion by 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin of hepatocarcinogenesis from diethylnitrosamine . Cancer Res. , 40 : 3616 – 3620 .
   PubMed Web of Science ®Google Scholar
• Poland , A. and Glover , E. 1979 . An estimate of the maximum in vivo covalent binding of 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin to rat liver protein, ribosomal RNA, and DNA . Cancer Res. , 39 : 3341 – 3344 .
   PubMed Web of Science ®Google Scholar
• Poland , A. , Glover , E. and Glende , A. S. 1976 . Stereo‐specific, high affinity binding of 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin by hepatic cytosol . J. Biol. Chem. , 247 : 1125 – 1137 .
   Google Scholar
• Poland , A. and Knutson , J. C. 1982 . 2,3,7,8‐Tetrachlorodibenzo‐p‐dioxin and related halogenated aromatic hydrocarbons: Examination of the mechanism of toxicity . Annu. Rev. Pharmacol. , 22 : 517 – 554 .
   Google Scholar
• Poland , A. , Palen , D. and Glover , E. 1982 . Tumour promotion by TCDD in skin of HRS/J hairless mice . Nature , 300 : 271 – 273 .
   PubMed Web of Science ®Google Scholar
• Poland , A. , Teitelbaum , P. and Glover , E. 1989a . The [125l]‐2‐iodo‐3,7,8‐trichlorodibenzo‐p‐dioxin binding species in mouse liver induced by agonists for the Ah receptor: Characterization and identification . Mol. Pharmacol. , 36 : 113 – 120 .
   PubMed Web of Science ®Google Scholar
• Poland , A. , Teitelbaum , P. , Glover , E. and Kende , A. 1989b . Stimulation of in vivo hepatic uptake and in vitro hepatic binding of [125l]‐2‐iodo‐3,7,8‐trichlorodibenzo‐p‐dioxin by the administration of agonists for the ah receptor . Mol. Pharmacol. , 36 : 121 – 127 .
   PubMed Web of Science ®Google Scholar
• Portier , C. J. , Hoel , D. G. and Ryzin , J. V. 1984 . “ Statistical analysis of the carcinogenesis bioassay data relating to the risks from exposure to 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin ” . In Public Health Risks of the Dioxins , Edited by: Lowrance , W. W. 99 – 120 . Los Altos , Calif. : William Kaufmann .
   Google Scholar
• Randerath , K. , Putnam , K. L. , Randerath , E. , Mason , G. , Kelley , M. and Safe , S. 1988 . Organ‐specific effects of long term feeding of 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin and 1,2,3,7,8‐pentachlorodibenzo‐p‐dioxin on l‐compounds in hepatic and renal DNA of female Sprague‐Dawley rats . Carcinogenesis , 9 : 2285 – 2289 .
   PubMed Web of Science ®Google Scholar
• Randerath , K. , Putnam , K. L. , Randerath , E. , Zacharewski , T. , Harris , M. and Safe , S. 1990 . Effects of 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin on l‐compounds in hepatic DNA of Sprague‐Dawley rats: Sex‐specific effects and structure‐activity relationships . Toxicol. Appl. Pharmacol. , 103 : 271 – 280 .
   PubMed Web of Science ®Google Scholar
• Reilly , W. K. April 10 1991 . “ Memorandum to E. W. Bretthauer, U.S. EPA Assistant Administrator for Research and Development, from W. K. Reilly, U.S. EPA Administrator ” . April 10 , Washington, D.C.
   Google Scholar
• Roberts , L. 1991 . Dioxin risks revisited . Science , 251 : 624 – 626 .
   PubMed Web of Science ®Google Scholar
• Romkes , M. and Safe , S. 1988 . Comparative activities of 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin and progesterone as antiestrogens in the female rat uterus . Toxicol. Appl. Pharmacol. , 92 : 368 – 380 .
   PubMed Web of Science ®Google Scholar
• Scheuplein , R. J. October 21–24 1990 . “ Statement of the outcome of The Banbury Conference “Biological Basis for Risk Assessment of Dioxins and Related Compounds,”; Cold Spring Harbor Laboratory ” . October 21–24 , Cold Spring Harbor , N.Y.
   Google Scholar
• Shu , H. P. , Paustenbach , D. J. and Murray , F. J. 1987 . A critical evaluation of the use of mutagenesis, carcinogenesis, and tumor promotion data in a cancer risk assessment of 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin . Regul. Toxicol. Pharmacol. , 7 : 57 – 88 .
   PubMed Web of Science ®Google Scholar
• Sielken , R. L. 1987 . Quantitative cancer risk assessments for 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin (TCDD) . Food Chem. Toxicol. , 25 : 257 – 267 .
   PubMed Web of Science ®Google Scholar
• Silbergeld , E. K. and Gasiewicz , T. A. 1989 . Dioxins and the Ah receptor . Am. J. Ind. Med. , 16 : 455 – 474 .
   PubMed Web of Science ®Google Scholar
• Squire , R. A. 1980 . “ Pathological evaluations of selected tissues from the Dow Chemical TCDD and 2,4,5‐T rat studies ” . Submitted to Carcinogen Assessment Group, U.S. EPA . (Cited in U.S. EPA, 1985)
   Google Scholar
• Squire , R. A. and Leavitt , M. H. 1975 . Report of a workshop on classification of specific hepatocellular lesions in rats . Cancer Res. , 35 : 3214 – 3223 .
   PubMed Web of Science ®Google Scholar
• Sunahara , G. I. , Lucier , G. W. , McCoy , Z. , Bresnick , E. H. , Sanchez , E. R. and Nelson , K. G. 1989 . Characterization of 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin mediated decrease in dexamethasone binding to rat hepatic cytosolic glucocorticoid receptors . Mol. Pharmacol. , 36 : 239 – 247 .
   PubMed Web of Science ®Google Scholar
• Tollefson , L. 1991 . Use of epidemiology data to assess the cancer risk of 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin . Regul. Toxicol. Pharmacol. , 13 : 150 – 169 .
   PubMed Web of Science ®Google Scholar
• Umbreit , T. H. and Gallo , M. J. 1988 . Physiological implications of estrogen receptor modulation by 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin . Toxicol. Lett. , 42 : 5 – 14 .
   PubMed Web of Science ®Google Scholar
• U.S. Environmental Protection Agency . 1984 . “ Ambient water quality criteria for 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin. EPA 440/5–84/007. Office of Water Regulations and Standards ” . Washington, D.C. : Environmental Protection Agency .
   Google Scholar
• U.S. Environmental Protection Agency . 1985 . Health Assessment Document for Polychlorinated Dibenzo‐p‐Dioxins , EPA/600/8–84/014F Washington, D.C. : Office of Health and Environmental Assessment .
   Google Scholar
• U.S. Environmental Protection Agency . 1986 . Guidelines for carcinogen risk assessment . Fed. Reg. , 45 : 79,347 – 79,357 .
   Google Scholar
• U.S. Environmental Protection Agency . 1988 . A Cancer Risk‐Specific Dose Estimate for 2,3,7,8‐TCDD. Review Draft , EPA/600/6–88/007Aa and Ab Washington, D.C. : Office of Health and Environmental Assessment .
   Google Scholar
• U.S. Food and Drug Administration . June 30 1983 . “ Statement by Sanford A. Miller, Director, Bureau of Foods, Food and Drug Administration, before the Subcommittee on Natural Resources, Agriculture, Research and Environment ” . June 30 , Committee on Science and Technology, U.S. House of Representatives .
   Google Scholar
• U.S. Food and Drug Administration . July 1986 . “ Biological Basis for Interspecies Extrapolation of Carcinogenicity Data. Prepared by Life Science Research Office & Federation of American Societies for Experimental Biology and submitted to the Center for Food Safety and Applied Nutrition ” . July , Washington, D.C. : Department of Health and Human Services .
   Google Scholar
• Vesselinovitch , S. D. and Negri , S. 1988 . Induction of focal and nodular liver lesions in rodents as an indication of human carcinogenic risk . Ann. N.Y. Acad. Sci. , 534 : 99 – 105 .
   PubMed Web of Science ®Google Scholar
• Wassom , J. S. , Huff , J. E. and Loprieno , N. 1978 . A review of the genetic toxicology of chlorinated dibenzo‐p‐dioxins . Mutat. Res. , 47 : 141 – 160 .
   Web of Science ®Google Scholar
• Yamamoto , K. R. 1985 . Steroid receptor‐regulated transcription of specific genes and gene networks . Annu. Rev. Genet , 19 : 209 – 252 .
   PubMed Web of Science ®Google Scholar
• Zober , A. , Messerer , P. and Huber , P. 1990 . Thirty‐four‐year mortality follow‐up of BASF employees exposed to 2,3,7,8‐TCDD after the 1953 accident . Int. Arch. Occup. Environ. Health , 62 : 139 – 157 .
   PubMed Web of Science ®Google Scholar